Peng Dong, Yu Yan, Yujun Fan, Hui Wang, Danzhu Wu, Liyuan Yang, Junpeng Zhang, Xiaoyang Yin, Yajuan Lv, Jiandong Zhang, Yuzhu Hou, Fengjun Liu, Xinshuang Yu
Pancreatic cancer has the highest mortality rate of all major cancers, with a 5-year survival rate of about 10%. Early warning signs and symptoms of pancreatic cancer are vague or nonexistent, and most patients are diagnosed in Stage IV, when surgery is not an option for about 80%-85% of patients. For patients with inoperable pancreatic cancer, current conventional treatment modalities such as chemotherapy and radiotherapy (RT) have suboptimal efficacy. Tumor progression is closely associated with the tumor microenvironment, which includes peripheral blood vessels, bone marrow-derived inflammatory cells, fibroblasts, immune cells, signaling molecules, and extracellular matrix...
2022: Technology in Cancer Research & Treatment