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Rat burn

Reza Vaghardoost, Yaser Ghavami, Behnam Sobouti
BACKGROUND: Burn is one of the most common injuries and the 4th common cause of trauma globally. This study was designed to evaluate the effect of the Mentha pulegium extract on second degree burn injuries in rats assessing histopathologic and macroscopic. METHODS: M. Pulegium extract dressings was used as a treatment to deep dermal contact burns in rats, compared with two control groups of vaseline dressing and simple dressing by normal saline. After creating second-degree burn on the dorsum of rats, the treatments were applied for 15 min in three groups...
January 2019: World Journal of Plastic Surgery
Maria Malmlöf, Mattias Nowenwik, Kristof Meelich, Iwona Rådberg, Ewa Selg, John Burns, Hermann Mascher, Per Gerde
The surface area of the air/liquid interface in the lungs is substantial, so deposited doses of aerosol medicines per interface surface area when administered via the inhalation route is always quite low. However, in most in vitro systems used for dissolution testing of dry powder inhalables, the dose per surface area is generally much higher. The aim of this study was to investigate in one in vitro lung dissolution system, the DissolvIt, the manner in which the deposited dose per test surface area of drug particles influences the simulated dissolution- and absorption rate...
March 9, 2019: European Journal of Pharmaceutics and Biopharmaceutics
Mehmet Sürmeli, Salih Maçin, Yakut Akyön, Aycan Uğur Kayikçioğlu
OBJECTIVE: To determine and quantitatively measure the protective and/or therapeutic effect of Lactobacillus plantarum (LP) application on a burn wound before and after the onset of meticillin-resistant Staphylococcus aureus (MRSA) infection. METHOD: Third-degree scald burns affecting 10% of body surface area were formed on the back of five groups of rats. Group 1 was designated as the control group. In Group 2, LP was applied immediately after the burn and then MRSA inoculated...
March 2, 2019: Journal of Wound Care
Zhiwen Hai, Yimeng Ren, Jiawen Hu, Huan Wang, Qi Qin, Tingtao Chen
Burn injury is a growing medical problem associated with public health, and few effective agents are available for treatment of this disease. In the present study, a burn injury rat model was developed and the accelerated effect of Aloe vera fermentation on burn injury healing was evaluated. Our results indicated that Aloe vera fermentation could markedly reduce the DPPH (56.12%), O2·- (93.5%), · OH (76.12%), Fe2+ chelation (82%), and oxygen-reduction activity (0.28  μ g/ml) and significantly inhibited the growth of pathogens S...
2019: Mediators of Inflammation
Charlotte Mungho Tata, Constance Rufaro Sewani-Rusike, Opeoluwa Oyehan Oyedeji, Ephraim Tobela Gwebu, Fikile Mahlakata, Benedicta Ngwenchi Nkeh-Chungag
BACKGROUND: Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects of the hydroethanol extract of S. serratuloides (HESS) in N-Nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats. METHODS: Acute toxicity of HESS was first determined to provide guidance on doses to be used in this study. Lorke's method was used to determine safety of the extract in mice...
February 28, 2019: BMC Complementary and Alternative Medicine
Yeliz Ekim, Selcuk Kara, Baran Gencer, Turan Karaca
PURPOSE: To investigate the preventive effects of topical sunitinib, sunitinib-hesperetin and sunitinib-doxycycline combinations on corneal neovascularization (CNV), apoptosis and fibrosis in a corneal alkali burn model. MATERIALS AND METHODS: The corneas of 32 Wistar albino rats were cauterized with silver nitrate to induce CNV. Four groups were created receiving artificial tears (sham), sunitinib (0.5 mg/ml), sunitinib-hesperetin (0.5 mg/ml-0.2 mg/ml), and sunitinib-doxycycline (0...
