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https://read.qxmd.com/read/30776174/safety-and-effectiveness-of-alectinib-in-a-real-world-surveillance-study-in-patients-with-alk-positive-nsclc-in-japan
#1
Masuda Noriyuki, Yuichiro Ohe, Akihiko Gemma, Masahiko Kusumoto, Ikuyo Yamada, Tadashi Ishii, Nobuyuki Yamamoto
We conducted a large-scale surveillance study as a post-marketing commitment to investigate safety and effectiveness of alectinib in patients with ALK-positive non-small-cell lung cancer (NSCLC) in Japan. Patients receiving 300mg twice-daily alectinib (September 2014 to June 2015) were monitored until termination of alectinib or completion of 18 months of treatment at 519 Japanese study sites. The primary endpoint was the incidence of adverse drug reactions (ADRs), which are important identified risks for alectinib in Japanese patients...
February 18, 2019: Cancer Science
https://read.qxmd.com/read/30775400/mineralogy-controlled-dissolution-of-uranium-from-airborne-dust-in-simulated-lung-fluids-slfs-and-possible-health-implications
#2
Eshani Hettiarachchi, Shaylene Paul, Daniel Cadol, Bonnie Frey, Gayan Rubasinghege
The recent increase in cardiovascular and metabolic disease in the Navajo population residing close to the Grants Mining District (GMD) in New Mexico is suggested to be due to exposure to environmental contaminants, in particular uranium in respirable dusts. However, the chemistry of uranium-containing-dust dissolution in lung fluids and the role of mineralogy are poorly understood, as is their impact on toxic effects. The current study is focused on the dissolution of xcontaining-dust, collected from several sites near Jackpile and St...
February 12, 2019: Environmental Science & Technology Letters
https://read.qxmd.com/read/30773535/-clinicopathological-characteristics-and-diagnosis-of-igg4%C3%AE-related-sialadenitis
#3
G Y Yu, X Hong, W Li, Y Y Zhang, Y Gao, Y Chen, Z Y Zhang, X Y Xie, Z G Li, Y Y Liu, J Z Su, W X Zhu, Z P Sun
Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. The comorbid diseases of head and neck region including rhinosinusitis, allergic rhinitis, and lymphadenopathy were commonly seen, which could occur more early than enlargement of major salivary glands...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/30773528/bullous-pemphigoid-with-atypical-skin-lesions-and-acute-interstitial-nephritis-a-case-report-and-focused-literature-review
#4
Bindu Ganapathineedi, Alaap Mehta, Susmitha Dande, Anjali Shinde, Gary Barsky, Nadew Sebro
BACKGROUND The hallmark of bullous pemphigoid (BP) is widespread tense blisters arising on normal or erythematous skin, often with marked pruritus, the diagnosis of which is confirmed by direct immunofluorescence (DIF). BP is an autoimmune process that can be induced, though rarely, by medications. Drug-induced BP often has atypical clinical presentation, which requires a good understanding of other dermatological conditions with similar presentations, in particular, bullous subtype of erythema multiforme. End organ involvement warrants differentiating it from one of the severe cutaneous adverse reaction (SCAR) syndromes...
February 18, 2019: American Journal of Case Reports
https://read.qxmd.com/read/30772037/chest-computed-tomography-imaging-improves-potential-lung-donor-assessment
#5
Jason M Gauthier, Andrew J Bierhals, Jingxia Liu, Keki R Balsara, Christine Frederiksen, Emily Gremminger, Ramsey R Hachem, Chad A Witt, Elbert P Trulock, Derek E Byers, Roger D Yusen, Patrick R Aguilar, Gary Marklin, Ruben G Nava, Benjamin D Kozower, Michael K Pasque, Bryan F Meyers, G Alexander Patterson, Daniel Kreisel, Varun Puri
OBJECTIVE: Chest computed tomography (CT) imaging is being increasingly used for potential lung donor assessment. However, the efficacy of CT imaging in this setting remains unknown. We hypothesize that chest CT imaging independently affects the decision-making process in donor lung utilization. METHODS: We conducted a retrospective cohort study of all adult donation after brain death donors managed through our local organ procurement organization from June 2011 to November 2016...
