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fMRI temporal lobe epilepsy

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https://read.qxmd.com/read/30771725/impaired-prefrontal-cortex-thalamus-pathway-in-intractable-temporal-lobe-epilepsy-with-aberrant-executive-control-function-mri-evidence
#1
Chao Zhang, Haiyan Zhang, Kai Xu, Hongyu Yang, Chang Liu, Tao Yu, Nan Chen, Kuncheng Li
OBJECTIVES: This study aimed to assess structural and functional connectivity alterations of the prefrontal cortex (PFC)-thalamus axis in individuals with unilateral intractable temporal lobe epilepsy (TLE) showing executive control function (ECF) impairment and to explore the potential mechanism. METHODS: Thirty-eight individuals with intractable left TLE and twenty-nine healthy controls (HCs) were recruited for diffusion tensor imaging (DTI) and resting-state fMRI (rs-fMRI) scanning...
January 18, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/30740666/fmri-prediction-of-naming-change-after-adult-temporal-lobe-epilepsy-surgery-activation-matters
#2
Xiaozhen You, Ashley N Zachery, Eleanor J Fanto, Gina Norato, Sierra C Germeyan, Eric J Emery, Leigh N Sepeta, Madison M Berl, Chelsea L Black, Edythe Wiggs, Kareem Zaghloul, Sara K Inati, William D Gaillard, William H Theodore
OBJECTIVE: We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability. METHOD: Thirty-five adults (mean age 37.5 ± 10.9 years, 13 male) with temporal lobe epilepsy completed a preoperative fMRI auditory description decision task, which reliably activates frontal and temporal language networks...
February 11, 2019: Epilepsia
https://read.qxmd.com/read/30734849/machine-learning-identifies-rsfmri-epilepsy-networks-in-temporal-lobe-epilepsy
#3
Rose Dawn Bharath, Rajanikant Panda, Jeetu Raj, Sujas Bhardwaj, Sanjib Sinha, Ganne Chaitanya, Kenchaiah Raghavendra, Ravindranadh C Mundlamuri, Arivazhagan Arimappamagan, Malla Bhaskara Rao, Jamuna Rajeshwaran, Kandavel Thennarasu, Kaushik K Majumdar, Parthasarthy Satishchandra, Tapan K Gandhi
OBJECTIVES: Experimental models have provided compelling evidence for the existence of neural networks in temporal lobe epilepsy (TLE). To identify and validate the possible existence of resting-state "epilepsy networks," we used machine learning methods on resting-state functional magnetic resonance imaging (rsfMRI) data from 42 individuals with TLE. METHODS: Probabilistic independent component analysis (PICA) was applied to rsfMRI data from 132 subjects (42 TLE patients + 90 healthy controls) and 88 independent components (ICs) were obtained following standard procedures...
February 8, 2019: European Radiology
https://read.qxmd.com/read/30666753/structural-and-functional-asymmetry-of-medial-temporal-subregions-in-unilateral-temporal-lobe-epilepsy-a-7t-mri-study
#4
Preya Shah, Danielle S Bassett, Laura E M Wisse, John A Detre, Joel M Stein, Paul A Yushkevich, Russell T Shinohara, Mark A Elliott, Sandhitsu R Das, Kathryn A Davis
Mesial temporal lobe epilepsy (TLE) is a common neurological disorder affecting the hippocampus and surrounding medial temporal lobe (MTL). Although prior studies have analyzed whole-brain network distortions in TLE patients, the functional network architecture of the MTL at the subregion level has not been examined. In this study, we utilized high-resolution 7T T2-weighted magnetic resonance imaging (MRI) and resting-state BOLD-fMRI to characterize volumetric asymmetry and functional network asymmetry of MTL subregions in unilateral medically refractory TLE patients and healthy controls...
