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REVIEW
Indu Sharma, Poonam Kataria, Jyoti Das
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum (P. falciparum) infection, with complex pathogenesis involving multiple factors, including the host's immunological response. T lymphocytes, specifically CD4+ T helper cells and CD8+ cytotoxic T cells, are crucial in controlling parasite growth and activating cells for parasite clearance via cytokine secretion. Contrary to this, reports also suggest the pathogenic nature of T lymphocytes as they are often involved in disease progression and severity...
April 15, 2024: International Reviews of Immunology
#2
JOURNAL ARTICLE
Raymond J So, Samuel L Collins, Yee Chan-Li, Ioan Lina, Alexander Gelbard, Kevin M Motz, Alexander T Hillel
OBJECTIVE: To present a comprehensive flow cytometry panel for idiopathic subglottic stenosis (iSGS). STUDY DESIGN: Controlled ex vivo cohort study. SETTING: Tertiary care academic hospital in a metropolitan area. METHODS: Flow cytometry and single-cell RNA sequencing were performed on 9 paired normal and scar tissue samples from iSGS patients. Flow cytometry was used to assess the presence of myeloid (CD11b, CD14, CD15, Siglec8), lymphoid (CD3, CD4, CD8, gamma delta [γδ], FOXP3), endothelial (CD31), fibroblast (CD90, SMA), and epithelial (CD326, CK5) markers...
April 12, 2024: Otolaryngology—Head and Neck Surgery
#3
JOURNAL ARTICLE
Cristiana Rodrigues, Paula Laranjeira, Aryane Pinho, Isabel Silva, Sandra Silva, Margarida Coucelo, Ana Catarina Oliveira, Ana Teresa Simões, Inês Damásio, Helena Matos Silva, Mafalda Urbano, Ana Bela Sarmento-Ribeiro, Catarina Geraldes, M Rosário Domingues, Julia Almeida, Ignacio Criado, Alberto Orfao, Artur Paiva
INTRODUCTION: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. METHODS: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease...
2024: Frontiers in Oncology
#4
JOURNAL ARTICLE
Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?
Magdalini Ioannou, Maria S Simon, Jenny Borkent, Annemarie Wijkhuijs, Raf Berghmans, Bartholomeus C M Haarman, Hemmo A Drexhage
The aim of this study was to elucidate the nature of T cell abnormalities in bipolar disorder (BD). With the use of multicolor flow cytometry, we first quantified the composition of the different memory and pro-inflammatory immune subpopulations in samples of 58 patients with BD and compared them to 113 healthy controls. Second, to assess if cytomegalovirus infection was related to the resulted immune subpopulation compositions in the two groups, we measured cytomegalovirus-specific antibodies in serum. Thirdly, we assessed differences between the two groups in the serum levels of the immune cell differentiation factor interleukin-7...
July 2024: Brain, behavior, & immunity health
#5
JOURNAL ARTICLE
Dongjiao Wang, Fei Zou, Yu Li, Jinqiu Hu, Ling Gao
The balance between T helper 1 (Th1) and T helper 2 (Th2) has a critical function in determining intratumoral immune response and anti-PD-1 immunotherapy. The level of maternal embryonic leucine zipper kinase (MELK) is reported to correlate with infiltration of immune cells in cancers, but the underlying molecular mechanism is not clarified. In the present study, we aimed to elucidate the potential function of MELK in cervical cancer. We found that MELK was upregulated and played an oncogenic role in cervical cancer...
March 21, 2024: Mol Ther Oncol
#6
JOURNAL ARTICLE
Hatim M Jaber, Saja Ebdah, Sameer A Al Haj Mahmoud, Luay Abu-Qatouseh, Yazan H Jaber
Various COVID-19 vaccines can affect the immune system. Discrepancies have been noted in immune system characteristics, such as T-lymphocyte levels, between vaccinated and non-vaccinated individuals. This study investigates the variations in immune responses among the four administered COVID-19 vaccines, influencing factors, and clinical outcomes in Jordan. A total of 350 adults, who were at least two doses vaccinated, were interviewed and blood samples were collected for subsequent laboratory analyses. The study involved the quantification of T-cells specifically targeting anti-SARS CoV-2 using Flow cytometry analysis...
