keyword
https://read.qxmd.com/read/38426378/surgical-resection-of-adrenal-metastasis-from-colorectal-cancers-a-systematic-review
#21
REVIEW
Thi Ai Van Terresa Nguyen, Sze Ling Wong, Zi Qin Ng
BACKGROUND: The decision for resection of adrenal metastasis from colorectal cancers remain controversial and there is no proposed standard treatment. The aim of the article is to review the available literature on outcomes and complications rates following adrenalectomy for adrenal metastasis from colorectal cancer. METHODS: Relevant papers were identified through electronic databases. Data was extracted independently by two authors on a Microsoft Excel spreadsheet up to June 2023...
March 1, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38415268/adrenocortical-carcinoma-with-a-renal-vein-thrombus-extending-to-the-inferior-vena-cava-successfully-resected-with-the-left-kidney-and-distal-pancreatectomy-a-case-report
#22
Takashi Miyata, Yuta Sannomiya, Taigo Nagayama, Ryosuke Kin, Hisashi Nishiki, Akifumi Hashimoto, Daisuke Kaida, Hideto Fujita, Nobuhiko Ueda, Hiroyuki Takamura
INTRODUCTION: Adrenocortical carcinoma (ACC) is an extremely rare and aggressive tumor, and its clinical characteristics are poorly defined because of its rarity. CASE PRESENTATION: We report a 64-year-old man who presented with upper abdominal pain and weight loss. Computed tomography revealed a 15 cm left adrenal tumor compressing the pancreas ventrally and a tumor thrombus in the inferior vena cava (IVC) originating from the left renal vein. Positron emission tomography-computed tomography revealed 18 F-fluorodeoxyglucose uptake only in the tumor and tumor thrombus, and radical surgery was planned...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38411694/validation-of-the-modified-ct-criteria-for-identifying-non-adenomas
#23
JOURNAL ARTICLE
Min Hwan Kwak, Ji-Sup Yun, Ji Na Kim, Young Rae Lee, Chan Kyo Kim, Kyung A Kang
PURPOSE: Although adrenal computed tomography (CT) percentage washout is a potentially powerful imaging technique for differentiating adrenal adenomas from non-adenomas, its application to non-adenomas can be problematic. Recently, modified criteria for diagnosing pheochromocytomas using adrenal CT were developed based on data from 199 patients with surgically proven pheochromocytomas and adenomas. However, these criteria have not been thoroughly validated. The purpose of this study was to validate the performance of the modified criteria for diagnosing non-adenomas including pheochromocytomas...
February 27, 2024: Abdominal Radiology
https://read.qxmd.com/read/38407266/molecular-classification-and-tumor-microenvironment-characteristics-in-pheochromocytomas
#24
JOURNAL ARTICLE
Sen Qin, Yawei Xu, Shimiao Yu, Wencong Han, Shiheng Fan, Wenxiang Ai, Kenan Zhang, Yizhou Wang, Xuehong Zhou, Qi Shen, Kan Gong, Luyang Sun, Zheng Zhang
Pheochromocytomas (PCCs) are rare neuroendocrine tumors that originate from chromaffin cells in the adrenal gland. However, the cellular molecular characteristics and immune microenvironment of PCCs are incompletely understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on 16 tissues from 4 sporadic unclassified PCC patients and 1 hereditary PCC patient with Von Hippel-Lindau (VHL) syndrome. We found that intra-tumoral heterogeneity was less extensive than the inter-individual heterogeneity of PCCs...
February 26, 2024: ELife
https://read.qxmd.com/read/38398154/adrenalectomy-for-metastasis-the-impact-of-primary-histology-on-survival-outcome
#25
JOURNAL ARTICLE
Mariaconsiglia Ferriero, Andrea Iannuzzi, Alfredo Maria Bove, Gabriele Tuderti, Umberto Anceschi, Leonardo Misuraca, Aldo Brassetti, Riccardo Mastroianni, Salvatore Guaglianone, Costantino Leonardo, Rocco Papalia, Michele Gallucci, Giuseppe Simone
Adrenalectomy is commonly considered a curative treatment in case of adrenal gland as site of metastasis. In the present study, we evaluated the impact of primary tumor histology on survival outcomes after a minimally invasive adrenal mastectomy for a solitary metachronous metastasis. From May 2004 to August 2020, we prospectively collected data on minimally invasive adrenalectomies whose pathological examination showed a metastasis. All patients only received metastasectomies that were performed with curative intent, or to achieve non-evidence of disease status...