November 24, 2018: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30771408/5-year-outcomes-of-a-single-institution-prospective-trial-of-19-gy-single-fraction-hdr-brachytherapy-for-low-and-intermediate-risk-prostate-cancer
#6
Zaid A Siddiqui, Gary S Gustafson, Hong Ye, Alvaro A Martinez, Beth Mitchell, Evelyn Sebastian, Amy Limbacher, Daniel J Krauss
PURPOSE: To update outcome and toxicity results of a prospective trial of 19 Gy single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer. MATERIALS AND METHODS: Patients were treated on a prospective study of single-fraction HDR brachytherapy. All patients had low- or intermediate-risk prostate cancer. Patients with prostate volumes > 50 cc, taking alpha-blockers for urinary symptoms, or baseline American Urologic Association (AUA) symptom scores > 12 were ineligible...
February 13, 2019: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30770917/how-to-treat-sj%C3%A3-gren-s-syndrome
#7
Elizabeth J Price, Alan N Baer
SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Systemic features may affect up to 70% and include inflammatory arthritis, skin involvement, haematological abnormalities, neuropathies, interstitial lung disease and a 5-10% lifetime risk of B cell lymphoma...
February 15, 2019: Rheumatology
https://read.qxmd.com/read/30770517/cyclophosphamide-for-systemic-sclerosis-related-interstitial-lung-disease-a-comparison-of-scleroderma-lung-study-i-and-ii
#8
Elizabeth R Volkmann, Donald P Tashkin, Myung Sim, Ning Li, Dinesh Khanna, Michael D Roth, Philip J Clements, Anna-Maria Hoffmann-Vold, Daniel E Furst, Grace Kim, Jonathan Goldin, Robert M Elashoff
OBJECTIVE: To compare safety and efficacy outcomes between the cyclophosphamide (CYC) arms of Scleroderma Lung Study (SLS) I and II. METHODS: Participants enrolled in the CYC arms of SLS I (n = 79) and II (n = 69) were included. SLS I and II randomized participants to oral CYC for 1 year and followed patients for an additional year off therapy (in SLS II, patients received placebo in Year 2). Eligibility criteria for SLS I and II were nearly identical. Outcomes included the forced vital capacity (FVC%)-predicted and DLCO%-predicted (measured every 3 mos) and quantitative radiographic extent of interstitial lung disease (measured at 1 and 2 yrs for SLS I and SLS II, respectively)...
February 15, 2019: Journal of Rheumatology
https://read.qxmd.com/read/30770218/inactivation-of-apoptosis-antagonizing-transcription-factor-in-tubular-epithelial-cells-induces-accumulation-of-dna-damage-and-nephronophthisis
#9
Manaswita Jain, Rainer W J Kaiser, Katrin Bohl, Martin Hoehne, Heike Göbel, Malte P Bartram, Sandra Habbig, Roman-Ulrich Müller, Agnes B Fogo, Thomas Benzing, Bernhard Schermer, Katja Höpker, Gisela G Slaats
Recent human genetic studies have suggested an intriguing link between ciliary signaling defects and altered DNA damage responses in nephronophthisis (NPH) and related ciliopathies. However, the molecular mechanism and the role of altered DNA damage response in kidney degeneration and fibrosis have remained elusive. We recently identified the kinase-regulated DNA damage response target Apoptosis Antagonizing Transcription Factor (AATF) as a master regulator of the p53 response. Here, we characterized the phenotype of mice with genetic deletion of Aatf in tubular epithelial cells...
February 12, 2019: Kidney International
https://read.qxmd.com/read/30769016/activation-of-the-calcium-sensing-receptor-in-human-valvular-interstitial-cells-promotes-calcification
#10
Hawraa Issa, Lucie Hénaut, Jeanne Bou Abdallah, Cédric Boudot, Gaëlle Lenglet, Carine Avondo, Aida Ibrik, Thierry Caus, Michel Brazier, Romuald Mentaverri, Kazem Zibara, Saïd Kamel
INTRODUCTION AND AIMS: Calcific aortic valve disease (CAVD) is the most common heart valve disease in western countries. It has been reported that activation of the calcium-sensing receptor(CaSR) expressed by vascular smooth muscle cells prevents vascular calcification. However, to date, the CaSR's expression and function in cardiac valves have not been studied. The present study sought to evaluate the presence of the CaSR within human valvular interstitial cells (hVICs), assess the CaSR's functionality, and ascertain its involvement in hVIC calcification...
