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burn AND wound

Xuekang Yang, Zhuoqun Fang, Mengdong Liu, Yue Zhang, Qiaohua Chen, Ke Tao, Juntao Han, Dahai Hu
This study aimed to introduce a novel technique for reconstructing electricity-damaged fingers using a method combining the free vascularized anterolateral thigh fascia lata flap with skin grafting. From February 2015 to March 2017, 11 patients were enrolled in this retrospective case series. All patients suffered from electrical injury of the fingers and had severe soft tissue defects, with the exposure of tendon, vessels, or nerves. All finger wounds were covered using free vascularized anterolateral thigh fascia lata flaps combined with skin grafting...
February 20, 2019: Journal of Burn Care & Research: Official Publication of the American Burn Association
Zhixue Wang, Jifeng Fang, Jizhou Xiao
Correlation of the expression of inflammatory factors with expression of apoptosis-related genes, B-cell lymphoma 2 ( Bcl-2 ) and Bcl-2 associated X protein ( Bax ), in burned rats was investigated. Forty healthy Sprague-Dawley rats were selected and randomly divided into SHAM group (n=10), I° burn group (n=10), II° burn group (n=10) and III° burn group (n=10). Changes in tumor necrosis factor-α (TNF-α), Bax messenger ribonucleic acid (mRNA), Bcl-2 mRNA, Bax protein and Bcl-2 protein expression levels were detected...
March 2019: Experimental and Therapeutic Medicine
Meiru Jiang, Qiaoxia Sun, Ganggang Liu, Hua Qu, Jiahai Ma
Burn-induced acute post-operative pain and the associated stress response may result in prolonged convalescence. The present study investigated the effects of dexmedetomidine (DEX) administration on post-operative pain and the quality of recovery following surgical treatment of moderate-to-severe burn injuries. A total of 60 adult patients undergoing tangential excision skin grafting were randomized into two groups. The DEX group (Group D) received an intravenous (i.v.) single-dose bolus injection of DEX 0...
March 2019: Experimental and Therapeutic Medicine
Lauren H Mangum, Joshua J Avila, Brady J Hurtgen, Alicia L Lofgren, Joseph C Wenke
BACKGROUND: Singular traumatic insults, such as bone fracture, typically initiate an appropriate immune response necessary to restore the host to pre-insult homeostasis with limited damage to self. However, multiple concurrent insults, such as a combination of fracture, blunt force trauma, and burns (polytrauma), are clinically perceived to result in abnormal immune response leading to inadequate healing and resolution. To investigate this phenomenon, we created a model rat model of polytrauma...
February 19, 2019: Journal of Orthopaedic Surgery and Research
Antonia Monica Neres Santos, Ana Paula Duarte Moreira, Carlos W Piler Carvalho, Rosa Luchese, Edlene Ribeiro, Garrett B McGuinness, Marisa Fernandes Mendes, Renata Nunes Oliveira
Manuka honey is a well-known natural material from New Zealand, considered to have properties beneficial for burn treatment. Gels created from polyvinyl alcohol (PVA) blended with natural polymers are potential burn-care dressings, combining biocompatibility with high fluid uptake. Controlled release of manuka honey from such materials is a possible strategy for improving burn healing. This work aimed to produce polyvinyl alcohol (PVA), PVA⁻sodium carboxymethylcellulose (PVA-CMC), PVA⁻gelatin (PVA-G), and PVA⁻starch (PVA-S) cryogels infused with honey and to characterize these materials physicochemically, morphologically, and thermally, followed by in vitro analysis of swelling capacity, degradation/weight loss, honey delivery kinetics, and possible activity against Staphylococcus aureus ...
February 13, 2019: Materials
Zurab Kakabadze, David Chakhunashvili, Ketevan Gogilashvili, Ketevan Ediberidze, Konstantine Chakhunashvili, Konstantine Kalandarishvili, Lia Karalashvili
OBJECTIVES: In this study, our aim was to create a bioactive wound dressing that combined decellularized and lyophilized human amniotic membrane and freeze-dried rat bone marrow stem cells for the treatment of nonhealing wounds. MATERIALS AND METHODS: For the decellularized human amniotic membrane, sodium dodecyl sulfate and 1% Triton X-100 were used. The mononuclear fraction of bone marrow stem cells was isolated by density gradient centrifugation using Ficoll Paque Plus (GE Healthcare Bio-Sciences, Pittsburgh, PA, USA)...
