Oskari Kantonen, Lauri Laaksonen, Michael Alkire, Annalotta Scheinin, Jaakko Långsjö, Roosa E Kallionpää, Kaike Kaisti, Linda Radek, Jarkko Johansson, Timo Laitio, Anu Maksimow, Joonas Scheinin, Mikko Nyman, Mika Scheinin, Olof Solin, Tero Vahlberg, Antti Revonsuo, Katja Valli, Harry Scheinin
Establishing the neural mechanisms responsible for the altered global states of consciousness during anesthesia and dissociating these from other drug-related effects remains a challenge in consciousness research. We investigated differences in brain activity between connectedness and disconnectedness by administering various anesthetics at concentrations designed to render 50% of the subjects unresponsive. One hundred and sixty healthy male subjects were randomized to receive either propofol (1.7 μg/ml; n = 40), dexmedetomidine (1...
June 28, 2023: Journal of Neuroscience