keyword
https://read.qxmd.com/read/34731345/correlation-between-clarithromycin-resistance-virulence-factors-and-clinical-characteristics-of-the-disease-in-helicobacter-pylori-infected-patients-in-shahrekord-southwest-iran
#21
JOURNAL ARTICLE
Razieh Sadat Hosseini, Ghorbanali Rahimian, Mohammad Hadi Shafigh, Majid Validi, Mansoor Khaledi, Abolfazl Gholipour
The purpose of this study was to determine the mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from biopsy samples that were collected from the endoscopic ward of Shahrekord Hajar teaching Hospital and also to study the frequency of virulence factor and their correlation and pathological findings with clarithromycin resistance during the years 2019-2020. In this cross-sectional descriptive study, 152 patients with Helicobacter pylori infection were considered, and then, two common A2142G and A2143G mutations in the 23SrRNA gene associated with resistance were analyzed by Real-time PCR (Taq man)...
November 3, 2021: AMB Express
https://read.qxmd.com/read/34718962/geographic-diversity-in-helicobacter-pylori-oipa-genotype-between-korean-and-united-states-isolates
#22
JOURNAL ARTICLE
Aeryun Kim, Jing Lai, D Scott Merrell, Ji-Hye Kim, Hanfu Su, Jeong-Heon Cha
Helicobacter pylori outer membrane inflammatory protein A (OipA) was originally named for its role in inducing inflammation in the host, as evidenced by high mucosal IL-8 levels. Expression of OipA is regulated by phase variation of a CT dinucleotide-repeat located in the 5' region of the gene. However, little is known about OipA geographic diversity across isolates. To address this gap, we conducted a large-scale molecular epidemiologic analysis using H. pylori clinical isolates obtained from two geographically distinct populations: Korea and the United States (US)...
October 31, 2021: Journal of Microbiology / the Microbiological Society of Korea
https://read.qxmd.com/read/34363898/the-crosstalk-between-h-pylori-virulence-factors-and-the-pd1-pd-l1-immune-checkpoint-inhibitors-in-progression-to-gastric-cancer
#23
JOURNAL ARTICLE
Merve Aydın, Dilan Demir, Nogayhan Seymen, Sawsan Sudqi Said, Sinem Oktem-Okullu, Arzu Tiftikci, Bahattin Cicek, Fatma Tokat, Nurdan Tozun, Umit Ince, Ugur Sezerman, Ayca Sayi-Yazgan
BACKGROUND: The progression to gastric cancer has been linked to chronic infection with Helicobacter pylori (H. pylori). Immune checkpoint inhibitors (programmed cell death -1, PD-1; programmed cell death -ligand 1, PD-L1) have a role in cancer immune escape. The relationship between H. pylori virulence factors with PD-1, PD-L1 T helper 1 (Th1), T helper 17 (Th17), and regulatory T cell (Treg) response genes, has not been thoroughly investigated in the development of gastric cancer. Therefore, we evaluated how H...
August 4, 2021: Immunology Letters
https://read.qxmd.com/read/34355101/frequency-of-virulence-associated-genotypes-of-helicobacter-pylori-and-their-correlation-with-clinical-outcome-and-histological-parameters-in-infected-patients
#24
JOURNAL ARTICLE
Milad Shahini Shams Abadi, Korosh Ashrafi-Dehkordi, Reza Ahmadi, Ghorbanali Rahimian, Yousef Mirzaei, Rana Fereidani, Mojtaba Shohan, Fatemeh Azadegan-Dehkordi
Helicobacter pylori ( H. pylori ) is a gram-negative which can cause several gastroduodenal diseases, including gastritis and peptic ulcer disease (PUD). H. pylori specific genotypes have been related to increased occurrence of gastritis and PUD. The aim of this study was to investigate the clinical relevance of the major virulence factors of H . pylori with clinical outcomes and histological parameters in Iranian patients. Totally, 200 subjects with PUD and gastritis disease who underwent gastroduodenal endoscopy were enrolled in this study...
July 2021: Heliyon
https://read.qxmd.com/read/34130751/geographic-distribution-of-the-caga-vaca-icea-oipa-and-dupa-genes-of-helicobacter-pylori-strains-isolated-in-china
#25
JOURNAL ARTICLE
Zhijing Xue, Hong Yang, Dongxing Su, Xiangfeng Song, Xin Deng, Changhong Yu, Chunhua Sun, Lihua He, Yuanhai You, Yanan Gong, Dongjie Fan, Lu Sun, Xiurui Han, Ruyue Fan, Maojun Zhang, Xiaomei Yan, Jiaming Qian, Jianzhong Zhang
BACKGROUND: There are geographic variations in the genotypes of Helicobacter pylori (H. pylori) cagA, vacA, iceA, oipA and dupA. The aim of the study was to investigate the distribution of these genotypes among H. pylori strains from five regions of China and their association with clinical outcomes. MATERIALS AND METHODS: Gastric biopsy specimens were obtained from 348 patients with different gastrointestinal diseases in the five regions of China. The regional distribution was 89 patients from Shandong, 91 from Guangxi, 57 from Hunan, 58 from Qinghai and 53 from Heilongjiang...
