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Clot composition

Sonu Bhaskar, Jawad Saab, Cecilia Cappelen-Smith, Murray Killingsworth, Xiao Juan Wu, Andrew Cheung, Nathan Manning, Patrick Aouad, Alan McDougall, Suzanne Hodgkinson, Dennis Cordato
BACKGROUND: Endovascular thrombectomy (EVT) has shown efficacy in acute ischemic stroke (AIS) patients with infective endocarditis (IE). The possibility to undertake advanced histopathological clot analysis following EVT offers a new avenue to establish the etiological basis of the stroke - which is often labelled "cryptogenic." In this paper, we present our findings from four consecutive patients with IE who underwent EVT following an AIS at our tertiary referral comprehensive stroke centre...
March 14, 2019: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Selin S Suner, Sahin Demirci, Berkant Yetiskin, Rawil Fakhrullin, Ekaterina Naumenko, Oguz Okay, Ramesh S Ayyala, Nurettin Sahiner
We present here preparation of mechanically strong and biocompatible cryogel composites based on hyaluronic acid (HA) and halloysite nanotubes (HNTs) of various compositions, and their applications as scaffold for different cell growing media. Uniaxial compression tests reveal that the incorporation of HNTs into HA cryogels leads to a ~2.5-fold increase in their Young moduli, e.g., from 38 ± 1 to 99 ± 4 kPa at a HA:HNTs weight ratio of 1:2. Although HA:HNTs based cryogels were found to be blood compatible with 1...
March 3, 2019: International Journal of Biological Macromolecules
Xiaoqiang Shang, Yun Long Li, Hao Chen, Lisha Yu, Zhugang Wang, Liping Xiao, Jie Fan
Zeolite is a multifunctional material, which recently exhibited promising prospects in emerging biological and medical applications. This study reported a new bio-inorganic hybrid of zeolite-fibrin clot composite serving as haemostatic agent in haemophilia A. The zeolite-fibrin clot composite promoted haemocompatibility and helped to achieve short clotting time both in vitro (22 ± 3 s vs. >600 s) and in vivo (4.5 min vs. >60 min) compared to control in coagulation factor VIII deficiency bleeding model...
February 28, 2019: Journal of Biomaterials Applications
Zbigniew Adamiak, Jan Borys, Wioletta Krystkiewicz, Andrzej Pomaniowski, Marek Jalynski, Piotr Holak, Maciej Brzezinski, Pawel Jastrzebski, Angelika Tobolska, Joanna Glodek
BACKGROUND/AIM: Coagulopathy can develop when hemostatic dressings are used to stop massive bleeding, even in patients without prior history of clotting disorders. The selection of procoagulants, which effectively control bleeding and prevent disseminated intravascular coagulation (DIC) and thrombosis, is a significant challenge. The aim of this study was to evaluate the effect of two prototypes of haemostatic dressing in the porcine haemostatic system. MATERIALS AND METHODS: The total number of animals used in our experiments was 24...
March 2019: In Vivo
Tomasz Nowakowski, Krzysztof Piotr Malinowski, Rafał Niżankowski, Teresa Iwaniec, Anetta Undas
INTRODUCTION: Hypolysible fibrin clots composed of tightly packed fibers characterize patients with peripheral artery disease (PAD) especially those with critical limb ischemia (CLI). Little is known about the impact of a prothrombotic clot phenotype on restenosis following endovascular revascularization in CLI. The goal of this study was to compare fibrin clot properties and their determinants in CLI patients with restenosis after endovascular treatment (ET) and those free of this complication...
February 14, 2019: Journal of Thrombosis and Thrombolysis
Garsiya Ekaterina Robertovna, Konovalov Dmitryi Alexeevich, Shamilov Arnold Alexeevich, Glushko Margarita Petrovna, Orynbasarova Kulpan Kenzhebaevna
For many years, plants have been used in the traditional medicine of different cultures. The biennial plant of the family Asteraceae, Onopordum acanthium L., also known as Scotch thistle, is used in traditional medicine as an anti-inflammatory, antitumor, and cardiotonic agent. The plant is widespread in the world; it grows in Europe and Asia and was introduced to America and Australia. Stems and buds of the first-year plant are used in cooking as an analogue of artichoke in European cuisine. Additionally, inflorescences contain a complex of proteolytic enzymes "onopordosin", which may be used as a milk-clotting agent in the dairy industry...