February 12, 2019: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/30768925/translational-research-in-pulmonary-fibrosis
#11
REVIEW
Susan K Mathai, David A Schwartz
Pulmonary fibrosis refers to the development of diffuse parenchymal abnormalities in the lung that cause dyspnea, cough, hypoxemia, and impair gas exchange, ultimately leading to respiratory failure. Though pulmonary fibrosis can be caused by a variety of underlying etiologies, ranging from genetic defects to autoimmune diseases to environmental exposures, once fibrosis develops it is irreversible and most often progressive, such that fibrosis of the lung is one of the leading indications for lung transplantation...
February 5, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/30767873/clinical-features-of-systemic-sclerosis-patients-with-anti-rna-polymerase-iii-antibody-in-a-single-centre-in-spain
#12
Eduardo Luis Callejas-Moraga, Alfredo Guillén-Del-Castillo, Ana María Marín-Sánchez, María Roca-Herrera, Eva Balada, Carles Tolosa-Vilella, Vicente Fonollosa-Pla, Carmen Pilar Simeón-Aznar
OBJECTIVES: To evaluate the clinical features and survival of patients with positive anti-RNA polymerase III (anti-RNAP III) in a Spanish single centre. METHODS: We analysed 221 patients with SSc according to LeRoy and Medsger criteria. Twenty-six patients with positivity for anti-RNAP III antibodies were compared with 195 negative patients. Epidemiological, clinical, immunological features and survival were analysed. RESULTS: In patients with anti-RNAP III positivity diffuse cutaneous SSc (dcSSc) subset was the most prevalent (20, 76...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767871/adult-onset-still-s-disease-associated-interstitial-lung-disease-represents-severe-phenotype-of-the-disease-with-higher-rate-of-haemophagocytic-syndrome-and-relapse
#13
Yukiko Takakuwa, Hironari Hanaoka, Tomofumi Kiyokawa, Harunobu Iida, Kana Ishimori, Toshimasa Uekusa, Hidehiro Yamada, Kimito Kawahata
OBJECTIVES: Adult-onset Still's disease (AOSD) is an inflammatory disorder characterised by sustained fevers, arthritis, and skin involvement. Interstitial lung disease (ILD) is a rare manifestation, and its clinical characteristics have yet to be determined. METHODS: We sought to examine the clinical characteristics of AOSD-associated ILD. We retrospectively investigated 78 patients diagnosed as AOSD. ILD was diagnosed based on chest high-resolution computed tomography (HRCT)...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767866/clinical-features-of-thirty-two-patients-with-anti-melanoma-differentiation-associated-gene-5-antibodies
#14
Wenhan Huang, Feifeng Ren, Qian Wang, Lei Luo, Jun Zhou, Dongmei Huang, Zhuma Pan, Lin Tang
OBJECTIVES: To investigate the clinical characteristics of patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse the potential pathogenesis of anti-MDA5 antibodies. METHODS: The clinical manifestations, serological tests, imaging features, treatments, and prognoses of 32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and Immunology Department of the Second Affiliated Hospital of Chongqing Medical University from September 2015 to August 2018 were analysed...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30766883/rapid-production-of-human-vegf-a-following-intradermal-injection-of-modified-vegf-a-mrna-demonstrated-by-cutaneous-microdialysis-in-the-rabbit-and-pig-in-vivo
#15
Susanne Pehrsson, Mikko Hölttä, Gunilla Linhardt, Regina Fritsche Danielson, Leif Carlsson
Chemically modified mRNA is a novel, highly efficient, biocompatible modality for therapeutic protein expression that may overcome the challenges and safety concerns with current gene therapy strategies. We explored the efficiency of intradermally injected modified VEGF-A165 mRNA (VEGF-A mRNA) formulated in a biocompatible citrate/saline buffer to locally produce human VEGF-A165 protein. Rabbits (n=4) and minipigs (n=3) were implanted with subcutaneous microdialysis probes close to the injection sites and interstitial-fluid samples and skin biopsies were analysed for production of VEGF-A protein over time for up to 8 hours...