December 31, 2024: Human Vaccines & Immunotherapeutics
#7
JOURNAL ARTICLE
Neslihan Kaya Terzi
INTRODUCTION: Primary cutaneous lymphomas, notably mycosis fungoides (MF), present diagnostic challenges in recognizing early mycosis fungoides (eMF) due to their diverse clinical and histopathologic manifestations. The aim of our study was to use adjunctive histopathologic and immunohistochemical methods in eMF cases to make an early diagnosis and to facilitate differentiation from other dermatoses. METHODS: This retrospective study analyzed 35 cases of eMF diagnosed at a single center...
April 2024: Curēus
#8
REVIEW
Adane Adugna, Yalew Muche, Mohammed Jemal, Samuel Derbie Habtegiorgis, Habtamu Belew, Gashaw Azanaw Amare
Lung cancer (LC) is the most common cause of cancer-related death worldwide and poses a severe threat to public health. Immunotherapy with checkpoint blockers has improved the outlook for advanced non-small cell lung cancer (NSCLC) therapy. For the treatment of patients with advanced NSCLC, antibodies such as anti-programmed death 1 (anti-PD1), anti-programmed death ligand 1 (anti-PD-L1), and anti-cytotoxic T lymphocyte-associated antigen 4 (anti-CTLA-4) are of paramount importance. Anti-PD-1 and anti-PD-L1 monoclonal antibody therapies are used to block the PD-1/PD-L1 pathway and identify cancerous cells to the body's defenses...
February 2024: Aging medicine
#9
JOURNAL ARTICLE
Jannatul Ruhan Raha, Ki-Hye Kim, Noopur Bhatnagar, Rong Liu, Chau Thuy Tien Le, Bo Ryoung Park, Phillip Grovenstein, Surya Sekhar Pal, Eun-Ju Ko, Chong Hyun Shin, Bao-Zhong Wang, Sang-Moo Kang
The conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in aged mice...
March 30, 2024: Antiviral Research
#10
JOURNAL ARTICLE
Kristin Happ Molitoris, Abhinav Reddy Balu, Mingjian Huang, Gurpreet Singh Baht
Inflammation is thought to be dysregulated with age leading to impaired bone fracture healing. However, broad analyses of inflammatory processes during homeostatic bone aging and during repair are lacking. Here, we assessed changes in inflammatory cell and cytokine profiles in circulation and in bone tissue to identify age- and sex-dependent differences during homeostasis and repair. During homeostatic aging, male mice demonstrated accumulation of CD4+ helper T cells and CD8+ cytotoxic T cells within bone while both pro-inflammatory "M1" and anti-inflammatory "M2" macrophage numbers decreased...
May 2024: JBMR Plus
#11
JOURNAL ARTICLE
Xinrui Mao, Xinyu Tang, Hong Pan, Muxin Yu, Sihan Ji, Wen Qiu, Nan Che, Kai Zhang, Zhendong Huang, Yunshan Jiang, Ji Wang, Zhaoyun Zhong, Jiaming Wang, Mingduo Liu, Mingkang Chen, Wenbin Zhou, Shui Wang
Metastasis is the major cause of cancer-related death, and lymph node is the most common site of metastasis in breast cancer. However, the alterations that happen in tumor-draining lymph nodes (TDLNs) to form a premetastatic microenvironment are largely unknown. Here, we first report the dynamic changes in size and immune status of TDLNs before metastasis in breast cancer. With the progression of tumor, the TDLN is first enlarged and immune-activated at early stage that contains specific antitumor immunity against metastasis...
