Danielle I Aronowitz, Tracy R Geoffrion, Sarah Piel, Emilie J Benson, Sarah R Morton, Jonathan Starr, Richard W Melchior, Hunter A Gaudio, Rinat E Degani, Nicholas J Widmann, M Katie Weeks, Tiffany S Ko, Daniel J Licht, Marco Hefti, J William Gaynor, Todd J Kilbaugh, Constantine D Mavroudis
Objectives: We previously demonstrated cerebral mitochondrial dysfunction in neonatal swine immediately following a period of full-flow cardiopulmonary bypass (CPB). The extent to which this dysfunction persists in the postoperative period and its correlation with other markers of cerebral bioenergetic failure and injury is unknown. We utilized a neonatal swine model to investigate the early evolution of mitochondrial function and cerebral bioenergetic failure after CPB. Methods: Twenty piglets (mean weight 4...
April 22, 2024: World Journal for Pediatric & Congenital Heart Surgery