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Vitamin d signaling

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https://read.qxmd.com/read/30900415/exonic-variants-of-genes-related-to-the-vitamin-d-signaling-pathway-in-the-families-of-familial-multiple-sclerosis-using-whole-exome-next-generation-sequencing
#1
Vanesa Pytel, Jordi A Matías-Guiu, Laura Torre-Fuentes, Paloma Montero-Escribano, Paolo Maietta, Javier Botet, Sara Álvarez, Ulises Gómez-Pinedo, Jorge Matías-Guiu
INTRODUCTION: Vitamin D (VD) deficiency has been associated with multiple sclerosis (MS) and other autoimmune diseases (AIDs). However, the effect of the genetics of VD on the risk of MS is subject to debate. This study focuses on genes linked to the VD signaling pathway in families with MS. The evaluation of gene variants in all the members of families could contribute to an additional knowledge on the information obtained from case-control studies that use nonrelated healthy people...
March 21, 2019: Brain and Behavior
https://read.qxmd.com/read/30891776/scutellarin-exerts-protective-effects-against-atherosclerosis-in-rats-by-regulating-the-hippo-foxo3a-and-pi3k-akt-signaling-pathways
#2
Yufeng Fu, Shuangyong Sun, Huijun Sun, Jinyong Peng, Xiaodong Ma, Liuchi Bao, Renpeng Ji, Chunxu Luo, Cong Gao, Xiaoxue Zhang, Yue Jin
Atherosclerosis (AS), a progressive disorder, is one of the tough challenges in the clinic. Scutellarin, an extract from Herba Erigerontis, is found to have oxygen-free radicals scavenging effects and antioxidant effects. In this study, we aimed to investigate the anti-AS effects of scutellarin is related to controlling the Hippo-FOXO3A and PI3K/AKT signal pathway. To establish an AS model, the rats in the scutellarin and model groups were intraperitoneally injected with vitamin D 3 and then fed a high-fat diet for 12 weeks...
March 19, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30890957/primary-vitamin-d-target-genes-of-human-monocytes
#3
REVIEW
Veijo Nurminen, Sabine Seuter, Carsten Carlberg
The molecular basis of vitamin D signaling implies that the metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes. Since the evolutionary role of nuclear receptors, such as VDR, was the regulation of cellular metabolism, the control of calcium metabolism became the primary function of vitamin D and its receptor. Moreover, the nearly ubiquitous expression of VDR enabled vitamin D to acquire additional physiological functions, such as the support of the innate immune system in its defense against microbes...
2019: Frontiers in Physiology
https://read.qxmd.com/read/30889441/profiling-of-alzheimer-s-disease-related-genes-in-mild-to-moderate-vitamin-d-hypovitaminosis
#4
Marcus O W Grimm, Anna A Lauer, Sven Grösgen, Andrea Thiel, Johannes Lehmann, Jakob Winkler, Daniel Janitschke, Christian Herr, Christoph Beisswenger, Robert Bals, Heike S Grimm, Tobias Hartmann
A vast majority of the elderly population shows a mild to moderate vitamin D deficiency. Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes. However very little is known whether genes are regulated, associated with Alzheimer's disease (AD). Here we investigate 117 genes, known to be affected in AD, in mouse brain samples with a mild vitamin D hypovitaminosis comparable to the vitamin D status of the elderly population (20%-30% deficiency)...
February 11, 2019: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/30885906/can-treating-vitamin-d-deficiency-reduce-exacerbations-of-chronic-obstructive-pulmonary-disease
#5
Rob Cook, Vaughan Thomas, Rosie Martin
The studyJolliffe D, Greenberg L, Hooper R, Mathyssen C, Rafiq R, de Jongh R, Camargo C, Griffiths C, Janssens W, Martineau A. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax 2019. doi:10.1136/thoraxjnl-2018-212092This project was funded by the National Institute for Health Research Health Technology Appraisal programme (project number 13/03/25).To read the full NIHR Signal, go to: https://discover.dc.nihr...
March 18, 2019: BMJ: British Medical Journal
https://read.qxmd.com/read/30879014/vitamin-d-ameliorates-angiotensin-ii-induced-human-endothelial-progenitor-cell-injury-via-the-ppar-%C3%AE-ho-1-pathway
#6
Wei Xu, Xiao Hu, Xi Qi, Rui Zhu, Chen Li, Yanjing Zhu, Shuai Yin, Liming Cheng, Rongrong Zhu
Vitamin D has an important protective effect on chronic inflammatory disease. Angiotensin II (AngII) triggers vascular damage and plays a key role in vascular diseases via several mechanisms, including inflammation. Conversely, vitamin D has been shown to have an important protective effect on chronic inflammation. There is evidence showing that vitamin D can reverse the effects of AngII, but the molecular mechanisms by which this occurs are not known. Our results demonstrate that vitamin D improved the viability, migration ability, and tube formation of AngII-pretreated endothelial progenitor cells (EPCs) and inhibited the apoptosis of EPCs induced by AngII...
