keyword
https://read.qxmd.com/read/38531201/cirp-increases-foxp3-regulatory-t-cells-and-inhibits-development-of-th17-cells-by-enhancing-tlr4-il-2-signaling-in-the-late-phase-of-sepsis
#1
JOURNAL ARTICLE
Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu
BACKGROUND: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4+ T cells towards a Th1 profile. However, the effect and underlying mechanisms of CIRP on Th17/Treg differentiation in sepsis still remains unknown. METHODS: A prospective exploratory study including patients with sepsis was conducted...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38530256/tolerogenic-cd11c-dendritic-cells-regulate-cd4-tregs-in-replacing-delayed-ischemic-preconditioning-to-alleviate-ischemia-reperfusion-acute-kidney-injury
#2
JOURNAL ARTICLE
Pingping Wang, Chunyao Li, Tao Peng, Longzhu Ruan, Aijie Wu, Jiaojiao Zhu, Wenlu Shi, Menghua Chen, Ting Zhang
Ischemia-reperfusion injury (IRI) is one of the primary clinical causes of acute kidney injury (AKI). The key to IRI lies in immune-inflammatory damage, where dendritic cells (DCs) play a central role in eliciting immune responses within the context of inflammation induced by ischemia-reperfusion. Our previous study has confirmed that delayed ischemic preconditioning (DIPC) can reduce the kidney injury by mediating DCs to regulate T-cells. However, the clinical feasibility of DIPC is limited, as pre-clamping of the renal artery is not applicable for the prevention and treatment of ischemia-reperfusion acute kidney injury (I/R-AKI) in clinical patients...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38529776/alterations-of-peripheral-lymphocyte-subsets-in-isolated-rapid-eye-movement-sleep-behavior-disorder
#3
JOURNAL ARTICLE
Yuanchu Zheng, Yatong Li, Huihui Cai, Wenyi Kou, Chen Yang, Siming Li, Jiawei Wang, Ning Zhang, Tao Feng
BACKGROUND: Adaptive immune dysfunction may play a crucial role in Parkinson's disease (PD) development. Isolated rapid eye movement sleep behavior disorder (iRBD) represents the prodromal stage of synucleinopathies, including PD. Elucidating the peripheral adaptive immune system is crucial in iRBD, but current knowledge remains limited. OBJECTIVE: This study aimed to characterize peripheral lymphocyte profiles in iRBD patients compared with healthy control subjects (HCs)...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38528555/formononetin-reverses-treg-th17-imbalance-in-immune-mediated-bone-marrow-failure-mice-by-regulating-the-pi3k-akt-signaling-pathway
#4
JOURNAL ARTICLE
Huixuan Lan, Wei Qiu, Jie Wu, Zhijing Hu, Xiaomin Zhang, Lingling Zhu
BACKGROUND: Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent studies have demonstrated that CD4 + T cell subsets, including T regulatory (Treg) and T helper 17 (Th17) cells, play a pivotal role in the pathogenesis of SAA. Formononetin (FMN) is a natural compound extracted from the traditional Chinese medicine Huangqi, which has the ability to regulate the imbalance of Treg/Th17 cells in some inflammatory diseases. Nevertheless, the therapeutic effect of FMN in SAA has yet to be definitively established...
March 25, 2024: Chinese Medicine
https://read.qxmd.com/read/38526054/characterization-of-humoral-and-cellular-immunologic-responses-to-an-mrna-based-human-cytomegalovirus-vaccine-from-a-phase-1-trial-of-healthy-adults
#5
JOURNAL ARTICLE
Kai Wu, Yixuan Jacob Hou, Dan Makrinos, Runxia Liu, Alex Zhu, Matthew Koch, Wen-Han Yu, Yamuna D Paila, Sumana Chandramouli, Lori Panther, Carole Henry, Anthony DiPiazza, Andrea Carfi
mRNA-1647 is an investigational mRNA-based vaccine against cytomegalovirus (CMV) that contains sequences encoding the CMV proteins glycoprotein B and pentamer. Humoral and cellular immune responses were evaluated in blood samples collected from healthy CMV-seropositive and CMV-seronegative adults who participated in a phase 1 trial of a three-dose series of mRNA-1647 (NCT03382405). Neutralizing antibody (nAb) titers against fibroblast and epithelial cell infection in sera from CMV-seronegative mRNA-1647 recipients were higher than those in sera from control CMV-seropositive samples and remained elevated up to 12 months after dose 3...
