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diabetic AND foot

Pei-Yueng Lee, Pui-Wah Kong, Yong-Hao Pua
BACKGROUND: Previous reliability studies on peak plantar pressure measurements in patients with previous diabetic foot ulceration (DFU) did not stratify their analyses according to whether the foot had a previous ulcer. RESEARCH QUESTION: Does test-retest reliability of peak foot pressure measurements from the various foot regions differ between the ulcerated and non-ulcerated feet? METHODS: Data from 23 participants with peripheral neuropathy and healed plantar DFU were analysed in this test-retest reliability comparison study...
February 4, 2019: Gait & Posture
Jesús Martín-Vaquero, Ascensión Hernández Encinas, Araceli Queiruga-Dios, Juan José Bullón, Alfonso Martínez-Nova, Jose Torreblanca González, Cristina Bullón-Carbajo
One of the diseases that could affect diabetic patients is the diabetic foot problem. Unnoticed minor injuries and subsequent infection can lead to ischemic ulceration, and may end in a foot amputation. Preliminary studies have shown that there is a positive relationship between increased skin temperature and the pre⁻ulceration phase. Hence, we have carried out a review on wearables, medical devices, and sensors used specifically for collecting vital data. In particular, we are interested in the measure of the foot⁻temperature...
February 14, 2019: Sensors
D J Saunders, L Bleasdale, L Summerton, A Hancock, S Homer-Vanniasinkam, D A Russell
OBJECTIVES: To assess the ability of a novel, automated CE marked vascular early warning system (VEWS) device to detect peripheral arterial disease in patients with incompressible ankle arteries and non-measurable ankle brachial pressure index (ABPI) secondary to diabetes. RESEARCH DESIGN AND METHODS: Recruited patients had diabetes, recent MRA evidence of PAD and incompressible vessels on ABPI. VEWS indices of each leg were automatically calculated by employing optical infrared and red sensors applied to the foot with readings obtained with the subject's leg both flat and elevated...
February 12, 2019: Annals of Vascular Surgery
Tania Woodrow, Theresa Chant, Harvey Chant
OBJECTIVE: To evaluate the potential benefit of an intact fish skin graft rich in omega-3 (Kerecis Omega3), in the management of postoperative diabetic foot wounds. METHOD: Prospective evaluation in eight patients with diabetes following forefoot surgery. The dressing was applied weekly for a period of six weeks in the diabetic foot clinic. At each visit the wound was photographed and independently measured using ImageJ software to calculate wound area. Secondary outcome measures were pain, infection, odour, discharge and irritation...
February 2, 2019: Journal of Wound Care
José Luis Lázaro-Martínez, Yolanda García-Álvarez, Francisco Javier Álvaro-Afonso, Esther García-Morales, I Sanz-Corbalán, Raúl Juan Molines-Barroso
OBJECTIVE: To describe the outcomes of a new product based on negatively charged polystyrene microspheres (NCM) technology, in non-responding diabetic foot ulcers (DFU). METHODS: A clinical case series of patients with a hard-to-heal DFU treated with NCM were recruited between March and June 2017 in a specialised diabetic foot unit. DFUs were treated daily with NCM over four weeks, although the health professional could decide to continue NCM treatment in some patients...
February 2, 2019: Journal of Wound Care
Jamie Corroon, Ryan Bradley
OBJECTIVE: There is a medical need to evaluate new treatments that may improve wound healing. This study aimed to determine if Original Healing Salve (OHS, Puremedy, Inc.) a topical, botanically-enriched salve (BES), changes distal leg tissue oxygenation in people with type 2 diabetes. METHOD: A randomised, controlled, crossover, double-blinded clinical trial comparing changes in cutaneous oxygen delivery (mean TcPO2 ) on multiple sites of the lower extremity following application of a botanically-enriched topical salve, as compared with application of the salve's base in patients with type 2 diabetes...
February 1, 2019: Journal of Wound Care
Safak Ozer Balin, Ayse Sagmak Tartar, Kader Uğur, Faruk Kilinç, Selda Telo, Ali Bal, Mehmet Balin, Ayhan Akbulut
This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin-3 (PTX-3) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX-3 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Patients who underwent amputation were also documented...
February 15, 2019: International Wound Journal
Musarrat Riaz, Zahid Miyan, Nazish Waris, Syed I H Zaidi, Bilal Tahir, Asher Fawwad, Abdul Basit
To compare the outcomes of diabetic foot ulcers (DFU) in terms of healing and lower extremity amputation (LEA) rate before and after training of multidisciplinary foot care team (MDFCT). Subjects were categorised into two groups; Group-A cases seen between 1997 and 2006 (before upgrading of training and services of MDFCT) and Group-B cases seen between 2007 and 2016 (after upgrading of training and services of MDFCT). Baseline demographic characteristics, biochemical results, and outcomes of DFU in terms of healing or amputation were analysed by using statistical package social science (SPSS) version 20...