January 2019: Experimental and Clinical Transplantation
Ju-Yi Li, Zhong-Jing Wang, Ai-Ping Deng, Yu-Ming Li
Objectives: Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality. The aim of our study was to identify novel biomarkers of impaired wound healing in diabetic foot ulcers. Methods: 109 patients with neuropathic diabetic foot ulcers and 30 burn victims otherwise healthy participated. Antibody-coated glass slide arrays were used to determine the levels of 80 human cytokines in pooled plasma or pooled wound exudate of diabetic foot ulcers with rapidly healing (RH, n = 12) and matched nonhealing (NH, n = 12) patients...
2019: Journal of Diabetes Research
Mariam ALfadli, Eman M El-Sehsah, Moustapha Ahmed-Maher Ramadan
Introduction: Patients with burn wounds are more susceptible to develop healthcare associated (HA) infection. Bacterial isolates from HA burn wound infection vary from one place to the other and also differ in terms of antimicrobial susceptibility pattern. The aim of our study was to assess the incidence of HA burn wound infection, risk factors and to determine the microbiological profile and antimicrobial susceptibility pattern of isolated pathogens. Methods: This was a one-year retrospective descriptive study conducted between January 2017 and December 2017, in Al-Babtain Burn and Plastic Surgery center, Kuwait...
December 2018: Germs
Priyamvada Tewari, James Garritano, Neha Bajwa, Shijun Sung, Haochong Huang, Dayong Wang, Warren Grundfest, Daniel B Ennis, Dan Ruan, Elliott Brown, Erik Dutson, Michael C Fishbein, Zachary Taylor
A method to register THz and visible images of cutaneous burn wounds and to calibrate THz image data is presented. Images of partial and full thickness burn wounds in 9 rats were collected over 435 mins. = 7.25 hours following burn induction. A two-step process was developed to reference the unknown structure of THz imaging contrast to the known structure and the features present in visible images of the injury. This process enabled the demarcation of a wound center for each THz image, independent of THz contrast...
January 1, 2019: Biomedical Optics Express
Parviz Farzadinia, Gholamhossein Mohebbi, Afshar Bargahi, Samad Akbarzadeh, Iraj Nabipour, Mohammadreza Abdi, Zeynab Hasanpour, Zahra Alipour, Adel Daneshi
Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Various bioactive compounds such as steroid glycosides, tannins, various vitamins, saponins, cardenolides and anthraquinones were identified into extract of the plant, which can be effective in burn wound healing. Twenty-one rats weighting every one 200±5 grams were divided equally into three groups. The second-degree burning induced on all groups...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Lei Zhao, Kai Wang, Weichao Li, Thanapop Soteyome, Hang Xiao, Zhuoyan Hu
The objective of this study was to evaluate the ability of a polyphenolic extract from longan seeds as a wound-healing material for deep second-degree burn wounds. The total phenol content of the extract reached 45.28 ± 1.22 mg GAE per g DW when 70% ethanol was used as the extraction solvent, and then AB-8 resin was used for purification. Results from the antioxidant assay in vitro (DPPH˙ and hydroxyl radical scavenging activity) and antimicrobial activity assay (ZOI, MIC and MBC) showed that the fractions eluted by 30% ethanol tend to have greater antioxidant ability, as well as higher bactericidal and antibacterial activities, than the other elution fractions...
February 15, 2019: Food & Function
Hassan Mahmoudi, Maryam Pourhajibagher, Nasim Chiniforush, Ali Reza Soltanian, Mohammad Yousef Alikhani, Abbas Bahador
OBJECTIVE: To investigate the relationship between biofilm formation and antibiotic resistance patterns in meticillin-resistant and meticillin-sensitive Staphylococcus aureus, isolated from burns. METHODS: In a cross-sectional study, pus/wound swab samples were obtained from burns. Presence of Staphylococcus aureus was confirmed, and biofilm formation-related icaABCDR and eta, etb genes were detected by polymerase chain reaction. Biofilm formation assay was assessed using the microtiter plate method...
February 2, 2019: Journal of Wound Care
Christopher H Pham, Zachary J Collier, Mike Fang, Anna Howell, Timothy J Gillenwater
OBJECTIVE: A systematic review and meta-analysis was performed to summarise the state of the literature in regard to the efficacy and uses of clostridial collagenase ointment (CCO) in the burn patient. METHOD: A systematic review of articles available on PubMed, Scopus and OvidSP Medline was performed. Keywords used in the search process included burns, thermal injury, collagenase, enzymatic debridement, wound care. Reviews, case reports, independent abstracts, consensus and opinion papers were excluded...
