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Diabetes Adult

Jace Schell, Nancy M Betts, Timothy J Lyons, Arpita Basu
BACKGROUND: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes. OBJECTIVE: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes...
February 14, 2019: Annals of Nutrition & Metabolism
Larissa Lucena Périco, Vinícius Peixoto Rodrigues, Rie Ohara, Vânia Vasti Alfieri Nunes, Lúcia Regina Machado da Rocha, Wagner Vilegas, Catarina Dos Santos, Clélia Akiko Hiruma-Lima
ETHNOPHARMACOLOGICAL RELEVANCE: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. We evaluated the gastric healing effect of the hydroalcoholic extract of the leaves of E. punicifolia (HEEP) in male and female Wistar rats against nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol...
February 11, 2019: Journal of Ethnopharmacology
Steven K Malin, Emily L Kullman, Amanda R Scelsi, Jean-Philippe Godin, Alastair B Ross, John P Kirwan
INTRODUCTION: Few data exist examining the effects of whole grain (WG) versus refined grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function. METHODS: In a double-blind crossover randomized controlled trial, 13 sedentary prediabetic adults (37.2±1.8 y, BMI: 33.6±1.4 kg/m2 , 2h glucose: 146.9±11.6 mg/dl) were provided isocaloric-matched WG and RG diets for 8-weeks each, with an 8-10 week washout between diets. Glucose, insulin and C-peptide metabolism was studied over 240 min following a 75g OGTT...
February 14, 2019: Molecular Nutrition & Food Research
Judit Bajor, Zsolt Szakács, Nelli Farkas, Péter Hegyi, Anita Illés, Margit Solymár, Erika Pétervári, Márta Balaskó, Gabriella Pár, Patrícia Sarlós, Ákos Szűcs, József Czimmer, Kata Szemes, Orsolya Huszár, Péter Varjú, Áron Vincze
BACKGROUND AND AIMS: Experimental data suggest that the HLA-DQ2 gene dose has a strong quantitative effect on clinical outcomes and severity of celiac disease (CD). We aimed to conduct a meta-analysis with systematic review to investigate the association between HLA-DQB1*02 gene doses and the characteristics of CD. METHODS: We searched seven medical databases for studies discussing HLA-DQB1 gene dose in CD and various disease characteristics, such as clinical presentation, histology, age at diagnosis, and comorbidities...
2019: PloS One
Yuliya Lytvyn, Petter Bjornstad, Julie A Lovshin, Sunita K Singh, Genevieve Boulet, Mohammed A Farooqi, Vesta Lai, Josephine Tse, Leslie Cham, Leif E Lovblom, Alanna Weisman, Hillary A Keenan, Michael H Brent, Narinder Paul, Vera Bril, Andrew Advani, Etienne Sochett, Bruce A Perkins, David Z I Cherney
AIMS: Higher plasma uric acid (PUA) concentrations are associated with renal vasoconstriction, renin angiotensin aldosterone system (RAAS) activation and vascular stiffness, however the timeline for these associations in type 1 diabetes (T1D) is not clear. We aimed to compare the changes in such associations over a wide range of T1D duration. MATERIALS AND METHODS: PUA, glomerular filtration rate (GFRINULIN ), effective renal plasma flow (ERPFPAH ), vascular stiffness parameters (aortic augmentation index [AIx], carotid AIx, carotid femoral pulse wave velocity [cfPWV]), plasma renin and aldosterone were measured during a euglycemic clamp in participants with T1D: 27 adolescents (age 16...
February 13, 2019: Diabetes, Obesity & Metabolism
Angelico Mendy, Radha Gopal, John F Alcorn, Erick Forno
BACKGROUND AND OBJECTIVE: Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory outcomes. Therefore, we examined the association of metformin use with the risk of mortality from CLRD. METHODS: We analysed data from the National Health and Nutrition Examination Survey during 1988-1994 and 1999-2010 for participants aged 40 years or older who had diabetes and were followed up for mortality through 2011...
February 13, 2019: Respirology: Official Journal of the Asian Pacific Society of Respirology
J Weissberg-Benchell, J Shapiro, K Hood, L M Laffel, D Naranjo, K Miller, K Barnard
AIM: Participants in clinical trials assessing automated insulin delivery systems report perceived benefits and burdens that reflect their experiences and may predict their likelihood of uptake and continued use of this novel technology. Despite the importance of understanding their perspectives, there are no available validated and reliable measures assessing the psychosocial aspects of automated insulin delivery systems. The present study assesses the initial psychometric properties of the INSPIRE measures, which were developed for youth and adults with Type 1 diabetes, as well as parents and partners...
