Abdalla Bowirrat, Igor Elman, Catherine A Dennen, Marjorie C Gondré-Lewis, Jean Lud Cadet, Jag Khalsa, David Baron, Diwanshu Soni, Mark S Gold, Thomas J McLaughlin, Debasis Bagchi, Eric R Braverman, Mauro Ceccanti, Panayotis K Thanos, Edward Justin Modestino, Keerthy Sunder, Nicole Jafari, Foojan Zeine, Rajendra D Badgaiyan, Debmalya Barh, Milan Makale, Kevin T Murphy, Kenneth Blum
Loneliness, an established risk factor for both, mental and physical morbidity, is a mounting public health concern. However, the neurobiological mechanisms underlying loneliness-related morbidity are not yet well defined. Here we examined the role of genes and associated DNA risk polymorphic variants that are implicated in loneliness via genetic and epigenetic mechanisms and may thus point to specific therapeutic targets. Searches were conducted on PubMed, Medline, and EMBASE databases using specific Medical Subject Headings terms such as loneliness and genes, neuro- and epigenetics, addiction, affective disorders, alcohol, anti-reward, anxiety, depression, dopamine, cancer, cardiovascular, cognitive, hypodopaminergia, medical, motivation, (neuro)psychopathology, social isolation, and reward deficiency...
2023: Psychology Research and Behavior Management