March 15, 2019: Journal of Vascular Research
https://read.qxmd.com/read/30867220/intratumoral-sterol-27-hydroxylase-cyp27a1-expression-in-relation-to-cholesterol-synthesis-and-vitamin-d-signaling-and-its-association-with-lethal-prostate-cancer
#7
Nabeela A Khan, Konrad H Stopsack, Emma H Allott, Travis Gerke, Edward L Giovannucci, Lorelei A Mucci, Philip W Kantoff
BACKGROUND: Higher intratumoral cholesterol synthesis is associated with a worse prognosis in prostate cancer. The vitamin D-regulated enzyme sterol-27-hydroxylase (CYP27A1) converts cholesterol to 27-hydroxycholesterol, potentially lowering intracellular cholesterol levels. We hypothesized that low CYP27A1 expression is associated with high cholesterol synthesis, low vitamin D signaling, and higher risk of lethal prostate cancer. METHODS: In 404 patients from the prospective prostate cancer cohorts within the Health Professionals Follow-up Study (HPFS) and the Physicians' Health Study (PHS), we assessed intratumoral CYP27A1 expression and proxies of cholesterol synthesis using transcriptome profiling, prediagnostic plasma 25-hydroxyvitamin D (25(OH)D, n = 132) and intratumoral vitamin D receptor protein expression (VDR, n = 300)...
March 13, 2019: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/30864841/vitamin-d-receptor-activation-protects-against-lipopolysaccharide-induced-acute-kidney-injury-through-suppression-of-tubular-cell-apoptosis
#8
Jie Du, Siqing Jiang, Zhaoxin Hu, Shiqi Tang, Yue Sun, Jinrong He, Zhi Li, Bin Yi, Jianwen Wang, Hao Zhang, Yan Chun Li
Acute kidney injury (AKI) is a common complication of sepsis characterized by a rapid degradation of renal function. The effect of vitamin D on AKI remains poorly understood. Here we showed that vitamin D receptor (VDR) activation protects against lipopolysaccharide (LPS)-induced AKI by blocking renal tubular epithelial cell apoptosis. Mice lacking VDR developed more severe AKI than wild-type (WT) controls following LPS treatment, manifested by marked increases in body weight loss, accumulation of serum BUN and creatinine as well as the magnitude of apoptosis of tubular epithelial cells...
March 13, 2019: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/30852589/the-effects-of-dietary-supplementation-with-hyodeoxycholic-acid-on-the-differentiation-and-function-of-enteroendocrine-cells-and-the-serum-biochemical-indices-in-weaned-piglets1
#9
Enyan Zong, Shanling Yan, Meiwei Wang, Lanmei Yin, Qiye Wang, Jia Yin, Jianzhong Li, Yali Li, Xueqin Ding, Pengfei Huang, Shanping He, Huansheng Yang, Yulong Yin
Bile acid, a cholesterol metabolite, promotes gastrointestinal tract digestion and absorption of cholesterol, lipids, and fat-soluble vitamins. It is a signaling regulatory molecule that influences a variety of endocrinal and metabolic activities. This study investigated the effects of hyodeoxycholic acid (HDCA) as a dietary supplement on endocrine cell differentiation and function and weaned piglet serum biochemical indices. Sixteen piglets [Duroc × (Landrace × Yorkshire)] were individually housed and weaned at 21 d of age (BW of 6...
February 11, 2019: Journal of Animal Science
https://read.qxmd.com/read/30813930/vitamin-d-vdr-signaling-inhibits-lps-induced-ifn%C3%AE-and-il-1%C3%AE-in-oral-epithelia-by-regulating-hypoxia-inducible-factor-1%C3%AE-signaling-pathway
#10
Xuejun Ge, Lixiang Wang, Mengdi Li, Na Xu, Feiyan Yu, Fang Yang, Ran Li, Fang Zhang, Bin Zhao, Jie Du
BACKGROUND: Oral lichen planus (OLP) is known as a chronic inflammatory disease. Our recent studies have suggested that vitamin D/vitamin D receptor (VDR) signaling exerts its protective effects on oral keratinocyte apoptosis by regulating microRNA-802 and p53-upregulated modulator of apoptosis (PUMA), but its roles in oral epithelial inflammatory responses in OLP are still unknown. Herein, we identify lipopolysaccharide (LPS) is able to enhance interferon gamma (IFNγ) and interleukin-1 beta (IL-1β) productions in human oral keratinocytes (HOKs) dependent on hypoxia-inducible factor-1α (HIF-1α)...