February 14, 2019: Diabetic Medicine: a Journal of the British Diabetic Association
A Stahl-Pehe, L Glaubitz, C Bächle, K Lange, K Castillo, T Tönnies, R Yossa, R W Holl, J Rosenbauer
AIM: This study aimed to determine cross-sectional relationships between diabetes distress and health-related variables, and prospective associations between diabetes distress and future glycaemic control (HbA1c ) and health status among young adults with early-onset Type 1 diabetes. METHODS: Data were collected from a nationwide cohort study of adults whose Type 1 diabetes onset occurred from 0 to 4 years of age during 1993-2002. Questionnaire surveys were conducted in 2012-2013 and 2015-2016 (N = 584)...
February 14, 2019: Diabetic Medicine: a Journal of the British Diabetic Association
Simina Toma, Lisa Fiksenbaum, Danielle Omrin, Benjamin I Goldstein
Background: Bipolar disorder (BD) is one of the most heritable medical conditions, and certain phenotypic characteristics are especially familial in BD. BD is also strongly associated with elevated and premature cardiovascular disease (CVD) morbidity and mortality. Thus, far, little is known regarding the familiality of cardiovascular risk in BD. We therefore examined the extent of CVD-related conditions among relatives of: adolescents with BD with a family history of BD (familial BD), adolescents with BD without a family history of BD (non-familial BD) and healthy controls (HC)...
2019: Frontiers in Psychiatry
Irit Meivar-Levy, Fatima Zoabi, Gil Nardini, Eugenia Manevitz-Mendelson, Gil S Leichner, Oranit Zadok, Michael Gurevich, Eytan Mor, Simona Dima, Irinel Popescu, Aviv Barzilai, Sarah Ferber, Shoshana Greenberger
BACKGROUND: Insulin-dependent diabetes is a multifactorial disorder that could be theoretically cured by functional pancreatic islets and insulin-producing cell (IPC) implantation. Regenerative medicine approaches include the potential for growing tissues and organs in the laboratory and transplanting them when the body cannot heal itself. However, several obstacles remain to be overcome in order to bring regenerative medicine approach for diabetes closer to its clinical implementation; the cells generated in vitro are typically of heterogenic and immature nature and the site of implantation should be readily vascularized for the implanted cells to survive in vivo...
February 13, 2019: Stem Cell Research & Therapy
Xuemei Wang, Wei Shu, Jian Du, Maolin Du, Peiyu Wang, Mingming Xue, Huiqiu Zheng, Yufeng Jiang, Shaohua Yin, Danyan Liang, Ruiqi Wang, Lina Hou
BACKGROUND: As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. The objective of this study was to carry out a systematic review and meta-analysis using the available literature reporting findings on mHealth interventions, which may improve the management of type 1 diabetes...
February 13, 2019: BMC Endocrine Disorders
Priscilla Hollander, Julie Hill, Jeremy Johnson, Zhi Wei Jiang, Gregory Golm, Susan Huyck, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring, Jie Liu
OBJECTIVE: To assess the safety and efficacy of ertugliflozin over 104 weeks in patients with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin. METHODS: In this double-blind, multicenter, randomized, Phase III study (VERTIS SU; NCT01999218), adults with T2DM and glycated hemoglobin (HbA1c) 7.0-9.0% on metformin ≥1500 mg/day received ertugliflozin 5 mg, 15 mg, or glimepiride. The primary efficacy time point was Week 52; double-blinded treatment continued until Week 104...
February 14, 2019: Current Medical Research and Opinion
Yunwen Xu, Scott J Pilla, G Caleb Alexander, Irene B Murimi
BACKGROUND: Clinical guidelines recommend that metformin be continued after insulin is initiated among patients with type 2 diabetes, yet little is known regarding how often metformin or other non-insulin diabetes medications are continued in this setting. METHODS: We conducted a retrospective cohort study to characterize rates and use patterns of six classes of non-insulin diabetes medications: biguanides (metformin), sulfonylureas, thiazolidinediones (TZDs), glucagon-like peptide 1 receptor agonists (GLP1 receptor agonists), dipeptidyl peptidase 4 inhibitors (DPP4 inhibitors), and sodium-glucose co-transporter inhibitors (SGLT2 inhibitors), among patients with type 2 diabetes initiating insulin...