January 21, 2019: Human Brain Mapping
https://read.qxmd.com/read/30653664/real-time-effects-of-interictal-spikes-on-hippocampus-and-amygdala-functional-connectivity-in-unilateral-temporal-lobe-epilepsy-an-eeg-fmri-study
#5
Xin Tong, Dongmei An, Fenglai Xiao, Du Lei, Running Niu, Wei Li, Jiechuan Ren, Wenyu Liu, Yingying Tang, Le Zhang, Baiwan Zhou, Qiyong Gong, Dong Zhou
OBJECTIVE: To explore the real-time effects of interictal epileptiform discharges (IEDs) on hippocampus and amygdala functional connectivity (FC) in unilateral temporal lobe epilepsy (TLE). METHODS: Patients with unilateral TLE were recruited and underwent simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) scanning. Simultaneous EEG was used to define the prespike (10 s before spike) and postspike (10 s after spike) periods. Dynamic FC analysis was applied using the left/right hippocampus and amygdala separately as a seed region to map the network alterations after IED occurrence...
January 17, 2019: Epilepsia
https://read.qxmd.com/read/30642762/nuclei-specific-thalamic-connectivity-predicts-seizure-frequency-in-drug-resistant-medial-temporal-lobe-epilepsy
#6
Hang Joon Jo, Daniel L Kenny-Jung, Irena Balzekas, Eduardo E Benarroch, David T Jones, Benjamin H Brinkmann, S Matt Stead, Jamie J Van Gompel, Kirk M Welker, Gregory A Worrell
BACKGROUND AND OBJECTIVES: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE). METHODS: Seventeen patients with mTLE and 17 sex-/age-/handedness-matched controls participated. A seed-based correlation method for the resting-state FMRI data was implemented to get RSFC maps of 70 thalamic nuclei seed masks. Group statistics for individual RSFC for subjects and seed masks were performed to obtain within-group characteristics and between-group differences with age covariates...
January 9, 2019: NeuroImage: Clinical
https://read.qxmd.com/read/30617780/disruption-of-functional-connectivity-among-subcortical-arousal-system-and-cortical-networks-in-temporal-lobe-epilepsy
#7
Rong Li, Chongyu Hu, Liangcheng Wang, Ding Liu, Dingyang Liu, Wei Liao, Bo Xiao, Huafu Chen, Li Feng
Growing evidence has demonstrated widespread brain network alterations in temporal lobe epilepsy (TLE). However, the relatively accurate portrait of the subcortical-cortical relationship for impaired consciousness in TLE remains unclear. We proposed that consciousness-impairing seizures may invade subcortical arousal system and corresponding cortical regions, resulting in functional abnormalities and information flow disturbances between subcortical and cortical networks. We performed resting-state fMRI in 26 patients with TLE and 30 matched healthy controls...
January 7, 2019: Brain Imaging and Behavior
https://read.qxmd.com/read/30541437/imaging-episodic-memory-during-development-and-childhood-epilepsy
#8
REVIEW
Leigh N Sepeta, Madison M Berl, William Davis Gaillard
Epilepsy affects 2.2 million adults in the USA, with 1 in 26 people developing epilepsy at some point in their lives. Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy as medial structures, and the hippocampus in particular, are prone to generating seizures. Selective anterior temporal resection (which removes the hippocampus) is the most effective intractable TLE treatment, but given the critical role of the mesial temporal lobe in memory functioning, resection can have negative effects on this crucial cognitive skill...
December 13, 2018: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/30538081/association-between-seizure-freedom-and-default-mode-network-reorganization-in-patients-with-unilateral-temporal-lobe-epilepsy
#9
Isabell Ofer, Carmelina LeRose, Hansjoerg Mast, Pierre LeVan, Birgitta Metternich, Karl Egger, Horst Urbach, Andreas Schulze-Bonhage, Kathrin Wagner
RATIONALE: The spontaneous synchronized activity and intrinsic organization of the Default Mode Network (DMN) has been found to be altered because of epileptic activity of temporal lobe origin. Thus, the aim of the present study was to compare DMN's topological properties in patients with seizure-free (SF) and not seizure-free (NSF) temporal lobe epilepsy (TLE). METHODS: Functional connectivity within the DMN was determined from an 8-minute resting state functional magnetic resonance imaging (fMRI) in 27 patients with TLE (12 SF, 15 NSF) and 15 healthy controls (HC)...
