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Wheezing infant

Yolanda Yu, Charles R Esther, Clement L Ren, Ceila Loughlin
Infants with persistent wheeze is a common diagnostic challenge for the general pediatrician because of the broad differential diagnoses. The initial diagnostic approach should include a comprehensive history, physical examination, and chest radiography. Additional testing may be warranted. Involvement of a pediatric pulmonary subspecialist may also be indicated. [Pediatr Ann. 2019;48(3):e110-e114.].
March 1, 2019: Pediatric Annals
Helen Skirrow, Thomas Wincott, Elizabeth Cecil, Alex Bottle, Ceire Costelloe, Sonia Saxena
BACKGROUND: Bronchiolitis causes significant infant morbidity worldwide from hospital admissions. However, studies quantifying the subsequent respiratory burden in children under 5 years are lacking. OBJECTIVE: To estimate the risk of subsequent respiratory hospital admissions in children under 5 years in England following bronchiolitis admission in infancy. DESIGN: Retrospective population-based birth cohort study. SETTING: Public hospitals in England...
March 6, 2019: Archives of Disease in Childhood
Javier Gracia-Tabuenca, Ville-Pekka Seppä, Milla Jauhiainen, Anne Kotaniemi-Syrjänen, Kristiina Malmström, Anna Pelkonen, Mika J Mäkelä, Jari Viik, Leo Pekka Malmberg
Overnight analysis of tidal breathing flow volume loops (TBFV), recorded by impedance pneumography (IP), has been successfully applied in the home monitoring of children with wheezing disorders. However, little is known on how sleep physiology modifies the relationship between TBFV profiles and wheeze. We studied such interactions in wheezing infants. 43 infants recruited due to recurrent lower airway symptoms were divided into 3 groups based on their risk of asthma, i.e. high (HR), intermediate (IR) or low (LR)...
February 14, 2019: Journal of Applied Physiology
Ondřej Mikeš, Markéta Vrbová, Jana Klánová, Pavel Čupr, Jan Švancara, Hynek Pikhart
The prevalence of the asthmatic symptoms among children increases globally over the time. Reduced exposure to pathogens in early childhood and increased exposure to anthropogenic irritants result in increased risk of wheezing in children, and all of this may be related to the usage of household chemicals. Objective of this analysis thus was to study the potential effects of overall exposure to home chemicals in the early life on the phenotypes of wheezing from birth until five years of age. 3411 mother-infant pairs from the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) participated in the study...
January 25, 2019: Science of the Total Environment
Jia Zhai, Yingxue Zou, Jie Liu, Xingnan Jin, Cuian Ma, Jiao Li, Run Guo, Bing Huang
BACKGROUND: Clinically, asthma in children under 5 years old is under estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing in infants. METHODS: One hundred forty-five infants under 3-year old hospitalized with respiratory diseases were enrolled into this study. Patients were followed up for one-year period after being discharged from the hospital and were, then, divided into recurrent wheezing group and non-recurrent wheezing group based on whether there was recurrent wheezing or not...
January 29, 2019: Italian Journal of Pediatrics
Maja Popovic, Valentina Fiano, Francesca Fasanelli, Morena Trevisan, Chiara Grasso, Manuela Bianca Assumma, Anna Gillio-Tos, Silvia Polidoro, Laura De Marco, Franca Rusconi, Franco Merletti, Daniela Zugna, Lorenzo Richiardi
BACKGROUND: Epigenetics may play a role in wheezing and asthma development. We aimed to examine infant saliva DNA methylation in association with early childhood wheezing. METHODS: A case-control study was nested within the NINFEA birth cohort with 68 cases matched to 68 controls by sex, age (between 6 and 18 months, median: 10.3 months) and season at saliva sampling. Using a bump hunting region-based approach we examined associations between saliva methylome measured using Illumina Infinium HumanMethylation450k array and wheezing between 6 and 18 months of age...
January 25, 2019: Pediatric Allergy and Immunology
Danielle Goetz, Benjamin T Kopp, Ann Salvator, Melissa Moore-Clingenpeel, Karen McCoy, Daniel H Leung, Margaret Kloster, Bonnie R Ramsey, Sonya H Heltshe, Drucy Borowitz
IMPORTANCE: Treatment recommendations for infants with CF standardize care, but most surveillance or treatment guidance of pulmonary manifestations are consensus-based due to sparse evidence. OBJECTIVE: To report observations about pulmonary correlates of growth and other clinical features in infants with CF. METHODS: We analyzed data from the prospective Baby Observational and Nutrition Study conducted in 28 centers across the US, including clinical features, medications, guardian diaries of respiratory symptoms, oropharyngeal swab cultures and chest radiographs (CXR) collected over the first year of life...