February 25, 2019: Current Eye Research
Wei Yang, Hongjie Xu, Yong Lan, Qiyu Zhu, Yu Liu, Shaoshan Huang, Shengjun Shi, Andrei Hancharou, Bing Tang, Rui Guo
To mimic the natural structure of tissue extracellular matrix, a novel silk fibroin (SF)/hyaluronic acid (HA)/sodium alginate (SA) composite scaffold (92% in porosity) was prepared by freeze-drying. Fourier-transform infrared spectroscopy and Raman spectra indicated interactions among SF, HA, and SA molecules. Scanning electron microscopy showed that the prepared SF/HA/SA scaffold had soft, elastic characteristics, with an average pore diameter of 93 μm. Mechanical property, thermogravimetric analyses and degradation results indicated that the SF/HA/SA scaffold had good physical stability in body fluid and mechanical movement-related environments...
February 21, 2019: International Journal of Biological Macromolecules
Cui'e Wei, Xiangsheng Ding, Changhai Liu, Yongdong Pei, Yuren Zhong, Wentao Sun
No abstract text is available yet for this article.
February 14, 2019: Minerva Medica
Zhixue Wang, Jifeng Fang, Jizhou Xiao
Correlation of the expression of inflammatory factors with expression of apoptosis-related genes, B-cell lymphoma 2 ( Bcl-2 ) and Bcl-2 associated X protein ( Bax ), in burned rats was investigated. Forty healthy Sprague-Dawley rats were selected and randomly divided into SHAM group (n=10), I° burn group (n=10), II° burn group (n=10) and III° burn group (n=10). Changes in tumor necrosis factor-α (TNF-α), Bax messenger ribonucleic acid (mRNA), Bcl-2 mRNA, Bax protein and Bcl-2 protein expression levels were detected...
March 2019: Experimental and Therapeutic Medicine
Lauren H Mangum, Joshua J Avila, Brady J Hurtgen, Alicia L Lofgren, Joseph C Wenke
BACKGROUND: Singular traumatic insults, such as bone fracture, typically initiate an appropriate immune response necessary to restore the host to pre-insult homeostasis with limited damage to self. However, multiple concurrent insults, such as a combination of fracture, blunt force trauma, and burns (polytrauma), are clinically perceived to result in abnormal immune response leading to inadequate healing and resolution. To investigate this phenomenon, we created a model rat model of polytrauma...
February 19, 2019: Journal of Orthopaedic Surgery and Research
Yanhui Bai, Weiqun Wang, Youmei Zhang, Fengyan Zhang, Haohao Zhang
BACKGROUND: Corneal neovascularization (CRNV) is a prevalence eye disorder that affects the transparency and refraction properties of eyes. The level of Angiotensin II (Ang II) is related to corneal angiogenesis, while the potential role was still unclear. METHODS: The rat model of CRNV was established using alkali-burn, while the human umbilical vein endothelial cells (HUVECs) were stimulated using VEGF to induce the CRNV cells in vitro. RNA immunoprecipitation (RIP) and RNA pull-down were performed to validate the relationship between MIAT and miR-1246...
February 20, 2019: Cell Cycle
Zurab Kakabadze, David Chakhunashvili, Ketevan Gogilashvili, Ketevan Ediberidze, Konstantine Chakhunashvili, Konstantine Kalandarishvili, Lia Karalashvili
OBJECTIVES: In this study, our aim was to create a bioactive wound dressing that combined decellularized and lyophilized human amniotic membrane and freeze-dried rat bone marrow stem cells for the treatment of nonhealing wounds. MATERIALS AND METHODS: For the decellularized human amniotic membrane, sodium dodecyl sulfate and 1% Triton X-100 were used. The mononuclear fraction of bone marrow stem cells was isolated by density gradient centrifugation using Ficoll Paque Plus (GE Healthcare Bio-Sciences, Pittsburgh, PA, USA)...
January 2019: Experimental and Clinical Transplantation
Priyamvada Tewari, James Garritano, Neha Bajwa, Shijun Sung, Haochong Huang, Dayong Wang, Warren Grundfest, Daniel B Ennis, Dan Ruan, Elliott Brown, Erik Dutson, Michael C Fishbein, Zachary Taylor
A method to register THz and visible images of cutaneous burn wounds and to calibrate THz image data is presented. Images of partial and full thickness burn wounds in 9 rats were collected over 435 mins. = 7.25 hours following burn induction. A two-step process was developed to reference the unknown structure of THz imaging contrast to the known structure and the features present in visible images of the injury. This process enabled the demarcation of a wound center for each THz image, independent of THz contrast...
