keyword
https://read.qxmd.com/read/38536962/acute-effects-of-vibrating-insoles-on-dynamic-balance-and-gait-quality-in-individuals-with-diabetic-peripheral-neuropathy-a-randomized-crossover-study
#1
JOURNAL ARTICLE
Giorgio Orlando, Steven Brown, Edward Jude, Frank L Bowling, Andrew J M Boulton, Neil D Reeves
OBJECTIVE: This study investigated the effects of vibrating insoles on dynamic balance and gait quality during level and stair walking and explored the influence of vibration type and frequency in individuals with diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS: Twenty-two men with DPN were assessed for gait quality and postural and dynamic balance during walking and stair negotiation using a motion capture system and force plates across seven vibratory insole conditions (Vcs) versus a control (Ctrl) condition (insole without vibration)...
March 27, 2024: Diabetes Care
https://read.qxmd.com/read/38536671/evaluating-a-promising-methylcellulose-hydrogel-for-enhanced-diabetic-foot-ulcer-therapy-through-comprehensive-preclinical-studies
#2
JOURNAL ARTICLE
Priya Patel, Sanika Dongre, Alkesh Patel, Gayatri Patel
The present research focuses on formulating and evaluating hydrogels modified with crosslinking agents using methylcellulose to treat diabetic foot ulcers (DFU). Methylcellulose hydrogels are prepared and characterized for their crosslinking capacity through FTIR and degradation studies. The optimized hydrogel is further assessed for viscosity, gel strength, contact angle, in-vitro biodegradation, water-vapor transmission rate, anti-bacterial activity, and in-vivo efficacy. The results demonstrate that the developed hydrogel exhibits promising properties for DFU treatment, including increased wound healing percentage, improved ulcer morphology, reduced levels of proinflammatory cytokines, and enhanced tissue characteristics...
March 27, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38536557/non-contrast-mri-of-micro-vascularity-of-the-feet-and-toes
#3
JOURNAL ARTICLE
Won C Bae, Vadim Malis, Diana Vucevic, Asako Yamamoto, Katsumi Nakamura, John Lane, Mitsue Miyazaki
PURPOSE: This study aimed to develop novel non-contrast MR perfusion techniques for assessing micro-vascularity of the foot in human subjects. METHODS: All experiments were performed on a clinical 3 T scanner using arterial spin labeling (ASL). Seven healthy subjects (30-72 years old, 5 males and 2 females) were enrolled and bilateral feet were imaged with tag-on and tag-off alternating inversion recovery spin labeling for determining micro-vascularity...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38536196/offloading-and-adherence-through-technological-advancements-modern-approaches-for-better-foot-care-in-diabetes
#4
REVIEW
Sicco A Bus, Neil D Reeves, David G Armstrong, Bijan Najafi
OBJECTIVE: This manuscript aims to provide a review and synthesis of contemporary advancements in footwear, sensor technology for remote monitoring, and digital health, with a focus on improving offloading and measuring and enhancing adherence to offloading in diabetic foot care. METHODS: A narrative literature review was conducted by sourcing peer-reviewed articles, clinical studies, and technological innovations. This paper includes a review of various strategies, from specifically designed footwear, smart insoles and boots to using digital health interventions, which aim to offload plantar pressure and help prevent and manage wounds more effectively by improving the adherence to such offloading...
February 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38536106/effects-of-photobiomodulation-therapy-on-the-expression-of-hypoxic-inducible-factor-vascular-endothelial-growth-factor-and-its-specific-receptor-a-randomized-control-trial-in-patients-with-diabetic-foot-ulcer
#5
JOURNAL ARTICLE
Giti Torkaman, Mahsa Hoseini-Sanati, Mehdi Hedayati, Maryam Mofid, Manouchehr Iranparvar Alamdari
Background: Impaired angiogenesis is a significant factor contributing to delayed healing in diabetic foot ulcers (DFUs) due to inadequate oxygenation. Objective: This study aimed to investigate the impact of photobiomodulation (PBM) using a Ga-As laser on the release of serum hypoxia-inducible factor 1-α (HIF-1α), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2, and nitric oxide (NO) in diabetic patients with DFUs. Materials and methods: In this double-blind RCT, a total of 30 patients with grade II DFUs were enrolled...
