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Diabetes AND Eyes

Krystal Khoo, Ryan E K Man, Gwyn Rees, Preeti Gupta, Ecosse L Lamoureux, Eva K Fenwick
IMPORTANCE: Previous work has reported a link between diabetic retinopathy/diabetic macular edema (DR/DME) and psychosocial functioning, although the extent and direction of the association remains uncertain. OBJECTIVE: To determine the relationship between DR/DME and psychosocial functioning, the latter an umbrella term used to capture the emotional and social aspects of functioning which may include, for example, depression; depressive disorder; anxiety; vision-specific distress; diabetes-specific distress and emotional and social well-being...
March 16, 2019: Quality of Life Research
Thomas J Wubben, Mark W Johnson
PURPOSE: To illustrate that patients with diabetic retinopathy who are treated exclusively with anti-VEGF therapy and have an interruption in treatment may experience marked progression of disease with potentially devastating visual consequences. DESIGN: Retrospective, multicenter, case series METHODS: Retrospective review of patients treated exclusively with anti-VEGF therapy for proliferative (PDR) or non-proliferative diabetic retinopathy (NPDR), with or without diabetic macular edema (DME), and temporarily lost to follow-up...
March 13, 2019: American Journal of Ophthalmology
Huabin Luo, Ronny A Bell, Seema Garg, Doyle M Cummings, Shivajirao P Patil, Katherine Jones
BACKGROUND There is limited information available in North Carolina on the current burden of, and racial disparities in, diabetic retinopathy (DR), a major complication associated with diabetes mellitus (DM). This study aims to describe the overall trend of, and racial/ethnic disparities in, DR among adults with DM in North Carolina. METHODS Data were from 13 waves (2000, 2002-2010, 2012, 2013, and 2015) of the Behavioral Risk Factor Surveillance System. The study sample included 16,976 adults aged ≥ 40 years with DM in North Carolina...
March 2019: North Carolina Medical Journal
Xinjun Ren, Shaochong Bu, Xiaomin Zhang, Yuanfeng Jiang, Liangzhang Tan, Hong Zhang, Xiaorong Li
BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of intravitreal conbercept (a recombinant fusion protein that primarily targets vascular endothelial growth factors) after vitrectomy for the management of proliferative diabetic retinopathy without tractional retinal detachment (TRD). SUBJECTS/METHODS: Fifty patients with non-clearing vitreous haemorrhage (VH) due to proliferative diabetic retinopathy without TRD were enroled. They were randomly divided into control and treatment groups (25 eyes to each group) after they provided informed consent...
March 14, 2019: Eye
Melissa M Toyos
AIM: Randomized pilot study comparing clinical outcomes with bromfenac ophthalmic solution 0.07% versus nepafenac 0.3% ophthalmic suspension administered as identical dosing regimens in patients undergoing uncomplicated phacoemulsification with intraocular lens implantation. METHODS: Forty-nine subjects were treated with bromfenac (n = 25) or nepafenac (n = 24) once daily starting 3 days before cataract surgery, continued on the day of surgery, and for 21 days following surgery, in addition to standard of care...
March 13, 2019: Ophthalmology and Therapy
Jingjing Zhang, Xuting Jin, Ruohan Li, Ya Gao, Jiamei Li, Gang Wang
INTRODUCTION: Although the proportion and duration of rapid eye movement (REM) sleep are correlated with neurological and cardiovascular diseases, whether REM sleep is associated with all-cause mortality in community-based populations remains unknown. METHODS: A prospective study was performed within the Sleep Heart Health Study (SHHS, Registration NO. NCT00005275). Total sleep time, sleep efficiency, and REM sleep were measured using polysomnography. Cox proportional hazards regression models were used to estimate the association of the REM sleep with all-cause mortality...
March 13, 2019: Aging
Rita Laiginhas, Marta Guimarães, Pedro Cardoso, Hugo Santos-Sousa, John Preto, Mário Nora, João Chibante, Fernando Falcão-Reis, Manuel Falcão
BACKGROUND: Idiopathic intracranial hypertension (IIH) is a serious condition that is frequently associated with irreversibly vision loss, having a higher incidence among obese women. Our aims were to screen subclinical IIH in obese patients scheduled to bariatric surgery using peripapillary retinal nerve fiber layer (RNFL) thickness and to evaluate if the findings demand the possible need of a preoperative evaluation in this population. METHODS: This study included 111 eyes from 36 obese patients (86% female, body mass index > 35 kg/m2 ) scheduled to bariatric surgery and 20 non-obese (body mass index < 25 kg/m2 ) age-matched controls...