January 2019: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/30472489/resting-state-functional-connectivity-patterns-associated-with-pharmacological-treatment-resistance-in-temporal-lobe-epilepsy
#10
Christina Pressl, Philip Brandner, Stefan Schaffelhofer, Karen Blackmon, Patricia Dugan, Manisha Holmes, Thomas Thesen, Ruben Kuzniecky, Orrin Devinsky, Winrich A Freiwald
There are no functional imaging based biomarkers for pharmacological treatment response in temporal lobe epilepsy (TLE). In this study, we investigated whether there is an association between resting state functional brain connectivity (RsFC) and seizure control in TLE. We screened a large database containing resting state functional magnetic resonance imaging (Rs-fMRI) data from 286 epilepsy patients. Patient medical records were screened for seizure characterization, EEG reports for lateralization and location of seizure foci to establish uniformity of seizure localization within patient groups...
November 17, 2018: Epilepsy Research
https://read.qxmd.com/read/30255350/altered-dynamic-functional-network-connectivity-in-frontal-lobe-epilepsy
#11
Benjamin Klugah-Brown, Cheng Luo, Hui He, Sisi Jiang, Gabriel Kofi Armah, Yu Wu, Jianfu Li, Wenjie Yin, Dezhong Yao
Frontal lobe epilepsy has recently been associated with disrupted brain functional connectivity; variations among various resting-state networks (RSNs) across time remains largely unclear. This study applied dynamic functional network connectivity (dFNC) analysis to investigate functional patterns in the temporal and spatial domains of various functional systems in FLE. Resting-state fMRI data were acquired from 19 FLE patients and 18 controls. Independent component analysis was used to decompose RSNs, which were grouped into seven functional systems...
September 25, 2018: Brain Topography
https://read.qxmd.com/read/30238918/typical-asymmetry-in-the-hemispheric-activation-during-an-fmri-verbal-comprehension-paradigm-is-related-to-better-performance-in-verbal-and-non-verbal-tasks-in-patients-with-epilepsy
#12
Irene Cano-López, Anna Calvo, Teresa Boget, Mar Carreño, Antonio Donaire, Xavier Setoain, Luis Pintor, Jordi Rumià, Esperanza González-Bono, Carme Junqué, Núria Bargalló, Liam Mason
Chronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activation during language fMRI and performance in verbal and non-verbal tasks. Whereas prior studies primarily used fMRI paradigms that favor frontal lobe activation and less prominent activation of the medial or superior temporal lobes, we used a verbal comprehension paradigm previously demonstrated to activate reliably receptive language areas...
2018: NeuroImage: Clinical
https://read.qxmd.com/read/30115603/brain-network-alterations-of-mesial-temporal-lobe-epilepsy-with-cognitive-dysfunction-following-anterior-temporal-lobectomy
#13
Chao Zhang, Hongyu Yang, Chang Liu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network connectivity alterations of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction before and after anterior temporal lobectomy (ATL) using resting-state functional magnetic resonance imaging (rs-fMRI) study and to further observe the correlation between the brain network connectivity with cognitive performance. Fourteen patients with unilateral left MTLE before and after ATL were compared with thirty healthy controls (HCs) on functional connectivity (FC) between resting-state networks (RSNs)...
August 13, 2018: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/30001910/executive-dysfunction-is-associated-with-an-altered-executive-control-network-in-pediatric-temporal-lobe-epilepsy
#14
Temitayo Oyefunmike Oyegbile, John W VanMeter, Gholam Motamedi, Nassim Zecavati, Cesar Santos, Christabel Lee Earn Chun, William D Gaillard, Bruce Hermann
OBJECTIVES: Children with temporal lobe epilepsy (TLE) exhibit executive dysfunction on traditional neuropsychological tests. However, there is limited evidence of neural network alterations associated with this clinical executive dysfunction. The objective of this study was to characterize working memory deficits in children with TLE via activation of the executive control network on functional magnetic resonance imaging (fMRI) and determine the relationships to fMRI behavioral findings and traditional neuropsychological tests...
September 2018: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/29956405/language-network-measures-at-rest-indicate-individual-differences-in-naming-decline-after-anterior-temporal-lobe-resection
#15
Samantha Audrain, Alexander J Barnett, Mary P McAndrews
While anterior temporal lobe (ATL) resection is an effective treatment for temporal lobe epilepsy, surgery on the dominant hemisphere is associated with variable decline in confrontation naming. Accurate prediction of naming impairment is critical to inform clinical decision making, and while there has been some degree of success using task-based functional MRI (fMRI) paradigms, there remains a growing interest in the predictive utility of resting-state connectivity as it allows for relatively shorter scans with low task demands...