March 27, 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38533581/diabetic-sensorimotor-polyneuropathy-an-overview-on-epidemiology-risk-factors-classification-diagnosis-and-treatment
#6
REVIEW
Georgia Anastasiou, Evangelos Liberopoulos, Nikolaos Tentolouris, Nikolaos Papanas
Diabetic distal symmetric sensorimotor polyneuropathy (DSPN) is a common complication of diabetes with devastating consequences. Hyperglycaemia is the major aetiological factor, while emerging data demonstrate that cardiometabolic risk factors also contribute to its development. Diagnosis of DSPN involves interview of medical and neurological history, foot inspection, and sensory and motor function examination with specific tests such as temperature and pinprick perception for small nerve fibers, and vibration and light touch assessments for large nerve fibers...
March 27, 2024: International Journal of Lower Extremity Wounds
https://read.qxmd.com/read/38532899/characterization-of-sensory-and-motor-dysfunction-and-morphological-alterations-in-late-stages-of-type-2-diabetic-mice
#7
JOURNAL ARTICLE
Ting Tian, Haofeng Li, Sensen Zhang, Maojun Yang
Diabetic neuropathy is the most common complication of diabetes and lacks effective treatments. Although sensory dysfunction during the early stages of diabetes has been extensively studied in various animal models, the functional and morphological alterations in sensory and motor systems during late stages of diabetes remain largely unexplored. In the current work, we examined the influence of diabetes on sensory and motor function as well as morphological changes in late stages of diabetes. The obese diabetic Leprdb/db mice (db/db) were used for behavioral assessments and subsequent morphological examinations...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532843/novel-design-and-development-of-centella-asiatica-extract-loaded-poloxamer-zno-nanocomposite-wound-closure-material-to-improve-anti-bacterial-action-and-enhanced-wound-healing-efficacy-in-diabetic-foot-ulcer
#8
JOURNAL ARTICLE
Lina Wang, Yan Yang, Weiwei Han, Hui Ding
Diabetic wounds can occur as a prevalent complication among people diagnosed with diabetes, frequently resulting in the necessity for amputation. The cause and effect of diabetic foot ulcer is complex, involving multiple factors. In the present study, wound healing strategies utilizing nanomaterials have proven to be effective in battling bacterial infections and improve wound regeneration. Poloxamers (PLX) exhibit extensive potential as a viable option for the development of nanomedicines owing to their inherent characteristics of self-assembly and encapsulation...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38532027/diagnostic-imaging-of-the-diabetic-foot-an-eanm-evidence-based-guidance
#9
JOURNAL ARTICLE
Chiara Lauri, Edel Noriega-Álvarez, Riddhika M Chakravartty, Olivier Gheysens, Andor W J M Glaudemans, Riemer H J A Slart, Thomas C Kwee, Frédéric Lecouvet, Emmanouil Panagiotidis, Jules Zhang-Yin, Jose Luis Lazaro Martinez, Benjamin A Lipsky, Luigi Uccioli, Alberto Signore
PURPOSE: Consensus on the choice of the most accurate imaging strategy in diabetic foot infective and non-infective complications is still lacking. This document provides evidence-based recommendations, aiming at defining which imaging modality should be preferred in different clinical settings. METHODS: This working group includes 8 nuclear medicine physicians appointed by the European Association of Nuclear Medicine (EANM), 3 radiologists and 3 clinicians (one diabetologist, one podiatrist and one infectious diseases specialist) selected for their expertise in diabetic foot...
March 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38531355/application-of-hyperbaric-oxygen-therapy-in-diabetic-foot-ulcers-a-meta-analysis
#10
JOURNAL ARTICLE
Hai-Rong Chen, Shi-Juan Lu, Qi Wang, Ming-Lan Li, Xun-Chun Chen, Bi-Yun Pan
Hyperbaric oxygen therapy (HBOT) has been used in patients with diabetic foot ulcers (DFU) for many years, but its clinical efficacy is still controversial. Therefore, this study explored the efficacy of HBOT applied to DFU by means of meta-analysis. PubMed, Cochrane Library, Embase, CNKI and Wanfang databases were searched, from database inception to October 2023, and published randomised controlled trials (RCTs) of HBOT in DFU were collected. Two investigators independently screened the collected literature, extracted relevant data and assessed the quality of the literature...