January 22, 2019: Pediatric Pulmonology
Xiaochen Wei, Ping Jiang, Jiangbo Liu, Rongfei Sun, Liqin Zhu
OBJECTIVE: The increased social and economic burdens for asthma in infants make the prevention of asthma a major public health goal. Probiotics may reduce the risk of asthma in infants. However, randomized controlled trials (RCTs) have shown mixed efficacy outcomes. We performed a meta-analysis of RCTs to investigate whether probiotics are associated with a lower asthma incidence in infants. METHODS: The PubMed, Cochrane library, and EMBASE databases were systematically searched from the inception dates to August 2018...
January 18, 2019: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Cornelius M Smuts, Tonderayi M Matsungo, Linda Malan, Herculina S Kruger, Marinel Rothman, Jane D Kvalsvig, Namukolo Covic, Karen Joosten, Saskia J M Osendarp, Maaike J Bruins, Leon G J Frenken, Carl J Lombard, Mieke Faber
Background: Evidence on the effect of small-quantity lipid-based nutrient supplements (SQ-LNSs) on early child growth and development is mixed. Objective: This study assessed the effect of daily consumption of 2 different SQ-LNS formulations on linear growth (primary outcome), psychomotor development, iron status (secondary outcomes), and morbidity in infants from age 6 to 12 mo within the context of a maize-based complementary diet. Methods: Infants (n = 750) were randomly assigned to receive SQ-LNS, SQ-LNS-plus, or no supplement...
January 15, 2019: American Journal of Clinical Nutrition
Yongsheng Guo, Yingxue Zou, Jia Zhai, Jiao Li, Jie Liu, Cuian Ma, Xingnan Jin, Liansheng Zhao
BACKGROUND: To identify inflammatory cell types by phenotypic analysis of the inflammatory cells in the induced sputum. METHODS: This retrospective study included 1232 children and infants, who were assigned into mild/moderate groups (326) and severe group (602) by clinical symptom scores. Phenotypes of sputum inflammatory cells were analyzed using liquid-based thin-cytologic test and eosinophil-derived neurotoxin (EDN) was quantified by ELISA. RESULTS: Blood eosinophil count, serum total IgE level, and allergen detection rate were significantly higher in the severe group...
January 15, 2019: Pediatric Research
Koos Korsten, Maarten O Blanken, Brigitte J M Buiteman, Elisabeth E Nibbelke, Christiana A Naaktgeboren, Louis J Bont, Joanne G Wildenbeest
Severe respiratory syncytial virus (RSV) infection during infancy is associated with ongoing respiratory morbidity. In a large birth cohort of 2210 healthy preterm infants born at 32-35 weeks of gestation, we aimed to determine the role of atopy in the link between RSV hospitalization and current wheeze at age 6. We defined current wheeze as parent-reported wheeze or the use of respiratory medication in the past 12 months. Based on a positive family history of atopic disease, we distinguished between children with and without atopic predisposition...
January 12, 2019: European Journal of Pediatrics
T Bakhtadze, K Nemsadze, V Beridze
Asthma is a common disease with increasing prevalence both in children and adults. WHO estimates that annually 15 million disability-adjusted life-years are lost and 250,000 asthma deaths are reported worldwide. Approximately 500,000 annual hospitalizations are due to asthma. To study the Relationship between environmental factors and childhood asthma has been studied. Maternal stress during pregnancy might affect fetal lung development and subsequently predispose to childhood asthma. The aim of the study was to assess the associations of maternal psychological stress during pregnancy and identify environmental correlates of the conditions with childhood asthma...
November 2018: Georgian Medical News
Matti Korppi, Minna Mecklin, Paula Heikkilä
AIM: Meta-analyses of randomised controlled trials on infant bronchiolitis do not support medication. We summarised the current data and evaluated the real-life use of medication for infants treated for bronchiolitis in hospitals, including paediatric wards, emergency departments and paediatric intensive care units (PICU). METHODS: We searched PubMed for studies published from 2009-2018 that provided data on the real-life use of adrenaline, salbutamol, corticosteroids or antibiotics for infants hospitalised for bronchiolitis...
January 7, 2019: Acta Paediatrica
Augusto A Litonjua
PURPOSE OF REVIEW: To review the literature of the past 18 months (April 2017 through September, 2018) relating to vitamin D and childhood asthma. RECENT FINDINGS: A combined analysis of two clinical trials of maternal vitamin D supplementation trials showed a significant protective effect of vitamin D supplementation trials in the primary prevention of asthma and recurrent wheeze up to age 3 years. Secondary analyses from these trials have also suggested that initial maternal vitamin D status could affect the response to supplementation during pregnancy, with the biggest protective effect in children born to mothers with initial 25hydroxyvitamin D (25OHD) levels of at least 30 ng/ml...
