Li Peng, Sisi Luan, Xin Shen, Huidong Zhan, Yueping Ge, Yixiao Liang, Jing Wang, Yang Xu, Shanshan Wu, Xia Zhong, Haiqing Zhang, Ling Gao, Jiajun Zhao, Zhao He
BACKGROUND: Central hypothyroidism (CH) is characterized by low T4 levels and reduced levels or bioactivity of circulating TSH. However, there is a lack of studies on CH-related intestinal maldevelopment. In particular, the roles of TH and TSH/TSHR signaling in CH-related intestinal maldevelopment are poorly understood. Herein, we utilized Tshr-/- mice as a congenital hypothyroidism model with TH deprival and absence of TSHR signaling. METHODS: The morphological characteristics of intestines were determined by HE staining, periodic acid-shiff staining, and immunohistochemical staining...
March 21, 2024: Life Sciences