March 25, 2024: Journal of Virology
https://read.qxmd.com/read/38523602/myd88-exacerbates-inflammation-induced-bone-loss-by-modulating-dynamic-equilibrium-between-th17-treg-cells-and-subgingival-microbiota-dysbiosis
#6
JOURNAL ARTICLE
Po-Yan Hsiao, Ren-Yeong Huang, Lin-Wei Huang, Ching-Liang Chu, Thomas Van Dyke, Lian-Ping Mau, Chia-Dan Cheng, Cheng-En Sung, Pei-Wei Weng, Yu-Chiao Wu, Yi-Shing Shieh, Wan-Chien Cheng
BACKGROUND: This study aimed to investigate the contribution of myeloid differentiation primary-response gene 88 (MyD88) on the differentiation of T helper type 17 (Th17) and regulatory T (Treg) cells and the emerging subgingival microbiota dysbiosis in Porphyromonas gingivalis-induced experimental periodontitis. METHODS: Alveolar bone loss, infiltrated inflammatory cells, immunostained cells for tartrate-resistant acid phosphatase (TRAP), the receptor activator of nuclear factor-kB ligand (RANKL), and osteoprotegerin (OPG) were quantified by microcomputerized tomography and histological staining between age- and sex-matched homozygous littermates (wild-type [WT, Myd88+/+ ] and Myd88-/- on C57BL/6 background)...
March 25, 2024: Journal of Periodontology
https://read.qxmd.com/read/38522129/a-reverse-translational-approach-reveals-the-protective-roles-of-mangifera-indica-in-inflammatory-bowel-disease
#7
JOURNAL ARTICLE
Anella Saviano, Anna Schettino, Nunzia Iaccarino, Adel Abo Mansour, Jenefa Begum, Noemi Marigliano, Federica Raucci, Francesca Romano, Gelsomina Riccardi, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Ivana Bello, Elisabetta Panza, Martina Smimmo, Valentina Vellecco, Peter Rimmer, Jonathan Cheesbrough, Zhaogong Zhi, Tariq H Iqbal, Stefano Pieretti, Vincenzo Maria D'Amore, Luciana Marinelli, Valeria La Pietra, Raffaella Sorrentino, Luisa Costa, Francesco Caso, Raffaele Scarpa, Giuseppe Cirino, Antonio Randazzo, Mariarosaria Bucci, Helen Michelle McGettrick, Asif Jilani Iqbal, Francesco Maione
Inflammatory bowel diseases (IBDs) are chronic intestinal disorders often characterized by a dysregulation of T cells, specifically T helper (Th) 1, 17 and T regulatory (Treg) repertoire. Increasing evidence demonstrates that dietary polyphenols from Mangifera indica L. extract (MIE, commonly known as mango) mitigate intestinal inflammation and splenic Th17/Treg ratio. In this study, we aimed to dissect the immunomodulatory and anti-inflammatory properties of MIE using a reverse translational approach, by initially using blood from an adult IBD inception cohort and then investigating the mechanism of action in a preclinical model of T cell-driven colitis...
March 23, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38519525/multipeptide-vaccines-for-melanoma-in-the-adjuvant-setting-long-term-survival-outcomes-and-post-hoc-analysis-of-a-randomized-phase-ii-trial
#8
JOURNAL ARTICLE
Emily K Ninmer, Hong Zhu, Kimberly A Chianese-Bullock, Margaret von Mehren, Naomi B Haas, Merrick I Ross, Lynn T Dengel, Craig L Slingluff
The critical roles of CD4+ T cells have been understudied for cancer vaccines. Here we report long-term clinical outcomes of a randomized multicenter phase II clinical trial (NCT00118274), where patients with high-risk melanoma received a multipeptide vaccine targeting CD8+ T cells (12MP) and were randomized to receive either of two vaccines for CD4+ (helper) T cells: 6MHP (6 melanoma-specific helper peptides), or tet (a nonspecific helper peptide from tetanus toxoid). Cyclophosphamide (Cy) pre-treatment was also assessed...
March 22, 2024: Nature Communications
https://read.qxmd.com/read/38517239/effect-of-stratified-dose-of-norepinephrine-on-cellular-immune-response-in-patients-with-septic-shock-and-the-construction-of-a-prognostic-risk-model
#9
JOURNAL ARTICLE
Qiang Wang, Jiefu Tang, Yao Li, Jiafei Lu, Dexing Yang, Chen He, Ting Li, Kai Fu, Rong Liu
OBJECTIVE: To explore the effect of a stratified dose of norepinephrine (NE) on cellular immune response in patients with septic shock, and to construct a prognostic model of septic shock. METHODS: A total of 160 patients with septic shock (B group) and 58 patients with sepsis (A group) were given standard cluster therapy. Patients with septic shock were divided into four groups (B1-B4 groups: 0.01-0.2, 0.2-0.5, 0.5-1.0, and > 1 μg/kg/min) according to the quartile method of the early (72 h) time-weighted average dose of NE and clinical application...