2019: BioMed Research International
https://read.qxmd.com/read/30765674/-a-case-of-drug-induced-interstitial-lung-disease-associated-with-epirubicin-and-cyclophosphamide-therapy-before-operation
#16
Hideyuki Omoto, Mamoru Takada, Shota Fujii, Hiroshi Ito, Sumio Yamashita
We report the case of a 60-year-old woman with right breast cancer. Approximately 18 years had passed since the treatment for left breast cancer without recurrence. She became aware of the right breast tumor with mild pain 5 months before she came to the hospital. The diagnosis was right-sided breast cancer, cT2N0M0, StageⅡA, ER(-), PgR(-), HER2(-). Neoadjuvant chemotherapy was chosen, and then combined treatment with epirubicin(EPI)and cyclophosphamide(CPA) was started. The breast tumor had become smaller, but she complained of shortness of breath during the third course of chemotherapy...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30765501/atrial-dysplasia-in-the-atria-of-humans-without-cardiovascular-disease
#17
Guo-Liang Li, Guy Fontaine, Jine Wu, Shuanliang Fan, Chaofeng Sun, Ardan M Saguner
Research on atrial histology of humans without cardiovascular disease is scarce. Therefore, our aim was to study human atrial histology in subjects without cardiovascular disease. Histology of the right atrium, left atrium or atrial septum was studied in eight patients (one newborn infant and seven adults) who died of a non-cardiac cause and who were not known to suffer from any cardiovascular pathology. Staining with hematoxylin phloxine saffron or Masson's trichrome was performed to have a better identification of fibrosis and H&E for better identification of lymphocytes...
February 14, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/30765393/association-of-muc5b-promoter-polymorphism-with-interstitial-lung-disease-in-myeloperoxidase-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#18
Natsumi Namba, Aya Kawasaki, Ken-Ei Sada, Fumio Hirano, Shigeto Kobayashi, Hidehiro Yamada, Hiroshi Furukawa, Kota Shimada, Atsushi Hashimoto, Toshihiro Matsui, Kenji Nagasaka, Takahiko Sugihara, Aika Suzuki, Kunihiro Yamagata, Takayuki Sumida, Shigeto Tohma, Sakae Homma, Shoichi Ozaki, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura, Masayoshi Harigai, Naoyuki Tsuchiya
No abstract text is available yet for this article.
February 14, 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30764873/detection-of-serum-mcp-1-and-tgf-%C3%AE-1-in-polymyositis-dermatomyositis-patients-and-its-significance
#19
Chun-Ye Wu, Li Li, Li-Hua Zhang
OBJECTIVE: This study aims to detect serum levels of monocyte chemoattractant protein-1 (MPC-1) and transforming growth factor-β1 (TGF-β1) in polymyositis/dermatomyositis (PM/DM) patients complicated with interstitial lung disease (ILD), to reveal the significance of the changes in these levels in the pathogenesis of PM/DM complicated with ILD. METHODS: Serum MCP-1 and TGF-β1 levels in PM/DM patients complicated with ILD, patients with pulmonary infections and normal controls (n = 30, each) were detected using enzyme-linked immunosorbent assay (ELISA), and the correlation between PM/DM complicated with ILD and serum MCP-1 and TGF-β1 levels was analyzed...
February 14, 2019: European Journal of Medical Research
https://read.qxmd.com/read/30764870/significance-of-anti-neutrophil-cytoplasmic-antibodies-in-systemic-sclerosis
#20
Jayne Moxey, Molla Huq, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Gemma Strickland, Michelle Wilson, Laura Ross, Gabor Major, Janet Roddy, Wendy Stevens, Mandana Nikpour
BACKGROUND: Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the significance of ANCA in these patients is unclear. The aim of this study is to determine the prevalence of ANCA in a well-characterised SSc cohort and to examine the association between ANCA and SSc clinical characteristics, other autoantibodies, treatments and mortality. METHODS: Clinical data were obtained from 5 centres in the Australian Scleroderma Cohort Study (ASCS)...
February 14, 2019: Arthritis Research & Therapy
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