March 12, 2019: Obesity Surgery
Andrew J Rong, Swarup S Swaminathan, Elizabeth A Vanner, Richard K Parrish
PURPOSE: To determine the risk factors for development of neovascular glaucoma (NVG) in patients after an acute central retinal vein occlusion (CRVO). DESIGN: Retrospective cohort study METHODS: Review of medical records of 646 patients with a diagnosis of CRVO between 2013 to 2017 at the Bascom Palmer Eye Institute. INCLUSION CRITERIA: 1) CRVO onset to presentation <90 days; 2) Absence of anterior segment neovascularization on presentation; 3) No intravitreal anti-VEGF injection before presentation...
March 9, 2019: American Journal of Ophthalmology
Joel Sampedro, Patricia Bogdanov, Hugo Ramos, Cristina Solà-Adell, Mireia Turch, Marta Valeri, Olga Simó-Servat, Carmen Lagunas, Rafael Simó, Cristina Hernández
The main goals of this work were to assess whether the topical administration of glucagon-like peptide-1 (GLP-1) could revert the impairment of the neurovascular unit induced by long-term diabetes (24 weeks) in diabetic mice and to look into the underlying mechanisms. For that reason, db/db mice were treated with eye drops of GLP-1 or vehicle for 3 weeks. Moreover, db/+ mice were used as control. Studies performed in vivo included electroretinogramand the assessment of vascular leakage by using Evans Blue. NF-κB, GFAP and Ki67 proteins were analyzed by immunofluorescence (IF)...
March 11, 2019: Journal of Clinical Medicine
Tetsuya Muto, Shigeki Machida
Purpose: To determine the effect of intravitreal aflibercept injection on the corneal endothelium in patients with diabetic or cystoid macular edema caused by retinal vein occlusion. Material and methods: Forty-six eyes of 44 consecutive patients (27 men, 17 women; age range: 55-88 years) were evaluated. All participants initially received a single intravitreal injection of aflibercept (2 mg in 0.05 mL), followed by pro re nata use and underwent central corneal specular microscopy before the injection and at 1, 3 and 6 months after the first injection during a 6-month follow-up period...
2019: Clinical Ophthalmology
Andrew M Williams, Benjamin Botsford, Peter Mortensen, Daniel Park, Evan L Waxman
Objective: The objective of the study was to characterize the population served by the student-led Guerrilla Eye Service (GES), a mobile outreach program that delivers comprehensive ophthalmic care to underserved communities in the greater Pittsburgh area. Patients and methods: Patients attending GES missions at a single urban free clinic from 2012 through 2017 were included in this retrospective case series. All patients underwent a comprehensive eye examination at no cost, with referral to a university eye clinic if necessary...
2019: Clinical Ophthalmology
S R Ebana Mvogo, H D Fouda Menye, V A Dohvoma, P W Atipo-Tsiba, M P Halle, A Ellong, C Ebana Mvogo
PURPOSE: To measure lacrimal secretion and to investigate dry eye symptoms in chronic hemodialysis patients. PATIENTS AND METHODS: This was a cross-sectional descriptive study carried out in the hemodialysis center of Douala General Hospital from June to August 2016. The degree of symptomatology related to dry eye was assessed by the Ocular Surface Disease Index (OSDI) questionnaire. Lacrimal secretion was measured by the Schirmer test without anesthesia. We defined normal as wetting>10mm and hyposecretion as a value≤10mm after 5minutes...
March 8, 2019: Journal Français D'ophtalmologie
M Clément, O Lebreton, L Chaillous, M Weber
INTRODUCTION: The goal of our study was to evaluate the results of screening for diabetic retinopathy using the non-mydriatic fundus camera combined with telemedicine in the university hospital of Nantes. PATIENTS AND METHODS: This is a retrospective study of all diabetic patients hospitalized in the endocrinology department between June and September 2016 inclusive. The photos were taken by a nurse if the patient had an indication for screening as determined by the attending physician...
March 8, 2019: Journal Français D'ophtalmologie
Kedija Abdella, Kylen D McReelis, M Hermina Strungaru
OBJECTIVE: To evaluate the screening rates for diabetic pediatric patients in a regional center according to the Canadian Diabetes Association guidelines. DESIGN: Retrospective study. PARTICIPANTS: The study consisted of 82 patients seen in the pediatric diabetes clinic at Peterborough Regional Health Center. METHODS: Medical records for all pediatric patients with diabetes were reviewed between July 2016 and February 2017...
February 2019: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Yanliang Fan, Xiaofeng Zheng, Yusuf Ali, Per-Olof Berggren, Say Chye Joachim Loo
The anterior chamber of the eye (ACE) has emerged as a promising clinical islet transplantation site because of its multiple advantages over the conventional intra-hepatic portal site. This includes reduced surgical invasiveness and increased islet graft survival rate. It also allows for enhanced accessibility and monitoring of the islets. Although the ACE is initially an immuno-privileged site, this privilege is disrupted once the islet grafts are re-vascularized. Given that the ACE is a confined space, achieving graft immune tolerance through local immunosuppressive drug delivery is therefore feasible...
