Yu Wang, Lin Chen, Chengye Yao, Tingting Wang, Jing Wu, You Shang, Bo Li, Haifa Xia, Shiqian Huang, Fuquan Wang, Shuyu Wen, Shaoxin Huang, Yun Lin, Nianguo Dong, Shanglong Yao
BACKGROUND: Early recognition of the risk of acute respiratory distress syndrome (ARDS) after cardiopulmonary bypass (CPB) may improve clinical outcomes. The main objective of this study was to identify proteomic biomarkers and develop an early prediction model for CPB-ARDS. METHODS: We conducted three prospective nested cohort studies of all consecutive patients undergoing cardiac surgery with CPB at XXX Hospital. Plasma proteomic profiling was performed in ARDS patients and matched controls (Cohort 1, April, 2021 to July, 2021) at multiple timepoints: before CPB (T1), at end of CPB (T2), and 24 h after CPB (T3)...
August 2, 2023: International Journal of Surgery