February 1, 2019: Journal of Wound Care
Yasuhiko Kaita, Takehiko Tarui, Hideaki Yoshino, Takeaki Matsuda, Yoshihiro Yamaguchi, Takatoshi Nakagawa, Michio Asahi, Masaaki Ii
Introduction: The purpose of this study was to evaluate whether cryopreserved (frozen) adipose-derived regenerative cells (ADRCs) have a therapeutic effect on burn wound healing as well as freshly isolated (fresh) ADRCs. Methods: Full thickness burns were created on dorsum of nude mice and burn wound was excised. The wound was covered by artificial dermis with; (i) fresh ADRCs, (ii) frozen ADRCs, and (iii) PBS (control). The assessment for wound healing was performed by morphological, histopathological and immunohistochemical analyses...
June 2019: Regenerative Therapy
K S Houschyar, C Tapking, D Duscher, C Wallner, A Sogorski, S Rein, D Pförringer, G Reumuth, K Weissenberg, G Grieb, L K Branski, F Siemers, B Behr, M Lehnhardt
BACKGROUND: Due to the loss of the natural skin barrier function with reduced immune competence as a result of a plasma loss and the numerous intensive care interventions, burn patients are particularly at risk for infection. STUDY DESIGN: systematic review METHODS: A systematic review of German and English literature between 1990 and 2018 analyzes the epidemiological and diagnostic aspects as well as the therapeutic use of antibiotics in infections of burn patients in clinical trials...
February 14, 2019: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Sajjad Yazdansetad, Ehsan Najari, Ezzat Allah Ghaemi, Naemeh Javid, Ali Hashemi, Abdollah Ardebili
OBJECTIVES: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a serious challenge and poses a threat to public health worldwide. This study aimed to determine drug susceptibility of A. baumannii, and then, investigate oxacillinase-encoding determinants and their association with ISAba1 sequence in CRAB isolates. METHODS: This study was performed on A. baumannii isolates recovered from patients with burn wound infections during 2013. All isolates were evaluated for antimicrobial susceptibility by disc agar diffusion method...
February 11, 2019: Journal of Global Antimicrobial Resistance
Şule Doğan, Barış Gökalsın, İsmail Şenkardeş, Ahmet Doğan, N Cenk Sesal
ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum perforatum L. (Hypericaceae) has been used as a traditional therapeutic for skin wounds, burns, cuts and stomach ailments including stomach ache, ulcers for a long time in many societies. Although many studies about its antibacterial properties can be found, there is a lack of studies about its quorum sensing inhibition properties, which effects bacterial vulnerability directly, on Pseudomonas aeruginosa. AIM OF THE STUDY: Evaluation of anti-quorum sensing (anti-QS) and anti-biofilm activity of ethanol, methanol, acetone and ultra-sonicated extracts of Hypericum perforatum L...
February 11, 2019: Journal of Ethnopharmacology
Cody C Frear, Bronwyn Griffin, Leila Cuttle, Steven M McPhail, Roy Kimble
BACKGROUND: Although negative pressure wound therapy (NPWT) is widely used in the management of several wound types, its efficacy as a primary therapy for acute burns has not yet been adequately investigated, with research in the paediatric population particularly lacking. There is limited evidence, however, that NPWT might benefit children with burns, amongst whom scar formation, wound progression and pain continue to present major management challenges. The purpose of this trial is to determine whether NPWT in conjunction with standard therapy accelerates healing, reduces wound progression and decreases pain more effectively than standard treatment alone...
February 13, 2019: Trials
Dinis Mateus, Joana Marto, Patrícia Trindade, Humberto Gonçalves, Ana Salgado, Paula Machado, António Melo-Gouveia, Helena M Ribeiro, António J Almeida
The use of morphine applied topically to painful wounds has potential advantages, such as dose reduction, fewer side effects and compound formulations, have been proposed for this purpose. Given the potential high impact of drug product quality on a patient's health, the aim of the present study was to develop two stable sterile hydrogels containing morphine hydrochloride, intended for topical application on painful wounds. Two carboxymethylcellulose sodium-based hydrogels were prepared containing 0.125% w / w (F1-MH semi-solid formulation) and 1...
February 12, 2019: Pharmaceutics
Shuang Long, Guojian Wang, Mingqiang Shen, Na Zhao, Huimin Wan, Yang Xu, Song Wang, Cheng Wang, Jining Gao, Yuhui Hao, Aiping Wang, Rong Li, Xinze Ran, Yongping Su, Junping Wang, Tao Wang
Exposure to ionizing radiation combined with traumatic tissue injury is an important life-threatening condition found in the civilian populations after nuclear and radiological events. The significance feature of radiation combined injury (RCI) is the severe combined effect, which makes the injury more complicated. At present, there are limited measures available to treat RCI. Here we show that a chimeric protein dTMP-GH, fusing human growth hormone (hGH) with a tandem dimer of thrombopoietin mimetic peptide (dTMP), could be an effective therapy agent for RCI in a mice model...
February 13, 2019: Radiation Research
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