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https://read.qxmd.com/read/30781608/9-methylfascaplysin-is-a-more-potent-a%C3%AE-aggregation-inhibitor-than-the-marine-derived-alkaloid-fascaplysin-and-produces-nanomolar-neuroprotective-effects-in-sh-sy5y-cells
#1
Qingmei Sun, Fufeng Liu, Jingcheng Sang, Miaoman Lin, Jiale Ma, Xiao Xiao, Sicheng Yan, C Benjamin Naman, Ning Wang, Shan He, Xiaojun Yan, Wei Cui, Hongze Liang
β-Amyloid (Aβ) is regarded as an important pathogenic target for Alzheimer's disease (AD), the most prevalent neurodegenerative disease. Aβ can assemble into oligomers and fibrils, and produce neurotoxicity. Therefore, Aβ aggregation inhibitors may have anti-AD therapeutic efficacies. It was found, here, that the marine-derived alkaloid, fascaplysin, inhibits Aβ fibrillization in vitro . Moreover, the new analogue, 9-methylfascaplysin, was designed and synthesized from 5-methyltryptamine. Interestingly, 9-methylfascaplysin is a more potent inhibitor of Aβ fibril formation than fascaplysin...
February 18, 2019: Marine Drugs
https://read.qxmd.com/read/30773204/plasma-androgen-receptor-and-docetaxel-for-metastatic-castration-resistant-prostate-cancer
#2
Vincenza Conteduca, Anuradha Jayaram, Nuria Romero-Laorden, Daniel Wetterskog, Samanta Salvi, Giorgia Gurioli, Emanuela Scarpi, Elena Castro, Mercedes Marin-Aguilera, Cristian Lolli, Giuseppe Schepisi, Antonio Maugeri, Anna Wingate, Alberto Farolfi, Valentina Casadio, Ana Medina, Javier Puente, Mª José Méndez Vidal, Rafael Morales-Barrera, Jose C Villa-Guzmán, Susana Hernando, Alejo Rodriguez-Vida, Aránzazu González-Del-Alba, Begoña Mellado, Enrique Gonzalez-Billalabeitia, David Olmos, Gerhardt Attard, Ugo De Giorgi
Plasma androgen receptor (AR) gain identifies metastatic castration-resistant prostate cancer (mCRPC) patients with worse outcome on abiraterone/enzalutamide, but its relevance in the context of taxane chemotherapy is unknown. We aimed to evaluate whether docetaxel is active regardless of plasma AR and to perform an exploratory analysis to compare docetaxel with abiraterone/enzalutamide. This multi-institutional study was a pooled analysis of AR status, determined by droplet digital polymerase chain reaction, on pretreatment plasma samples...
March 2019: European Urology
https://read.qxmd.com/read/30769916/collagen-of-extracellular-matrix-from-marine-invertebrates-and-its-medical-applications
#3
REVIEW
M Azizur Rahman
The extraction and purification of collagen are of great interest due to its biological function and medicinal applications. Although marine invertebrates are abundant in the animal kingdom, our knowledge of their extracellular matrix (ECM), which mainly contains collagen, is lacking. The functions of collagen isolated from marine invertebrates remain an untouched source of the proteinaceous component in the development of groundbreaking pharmaceuticals. This review will give an overview of currently used collagens and their future applications, as well as the methodological issues of collagens from marine invertebrates for potential drug discovery...
February 14, 2019: Marine Drugs
https://read.qxmd.com/read/30763841/veterinary-pharmaceutical-residues-in-water-resources-and-tap-water-in-an-intensive-husbandry-area-in-france
#4
Lise Charuaud, Emilie Jardé, Anne Jaffrézic, Marine Liotaud, Quentin Goyat, Fabien Mercier, Barbara Le Bot
In intensive livestock areas, veterinary pharmaceutical residues (VPRs) can occur in water resources, but also in tap water because treatment processes are not designed to remove these contaminants. The main objective of this study is to assess the occurrence of VPRs in water resources and tap waters in Brittany. As several identical compounds are used in both veterinary and human medicine, a toolbox (stanols and pharmaceuticals) is used to help determine the origin of contamination in the case of mixed-use molecules...