February 27, 2019: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/30792721/1-25-dihydroxyvitamin-d3-ameliorates-collagen-induced-arthritis-via-suppression-of-th17-cells-through-mir-124-mediated-inhibition-of-il-6-signaling
#11
Li Zhou, Julie Wang, Jingren Li, Ting Li, Yanming Chen, Rayford R June, Song Guo Zheng
Objectives: To explore the molecular mechanisms in which vitamin D (VD) regulates T cells, especially Th17 cells in collagen-induced arthritis (CIA). Methods: DBA1/J mice induced for CIA were intraperitoneally treated with VD. CIA clinical symptoms and inflammatory responses including Th1/Th17/Tregs percentages were determined and compared. Mouse naïve CD4+ T cells transduced with miR-124 inhibitor or not were polarized to Th17 cells with or without VD. Subsequently, cellular differentiation and IL-6 signaling moleculars were analyzed...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30774359/anticancer-activity-of-1-25-oh-2-d-3-against-human-breast-cancer-cell-lines-by-targeting-ras-mek-erk-pathway
#12
Wei Zheng, Lin Cao, Linna Ouyang, Qian Zhang, Bofeng Duan, Wei Zhou, Shan Chen, Wei Peng, Yi Xie, Qing Fan, Daoxing Gong
Purpose: Breast cancer is the most common cancer among women with ~1.67 million cases diagnosed annually worldwide, and ~1 in 37 women succumbed to breast cancer. Over the past decades, new therapeutic strategy has substantially improved the curative effect for women with breast cancer. However, the currently available ER-targeted and HER-2-based therapies are not effective for triple-negative breast cancer patients, which account for ~15% of total breast cancer cases. Materials and methods: We reported that 1,25-(OH)2 D3 , a biologically active form of vitamin D3 , exhibited a strong anticancer effects on the proliferation, migration, invasion, cell cycle arrest, and apoptosis of both ER-positive (MCF-7) and ER-negative breast cancer cells (MDA-MB-453)...
2019: OncoTargets and Therapy
https://read.qxmd.com/read/30760068/association-of-vitamin-d-receptor-gene-foki-and-taqi-polymorphisms-and-risk-of-rds
#13
Nuran Ustun, Nilnur Eyerci, Nilgun Karadag, Ahmet Yesilyurt, Aysegul Zenciroglu, Nurullah Okumus
BACKGROUND: Vitamin D and its receptor (VDR) have important roles in perinatal lung development. The objective of this study was to investigate the possible association between VDR FokI and TaqI polymorphism and development of respiratory distress syndrome (RDS) in preterm infants. METHOD: A total of 173 premature infants <34 weeks: 82 with RDS and 91 without RDS were enrolled. Genotyping of VDR polymorphisms was assayed by real-time PCR. Serum 25-hydroxyvitamin D (25-OHD) levels were measured by ELISA in blood samples that were obtained at the time of admission to the neonatal intensive care unit...
February 27, 2019: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/30733856/growth-inhibition-and-apoptosis-in-colorectal-cancer-cells-induced-by-vitamin-d-nanoemulsion-nvd-involvement-of-wnt-%C3%AE-catenin-and-other-signal-transduction-pathways
#14
Suhail Razak, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam, Sarwat Jahan
Background: More than the two decades, the question of whether vitamin D has a role in cancer frequency, development, and death has been premeditated in detail. Colorectal, breast, and prostate cancers have been a scrupulous spot of center, altogether, these three malignancies report for approximately 35% of cancer cases and 20% of cancer demises in the United States, and as such are a chief public health apprehension. The aim was to evaluate antitumor activity of Vitamin D-Nanoemulsion (NVD) in colorectal cancer cell lines and HCT116 xenograft model in a comprehensive approach...
2019: Cell & Bioscience
https://read.qxmd.com/read/30733421/tumor-metastasis-to-lymph-nodes-requires-yap-dependent-metabolic-adaptation
#15
Choong-Kun Lee, Seung-Hwan Jeong, Cholsoon Jang, Hosung Bae, Yoo Hyung Kim, Intae Park, Sang Kyum Kim, Gou Young Koh
In cancer patients, metastasis of tumors to sentinel lymph nodes (LNs) predicts disease progression and often guides treatment decisions. The mechanisms underlying tumor LN metastasis are poorly understood. By using comparative transcriptomics and metabolomics analyses of primary and LN-metastatic tumors in mice, we found that LN metastasis requires that tumor cells undergo a metabolic shift toward fatty acid oxidation (FAO). Transcriptional coactivator yes-associated protein (YAP) is selectively activated in LN-metastatic tumors, leading to the up-regulation of genes in the FAO signaling pathway...