February 13, 2024: Cancers
https://read.qxmd.com/read/38371957/deep-learning-vs-robust-federal-learning-for-distinguishing-adrenal-metastases-from-benign-lesions-with-multi-phase-ct-images
#26
JOURNAL ARTICLE
Bao Feng, Changyi Ma, Yu Liu, Qinghui Hu, Yan Lei, Meiqi Wan, Fan Lin, Jin Cui, Wansheng Long, Enming Cui
BACKGROUND: Differentiating adrenal adenomas from metastases poses a significant challenge, particularly in patients with a history of extra-adrenal malignancy. This study investigates the performance of three-phase computed tomography (CT) based robust federal learning algorithm and traditional deep learning for distinguishing metastases from benign adrenal lesions. MATERIAL AND METHODS: This retrospective analysis includes 1187 instances who underwent three-phase CT scans between January 2008 and March 2021, comprising 720 benign lesions and 467 metastases...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38347972/bilateral-adrenal-hemorrhage-heralds-bronchogenic-carcinoma
#27
Faysal Azani, Abdur Rehman Alozai, Jimmy William, Jayant Sharma
This case study delves into the unusual presentation of non-small cell lung carcinoma (NSCLC), where bilateral hemorrhagic adrenal metastasis served as the primary indication of an underlying malignancy. Our patient, a 58-year-old male, sought medical attention due to acute abdominal pain and lower back discomfort, leading to an in-depth diagnostic exploration. Radiological examinations revealed bilateral adrenal masses exhibiting hemorrhagic characteristics, a distinctive feature not commonly associated with NSCLC...
January 2024: Curēus
https://read.qxmd.com/read/38342223/surgery-for-adrenal-metastasis-surgical-outcomes-and-prognostic-factors-for-long-term-survival
#28
JOURNAL ARTICLE
César Mínguez Ojeda, Victoria Gómez Dos Santos, Javier Ÿlvaro Lorca, Ignacio Ruz-Caracuel, Héctor Pian, Alfonso Sanjuanbenito Dehesa, Elvira Gutiérrez Gutiérrez, Juan Luis Sanz Miguelañez, Bernabé Pozo Mengual, Francisco Javier Burgos Revilla, Marta Araujo-Castro
PURPOSE: To analyze surgical outcomes and predictive factors for long-term overall and disease-specific survival in patients undergoing surgical resection of adrenal metastasis. METHODS: A multicenter retrospective study included patients who underwent adrenalectomy for adrenal metastasis in two Spanish hospitals between 2005 and 2021. Clinical variables associated with surgical complications and survival during follow-up were analyzed. RESULTS: Thirty-three patients were included...
February 9, 2024: Annales D'endocrinologie
https://read.qxmd.com/read/38339971/c9orf10-ossa-regulates-the-bone-metastasis-of-established-lung-adenocarcinoma-cell-subline-h322l-bo4-in-a-mouse-model
#29
JOURNAL ARTICLE
Takamasa Uekita, Reiko Yagi, Tohru Ichimura, Ryuichi Sakai
Lung cancer frequently metastasizes to the bones. An in vivo model is urgently required to identify potential therapeutic targets for the prevention and treatment of lung cancer with bone metastasis. We established a lung adenocarcinoma cell subline (H322L-BO4) that specifically showed metastasis to the leg bones and adrenal glands. This was achieved by repeated isolation of metastatic cells from the leg bones of mice. The cells were intracardially injected into nude mice. Survival was prolonged for mice that received H322L-BO4 cells versus original cells (H322L)...
February 10, 2024: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/38327598/multi-disciplinary-surgery-for-simultaneous-resection-of-multiple-tumors-in-a-patient-with-newly-diagnosed-metastatic-pheochromocytoma-paraganglioma
#30
Jibo Jing, Lingfeng Meng, Yaoguang Zhang, Runhua Tang, Haoran Wang, Jiaxing Ning, Xinhao Wang
Metastatic pheochromocytoma/paraganglioma (MPP) is a rare endocrine tumor that originates from extra-adrenal chromaffin cells such as the paraganglia cells of sympathetic and parasympathetic nerves. It usually causes multiple solid tumors and exhibits strong aggressiveness with poor prognosis, with a reported 5-year survival rate of less than 50%. Cases of brain and retroperitoneal metastases at the initial diagnosis have not yet been reported. We report a 41-year-old male patient initially diagnosed with MPP in the brain and retroperitoneum who underwent multi-disciplinary collaborative surgery and simultaneous removal of two tumors at our center...
