Riccardo Giuseppe Abbasciano, Guido Maria Olivieri, Rachel Chubsey, Francesca Gatta, Nathan Tyson, Keertana Easwarakumar, Daniel P Fudulu, Roberto Marsico, Markus Kofler, Ghazi Elshafie, Florence Lai, Mahmoud Loubani, Simon Kendall, Mustafa Zakkar, Gavin J Murphy
BACKGROUND: Cardiac surgery triggers a strong inflammatory reaction, which carries significant clinical consequences. Corticosteroids have been suggested as a potential perioperative strategy to reduce inflammation and help prevent postoperative complications. However, the safety and effectiveness of perioperative corticosteroid use in adult cardiac surgery is uncertain. This is an update of the 2011 review with 18 studies added. OBJECTIVES: Primary objective: to estimate the effects of prophylactic corticosteroid use in adults undergoing cardiac surgery with cardiopulmonary bypass on the: - co-primary endpoints of mortality, myocardial complications, and pulmonary complications; and - secondary outcomes including atrial fibrillation, infection, organ injury, known complications of steroid therapy, prolonged mechanical ventilation, prolonged postoperative stay, and cost-effectiveness...
March 20, 2024: Cochrane Database of Systematic Reviews