2024: Research: a science partner journal
#12
JOURNAL ARTICLE
Antoine Guérin, Marcela Moncada-Vélez, Katherine Jackson, Masato Ogishi, Jérémie Rosain, Mathieu Mancini, David Langlais, Andrea Nunez, Samantha Webster, Jesse Goyette, Taushif Khan, Nico Marr, Danielle T Avery, Geetha Rao, Tim Waterboer, Birgitta Michels, Esmeralda Neves, Cátia Iracema Morais, Jonathan London, Stéphanie Mestrallet, Pierre Quartier Dit Maire, Bénédicte Neven, Franck Rapaport, Yoann Seeleuthner, Atar Lev, Amos J Simon, Jorge Montoya, Ortal Barel, Julio Gómez-Rodríguez, Julio C Orrego, Anne-Sophie L'Honneur, Camille Soudée, Jessica Rojas, Alejandra C Velez, Irini Sereti, Benjamin Terrier, Nancy Marin, Luis F García, Laurent Abel, Stéphanie Boisson-Dupuis, Joel Reis, Antonio Marinho, Andrea Lisco, Emilia Faria, Christopher C Goodnow, Julia Vasconcelos, Vivien Béziat, Cindy S Ma, Raz Somech, Jean-Laurent Casanova, Jacinta Bustamante, Jose Luis Franco, Stuart G Tangye
CD4+ T cells are vital for host defense and immune regulation. However, the fundamental role of CD4 itself remains enigmatic. We report seven patients aged 5-61 years from five families of four ancestries with autosomal recessive CD4 deficiency and a range of infections, including recalcitrant warts and Whipple's disease. All patients are homozygous for rare deleterious CD4 variants impacting expression of the canonical CD4 isoform. A shorter expressed isoform that interacts with LCK, but not HLA class II, is affected by only one variant...
May 6, 2024: Journal of Experimental Medicine
#13
JOURNAL ARTICLE
Daphne M Hullegie-Peelen, Dennis A Hesselink, Marjolein Dieterich, Robert C Minnee, Annemiek Peeters, Martin J Hoogduijn, Carla C Baan
BACKGROUND: Machine perfusion is the preferred preservation method for deceased donor kidneys. Perfusate fluid, which contains a complex mixture of components, offers potential insight into the organ's viability and function. This study explored immune cell release, particularly tissue-resident lymphocytes (TRLs), during donor kidney machine perfusion and its correlation with injury markers. METHODS: Perfusate samples from hypothermic machine perfusion (HMP; n = 26) and normothermic machine perfusion (NMP; n = 16) of human donor kidneys were analyzed for TRLs using flow cytometry...
April 1, 2024: Transplantation
#14
JOURNAL ARTICLE
Karsten Eichholz, Yoshinori Fukazawa, Christopher W Peterson, Francoise Haeseleer, Manuel Medina, Shelby Hoffmeister, Derick M Duell, Benjamin D Varco-Merth, Sandra Dross, Haesun Park, Caralyn S Labriola, Michael K Axthelm, Robert D Murnane, Jeremy V Smedley, Lei Jin, Jiaxin Gong, Blake J Rust, Deborah H Fuller, Hans-Peter Kiem, Louis J Picker, Afam A Okoye, Lawrence Corey
Programmed cell death protein 1 (PD-1) is an immune checkpoint marker commonly expressed on memory T cells and enriched in latently HIV-infected CD4+ T cells. We engineered an anti-PD-1 chimeric antigen receptor (CAR) to assess the impact of PD-1 depletion on viral reservoirs and rebound dynamics in SIVmac239-infected rhesus macaques (RMs). Adoptive transfer of anti-PD-1 CAR T cells was done in 2 SIV-naive and 4 SIV-infected RMs on antiretroviral therapy (ART). In 3 of 6 RMs, anti-PD-1 CAR T cells expanded and persisted for up to 100 days concomitant with the depletion of PD-1+ memory T cells in blood and tissues, including lymph node CD4+ follicular helper T (TFH) cells...
April 1, 2024: Journal of Clinical Investigation
#15
JOURNAL ARTICLE
Gelan Zhu, Wenjing Lang, Wanbin Fu, Lan Xu, Jiayi Cai, Hua Zhong
Acute myeloid leukemia (AML) presents as a remarkably heterogeneous disease, and the intricate role of various T cell subtypes, including T helper (Th) cells and regulatory T (Treg) cells, in immune dysregulation and the promotion of leukemia cell proliferation and survival is not yet fully understood. In this study, we conducted a comparative analysis of transcriptome profiles in T cells derived from bone marrow samples of three leukemia patients, both before and after treatment, as well as from a relapse sample...