2019: PloS One
Yifan Zhong, Song Yue, Jingyang Wu, Peng Guan, Guisen Zhang, Lei Liu, Lei Chen
INTRODUCTION: The relationship of total cholesterol (TC) or triglyceride (TG) to diabetic retinopathy (DR) has proven difficult to determine. In addition, there is no report of any study of the correlation between the TC/TG ratio and DR. This study was therefore undertaken to investigate the relationship between the TC/TG ratio and DR in Chinese adults with type 2 diabetes mellitus. METHODS: A community-based study was conducted from August to October 2014 in Fengyutan, Shenyang, China...
February 13, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Leigh Perreault, Marilyn K Boardman, Jonathan Pak
INTRODUCTION: It is unclear whether patients and their loved ones appreciate that cardiovascular disease (CVD) is the major cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). The purpose of this survey was to evaluate the degree of awareness regarding the link between T2DM and CVD. METHODS: An online survey was conducted among US adults (general population) and adults with self-reported T2DM. RESULTS: Of 13,027 participants recruited, 1505 completed the survey (12% response rate): 501 with T2DM and 1004 from the general population, of whom 364 knew someone with T2DM (e...
February 13, 2019: Advances in Therapy
Mikael Rydén, Paul Petrus, Daniel P Andersson, Gema Medina-Gómez, Elia Escasany, Patricia Corrales Cordón, Ingrid Dahlman, Agné Kulyté, Peter Arner
OBJECTIVE: Many overweight/obese subjects appear metabolically healthy with normal in vivo insulin sensitivity. Still, they have increased long-term risk of developing type 2 diabetes. We hypothesized that adipose tissue dysfunction involving decreased insulin action in adipocytes is present in apparently healthy overweight/obese subjects. DESIGN/METHODS: Subjects with normal metabolic health according to Adult Treatment Panel-III or Framingham risk score criteria were subdivided into 67 lean, 32 overweight and 37 obese according to body mass index...
February 13, 2019: Journal of Internal Medicine
Peter Sarich, Karen Canfell, Emily Banks, Ellie Paige, Sam Egger, Grace Joshy, Rosemary Korda, Marianne Weber
BACKGROUND: Evidence suggests that people who develop serious health conditions are likely to cease drinking alcohol (sometimes known as 'sick-quitters'). We quantified the likelihood of quitting drinking in relation to the onset of a variety of health conditions. METHODS: Odds ratios (OR) and 95% confidence intervals (CI) of ceasing alcohol consumption after diagnosis of 28 health conditions and four general indicators of health were derived from logistic regression among 97,852 drinkers aged ≥45 years between baseline (2006-2009) and median 5...
February 13, 2019: Alcoholism, Clinical and Experimental Research
Huanhuan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Hiroko Okazaki, Makoto Yamamoto, Toshiaki Miyamoto, Masafumi Eguchi, Takeshi Kochi, Makiko Shimizu, Taizo Murakami, Kentaro Tomita, Takayuki Ogasawara, Naoko Sasaki, Akihiko Uehara, Keisuke Kuwahara, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
AIMS/INTRODUCTION: We examined a prospective association between serum creatinine levels and diabetes. MATERIALS AND METHODS: This study included 31,343 male workers without diabetes and aged between 20 and 64 years old at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either HbA1c levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL, or receiving antidiabetic treatment...
February 12, 2019: Journal of Diabetes Investigation
Tomoko Udo, Carlos M Grilo
OBJECTIVE: To examine psychiatric and somatic correlates of DSM-5 eating disorders (EDs)-anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)-in a nationally representative sample of adults in the United States. METHOD: A national sample of 36,309 adult participants in the national epidemiologic survey on alcohol and related conditions III (NESARC-III) completed structured diagnostic interviews (AUDADIS-5) to determine psychiatric disorders, including EDs, and reported 12-month diagnosis of chronic somatic conditions...
January 2019: International Journal of Eating Disorders
Armando De Alba, Denise H Britigan, Elizabeth Lyden, Patrik Johansson
BACKGROUND: Predictions from the US census indicate that by 2060 one of every three individuals living in the nation will be of Hispanic origin. Hispanics experience health disparities manifested with higher rates of chronic conditions such as hypertension and diabetes in contrast with other US population groups. Health literacy and acculturation have been well identified as key contributors for this issue. However, very few studies have examined the association between health literacy and levels of acculturation in Spanish-speaking Hispanics living in rural and urban areas of the USA...
February 12, 2019: Journal of Racial and Ethnic Health Disparities
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