June 15, 2021: Gut Pathogens
https://read.qxmd.com/read/33732225/the-role-of-a-dipeptide-transporter-in-the-virulence-of-human-pathogen-helicobacter-pylori
#26
JOURNAL ARTICLE
Xiaohong Xu, Junwei Chen, Xiaoxing Huang, Shunhang Feng, Xiaoyan Zhang, Feifei She, Yancheng Wen
Helicobacter pylori harbors a dipeptide (Dpp) transporter consisting of a substrate-binding protein (DppA), two permeases (DppB and C), and two ATPases (DppD and F). The Dpp transporter is responsible for the transportation of dipeptides and short peptides. We found that its expression is important for the growth of H . pylori . To understand the role of the Dpp transporter in the pathogenesis of H . pylori , the expression of virulence factors and H . pylori -induced IL-8 production were investigated in H...
2021: Frontiers in Microbiology
https://read.qxmd.com/read/33440259/contrasting-association-of-helicobacter-pylori-oipa-genotype-with-risk-of-peptic-ulceration-and-gastric-cancer
#27
JOURNAL ARTICLE
Omolbanin Feili, Seyedeh Zahra Bakhti, Saeid Latifi-Navid, Saber Zahri, Abbas Yazdanbod
Helicobacter pylori OipA (outer inflammatory protein A) is an outer membrane protein that involves in the binding and colonization of the bacterium in the stomach. The oipA status is associated with the risk of peptic ulcerations (PUs) and gastric cancer (GC) diseases. However, the association trend with PUs compared to GC is often different and highly challenging. We therefore aimed to determine the presence of this genotype in Iranian strains and assess its association with the risk of PUs and GC in a larger number of samples...
January 10, 2021: Infection, Genetics and Evolution
https://read.qxmd.com/read/33073485/a-comparative-whole-genome-analysis-of-helicobacter-pylori-from-a-human-dense-south-asian-setting
#28
JOURNAL ARTICLE
Shamsul Qumar, Trang Hoa Nguyen, Shamsun Nahar, Nishat Sarker, Stephen Baker, Dieter Bulach, Niyaz Ahmed, Motiur Rahman
Helicobacter pylori, a Gram-negative bacterium, is associated with a wide range of gastric diseases such as gastritis, duodenal ulcer, and gastric cancer. The prevalence of H pylori and risk of disease vary in different parts of the world based on the prevailing bacterial lineage. Here, we present a contextual and comparative genomics analysis of 20 clinical isolates of H pylori from patients in Bangladesh. Despite a uniform host ethnicity (Bengali), isolates were classified as being part of the HpAsia2 (50%) or HpEurope (50%) population...
October 18, 2020: Helicobacter
https://read.qxmd.com/read/32928496/up-regulated-ccl18-ccl28-and-cxcl13-expression-is-associated-with-the-risk-of-gastritis-and-peptic-ulcer-disease-in-helicobacter-pylori-infection
#29
JOURNAL ARTICLE
Mohammad-Javad Sanaei, Hedayatollah Shirzad, Amin Soltani, Meghdad Abdollahpour-Alitappeh, Mohammad-Hadi Shafigh, Ghorbanali Rahimian, Yousef Mirzaei, Nader Bagheri
BACKGROUND: Helicobacter pylori (H. pylori) infection causes inflammation and increases the risk of developing peptic ulcer disease (PUD); however, the exact molecular mechanisms of PUD development remain unclear. The aim of this study was to investigate the expression of CCL18, CCL28, and CXCL13 in H. pylori-positive subjects in comparison with H. pylori-negative subjects, and to determine its association with different clinical outcomes and virulence factors. METHODS: In total, 55 H...
July 28, 2020: American Journal of the Medical Sciences
https://read.qxmd.com/read/32908495/analysis-of-correlation-between-the-seven-important-helicobacter-pylori-h-pylori-virulence-factors-and-drug-resistance-in-patients-with-gastritis
#30
JOURNAL ARTICLE
Sinem Oktem-Okullu, Zehra Cekic-Kipritci, Elif Kilic, Nogayhan Seymen, Nesteren Mansur-Ozen, Ugur Sezerman, Yesim Gurol
The aim of this study is to evaluate the association between seven important H . pylori virulence factors and antibiotic resistance in patients with gastritis. H . pylori strains isolated from 33 patients with gastritis were examined. Antimicrobial susceptibilities were tested by GenoType® HelicoDR (Hain Life Science, Germany) test kit and RT-PCR. The virulence-factors were determined using conventional PCR. 39% of patients were resistant for clarithromycin and 27% of patients were resistant for fluoroquinolone...