March 30, 2024: International Immunopharmacology
#16
REVIEW
Chou-Yi Hsu, Mohammed Ahmed Mustafa, Ashwani Kumar, Atreyi Pramanik, Rajiv Sharma, Faraj Mohammed, Israa Abed Jawad, Imad Jasim Mohammed, Mohammad Y Alshahrani, Noor Alhuda Mohammad Ali Khalil, Ali Turki Shnishil, Munther Kadhim Abosaoda
Hepatic tumors present a formidable challenge in cancer therapeutics, necessitating the exploration of novel treatment strategies. In recent years, targeting the immune system has attracted interest to augment existing therapeutic efficacy. The immune system in hepatic tumors includes numerous cells with diverse actions. CD8+ T lymphocytes, T helper 1 (Th1) CD4+ T lymphocytes, alternative M1 macrophages, and natural killer (NK) cells provide the antitumor immunity. However, Foxp3+ regulatory CD4+ T cells (Tregs), M2-like tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) are the key immune inhibitor cells...
March 19, 2024: Pathology, Research and Practice
#17
JOURNAL ARTICLE
Theodoros-Ioannis Papadimitriou, Jacqueline M J Lemmers, Arjan P M van Caam, Jacqueline Vos, Elly Vitters, Lizan Stinessen, Sander I van Leuven, Marije Koenders, Peter M van der Kraan, Hans J P M Koenen, Ruben Smeets, Robin Nijveldt, Madelon C Vonk, R M Thurlings
OBJECTIVES: Systemic sclerosis (SSc) is characterized by multiple clinical manifestations. Vasculopathy is a main disease hallmark and ranges in severity from an exacerbated Raynaud phenomenon to pulmonary arterial hypertension (PAH). The potential involvement of immune system in SSc associated vascular abnormalities is not clear. Here, we set out to study SSc-related immune parameters and determine whether and which peripheral T cell subsets associate with vascular severity in SSc patients...
March 29, 2024: Rheumatology
#18
JOURNAL ARTICLE
Tianye Li, Weijiang Zhang, Mengke Niu, Yuze Wu, Xinyue Deng, Jianwei Zhou
BACKGROUND: Cervical cancer poses a significant global threat to women's health. However, current therapeutic interventions, such as radiotherapy, chemotherapy, surgical resection, and immune checkpoint inhibitors, face limitations in the advanced stages of the disease. Given the immunosuppressive microenvironment in cervical cancer, it is imperative to explore novel perspectives. In this regard, STING agonists have emerged as promising candidates. METHODS: The expression profiles and clinicopathological data were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets...
2024: Frontiers in Immunology
#19
JOURNAL ARTICLE
Yevgeniya Gartshteyn, Laura Geraldino-Pardilla, Leila Khalili, Shoiab Bukhari, Shalom Lerrer, Robert J Winchester, Anca D Askanase, Adam Mor
INTRODUCTION: T follicular (TFH) and peripheral helper (TPH) cells have been increasingly recognized as a pathogenic subset of CD4 T cells in systemic lupus erythematosus (SLE). The SLAM Associated Protein (SAP) regulates TFH and TPH function by binding to the co-stimulatory signaling lymphocyte activation molecule family (SLAMF) receptors that mediate T cell - B cell interactions. SAP and SLAMF are critical for TPH-dependent B cell maturation into autoantibody-producing plasma cells that characterize SLE pathogenesis...
2024: Frontiers in Immunology
#20
JOURNAL ARTICLE
Jaisheela Vimali, Yean K Yong, Amudhan Murugesan, Hong Y Tan, Ying Zhang, Rajeev Ashwin, Sivadoss Raju, Pachamuthu Balakrishnan, Marie Larsson, Vijayakumar Velu, Esaki M Shankar
BACKGROUND: Chronic viral infection results in impaired immune responses rendering viral persistence. Here, we compared the quality of T-cell responses among chronic hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-infected individuals by examining the levels of expression of selected immune activation and exhaustion molecules on circulating MAIT cells and Tfh cells. METHODS: Cytokines were measured using a commercial Bio-plex Pro Human Cytokine Grp I Panel 17-plex kit (BioRad, Hercules, CA, USA)...
March 22, 2024: Frontiers in Bioscience (Landmark Edition)
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