January 24, 2019: Science of the Total Environment
https://read.qxmd.com/read/30761110/hyper-osmotic-stress-elicits-membrane-depolarization-and-decreased-permeability-in-halotolerant-marine-debaryomyces-hansenii-strains-and-in-saccharomyces-cerevisiae
#5
Claudia Capusoni, Stefania Arioli, Silvia Donzella, Benedetta Guidi, Immacolata Serra, Concetta Compagno
The use of seawater and marine microorganisms can represent a sustainable alternative to avoid large consumption of freshwater performing industrial bioprocesses. Debaryomyces hansenii , which is a known halotolerant yeast, possess metabolic traits appealing for developing such processes. For this purpose, we studied salt stress exposure of two D. hansenii strains isolated from marine fauna. We found that the presence of sea salts during the cultivation results in a slight decrease of biomass yields. Nevertheless, higher concentration of NaCl (2 M) negatively affects other growth parameters, like growth rate and glucose consumption rate...
2019: Frontiers in Microbiology
https://read.qxmd.com/read/30759850/chemical-diversity-and-biological-activities-of-marine-sponges-of-the-genus-suberea-a-systematic-review
#6
REVIEW
Amr El-Demerdash, Atanas G Atanasov, Olaf K Horbanczuk, Mohamed A Tammam, Mamdouh Abdel-Mogib, John N A Hooper, Nazim Sekeroglu, Ali Al-Mourabit, Anake Kijjoa
Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida...
February 12, 2019: Marine Drugs
https://read.qxmd.com/read/30755364/bioactivity-assessment-of-the-saudi-arabian-marine-streptomyces-sp-al-dhabi-90-metabolic-profiling-and-its-in-vitro-inhibitory-property-against-multidrug-resistant-and-extended-spectrum-beta-lactamase-clinical-bacterial-pathogens
#7
Naif Abdullah Al-Dhabi, Abdul-Kareem Mohammed Ghilan, Galal Ali Esmail, Mariadhas Valan Arasu, Veeramuthu Duraipandiyan, Karuppiah Ponmurugan
BACKGROUND: Metabolites obtained from the marine microorganisms were known for their important role in microbial inhibition. Interestingly, bioprospecting of secondary metabolites from marine derived actinomycetes has huge demand especially in the treatment of multi drug resistant clinical pathogens. The present study subjected towards the identification of promising antimicrobial actinomycetes from the Arabian Gulf regions and metabolic profiling of the crude organic solvent extract by chromatographic techniques...
February 9, 2019: Journal of Infection and Public Health
https://read.qxmd.com/read/30755162/a-fragment-activity-assay-reveals-the-key-residues-of-tbc1d15-gtpase-activating-protein-gap-in-chiloscyllium-plagiosum
#8
Yangyang Jin, Guodong Lin, Yanna Chen, Yinghua Ge, Ruofeng Liang, Jia Wu, Jianqing Chen, Dan Wang, Hengbo Shi, Hui Fei, Zhengbing Lv
BACKGROUND: GTPase-activating proteins (GAPs) with a TBC (Tre-2/Bub2/Cdc16) domain architecture serve as negative regulators of Rab GTPases. The related crystal structure has been studied and reported by other members of our research group in 2017 (Chen et al. in Protein Sci 26(4):834-846, 2017). The protein crystal structure and sequencing data accession numbers in Protein structure database (PDB) are 5TUB (Shark TBC1D15 GAP) and 5TUC (Sus TBC1D15 GAP), respectively. In this paper, we analyzed the Rab-GAP specificity of TBC1D15 in the evolution and influence of key amino acid residue mutations on Rab-GAP activity...
February 12, 2019: BMC Molecular Biology
https://read.qxmd.com/read/30754694/5-o-acetyl-renieramycin-t-from-blue-sponge-xestospongia-sp-induces-lung-cancer-stem-cell-apoptosis
#9
Wipa Chantarawong, Supakarn Chamni, Khanit Suwanborirux, Naoki Saito, Pithi Chanvorachote
Lung cancer is one of the most significant cancers as it accounts for almost 1 in 5 cancer deaths worldwide, with an increasing incident rate. Management of the cancer has been shown to frequently fail due to the ability of the cancer cells to resist therapy as well as metastasis. Recent evidence has suggested that the poor response to the current treatment drugs and the ability to undergo metastasis are driven by cancer stem cells (CSCs) within the tumor. The discovery of novel compounds able to suppress CSCs and sensitize the chemotherapeutic response could be beneficial to the improvement of clinical outcomes...