2020: Gastroenterology Research and Practice
https://read.qxmd.com/read/32765194/-helicobacter-pylori-oncogenicity-mechanism-prevention-and-risk-factors
#31
REVIEW
Muzaheed
Helicobacter pylori ( H . pylori ) is the most common cause of gastric ulcer; however, its association with gastric cancer has been proved through a variety of studies. Importantly, H . pylori infection affects around half of the world's population leading to a variety of gastric problems and is mostly present in asymptomatic form. Although about 20% of people infected with H . pylori develop preneoplastic gastric lesions in later stages of their life, around 2% of infected individuals develop gastric cancer...
2020: TheScientificWorldJournal
https://read.qxmd.com/read/32677810/role-of-the-outer-inflammatory-protein-a-cystine-glutamate-transporter-pathway-in-gastric-mucosal-injury-induced-by-helicobacter-pylori
#32
JOURNAL ARTICLE
Jie Du, Xiao-Hui Li, Fen Liu, Wen-Qun Li, Zhi-Cheng Gong, Yuan-Jian Li
INTRODUCTION: Helicobacter pylori infection is a major cause of gastrointestinal diseases. However, the pathogenesis of gastric mucosal injury by H. pylori remains unclear. Exogenous glutamate supplementation protects against gastric mucosal injury caused by H. pylori. Previously, we showed that aspirin-induced gastric injury is associated with reduction in glutamate release by inhibition of cystine-glutamate transporter (xCT) activity. We hypothesized that the xCT pathway is involved in H...
May 2020: Clinical and Translational Gastroenterology
https://read.qxmd.com/read/32607764/outer-inflammatory-protein-of-helicobacter-pylori-impacts-il-8-expression-adherence-cell-apoptosis-and-cell-cycle-of-gastric-cells-independent-of-its-copy-number
#33
JOURNAL ARTICLE
Qiaoyun Zhao, Wenzhu Yin, Rulin Zhao, Youhua Wang, Conghua Song, Huan Wang, Jianfang Rong, Fangfei Wang, Yong Xie
Outer inflammatory protein (OipA) is an important virulence factor of Helicobacter pylori (H. pylori), but the correlation between oipA copy number and its virulence remains unknown. The study was designed to investigate whether the duplicate oipA gene loci showed more virulent than one oipA gene in vitro. H. pylori strain CCS9803 (China Chongqing Strain 9803) that carries duplicate oipA loci was used to construct one or two oipA knockout mutant strain, which was further verified by qPCR and western blot. Gastric epithelial cells AGS and GES-1 were infected with wild-type (WT) or oipA mutants for 6 or 24 h...
June 30, 2020: Medical Microbiology and Immunology
https://read.qxmd.com/read/32557327/virulence-of-helicobacter-pylori-outer-membrane-proteins-an-updated-review
#34
REVIEW
Chenjing Xu, Djaleel Muhammad Soyfoo, Yao Wu, Shunfu Xu
Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H. pylori, which play a vital role in severe clinical outcomes. Additionally, the expression of outer membrane proteins (OMPs) helps H. pylori attach to gastric epithelial cells at the primary stage and increases the virulence of H. pylori. In this review, we have summarized the paralogs of H. pylori OMPs, their genomic loci, and the different receptors of OMPs identified so far...
June 17, 2020: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/32219508/prevalence-of-helicobacter-pylori-baba-oipa-saba-and-homb-genes-in-isolates-from-chinese-patients-with-different-gastroduodenal-diseases
#35
JOURNAL ARTICLE
Qiaoyun Zhao, Conghua Song, Ke Wang, Donghong Li, Yang Yang, Dongsheng Liu, Le Wang, Nanjin Zhou, Yong Xie
Disease outcome is associated with virulence factors of Helicobacter pylori (H. pylori), which are partially attributed to the outer membrane protein (OMP). This study aimed to investigate the correlation between the four OMP genes (babA, oipA, sabA, and homB) and gastroduodenal diseases. One hundred and seventy-seven H. pylori strains were isolated from Chinese patients with different gastroduodenal diseases (49 chronic gastritis, 19 gastric ulcer, 33 gastric cancer, and 76 duodenal ulcer), 94 of which contained pathological information (41 superficial gastritis, 24 intestinal hyperplasia, and 29 gastric adenocarcinoma)...