October 2023: Cancer Pathog Ther
https://read.qxmd.com/read/38325317/adrenal-metastasis-of-bilateral-renal-cell-carcinoma-a-case-presentation-12-years-after-diagnosis
#31
JOURNAL ARTICLE
M Karli, B Cakiroglu
This case presentation describes the scenario of a patient diagnosed with renal cell carcinoma (RCC) who remained asymptomatic for an extended follow-up period, only to develop adrenal metastasis. Despite a 12-year surveillance period without any evidence of recurrence or metastasis, subsequent investigations revealed the presence of rectosigmoid colon cancer and adrenal metastasis. This case highlights the insidious and aggressive nature of RCC, emphasizing the significance of early detection and regular monitoring for metastatic disease...
December 2023: Georgian Medical News
https://read.qxmd.com/read/38322234/pheochromocytoma-in-the-organ-of-zuckerkandl-with-distant-skeletal-metastases-a-case-report
#32
Abdul Rehman Ahmad Akhtar, Zayed Mohiyuddin, Muiz Khan Tareen, Kamran Malik
Pheochromocytomas are rare catecholamine-secreting neuroendocrine tumors that originate from chromaffin cells in the adrenal medulla. They cause severe hypertension and various clinical manifestations. While most arise in the adrenal medulla, some occur in extra-adrenal locations.We present a case report with clinical, laboratory and radiographic data, along with a brief literature review. We report a 33-year-old woman who presented with flushing and sharp lower abdominal pain. Abdominal ultrasound and urinary metanephrines suggested a pheochromocytoma...
April 2024: Radiology Case Reports
https://read.qxmd.com/read/38316662/comparative-outcomes-and-prognostic-indicators-in-adrenalectomy-for-adrenal-metastasis
#33
JOURNAL ARTICLE
JungHak Kwak, Hye Lim Bae, Younghoon Jung, Jaebong Choi, Hyeonuk Hwang, Jung Hee Kim, Su-Jin Kim, Kyu Eun Lee
PURPOSE: The indications for adrenalectomy and feasibility of laparoscopic adrenalectomy for adrenal metastasis are controversial. This study aimed to compare the surgical outcomes between open adrenalectomy (OA) and laparoscopic adrenalectomy (LA) and to evaluate the prognostic factors for oncological outcomes of adrenal metastasis. MATERIALS AND METHODS: We conducted a retrospective chart review of 141 consecutive patients who underwent adrenalectomy for adrenal metastasis at Seoul National University Hospital from April 2005 to February 2021...
February 5, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38313802/case-report-acute-pancreatitis-in-lung-adenocarcinoma-with-small-cell-transformation-after-multiple-line-targeted-therapy
#34
Yaoyao Jing, Xiaoxiao Li, Xiaoyuan Sun, Minghan Ren, Ruoxi Xiao, Jiayu Zhao, Zimin Liu
In lung cancer, metastasis to the liver, bones, brain, and adrenal glands is more commonly observed, whereas pancreatic metastasis from lung cancer is relatively rare. We present a case of a patient with an 8-year history of lung adenocarcinoma (LUAD) who was admitted to our institution exhibiting symptoms consistent with acute pancreatitis. Subsequent histopathological examination through puncture confirmed the occurrence of pancreatic metastasis originating from small cell lung cancer (SCLC). During a multidisciplinary team discussion, we reached a consensus in diagnosing the patient with post-transformation small cell carcinoma alongside moderately severe pancreatitis, which was determined to be a consequence of pancreatic metastasis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38306874/a-rare-case-report-of-ectopic-adrenal-paraganglioma-with-inferior-vena-cava-infiltration-case-report-and-literature-review
#35
Charles John Nhungo, Jabu Abbysinia Mavundla, Geofrey Chiloleti, Gabriel Mtaturu, Charles Mkony, Ali Mwanga
INTRODUCTION AND IMPORTANCE: Phaeochromocytomas are neuroendocrine neoplasms arising from chromaffin cells of the adrenal medulla and are known as intra-adrenal paragangliomas. On the contrary, paragangliomas are non-epithelial neuroendocrine neoplasms that produce other peptide hormones such as norepinephrine, epinephrine, and dopamine. In a setting with limited resources, such a condition may result in inaccurate diagnosis and treatment, which may lose a patient life if left untreated...
