Hongxu Pu, Chenghao Gao, Yi Zou, Liming Zhao, Guanghao Li, Changyu Liu, Libo Zhao, Meng Zheng, Gaohong Sheng, Xuying Sun, Xingjie Hao, Chaolong Wang, Ximiao He, Jun Xiao
OBJECTIVES: Osteoarthritis (OA) is a whole-joint disease in which the role of the infrapatellar fat pad (IFP) in its pathogenesis is unclear. Our study explored the cellular heterogeneity of IFP to understand OA and identify therapeutic targets. METHODS: Single-cell and single-nuclei RNA sequencing were used to analyze 10 IFP samples, comprising 5 from OA patients and 5 from healthy controls. Analyses included differential gene expression, enrichment, pseudotime trajectory, and cellular communication, along with comparative studies with visceral and subcutaneous fats...
March 23, 2024: International Immunopharmacology