March 8, 2019: Scientific Reports
Mukharram M Bikbov, Rinat M Zainullin, Gyulli M Kazakbaeva, Timur R Gilmanshin, Venera F Salavatova, Inga I Arslangareeva, Nikolai A Nikitin, Songhomitra Panda-Jonas, Artur F Zaynetdinov, Renat A Kazakbaev, Ildar F Nuriev, Renat I Khikmatullin, Yulia V Uzianbaeva, Dilya F Yakupova, Said K Aminev, Jost B Jonas
PURPOSE: To assess the prevalence of pterygia and its associations in a population of Russia. DESIGN: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study was performed in a rural and urban area in Ufa/Bashkortostan 1300 km East of Moscow. Out of 7328 eligible individuals aged 40+ years, 5,899 (80.5%) individuals participated and underwent an ocular and systemic examination. Pterygia defined as conjunctival extensions onto the clear cornea were diagnosed upon slit lamp examination and on corneal photographs...
March 5, 2019: American Journal of Ophthalmology
Mukharram M Bikbov, Gyulli M Kazakbaeva, Rinat M Zainullin, Venera F Salavatova, Timur R Gilmanshin, Dilya F Yakupova, Yulia V Uzianbaeva, Inga I Arslangareeva, Songhomitra Panda-Jonas, Svetlana R Mukhamadieva, Renat I Khikmatullin, Said K Aminev, Ildar F Nuriev, Artur F Zaynetdinov, Jost B Jonas
PURPOSE: To assess the normal distribution of intraocular pressure (IOP) and its associations with ocular, medical, and socioeconomic factors in a Russian population. DESIGN: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study conducted in a rural and urban area in Ufa/Bashkortostan included 5,899 (80.5%) participants out of 7328 eligible individuals aged 40+ years. IOP was measured by non-contact tonometry. RESULTS: After excluding individuals after glaucoma surgery or with anti-glaucomatous therapy, mean IOP was 13...
March 5, 2019: American Journal of Ophthalmology
Anthony J Aldave, Mark A Terry, Loretta B Szczotka-Flynn, Wendi Liang, Allison R Ayala, Maureen G Maguire, Robert C O'Brien, Beth Ann Benetz, John E Bokosky, Steven P Dunn, Thomas E Gillette, Kristin M Hammersmith, David R Hardten, Bennie H Jeng, Marc F Jones, Richard L Lindstrom, Kenneth J Maverick, Verinder S Nirankari, Matthew S Oliva, Irving M Raber, Christopher J Rapuano, George O D Rosenwasser, Kevin W Ross, John W Seedor, Neda Shamie, Christopher G Stoeger, Shachar Tauber, Woodford S Van Meter, David D Verdier, Jonathan H Lass
PURPOSE: To examine the association of donor, recipient, and operative factors on graft dislocation after Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS) as well as the effects of graft dislocation and elevated IOP on graft success and endothelial cell density (ECD) 3 years postoperatively. DESIGN: Cohort study within a multi-center, double-masked, randomized clinical trial. METHODS: 1,090 individuals (1,330 study eyes), median age 70 years, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphakic corneal edema (6% of eyes)...
March 5, 2019: American Journal of Ophthalmology
Yoichi Yamada, Sayaka Nakamura-Yamada, Kaoru Kusano, Shunsuke Baba
Dental pulp stem cells (DPSCs) are mesenchymal stem cells (MSCs) that have multipotent differentiation and a self-renewal ability. They have been useful not only for dental diseases, but also for systemic diseases. Extensive studies have suggested that DPSCs are effective for various diseases, such as spinal cord injuries, Parkinson's disease, Alzheimer's disease, cerebral ischemia, myocardial infarction, muscular dystrophy, diabetes, liver diseases, eye diseases, immune diseases, and oral diseases. DPSCs have the potential for use in a cell-therapeutic paradigm shift to treat these diseases...
March 6, 2019: International Journal of Molecular Sciences
Qi Sheng You, Yukun Guo, Jie Wang, Xiang Wei, Acner Camino, Pengxiao Zang, Christina J Flaxel, Steven T Bailey, David Huang, Yali Jia, Thomas S Hwang
PURPOSE: To evaluate wide-field optical coherence tomography angiography (OCTA) for detection of clinically unsuspected neovascularization (NV) in diabetic retinopathy (DR). METHODS: This prospective observational single-center study included adult patients with a clinical diagnosis of nonproliferative DR. Participants underwent a clinical examination, standard 7-field color photography, and OCTA with commercial and prototype swept-source devices. The wide-field OCTA was achieved by montaging five 6 × 10-mm scans from a prototype device into a 25 × 10-mm image and three 6 × 6-mm scans from a commercial device into a 15 × 6-mm image...
March 4, 2019: Retina
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