March 26, 2020: Medical Microbiology and Immunology
https://read.qxmd.com/read/32099418/phenotypic-and-genotypic-assessment-of-antibiotic-resistance-and-genotyping-of-vaca-caga-icea-oipa-cage-and-baba2-alleles-of-helicobacter-pylori-bacteria-isolated-from-raw-meat
#36
JOURNAL ARTICLE
Zohreh Mashak, Sedigheh Jafariaskari, Iman Alavi, Mohammadhossein Sakhaei Shahreza, Farhad Safarpoor Dehkordi
Background: Foodstuffs with animal origins, particularly meat, are likely reservoirs of Helicobacter pylori . Purpose: An existing survey was accompanied to assess phenotypic and genotypic profiles of antibiotic resistance and genotyping of vacA, cagA, cagE, iceA, oipA , and babA2 alleles amongst the H. pylori bacteria recovered from raw meat. Methods: Six-hundred raw meat samples were collected and cultured. H. pylori isolates were tested using disk diffusion and PCR identification of antibiotic resistance genes and genotyping...
2020: Infection and Drug Resistance
https://read.qxmd.com/read/31752394/-helicobacter-pylori-virulence-factors-exploiting-gastric-colonization-and-its-pathogenicity
#37
REVIEW
Shamshul Ansari, Yoshio Yamaoka
Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world's population, and it is the strongest risk factor for developing gastric complications like chronic gastritis, ulcer diseases, and gastric cancer. To successfully colonize and establish a persistent infection, the bacteria must overcome harsh gastric conditions. H. pylori has a well-developed mechanism by which it can survive in a very acidic niche. Despite bacterial factors, gastric environmental factors and host genetic constituents together play a co-operative role for gastric pathogenicity...
November 19, 2019: Toxins
https://read.qxmd.com/read/31744181/high-prevalence-of-antibiotic-resistance-in-iranian-helicobacter-pylori-isolates-importance-of-functional-and-mutational-analysis-of-resistance-genes-and-virulence-genotyping
#38
JOURNAL ARTICLE
Nastaran Farzi, Abbas Yadegar, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Sinéad Marian Smith, Josette Raymond, Hidekazu Suzuki, Mohammad Reza Zali
The high prevalence of antibiotic resistance in Helicobacter pylori has become a great challenge in Iran. The genetic mutations that contribute to the resistance have yet to be precisely identified. This study aimed to investigate the prevalence of antibiotic resistance and virulence markers in Iranian H. pylori isolates and to analyze if there is any association between resistance and genotype. Antibiotic susceptibility patterns of 68 H. pylori isolates were investigated against metronidazole, clarithromycin, amoxicillin, rifampicin, ciprofloxacin, levofloxacin, and tetracycline by the agar dilution method...
November 17, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/31629103/co-expression-of-interleukin-17a-molecular-adjuvant-and-prophylactic-helicobacter-pylori-genetic-vaccine-could-cause-sterile-immunity-in-treg-suppressed-mice
#39
JOURNAL ARTICLE
Mehran Nemattalab, Mohammad Shenagari, Mojtaba Taheri, Mohammad Mahjoob, Foroogh Nazari Chamaki, Ali Mojtahedi, Elham Hasan-Alizadeh, Babak Ashrafkhani, Neda Mousavi Niri
The increasing clinical significance of Helicobacter pylori (H. pylori) in human stomach cancer has led to global efforts to eradicate this pathogen. Recent studies have confirmed the importance of some cytokines such as Interleukin-18 (IL-18), Interleukin-8 (IL-8), Interleukin-17A (IL-17A) and Interleukin-22 (IL-22) in the pathogenesis of the so-called bacterium. This study was designed to compare the effects of Type 1T helper (Th1), Type 2T helper (Th2) cells, Regulatory T cells (Treg) and T helper 17 (Th17) modulatory effects on the efficacy of designed H...
October 16, 2019: Cytokine
https://read.qxmd.com/read/31527719/immunoinformatics-approaches-to-explore-helicobacter-pylori-proteome-virulence-factors-to-design-b-and-t-cell-multi-epitope-subunit-vaccine
#40
JOURNAL ARTICLE
Mazhar Khan, Shahzeb Khan, Asim Ali, Hameed Akbar, Abrar Mohammad Sayaf, Abbas Khan, Dong-Qing Wei
Helicobacter Pylori is a known causal agent of gastric malignancies and peptic ulcers. The extremophile nature of this bacterium is protecting it from designing a potent drug against it. Therefore, the use of computational approaches to design antigenic, stable and safe vaccine against this pathogen could help to control the infections associated with it. Therefore, in this study, we used multiple immunoinformatics approaches along with other computational approaches to design a multi-epitopes subunit vaccine against H...
September 16, 2019: Scientific Reports
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