March 14, 2024: Shock
https://read.qxmd.com/read/38516242/metadherin-promotes-stem-cell-phenotypes-and-correlated-with-immune-infiltration-in-hepatocellular-carcinoma
#10
JOURNAL ARTICLE
Yi-Ying Wang, Mei-Mei Shen, Jian Gao
BACKGROUND: Metadherin ( MTDH ) is a key oncogene in most cancer types, including hepatocellular carcinoma (HCC). Notably, MTDH does not affect the stemness pheno-type or immune infiltration of HCC. AIM: To explore the role of MTDH on stemness and immune infiltration in HCC . METHODS: MTDH expression in HCC tissues was detected using TCGA and GEO databases. Immunohistochemistry was used to analyze the tissue samples. MTDH was stably knocked down or overexpressed by lentiviral transfection in the two HCC cell lines...
February 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38514370/pathways-and-mechanisms-of-cd4-cd8%C3%AE-%C3%AE-intraepithelial-t-cell-development
#11
REVIEW
Can Li, Dominic Lanasa, Jung-Hyun Park
The mammalian small intestine epithelium harbors a peculiar population of CD4+ CD8αα+ T cells that are derived from mature CD4+ T cells through reprogramming of lineage-specific transcription factors. CD4+ CD8αα+ T cells occupy a unique niche in T cell biology because they exhibit mixed phenotypes and functional characteristics of both CD4+ helper and CD8+ cytotoxic T cells. The molecular pathways driving their generation are not fully mapped. However, recent studies demonstrate the unique role of the commensal gut microbiota as well as distinct cytokine and chemokine requirements in the differentiation and survival of these cells...
March 20, 2024: Trends in Immunology
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#12
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38511768/serum-autophagy-related-gene-5-level-in-stroke-patients-correlation-with-cd4-t-cells-and-cognition-impairment-during-a-3-year-follow-up
#13
JOURNAL ARTICLE
Juanjuan Qu, Linxia Wu, Meng Zhang, Minchen Kan, Huimin Chen, Yanqing Shi, Shuangyu Wang, Xiaohua Wang, Fan Chen
Autophagy-related gene (ATG) 5 regulates blood lipids, chronic inflammation, CD4+ T-cell differentiation, and neuronal death and is involved in post-stroke cognitive impairment. This study aimed to explore the correlation of serum ATG5 with CD4+ T cells and cognition impairment in stroke patients. Peripheral blood was collected from 180 stroke patients for serum ATG5 and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cell detection via enzyme-linked immunosorbent assays and flow cytometry. The Mini-Mental State Examination (MMSE) scale was completed at enrollment, year (Y)1, Y2, and Y3 in stroke patients...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38507609/lack-of-atp2b1-in-cd4-t-cells-causes-colitis
#14
JOURNAL ARTICLE
Amarsanaa Javkhlant, Kensuke Toyama, Yasunori Abe, Joshua M Spin, Masaki Mogi
BACKGROUND: The ATP2B1 gene encodes for a calcium pump, which plays a role in removing Ca2+ from cells and maintaining intracellular Ca2+ homeostasis. Reduction of the intracellular Ca2+ concentration in CD4+ T cells is thought to reduce the severity of colitis, while elevation of Ca2+ in CD4+ T cells induces T cell hyperactivity. Our aim was to clarify the role of ATP2B1 in CD4+ T cells and in inflammatory bowel disease development. METHODS: A murine CD4+ T cell-specific knockout (KO) of ATP2B1 was created using a Cre-loxP system...
March 20, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38504977/t-cell-specific-deletion-of-casitas-b-lineage-lymphoma-b-reduces-atherosclerosis-but-increases-plaque-t-cell-infiltration-and-systemic-t-cell-activation
#15
JOURNAL ARTICLE
Winnie G Vos, Bram W van Os, Myrthe den Toom, Linda Beckers, Cindy P A A van Roomen, Claudia M van Tiel, Bhopal C Mohapatra, Hamid Band, Katrin Nitz, Christian Weber, Dorothee Atzler, Menno P J de Winther, Laura A Bosmans, Esther Lutgens, Tom T P Seijkens
INTRODUCTION: Atherosclerosis is a lipid-driven inflammatory disease of the arterial wall, and the underlying cause of the majority of cardiovascular diseases. Recent advances in high-parametric immunophenotyping of immune cells indicate that T cells constitute the major leukocyte population in the atherosclerotic plaque. The E3 ubiquitin ligase Casitas B-lymphoma proto-oncogene-B (CBL-B) is a critical intracellular regulator that sets the threshold for T cell activation, making CBL-B a potential therapeutic target to modulate inflammation in atherosclerosis...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38503017/interleukin-2-anti-interleukin-2-complex-attenuates-inflammation-in-a-mouse-copd-model-by-expanding-cd4-cd25-foxp3-regulatory-t-cells
#16
JOURNAL ARTICLE
Ruirui Duan, Ke Huang, Tao Yu, Chenli Chang, Xu Chu, Yuhang Huang, Zhoude Zheng, Linxi Ma, Baicun Li, Ting Yang
BACKGROUND AND PURPOSE: Chronic, nonspecific inflammation of the alveoli and airways is an important pathological feature of chronic obstructive pulmonary disease (COPD), while sustained inflammatory reactions can cause alveolar damage. Regulatory T cells (Tregs) inhibit inflammation, whereas the interleukin-2/anti-interleukin-2 complex (IL-2C) increases the number of Tregs; however, whether the IL-2C has a therapeutic role in COPD remains unknown. Therefore, this study investigated whether IL-2C alleviates lung inflammation in COPD by increasing the number of Tregs...