February 11, 2019: Marine Drugs
https://read.qxmd.com/read/30747721/inhibitory-effect-of-iota-carrageenan-on-porcine-reproductive-and-respiratory-syndrome-virus-in-vitro
#10
Chunhe Guo, Zhenbang Zhu, Piao Yu, Xiaoxiao Zhang, Wenjuan Dong, Xiaoying Wang, Yaosheng Chen, Xiaohong Liu
BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen and causes significant economic losses to the swine industry worldwide each year. Current vaccination strategies do not effectively prevent and control the virus. Consequently, it is necessary to develop novel antiviral strategies. Carrageenan, extracted from marine red algae, exhibits anti-coagulant, anti-tumor, anti-virus and immunomodulatory activities. METHODS: We investigate the inhibitory effect of iota-carrageenan (CG) on PRRSV strain CH-1a via antiviral assay and viral binding, entry and release assays...
February 12, 2019: Antiviral Therapy
https://read.qxmd.com/read/30747102/fish-hunting-cone-snail-venoms-are-a-rich-source-of-minimized-ligands-of-the-vertebrate-insulin-receptor
#11
Peter Ahorukomeye, Maria M Disotuar, Joanna Gajewiak, Santhosh Karanth, Maren Watkins, Samuel D Robinson, Paula Flórez Salcedo, Nicholas A Smith, Brian J Smith, Amnon Schlegel, Briony E Forbes, Baldomero Olivera, Danny Hung-Chieh Chou, Helena Safavi-Hemami
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin therapeutics. Here, we show that fish-hunting cone snails provide a rich source of minimized ligands of the vertebrate insulin receptor. Insulins from C. geographus , Conus tulipa and Conus kinoshitai exhibit diverse sequences, yet all bind to and activate the human insulin receptor...
February 12, 2019: ELife
https://read.qxmd.com/read/30745320/the-role-of-ackr3-in-breast-lung-and-brain-cancer
#12
Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on ACKR3. This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumour cell proliferation and migration, tumour angiogenesis or resistance to drugs, thus contributing to cancer progression and metastasis occurrence. Here we focus on the clinical significance and potential mechanisms underlying the pathological role of ACKR3 in breast, lung and brain cancer and discuss its possible relevance as prognostic factor and potential therapeutic target in these contexts...
February 11, 2019: Molecular Pharmacology
https://read.qxmd.com/read/30744443/unraveling-the-cancer-genome-atlas-information-on-the-role-of-slc-transporters-in-anticancer-drug-uptake
#13
Ruba Al-Abdulla, Laura Perez-Silva, Lorena Abete, Marta R Romero, Oscar Briz, Jose J G Marin
Anticancer chemotherapy often faces the problem of intrinsic or acquired drug refractoriness due in part to efficient mechanisms of defense present or developed, respectively, in cancer cells. Owing to their polarity and/or high molecular weight, many cytostatic agents cannot freely cross the plasma membrane by simple diffusion and hence depend on SLC proteins to enter cancer cells. The downregulation of these transporters and the appearance of either inactivating mutations or aberrant splicing, hampers the possibility of anticancer drugs to interact with their intracellular targets...
February 11, 2019: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/30737714/effects-of-acetaminophen-in-oxidative-stress-and-neurotoxicity-biomarkers-of-the-gastropod-phorcus-lineatus
#14
Filipa Almeida, Bruno Nunes
The growing use of pharmaceutical drugs has become a major environmental issue considering that these substances (or their metabolites) end up inevitably in sewage waters after excretion. In the wild, these chemicals may affect non-target organisms, and their potential toxicity is not sufficiently studied, a reality that is particularly true for marine organisms. Acetaminophen (also known as paracetamol) is known to be toxic in high dosages, namely, by triggering oxidative effects. These effects may be potentiated in marine organisms subjected to contamination resulting from large human settlements along coastal areas...
February 8, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30737391/light-sheet-microscopy-with-acoustic-sample-confinement
#15
Zhengyi Yang, Katy L H Cole, Yongqiang Qiu, Ildikó M L Somorjai, Philip Wijesinghe, Jonathan Nylk, Sandy Cochran, Gabriel C Spalding, David A Lyons, Kishan Dholakia
Contactless sample confinement would enable a whole host of new studies in developmental biology and neuroscience, in particular, when combined with long-term, wide-field optical imaging. To achieve this goal, we demonstrate a contactless acoustic gradient force trap for sample confinement in light sheet microscopy. Our approach allows the integration of real-time environmentally controlled experiments with wide-field low photo-toxic imaging, which we demonstrate on a variety of marine animal embryos and larvae...