February 12, 2019: Plants (Basel, Switzerland)
M Nivedhitha Sundaram, Sivashanmugam Amirthalingam, Ullas Mony, Praveen Kerala Varma, RangasamyJayakumar
Effective bleeding control is a major concern in trauma and major surgeries. Chitosan (Ch) as hemostatic agent has been widely used and when applied at the site of injury it acts by aggregating blood cells and forming a plug. Our prime interest is to enhance the blood clotting potential of Ch hydrogel. Incorporation of nano bioglass (nBG) with silica (activate coagulation factor XII), calcium (activate intrinsic pathway) and phosphate (initiates extrinsic pathway) ions into Ch hydrogel (protonated amine group) would act simultaneously on mechanisms involved in hemostasis and bring about effective bleeding control...
February 6, 2019: International Journal of Biological Macromolecules
Gastón Meza, Denisse Urrejola, Nicole Saint Jean, Carolina Inostroza, Valentina López, Maroun Khoury, Claudia Brizuela
INTRODUCTION: Regenerative endodontic procedures have emerged as a new treatment. The aim of this case report was to describe a regenerative autologous cellular therapy using mesenchymal stem cells from inflamed dental pulp and leukocyte platelet-rich fibrin (L-PRF) in a mature tooth. METHODS: A healthy 50-year-old man consulting for spontaneous dental pain was referred for endodontic treatment in tooth #28, which was diagnosed with symptomatic irreversible pulpitis...
February 2019: Journal of Endodontics
Néstor Gutiérrez-Méndez, Alejandro Balderrama-Carmona, Socorro E García-Sandoval, Pamela Ramírez-Vigil, Martha Y Leal-Ramos, Antonio García-Triana
Cream cheese is a fresh acid-curd cheese with pH values of 4.5⁻4.8. Some manufacturers add a small volume of rennet at the beginning of milk fermentation to improve the texture of the cream cheese. However, there is no information about the effect that proteases other than chymosin-like plant-derived proteases may have on cream cheese manufacture. This work aimed to describe some proteolytic features of the protease extracted from fruits of Solanum elaeagnifolium Cavanilles and to assess the impact that this plant coagulant has on the viscoelastic properties of cream cheeses...
January 30, 2019: Foods (Basel, Switzerland)
Fiona M Weafer, Sharon Duffy, Ines Machado, Gillian Gunning, Pasquale Mordasini, Ellen Roche, Peter E McHugh, Michael Gilvarry
BACKGROUND: Although it is common practice to wait for an 'embedding time' during mechanical thrombectomy (MT) to allow strut integration of a stentriever device into an occluding thromboembolic clot, there is a scarcity of evidence demonstrating the value or optimal timing for the wide range of thrombus compositions. This work characterizes the behavior of clot analogs of varying fibrin and cellular compositions subject to indentation forces and embedding times representative of those imparted by a stentriever during MT...
January 19, 2019: Journal of Neurointerventional Surgery
Li Gong, Xiaoran Zheng, Lijin Feng, Xiang Zhang, Qiong Dong, Xiaoyu Zhou, Haichao Wang, Xiaojun Zhang, Zhongwen Shu, Yanxin Zhao, Xueyuan Liu
Mechanical thrombectomy (MT) is effective in managing patients with acute ischemic stroke (AIS) caused by large-vessel occlusions and allows for valuable histological analysis of thrombi. However, whether bridging therapy (pretreatment with intravenous thrombolysis before MT) provides additional benefits in patients with middle cerebral artery (MCA) occlusion remains unclear. Therefore, this study aimed to compare the effects of direct MT and bridging therapy, and to elucidate the correlation between thrombus composition and stroke subtypes...
January 18, 2019: Cell Transplantation
Xun Sun, Yan Fang, Zonghao Tang, Zhengchao Wang, Xinqing Liu, Haiqing Liu
Chitosan has been made into various hemostats, but their hemostatic efficiency for controlling severe traumatic bleeding is still inadequate. The aim of this work is to make quick hemostats by incorporating mesoporous silica nanoparticles into chitosan. Porous chitosan-silica composite microspheres (CSMS-S) with high hemostatic efficacy were fabricated through a combination of the microemulsion, thermally induced phase separation, and surfactant templating method. A large number of mesoporous silica nanoparticles were formed on and within the CSMS-S microspheres, which had abundant surface and inner macropores...
January 9, 2019: International Journal of Biological Macromolecules
Ramshanker Ramanathan, Jørgen B Gram, Johannes J Sidelmann, Damini Dey, Martin W Kusk, Bjarne L Nørgaard, Niels Peter R Sand
INTRODUCTION: Fibrin clot lysability is associated with development of cardiovascular disease (CVD). We evaluated sex-differences in fibrin clot lysability and the association with coronary plaque composition determined by computed tomography angiography (CTA). METHODS: Middle-aged citizens without known CVD were randomly selected from a national registry. A coronary CTA assessed volumes of calcified-, non-calcified-, low-density non-calcified-, and total- plaque using a validated plaque quantification software...