January 1, 2019: Biomedical Optics Express
Parviz Farzadinia, Gholamhossein Mohebbi, Afshar Bargahi, Samad Akbarzadeh, Iraj Nabipour, Mohammadreza Abdi, Zeynab Hasanpour, Zahra Alipour, Adel Daneshi
Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Various bioactive compounds such as steroid glycosides, tannins, various vitamins, saponins, cardenolides and anthraquinones were identified into extract of the plant, which can be effective in burn wound healing. Twenty-one rats weighting every one 200±5 grams were divided equally into three groups. The second-degree burning induced on all groups...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Rui He, Li Han, Ping Liu, Hai Hu, Jia Yang, Hong Cai, Chang Huang, Lei Wang, Juntian Liu, Jian Huang, Lue Ha, Yaomeng Liu, Jihong Wu, Maoxiang Zhu, Baixiao Zhao
Objective: Moxibustion is a complementary therapy that has been used for thousands of years. Burning moxa produces smoke and inhalable particulates. Recent research has indicated that smoke inhalation is associated with negative lung effects. This study aimed to evaluate the lung function of rats after moxa smoke exposure at different concentrations. Methods: Using a randomised block experiment design, 28 male Wistar rats were randomly divided into three moxa smoke groups (opacity) (n=7): low concentration (27...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Shuai Shi, Fangli Peng, Qianqian Zheng, Li Zeng, Hao Chen, Xingyi Li, Jinhai Huang
The development of new blood vessels is directly related to the occurrence of eye diseases. Anti-angiogenic drugs can theoretically be extended to the treatment of ophthalmic diseases. In this study, axitinib, a class of tyrosine kinase inhibitors, was loaded via the amphiphilic copolymer MPEG-PCL, improving its dispersibility in water. Axitinib-loaded micelles showed low toxicity in concentration gradient assays. Additionally, multiple doses by scratch assay confirmed that axitinib had no significant effect on normal cell migration, and biosafety test results showed good cell compatibility...
January 30, 2019: International Journal of Pharmaceutics
Cheirmadurai Kalirajan, Pearlin Hameed, Nagaraj Subbiah, Thanikaivelan Palanisamy
Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO2 nanoparticles and cross-linked with oxidized sago starch. The biocompatibility, thermal stability and antimicrobial property of hybrid scaffold enabled its application in burn wound healing demonstrated through albino rat models...
January 31, 2019: Scientific Reports
Mohammad Heidari, Roodabeh Bahramsoltani, Amir Hossein Abdolghaffari, Roja Rahimi, Mohammadamin Esfandyari, Maryam Baeeri, Gholamreza Hassanzadeh, Mohammad Abdollahi, Mohammad Hosein Farzaei
Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period...
January 2019: Journal of Traditional and Complementary Medicine
Meghan Samberg, Randolph Stone, Shanmugasundaram Natesan, Andrew Kowalczewski, Sandra Becerra, Nicole Wrice, Andrew Cap, Robert Christy
Despite great advances in skin wound care utilizing grafting techniques, the resulting severe scarring, deformity and ineffective vascularization remains a challenge. Alternatively, tissue engineering of new skin using patient-derived stem cells and scaffolding materials promises to greatly increase the functional and aesthetic outcome of skin wound healing. This work focused on the optimization of a polyethylene glycol modified (PEGylated) platelet-rich plasma (PRP) hydrogel for the protracted release of cytokines, growth factors, and signaling molecules and also the delivery of a provisional physical framework for stem cell angiogenesis...
March 15, 2019: Acta Biomaterialia
Bora Yucel, Atilla Coruh, Kemal Deniz
Saving the zone of stasis is a major subject of the burn wound studies. If pathological changes in zone of stasis can be minimized, conversion of burns may be prevented. The aim of this study was to investigate the effects of pentoxifylline (PTX) on the zone of stasis in burns and burn wound healing. Twenty Sprague Dawley rats were used in this study. Comb model was used to create zone of stasis in burns. Rats were randomly divided into two groups. Treatment group received a total of 200 mg/kg/day of pentoxifylline in two equal doses intraperitoneally whilst isotonic saline solution was administered intraperitoneally to the control group...
January 12, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
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