January 31, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38303340/-a-case-of-sigmoid-colon-cancer-with-simultaneous-solitary-adrenal-metastasis-refractory-to-preoperative-diagnosis
#36
JOURNAL ARTICLE
Takeshi Saito, Masatsune Shibutani, Tatsunari Fukuoka, Hiroaki Kasashima, Kishu Kitayama, Tatsuro Tamura, Takahiro Toyokawa, Shigeru Ree, Hiroaki Tanaka, Minoru Kato, Yukiyoshi Hirayama, Taisuke Matsue, Kazuki Masuda, Junji Uchida, Kiyoshi Maeda
A 72-year-old man was referred to our urology department due to a giant adrenal tumor detected by computed tomography( CT). Endocrine screening showed that cortisol, renin, aldosterone, adrenaline, and noradrenaline levels were all normal, and there was no evidence of adrenal hyperfunction. The adrenal tumor was so large that we suspected malignancy. Contrast-enhanced CT of the abdomen was performed for qualitative diagnostic purposes, and showed wall thickening of the sigmoid colon extending for approximately 6 cm...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38303328/-brain-metastasis-following-conversion-surgery-for-sigmoid-colon-cancer-a-case-report
#37
JOURNAL ARTICLE
Takashi Takenoya, Shinji Murai, Hiroaki Ando, Fumitaka Nakayama, Yusuke Asada, Ippei Oto, Takahisa Yoshikawa, Tetsuya Nakamura, Nobushige Yabe, Koji Osumi, Noriaki Kameyama
A 64-year-old man was diagnosed with KRAS-mutant type sigmoid colon cancer with metastasis in the lung, liver, left adrenal gland, and para-aortic lymph node(T3N1M1b, Stage ⅣB[Union for International Cancer Control 8th edition]). Laparoscopic transverse colostomy was performed to treat colonic obstruction. Subsequently, a combination regimen of capecitabine plus oxaliplatin plus bevacizumab was administered. After 5 courses of chemotherapy, the S8 liver tumor disappeared completely. Sigmoidectomy, para-aortic lymph node dissection, and left adrenal gland resection were performed...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38303243/-a-case-of-juvenile-afp-producing-gastric-cancer-with-virchow-lymph-node-metastasis-achieved-long-term-survival-with-multimodal-therapy
#38
JOURNAL ARTICLE
Hidetaka A Ono, Hirokazu Suwa, Yuta Minami, Kazunori Nojiri, Kenichi Yoshida, Hidenobu Masui, Kaoru Nagahori
A 25-year-old male received palliative total gastrectomy plus D1 dissection plus Roux-en-Y reconstruction for hemorrhagic gastric cancer with left Virchow lymph node metastasis in 2013. The final diagnosis was Type 2, pT4a(se), pap>tub2 >hepatoid adenocarcinoma, pN3b, sM1, fStage Ⅳ. Because AFP was as high as 11,000 ng/mL, he was diagnosed with AFP-producing gastric cancer and started S-1 plus CDDP therapy. Left adrenal gland metastasis and #106pre, #16b1int lymph node metastasis were observed after 9 courses, and the therapy was changed to irinotecan plus CDDP therapy...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38303214/-a-case-of-advanced-gastric-cancer-with-preoperative-liver-metastasis-and-postoperative-adrenal-metastasis-that-obtained-long-term-recurrence-free-survival-after-resection-and-chemotherapy
#39
JOURNAL ARTICLE
Hiroshi Noro, Toru Sasaki, Yu Takeda, Hideki Sakisaka, Shin Mizutani, Masato Minami
The case was a 70-year-old man of highly advanced gastric cancer with 2 liver metastases(S3, S8)and pancreatic invasion. Three courses of S-1 plus L-OHP(SOX therapy)were performed, and total gastrectomy and combined resection of the spleen and body and tail of the pancreas and partial resection of the liver S3 and S8 were performed after reduction of primary tumor and liver metastasis. S-1 therapy was continued for 1 year as postoperative adjuvant chemotherapy. Left adrenal metastasis was detected by CT, 1 year and 6 months after the operation...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38298769/metastatic-sites-in-rare-genitourinary-malignancies-and-primary-cancer-sites-in-genitourinary-organ-metastases-a-secondary-analysis-using-the-japanese-pathological-autopsy-registry-database
#40
JOURNAL ARTICLE
Suguru Oka, Tomohiko Hara, Shinji Ito, Michikata Hayashida, Kazushige Sakaguchi, Shinji Urakami
BACKGROUND: The epidemiology of metastases from rare genitourinary cancer and metastases to genitourinary organs from other primary neoplasms remains poorly understood. OBJECTIVE: To investigate the epidemiology of rare genitourinary metastases from rare genitourinary organ-type cancer and to genitourinary organs using data from a large national autopsy registry in Japan. DESIGN SETTING AND PARTICIPANTS: A secondary analysis of the data reported in the Annual of the Pathological Autopsy Cases in Japan and the Japanese Mortality Database from 1993 to 2020 was performed...
January 2024: European urology open science
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