December 19, 2018: Thrombosis Research
Andrea M Matuska, Marina K Klimovich, John R Chapman
Thrombin is a coagulation protein of central importance to hemostasis and wound healing that can be sourced from human blood, bovine blood, and engineered cell lines. Only autologous thrombin lacks the risks of transmitting emergent pathogens or eliciting an immunogenic response. Previous commercial autologous thrombin devices require the use of high concentrations of ethanol to achieve thrombin stability, introducing cytotoxicity risks. A new point of care device for preparing an ethanol-free autologous thrombin serum was investigated...
December 2018: Journal of Extra-corporeal Technology
E S Krasnikova, O S Larionova, A V Krasnikov, G Kh Kazieva
The questions of quality control and safety of milk raw materials has always been relevant for the dairy industry. One of the most common cattle infection is bovine leukemia (causative agent - BLV), which often occurs in conjunction with a closely related infection -bovine immunodeficiency (causative agent - BIV). These retroviruses are considered to be species-specific, so the key issue for the dairy industry is the nutritional and raw value of milk of infected cows (without clinical signs). Milk of infected with leukemia cows has changed physical and chemical properties and microbiological parameters, but it is allowed to be processed after a single pasteurization...
2018: Voprosy Pitaniia
Matthew D Lee, Calum Wilson, Christopher D Saunter, Charles Kennedy, John M Girkin, John G McCarron
Blood flow, blood clotting, angiogenesis, vascular permeability, and vascular remodeling are each controlled by a large number of variable, noisy, and interacting chemical inputs to the vascular endothelium. The endothelium processes the entirety of the chemical composition to which the cardiovascular system is exposed, carrying out sophisticated computations that determine physiological output. Processing this enormous quantity of information is a major challenge facing the endothelium. We analyzed the responses of hundreds of endothelial cells to carbachol (CCh) and adenosine triphosphate (ATP) and found that the endothelium segregates the responses to these two distinct components of the chemical environment into separate streams of complementary information that are processed in parallel...
December 18, 2018: Science Signaling
Kristopher W Kolewe, Kerianne M Dobosz, Todd Emrick, Stephen S Nonnenmann, Jessica D Schiffman
Biofilm-associated infections stemming from medical devices are increasingly challenging to treat due to the spread of antibiotic resistance. In this study, we present a simple strategy that significantly enhances the antifouling performance of covalently crosslinked poly(ethylene glycol) (PEG) and physically crosslinked agar hydrogels by incorporation of the fouling-resistant polymer zwitterion, poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC). Dopamine polymerization was initiated during swelling of the hydrogels, which provided dopamine and pMPC an osmotic driving force into the hydrogel interior...
July 16, 2018: ACS Applied Bio Materials
Vail Natale Júnior, Francisley Ávila Souza, Eduardo Vedovatto, Renato Sussumu Nishioka, Pier Paolo Poli, Paulo Sérgio Perri de Carvalho
The purpose of this study was to evaluate the preservation of alveolar dimensions in human fresh extraction sockets filled with a composite bovine bone graft by means of design of single-blind randomized clinical trial. Forty participants had monoradicular teeth extracted (one teeth in each participant), and after were randomly divided into 2 groups: individuals whose fresh sockets were filled with the composite heterologous bone graft (Biomaterial Group), or with blood clot (Control Group). After extraction, the fresh sockets were measured at their greatest mesiodistal (MD) and bucco-lingual/palatal (BL/P) distance...
November 2018: Brazilian Dental Journal
Seán Fitzgerald, Oana M Mereuta, Karen M Doyle, Daying Dai, Ramanathan Kadirvel, David F Kallmes, Waleed Brinjikji
Mechanical thrombectomy has become the stand of care for patients with large vessel occlusions, yet major improvements in thrombectomy speed, efficacy, and completeness can still be achieved. High rates of clot fragmentation and failure to remove the clot resulting in poor neurological outcomes suggest that in order to further advance the field of stroke intervention; we must turn our attention towards understanding the science of clot. Accurately identifying the composition of the occlusive clot prior to intervention could significantly influence the success of the revascularization strategy used to treat them...
December 5, 2018: Journal of Neurosurgical Sciences
Yu Zhong, Xingtao Chen, Haitao Peng, Zhengwen Ding, Yonggang Yan
The novel Ca-zeolite/poly(amino acid) (CaY/PAA) composites for bone substitute applications with hemostatic activity were prepared using the in situ melting polymerization method. In this study, Ca-zeolite (CaY) loaded with Ca2+ was obtained from Y-type zeolite (NaY) by ion-exchange method. The properties of the CaY/PAA composites and PAA, including composition, structure, compressive strength, in vitro degradability in phosphate-buffered solution (PBS), bioactivity, cytocompatibility and in vitro coagulation tests were characterized and investigated...
November 24, 2018: Journal of Biomaterials Science. Polymer Edition
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