February 8, 2019: Science
https://read.qxmd.com/read/30723655/parathyroid-gland-response-to-vitamin-d-deficiency-in-type-2-diabetes-mellitus-an-observational-study
#16
Azhar Hussain, Omar B Latiwesh, Alia Ali, Elsa Tabrez, Lalit Mehra, Fidelis Nwachukwu
Background Studies have linked vitamin D deficiency with the risk of type 2 diabetes mellitus (T2DM) and to the development of chronic complication of diabetes. Vitamin D receptors (VDR) have been found in many tissues in the body including the pancreas, a finding that indicates its role in insulin secretion. In addition, many studies have demonstrated the role of vitamin D and its receptor in insulin sensitivity and signal transduction. Vitamin D deficiency is common throughout the world, but not all vitamin D deficiencies are accompanied by a rise in parathyroid hormone (PTH)...
November 28, 2018: Curēus
https://read.qxmd.com/read/30721022/abnormal-cannabidiol-modulates-vitamin-a-metabolism-by-acting-as-a-competitive-inhibitor-of-crbp1
#17
Josie A Silvaroli, Made Airanthi K Widjaja-Adhi, Thomas Trischman, Sylwia Chelstowska, Samantha Horwitz, Surajit Banerjee, Philip D Kiser, William S Blaner, Marcin Golczak
Cellular retinol-binding proteins (CRBPs) facilitate the uptake and intracellular transport of vitamin A. They integrate retinoid metabolism, playing an important role in regulating the synthesis of bioactive vitamin A metabolites. Thus, CRBPs constitute potential pharmacological targets to modulate cellular retinoid status that in turn may have applications in the treatment of certain immunological, metabolic, and ocular disorders. Here we identify abnormal cannabidiol (abn-CBD) as a non-retinoid inhibitor of cellular retinol-binding protein 1 (CRBP1)...
February 5, 2019: ACS Chemical Biology
https://read.qxmd.com/read/30718230/vitamin-d-receptor-mediated-skewed-differentiation-of-macrophages-initiates-myelofibrosis-and-subsequent-osteosclerosis
#18
Kanako Wakahashi, Kentaro Minagawa, Yuko Kawano, Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Akiko Sada, Noboru Asada, Mari Sato, Shigeaki Kato, Kotaro Shide, Kazuya Shimoda, Toshimitsu Matsui, Yoshio Katayama
Myelofibrosis in myeloproliferative neoplasms (MPNs) with mutations such as JAK2V617F is an unfavorable sign for uncontrollable disease progression in the clinic and is complicated with osteosclerosis whose pathogenesis is largely unknown. Because several studies have revealed that macrophages are indispensable supporter for bone forming osteoblasts, we speculated that macrophages might play a significant role in the proliferation of collagen-producing myofibroblasts in marrow fibrotic tissues. Here, we show that myelofibrosis critically depends on macrophages whose differentiation is skewed by vitamin D receptor (VDR) signaling...
February 4, 2019: Blood
https://read.qxmd.com/read/30714636/vitamin-d-levels-and-vitamin-d-receptor-variants-are-associated-with-chronic-heart-failure-in-chinese-patients
#19
Yi Hao, Yueling Chen
BACKGROUND: Vitamin D is an indispensable molecule for human health. Wide ranges of diseases are linked with vitamin D deficiencies. Role of vitamin D in chronic heart failure has been demonstrated in different populations; however, reports are limited in Chinese population. Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. In the present study, we hypothesized that both vitamin D levels and VDR variants could be associated with the development of chronic heart failure...
February 4, 2019: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/30713073/vitamin-d-stimulates-cardiomyocyte-proliferation-and-controls-organ-size-and-regeneration-in-zebrafish
#20
Yanchao Han, Anzhi Chen, Kfir-Baruch Umansky, Kelsey A Oonk, Wen-Yee Choi, Amy L Dickson, Jianhong Ou, Valentina Cigliola, Oren Yifa, Jingli Cao, Valerie A Tornini, Ben D Cox, Eldad Tzahor, Kenneth D Poss
Attaining proper organ size during development and regeneration hinges on the activity of mitogenic factors. Here, we performed a large-scale chemical screen in embryonic zebrafish to identify cardiomyocyte mitogens. Although commonly considered anti-proliferative, vitamin D analogs like alfacalcidol had rapid, potent mitogenic effects on embryonic and adult cardiomyocytes in vivo. Moreover, pharmacologic or genetic manipulation of vitamin D signaling controlled proliferation in multiple adult cell types and dictated growth rates in embryonic and juvenile zebrafish...
January 30, 2019: Developmental Cell
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