April 2024: International Wound Journal
https://read.qxmd.com/read/38531354/antibiotic-bone-cement-accelerates-diabetic-foot-wound-healing-elucidating-the-role-of-rock1-protein-expression
#11
JOURNAL ARTICLE
Chenglan Yang, Dali Wang
Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure...
April 2024: International Wound Journal
https://read.qxmd.com/read/38529404/plantar-pressure-gradient-and-pressure-gradient-angle-are-affected-by-inner-pressure-of-air-insole
#12
JOURNAL ARTICLE
Fahni Haris, Yih-Kuen Jan, Ben-Yi Liau, Chang-Wei Hsieh, Wei-Cheng Shen, Chien-Cheng Tai, Yin-Hwa Shih, Chi-Wen Lung
Clinically, air insoles may be applied to shoes to decrease plantar pressure gradient (PPG) and increase plantar gradient angle (PGA) to reduce foot ulcers. PPG and PGA may cause skin breakdown. The effects of different inner pressures of inflatable air insoles on dynamic PPG and PGA distributions are largely unknown in non-diabetics and people with diabetes. This study aimed to explore the impact of varying inner air insole pressures on PPG and PGA to establish early mitigation strategies for people at risk of foot ulcers...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38528847/hyperbaric-oxygen-therapy-for-diabetic-foot-ulcers-based-on-wagner-grading-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Mendy Hatibie Oley, Maximillian Christian Oley, Billy Johnson Kepel, Muhammad Faruk, Angelica Maurene Joicetine Wagiu, Irawan Sukarno, Marcella Tirsa Tulong, Vania Sukarno
BACKGROUND: Diabetic foot ulcers (DFUs) are common complications of uncontrolled diabetes mellitus that can result in infection and amputation of the lower extremities. This study compared the benefits and risks of hyperbaric oxygen therapy with those of other DFU treatments, based on the Wagner grading system. METHODS: Systematic searches for randomly controlled trials using hyperbaric oxygen therapy for DFUs were performed using PubMed, the Cochrane Library, and Embase...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38528713/clinical-guideline-highlights-for-the-hospitalist-diagnosis-and-treatment-of-diabetes-related-foot-infections
#14
JOURNAL ARTICLE
Charles D Pham, Jessica Lo, Duong T Hua
IWGDF/IDSA Guidelines on the Diagnosis and Treatment of Diabetes-related Foot Infections RELEASE DATE: October 2, 2023 PRIOR VERSION: March 16, 2020 DEVELOPER: IWGDF Editorial Board FUNDING SOURCE: International Working Group on the Diabetic Foot (IWGDF), Infectious Diseases Society of America (IDSA) TARGET POPULATION: Adults with suspected or confirmed diabetes-related foot infections.
March 25, 2024: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://read.qxmd.com/read/38528132/prevalence-of-diabetic-kidney-disease-and-the-associated-factors-among-patients-with-type-2-diabetes-in-a-multi-ethnic-asian-country
#15
JOURNAL ARTICLE
Kim Sui Wan, Noran Naqiah Hairi, Feisul Mustapha, Muhammad Fadhli Mohd Yusoff, Halizah Mat Rifin, Mastura Ismail, Foong Ming Moy, Noor Ani Ahmad
The actual prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D) in Malaysia is unknown. We aimed to determine the prevalence of DKD and its associated risk factors among T2D patients in Malaysia. An analytical cross-sectional study was conducted using the year 2022 clinical audit dataset from the National Diabetes Registry. DKD was defined as albuminuria, a decreased glomerular filtration rate, or both. Among 80,360 patients, 62.2% were female, 68.4% were Malay, and the mean age was 61...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527332/impact-of-synthetic-extracellular-matrices-in-combination-therapy-with-amniotic-allografting-in-the-treatment-of-diabetic-foot-wounds-a-case-series
#16
JOURNAL ARTICLE
Arthur Evensen, Jodi Walters, James Dancho, Valarie Samoy, David Jolley
Synthetic extracellular matrices are artificial polymers that are elongated and deposited as a matrix of nanofibers which mimic the native extracellular matrix. RenovoDerm® Anthem™ Wound Matrix (Columbus, Ohio) is comprised of polyglycolic acid and poly (L-lactide-co-caprolactone) which degrade by hydrolysis into a-hydroxy and fatty acids, lowering the pH and promoting regenerative cellular activity including angiogenesis. Amniotic allografts contain growth factors, cytokines, amino acids, extracellular matrix proteins, and hyaluronic acid which are recognized as intrinsic to the wound healing process...