March 18, 2024: International Immunopharmacology
https://read.qxmd.com/read/38501859/id1-expression-in-cd4-t-cells-promotes-differentiation-and-function-of-follicular-helper-t-cells-and-upregulation-of-related-functional-molecules
#17
JOURNAL ARTICLE
Chen Liu, Xingyue Zeng, Ziqi Xiong, Ayibaota Bahabayi, Ainizati Hasimu, Tianci Liu, Mohan Zheng, Liwei Ren, Xiayidan Alimu, Songsong Lu
Although the roles of E proteins and inhibitors of DNA-binding (Id) in T follicular helper (TFH) and T follicular regulatory (TFR) cells have been previously reported, direct models demonstrating the impact of multiple E protein members have been lacking. To suppress all E proteins including E2A, HEB and E2-2, we overexpressed Id1 in CD4 cells using a CD4-Id1 mouse model, to observe any changes in TFH and TFR cell differentiation. Our objective was to gain better understanding of the roles that E proteins and Id molecules play in the differentiation of TFH and TFR cells...
March 19, 2024: Immunology
https://read.qxmd.com/read/38501302/single-cell-transcriptomic-and-t-cell-antigen-receptor-analysis-of-human-cytomegalovirus-hcmv-specific-memory-t-cells-reveals-effectors-and-pre-effectors-of-cd8-and-cd4-cytotoxic-t-cells
#18
JOURNAL ARTICLE
Raunak Kar, Somdeb Chattopadhyay, Anjali Sharma, Kirti Sharma, Shreya Sinha, Gopalakrishnan Aneeshkumar Arimbasseri, Veena S Patil
Latent human cytomegalovirus (hCMV) infection can pose a serious threat of reactivation and disease occurrence in immune-compromised individuals. Although T cells are at the core of the protective immune response to hCMV infection, a detailed characterization of different T cell subsets involved in hCMV immunity is lacking. Here, in an unbiased manner, we characterized over 8000 hCMV-reactive peripheral memory T cells isolated from seropositive human donors, at a single-cell resolution by analysing their single-cell transcriptomes paired with the T cell antigen receptor (TCR) repertoires...
March 19, 2024: Immunology
https://read.qxmd.com/read/38501063/cd39-expression-defines-exhausted-cd4-t%C3%A2-cells-associated%C3%A2-with-poor-survival-and-immune-evasion-in-human-gastric-cancer
#19
JOURNAL ARTICLE
Zhen-Quan Duan, Yu-Xian Li, Yuan Qiu, Yang Shen, Ying Wang, Yuan-Yuan Zhang, Bao-Hang Zhu, Xiao-Hong Yu, Xue-Ling Tan, Weisan Chen, Yuan Zhuang, Ping Cheng, Wei-Jun Zhang, Quan-Ming Zou, Dai-Yuan Ma, Liu-Sheng Peng
OBJECTIVES: CD4+ T cell helper and regulatory function in human cancers has been well characterised. However, the definition of tumor-infiltrating CD4+ T cell exhaustion and how it contributes to the immune response and disease progression in human gastric cancer (GC) remain largely unknown. METHODS: A total of 128 GC patients were enrolled in the study. The expression of CD39 and PD-1 on CD4+ T cells in the different samples was analysed by flow cytometry...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38496604/exposure-to-live-saprophytic-leptospira-before-challenge-with-a-pathogenic-serovar-prevents-severe-leptospirosis-and-promotes-kidney-homeostasis
#20
Suman Kundu, Advait Shetty, Maria Gomes-Solecki
UNLABELLED: Previous studies demonstrated that Leptospira biflexa , a saprophytic species, triggers innate immune responses in the host during early infection. This raised the question of whether these responses could suppress a subsequent challenge with pathogenic Leptospira . We inoculated male C3H/HeJ mice with a single or a double dose of L. biflexa before challenge with a pathogenic serovar, L. interrogans ser. Copenhageni FioCruz (LIC). Pre-challenge exposure to L. biflexa did not prevent LIC dissemination and colonization of the kidney...
March 4, 2024: bioRxiv
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