February 15, 2019: International Wound Journal
Jun Yuan, Joanne Tm Tan, Kushwin Rajamani, Emma L Solly, Emily J King, Laura Lecce, Philippa Jl Simpson, Yuen Ting Lam, Alicia J Jenkins, Christina A Bursill, Anthony C Keech, Martin Kc Ng
Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist, reduces lower limb amputations in patients with type 2 diabetes mellitus. The mechanism is, however, unknown. Here we demonstrate that fenofibrate markedly attenuates diabetes-related impairment of ischemia-mediated angiogenesis. In a murine model of hindlimb ischemia, daily oral fenofibrate treatment restored diabetes-impaired blood flow recovery, foot movement, hindlimb capillary density, vessel diameter, and vascular endothelial growth factor (VEGF) signaling to non-diabetic levels in both wildtype and PPARα-knockout mice, indicating that these fenofibrate effects are largely PPARα-independent...
February 14, 2019: Diabetes
Michael L Anthony, Kimberly S Cravey, Said A Atway
Only a small percentage of the general diabetic population develops Charcot neuroarthropathy. Charcot arthropathy greatly increases the risk of foot complications. At our academic institution, there appeared to be an increased incidence of Charcot arthropathy in transplant patients. We hypothesized that Charcot neuroarthropathy incidence is higher in the diabetic patients who had received kidney or kidney-pancreas transplants. The charts of 1000 patients were reviewed from January 2000 to January 2011. Four hundred and eighty-seven patients were included in the study...
February 11, 2019: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Meltem Sertbas, Yasar Sertbas, Ozden Ezgi Uner, Serkan Elarslan, Nalan Okuroglu, Feyza Ak, Akin Dayan, Ali Ozdemır
INTRODUCTION Diabetes and its complications are a significant cause of morbidity and mortality. Advanced glycation endproducts (AGEs) play a major role in the pathogenesis of  diabetes complications. OBJECTIVES To investigate the possible uses of a biomicroscope (ClearPath DS-120) that shows age-adjusted lens fluorescence ratios (LFRs) for the diagnosis of diabetic peripheral neuropathy (DPN). PATIENTS AND METHODS One hundred and sixty type 2 diabetic patients who underwent LFR measurement were recruited to this study...
February 14, 2019: Polish Archives of Internal Medicine
Anıl Murat Öztürk, Meltem Taşbakan, Dilek Yeşim Metin, Can Yener, Serhat Uysal, Ilgın Yıldırım Şımşır, İlgen Ertam, Hüsnü Pullukçu, Bilgin Arda, Şevki Çetinkalp
Background/aim: Clinicians often neglect fungal infections and do not routinely investigate deep tissue from the wound for fungal culture and sensitivity due to insufficient information in the literature. In this study, we aimed to evaluate fungal etiology of invasive fungal diabetic foot which is rarely reported in the literature. Materials and methods: The patients who were unresponsive to antibiotic therapy and those with positive fungal in bone or deep tissue culture were enrolled in the study...
February 11, 2019: Turkish Journal of Medical Sciences
Francisco Javier Álvaro-Afonso, José Luis Lázaro-Martínez, Nikolaos Papanas
Diabetic foot ulcers (DFUs) have a complex pathophysiology and require an expert multidisciplinary treatment. There are several, both systemic and local, risk factors for DFUs. A recent meta-analysis of 18 studies has now provided robust evidence on the detrimental effect of smoking on healing of DFUs. Indeed, healing rates were consistently lower among smokers than among nonsmokers. Based on this new evidence, it is reasonable to consider the utility of smoking cessation programs. Incorporation of the latter into the holistic therapeutic strategy for DFUs may be anticipated to improve healing rates, but this remains to be shown...