November 2018: Human Brain Mapping
https://read.qxmd.com/read/29952080/the-impact-of-brain-derived-neurotrophic-factor-val66met-polymorphism-on-cognition-and-functional-brain-networks-in-patients-with-intractable-partial-epilepsy
#16
Meneka K Sidhu, Pamela J Thompson, Britta Wandschneider, Alexandra Foulkes, Jane de Tisi, Jason Stretton, Marina Perona, Maria Thom, Silvia B Bonelli, Jane Burdett, Elaine Williams, John S Duncan, Mar Matarin
INTRODUCTION: Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with cognition and variability in structural and functional hippocampal indices in healthy controls and some patient groups. AIMS: We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE...
June 27, 2018: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/29934057/memory-loss-and-memory-reorganization-patterns-in-temporal-lobe-epilepsy-patients-undergoing-anterior-temporal-lobe-resection-as-demonstrated-by-pre-versus-post-operative-functional-mri
#17
Chusak Limotai, Richard S McLachlan, Susan Hayman-Abello, Brent Hayman-Abello, Suzan Brown, Frank Bihari, Seyed M Mirsattari
This study was aimed to longitudinally assess memory function and whole-brain memory circuit reorganization in patients with temporal lobe epilepsy (TLE) by comparing activation potentials before versus after anterior temporal lobe (ATL) resection. Nineteen patients with medically-intractable TLE (10 left TLE, 9 right TLE) and 15 healthy controls were enrolled. Group analyses were conducted pre- and post-ATL of a novelty complex scene-encoding paradigm comparing areas of blood oxygen-level-dependent (BOLD) signal activations on functional magnetic resonance imaging (fMRI)...
September 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/29932365/changes-in-resting-state-connectivity-in-pediatric-temporal-lobe-epilepsy
#18
Fabio Grassia, Andrew V Poliakov, Sandra L Poliachik, Kaitlyn Casimo, Seth D Friedman, Hillary Shurtleff, Carlo Giussani, Edward J Novotny, Jeffrey G Ojemann, Jason S Hauptman
OBJECTIVE Functional connectivity magnetic resonance imaging (fcMRI) is a form of fMRI that allows for analysis of blood oxygen level-dependent signal changes within a task-free, resting paradigm. This technique has been shown to have efficacy in evaluating network connectivity changes with epilepsy. Presurgical data from patients with unilateral temporal lobe epilepsy were evaluated using the fcMRI technique to define connectivity changes within and between the diseased and healthy temporal lobes using a within-subjects design...
September 2018: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/29883917/functional-network-changes-in-the-hippocampus-contribute-to-depressive-symptoms-in-epilepsy
#19
Weifeng Peng, Lingyan Mao, Dazhi Yin, Wei Sun, He Wang, Qianqian Zhang, Jing Wang, Caizhong Chen, Mengsu Zeng, Jing Ding, Xin Wang
PURPOSE: Our study aimed to investigate the functional connectivity (FC) between the hippocampus and other brain regions in epilepsy patients with depressive symptoms. METHODS: Epilepsy patients with and without depressive symptoms, assessed using the 17-item Hamilton Depression Rating Scale scores, were enrolled. Healthy volunteers were recruited as the control group. Resting state functional magnetic resonance imaging was performed, and the data were processed using Resting-State fMRI (DPARSFA2...
August 2018: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/29878076/revealing-the-dynamic-modulations-that-underpin-a-resilient-neural-network-for-semantic-cognition-an-fmri-investigation-in-patients-with-anterior-temporal-lobe-resection
#20
Grace E Rice, Helen Caswell, Perry Moore, Matthew A Lambon Ralph, Paul Hoffman
One critical feature of any well-engineered system is its resilience to perturbation and minor damage. The purpose of the current study was to investigate how resilience is achieved in higher cognitive systems, which we explored through the domain of semantic cognition. Convergent evidence implicates the bilateral anterior temporal lobes (ATLs) as a conceptual knowledge hub. While bilateral damage to this region produces profound semantic impairment, unilateral atrophy/resection or transient perturbation has a limited effect...
August 1, 2018: Cerebral Cortex
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