Bui Hoang Phuc, Vo Phuoc Tuan, Tran Thanh Binh, Pham Huu Tung, Tran Dinh Tri, Ho Dang Quy Dung, Ngo Phuong Minh Thuan, Kartika Afrida Fauzia, Evariste Tshibangu-Kabamba, Ricky Indra Alfaray, Batsaikhan Saruuljavkhlan, Takashi Matsumoto, Junko Akada, Yoshio Yamaoka
Helicobacter pylori is involved in the etiology and severity of several gastroduodenal diseases; however, plasticity of the H. pylori genome makes complete genome assembly difficult. We report here the full genomes of H. pylori strains CHC155 and VN1291 isolated from a non-cardia gastric cancer patient and a duodenal ulcer patient, respectively, and their virulence demonstrated by in vitro infection. Whole-genome sequences were obtained by combining long- and short-reads with a hybrid-assembly approach. Both CHC155 and VN1291 genome possessed four kinds of genomic island: a cag pathogenicity island (cagPAI), two type 4 secretion system islands within an integrative and conjugative element (tfs ICE), and prophage...
May 31, 2023: Scientific Reports