December 2018: International Journal of Lower Extremity Wounds
Jennifer Pasquier, Mark Spurgeon, Martina Bradic, Binitha Thomas, Amal Robay, Omar Chidiac, Marie-Joe Dib, Rebal Turjoman, Alexandra Liberska, Michelle Staudt, Khalid A Fakhro, Robert Menzies, Amin Jayyousi, Mahmoud Zirie, Jassim Al Suwaidi, Rayaz A Malik, Talal Talal, Arash Rafii, Jason Mezey, Juan Rodriguez-Flores, Ronald G Crystal, Charbel Abi Khalil
AIM: To assess whether DNA methylation of monocytes play a role in the development of acute diabetic Charcot foot (CF). PATIENTS & METHODS: We studied the whole methylome (WM) of circulating monocytes in 18 patients with Type 2 diabetes (T2D) and acute CF, 18 T2D patients with equivalent neuropathy and 18 T2D patients without neuropathy, using the enhanced reduced representation bisulfite sequencing technique. RESULTS & CONCLUSION: WM analysis demonstrated that CF monocytes are differentially methylated compared with non-CF monocytes, in both CpG-site and gene-mapped analysis approaches...
February 2019: Epigenomics
Kimie Takehara, Makoto Oe, Yumiko Ohashi, Yuichiro Tsunemi, Takashi Kadowaki, Hiromi Sanada
PURPOSE: The primary aim of this study was to compare patient reported versus clinician-observed nonulcerative foot conditions in patients attending a diabetic foot clinic and deemed at risk for diabetic foot ulcers. DESIGN: Retrospective review of medical records. SUBJECTS AND SETTING: The medical records of 126 patients with diabetes mellitus and deemed at risk for developing diabetic foot ulcers were reviewed. All patients received care from a diabetic foot outpatient clinic in a university-based hospital in Tokyo, Japan, between November 2008 and October 2009...
February 8, 2019: Journal of Wound, Ostomy, and Continence Nursing
Pablo Carnero-Martín de Soto, David Bautista-Enrique, Abel Gómez-Cáceres, Alfredo Rodríguez-León, María José Bravo-Zurita, María Teresa Santos-Maraver
Avulsion fractures of the posterior calcaneal tuberosity are rare injuries, and little is known about the underlying factors, outcomes, and prognosis. Furthermore, classifications described previously focus on fracture morphology, with uncertain clinical utility. We present the results of a retrospective study of 21 patients treated for this pathology from January 2002 to December 2015. Features analyzed were age; sex; mechanism of injury; medical comorbidities; type of fracture, as proposed by Beavis; fracture displacement; fragment size; type of treatment; complications; need for secondary surgery; and the American Orthopaedic Foot and Ankle Society score after treatment and follow-up care...
February 8, 2019: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Yesi Hasneli, Yufitriana Amir
OBJECTIVE: To measure foot sensitivity and blood glucose levels among diabetic patients as measures of improvement pre and post Apiyu massage. METHOD: Quasi experimental research was employed to measure foot sensitivity and blood glucose levels before and after APIYU massage for fifty-five (55) purposive sampled consented adult patients with diabetes from Rejosari and Langsat Health Centers in Pekanbaru Riau, Indonesia. The intervention was given about three times in a week for thirty (30) minutes...
February 8, 2019: Enfermería Clínica
Y Y Jiang, X X Zhang, F Mao, W L Dong, J Q Dong
Objective: To evaluate the effect of a community-based intervention supporting type 2 diabetes mellitus patients in their self-management of the disease. Methods: This research was a randomized controlled trial conducted in communities in Fangshan District, Beijing, China. Adult patients with type 2 diabetes from 17 communities in 4 sub-district of Fangshan District were randomly assigned to either the intervention or control group. Participants in the intervention group participated in a three-month group-based diabetes self-management intervention service...
February 6, 2019: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Victor Mogre, Zakaria Osman Abanga, Flora Tzelepis, Natalie A Johnson, Christine Paul
AIMS: We evaluated the content validity, factorial structure, internal consistency, construct validity, and floor and ceiling effects of the SDSCA among Ghanaian persons with type 2 diabetes. METHODS: The summary of diabetes self-care activities measure (SDSCA) was administered to 187 adults living with type 2 diabetes from three diabetes clinics. RESULTS: A confirmatory factor analysis maintained the four factor structure of the SDSCA. However, two items, 3 (fruit and vegetable servings) and 4 (red meat or full-fat dairy products) had factor loadings of 0...
February 8, 2019: Diabetes Research and Clinical Practice
Andrew J Hale, Emily Vicks, Mary T LaSalvia, John M Giurini, Adolf W Karchmer
Diabetic foot infections are a common cause of morbidity and mortality in the United States, and successful treatment often requires an aggressive and prolonged approach. Recent work has elucidated the importance of appropriate therapy for a given severity of diabetic foot infection, and highlighted the ongoing risk such patients have for subsequent invasive life-threatening infection should diabetic foot ulcers fail to heal. The authors describe the case of a man with diabetes who had prolonged, delayed healing of a diabetic foot ulcer...
November 2018: Journal of the American Podiatric Medical Association
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