February 8, 2019: Nature Communications
https://read.qxmd.com/read/30737349/the-detection-of-natural-products-and-their-producers-in-ocean-sediments
#16
Robert N Tuttle, Alyssa M Demko, Nastassia Patin, Clifford A Kapono, Mohamed S Donia, Pieter Dorrestein, Paul R Jensen
Thousands of natural products have been identified from cultured microorganisms yet evidence of their production in the environment has proven elusive. Technological advances in mass spectrometry combined with public databases now make it possible to address this disparity by detecting compounds directly from environmental samples. Here we used adsorbent resins, tandem mass spectrometry, and next generation sequencing to assess the metabolome of marine sediments and its relationship to bacterial community structure...
February 8, 2019: Applied and Environmental Microbiology
https://read.qxmd.com/read/30736491/synergistic-anti-candida-activity-of-bengazole-a-in-the-presence-of-bengamide-a-%C3%A2
#17
Matthew T Jamison, Xiao Wang, Tina Cheng, Tadeusz F Molinski
Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and surface culture on Mueller-Hinton agar. Pronounced dose-dependent synergistic antifungal activity was observed with bengazole A in the presence of bengamide A, which is also a natural product from Jaspis sp. The MOA of bengazole A was further explored by monitoring the sterol composition of C...
February 7, 2019: Marine Drugs
https://read.qxmd.com/read/30732778/polysaccharides-as-potential-anticancer-agents-a-review-of-their-progress
#18
REVIEW
Tabassum Khan, Amrita Date, Hardik Chawda, Krina Patel
Cancer is one of the most common diseases seen in developed countries, with over 1.6 million new cases estimated in 2017, in the US alone. The current chemotherapeutic drugs available for the therapeutic management of cancer are associated with major adverse effects like alopecia, anemia, immunodeficiency, fatigue, peripheral neuropathy, fertility issues and neurological problems, to name a few of them. Polysaccharides have emerged as potential chemical entities exhibiting good anticancer activity across a variety of cancer cell lines and can be developed as alternatives of existing cancer chemotherapeutic agents, possessing selective activity against tumor cells with minimal toxic side-effects...
April 15, 2019: Carbohydrate Polymers
https://read.qxmd.com/read/30732758/structure-activity-relationship-of-propylene-glycol-alginate-sodium-sulfate-derivatives-for-blockade-of-selectins-binding-to-tumor-cells
#19
He Ma, Peiju Qiu, Meng Xin, Ximing Xu, Zhuoya Wang, Huixin Xu, Rilei Yu, Xiaoxiao Xu, Chenyang Zhao, Xin Wang, Huashi Guan, Jinbo Yang, Chunxia Li
Selectins dominate the formation of the metastasis niche and are considered important targets for exploring antimetastatic drugs. In this study, we evaluated the effect of the marine drug propylene glycol alginate sodium sulfate (PSS) and a series of PSS derivatives on P-, L- or E-selectin-mediated binding with tumor cells. We found that PSS effectively prevented the binding of P- or L-selectin with tumor cells. Moreover, the structure-activity relationship study indicated that the activity of PSS is related to the sulfate group at the C-2/C-3 position, the propylene glycol substituent at the C-6 position, the ratio of guluronic acid to mannuronic acid, and the molecular weight...
April 15, 2019: Carbohydrate Polymers
https://read.qxmd.com/read/30719879/early-diagnosis-of-traumatic-intracranial-hematomas
#20
Hasan Ayaz, Meltem Izzetoglu, Kurtulus Izzetoglu, Banu Onaral, Baruch Ben Dor
Timing of the intervention for intracranial hematomas is critical for its success, specifically since expansion of the hemorrhage can result in debilitating and sometimes fatal outcomes. Led by Britton Chance, we and an extended team from University of Pennsylvania, Baylor and Drexel universities developed a handheld brain hematoma detector for early triage and diagnosis of head trauma victims. After obtaining de novo Food and Drug Administration clearance, over 200 systems are deployed in all Marine battalion aid stations around the world...
February 2019: Journal of Biomedical Optics
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