April 2019: Current Opinion in Allergy and Clinical Immunology
Erick Forno, Ting Wang, Cancan Qi, Qi Yan, Cheng-Jian Xu, Nadia Boutaoui, Yueh-Ying Han, Daniel E Weeks, Yale Jiang, Franziska Rosser, Judith M Vonk, Sharon Brouwer, Edna Acosta-Perez, Angel Colón-Semidey, María Alvarez, Glorisa Canino, Gerard H Koppelman, Wei Chen, Juan C Celedón
BACKGROUND: Epigenetic mechanisms could alter the airway epithelial barrier and ultimately lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that are associated with-and could accurately classify-atopy and atopic asthma in school-aged children. METHODS: We did a genome-wide study of DNA methylation in nasal epithelium and atopy or atopic asthma in 483 Puerto Rican children aged 9-20 years, recruited using multistage probability sampling...
December 21, 2018: Lancet Respiratory Medicine
Gary M Ginsberg, Eli Somekh, Yechiel Schlesinger
BACKGROUND: Passive immunization against RSV (Respiratory Syncytial Virus) is given in most western countries (including Israel) to infants of high risk groups such as premature babies, and infants with Congenital Heart Disease or Congenital Lung Disease. However, immunoprophylaxis costs are extremely high ($2800-$4200 per infant). Using cost-utility analysis criteria, we evaluate whether it is justified to expand, continue or restrict nationwide immunoprophylaxis using palivizumab of high risk infants against RSV...
December 17, 2018: Israel Journal of Health Policy Research
B H Zhang, X Y Luo, A M Chen, Y Q Jiang
Objective: To investigate the clinical features and the treatment of moderate-severe laryngeallacia, and the application of CO₂laser supraglotation in laryngeallacia. Method: Collecting the clinical data of 18 infants with moderate-to-severe laryngeallacia diagnosed in our hospital,10 cases were moderate. Eight cases were severe children; according to the classification of laryngeallacia, most of them were mixed type, including 2 cases of type Ⅱ, 3 cases of type Ⅲ, 5 cases of typeⅠ + type Ⅱ, 7 cases of typeⅡ+ type Ⅲ, and 1 case of typeⅠ+ typeⅡ + type Ⅲ...
September 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Patricia A Jorquera, Cynthia Mathew, Jennifer Pickens, Colin Williams, Jasmina M Luczo, Sharon Tamir, Reena Ghildyal, Ralph A Tripp
Respiratory syncytial virus (RSV) is a leading cause of hospitalization of infants and young children causing considerable respiratory disease and repeat infections that may lead to chronic respiratory conditions such as asthma, wheezing, and bronchitis. RSV causes ∼34 million new episodes of lower respiratory tract illness (LTRI) in children younger than 5 years of age with >3 million hospitalizations due to severe RSV-associated LRTI. The standard of care is limited to symptomatic relief as there are no approved vaccines and few effective antiviral drugs, thus a safe and efficacious RSV therapeutic is needed...
December 12, 2018: Journal of Virology
Carolina Sanchez Aranda, Gustavo Falbo Wandalsen, Ana Caroline Cavalcanti Dela Bianca, Ellen de Oliveira Dantas, Javier Mallol, Dirceu Solé
OBJECTIVE: To assess the prevalence and severity of wheezing in the first year of life of infants, using the standardized protocol of the Estudio Internacional de Sibilancias en Lactantes- phase 3, and compare the values obtained with those found in phase 1, conducted at the same center. METHODS: Between 2009 and 2010, parents and guardians of infants answered the written questionnaire of the Estudio Internacional de Sibilancias en Lactantes - phase 3, and its results were compared to those of phase 1, performed between 2005 and 2006...
October 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Cosby A Stone, Joan Cook-Mills, Tebeb Gebretsadik, Christian Rosas-Salazar, Kedir Turi, Steven M Brunwasser, Alexandra Connolly, Patty Russell, Zhouwen Liu, Kaitlin Costello, Tina V Hartert
OBJECTIVES: To test the hypothesis that maternal plasma alpha-tocopherol levels are associated with protection from childhood wheeze and that this protection is modified by gamma-tocopherol. STUDY DESIGN: We conducted a prospective nested study in the Infant Susceptibility to Pulmonary Infections and Asthma Following Respiratory Syncytial Virus Exposure birth cohort of 652 children with postpartum maternal plasma vitamin E isoforms used as a surrogate for pregnancy concentrations...
March 2019: Journal of Pediatrics
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