March 22, 2024: Surgical Technology International
https://read.qxmd.com/read/38526063/triple-threat-how-diabetes-results-in-worsened-bacterial-infections
#17
REVIEW
Benjamin P Darwitz, Christopher J Genito, Lance R Thurlow
Diabetes mellitus, characterized by impaired insulin signaling, is associated with increased incidence and severity of infections. Various diabetes-related complications contribute to exacerbated bacterial infections, including hyperglycemia, innate immune cell dysfunction, and infection with antibiotic-resistant bacterial strains. One defining symptom of diabetes is hyperglycemia, resulting in elevated blood and tissue glucose concentrations. Glucose is the preferred carbon source of several bacterial pathogens, and hyperglycemia escalates bacterial growth and virulence...
March 25, 2024: Infection and Immunity
https://read.qxmd.com/read/38525394/the-effectiveness-of-neurodynamic-techniques-in-patients-with-diabetic-peripheral-neuropathy-study-protocol-for-a-randomized-sham-controlled-trial
#18
JOURNAL ARTICLE
Mahdi Ashoori, Mohammadreza Pourahmadi, Seyed Ebrahim Hashemi, Mehdi Dadgoo, Mahboobeh Sadat Hosseini
BACKGROUND: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus (DM). DPN is the primary risk factor for diabetic foot ulcers that can cause amputation. Although several observational studies have investigated the morphological and biomechanical characteristics of peripheral nerves in DPN, interventional studies regarding the effectiveness of neurodynamic techniques (NDT) in DPN patients are confined to a handful. The effects of NDT on neuropathy severity, nerve conduction parameters, quality of life (QoL), and mechanosensitivity have not been explored yet in this population...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38524870/tibial-cortex-transverse-transport-regulates-orai1-stim1-mediated-no-release-and-improve-the-migration-and-proliferation-of-vessels-via-increasing-osteopontin-expression
#19
JOURNAL ARTICLE
Lingchao Kong, Yangyang Li, Zhongfang Deng, Xiaoyu Chen, Yin Xia, Bing Shen, Rende Ning, Lesha Zhang, Zongsheng Yin
BACKGROUND: Diabetic foot is a major complication of diabetes. The bone transverse transport method could be applied in clinics for treatment, which could improve the metabolism of the tissues via lasting distraction forces. However, the process' specific regulating mechanism is still unknown. METHODS: Based on the notion that the healing of bones involves the recruitment of calcium ions, in this study, we established the model of tibial cortex transverse transport (TTT) on rats and then used tissue immunologic detection, such as the double fluorescent staining to explore the expression of the calcium channels' calcium release-activated calcium modulator 1 (Orai1)/stromal interaction molecule 1 (STIM1), which belong to the store-operated calcium entry (SOCE) signaling pathways on the tissues around the bone transport area...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38524772/cost-effectiveness-analysis-for-commonly-used-human-cell-and-tissue-products-in-the-management-of-diabetic-foot-ulcers
#20
JOURNAL ARTICLE
Leo M Nherera, Jaideep Banerjee
BACKGROUND AND AIMS: This study considers the cost-effectiveness of commonly used cellular, acellular, and matrix‑like products (CAMPs) of human origin also known as human cell and tissue products (HCT/Ps) in the management of diabetic foot ulcers. METHODS: We developed a 1-year economic model assessing six CAMPs [cryopreserved placental membrane with viable cells (vCPM), bioengineered bilayered living cellular construct (BLCC), human fibroblast dermal substitute (hFDS), dehydrated human amnion chorion membrane (dHACM), hypothermically stored amniotic membrane (HSAM) and human amnion membrane allograft (HAMA) which had randomized controlled trial evidence compared with standard of care (SoC)...
March 2024: Health Science Reports
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