Aleksander Adamiec, Maja Cieślik, Katarzyna Mączka, Joanna Tarnoruda, Signe Jensen, Bo Chawes, Klaus Bønnelykke, Jon R Konradsen, Cilla Söderhäll, Heidi Makrinioti, Carlos A Camargo, Kohei Hasegawa, Dominika Ambrożej, Tuomas Jartti, Marek Ruszczyński, Wojciech Feleszko
Preschool children with wheezing disorders pose diagnostic and therapeutic challenges and consume substantial healthcare resources. Peripheral eosinophil blood count (EBC) has been proposed as a potential indicator for future asthma development. This review by the European Academy of Allergy and Clinical Immunology (EAACI) Preschool Wheeze Task Force aimed to provide systematic evidence for the association between increased EBC and the risk of future asthma, as well as to identify potential cutoff values. In February 2023, a search of PubMed, EMBASE, and Cochrane Library databases was conducted to identify studies comparing EBCs in preschool children with wheezing who continued to wheeze later in life and those who did not...
February 2024: Pediatric Allergy and Immunology