Madison S Strine, Eric Fagerberg, Patrick W Darcy, Gabriel M Barrón, Renata B Filler, Mia Madel Alfajaro, Nicole D'Angelo-Gavrish, Fang Wang, Vincent R Graziano, Bridget L Menasché, Martina Damo, Ya-Ting Wang, Michael R Howitt, Sanghyun Lee, Nikhil S Joshi, Daniel Mucida, Craig B Wilen
The persistent murine norovirus strain MNVCR6 is a model for human norovirus and enteric viral persistence. MNVCR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNVCR6 induces functional MNV-specific CD8+ T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell interactions with CD8+ T cells by adoptively transferring JEDI (just EGFP death inducing) CD8+ T cells into Gfi1b-GFP tuft cell reporter mice...
March 22, 2024: Science Immunology