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Adrenal metastasis

Charlie Pierre, Mikaël Agopiantz, Laurent Brunaud, Shyue-Fang Battaglia-Hsu, Antoine Max, Celso Pouget, Claire Nomine, Sandra Lomazzi, Jean-Michel Vignaud, Georges Weryha, Abderrahim Oussalah, Guillaume Gauchotte, Hélène Busby-Venner
Current histoprognostic parameters and prognostic scores used in paragangliomas and pheochromocytomas do not adequately predict the risk of metastastic progression and survival. Here, using a series of 147 cases of paraganglioma and pheochromocytoma, we designed and evaluated the potential of a new score, the COPPS (COmposite Pheochromocytoma/paraganglioma Prognostic Score), by taking into consideration three clinico-pathological features (including tumor size, necrosis, and vascular invasion), and the losses of PS100 and SDHB immunostain to predict the risk of metastasis...
March 13, 2019: Virchows Archiv: An International Journal of Pathology
Jiayi Zhao, Yiping Han, Jiamei Li, Rong Chai, Chong Bai
The present study explored the association between KRAS proto-oncogene GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) and tumor protein p53 (TP53) mutations, and the clinical features and survival prognosis in 50 patients with non-small cell lung cancer (NSCLC). The most common concurrent single gene mutation was TP53, followed by KRAS and PIK3CA . Co-existing mutations were found in 17 patients. KRAS, PIK3CA and TP53 mutations were associated with carbohydrate antigen 19-9 expression, invasive growth, vacuolar signs and margin lobulation on chest CT...
March 2019: Oncology Letters
Vincent Amodru, David Taieb, Carole Guerin, Nunzia Cinzia Paladino, Thierry Brue, Frederic Sebag, Frederic Castinetti
INTRODUCTION: The management of large non secreting adrenal tumors (at least 4 cm) is still a matter of debate as it is unclear whether imaging, especially 18F-FDG, can be used to characterize their potential malignancy. Moreover, the risk of new hypersecretion in non-operated tumors is uncertain. Our aim was to better characterize these large adrenal incidentalomas. METHODS: Patients followed in our Center for a non-secreting large (at least 4 cm) adrenal incidentaloma, with an initial CT and 18F-FDG PET CT, were retrospectively included...
March 13, 2019: Endocrine Practice
Ghulam Jilany Khan, Li Sun, Muhammad Abbas, Muhammad Naveed, Talha Jamshaid, Mirza Muhammad Faran Ashraf Baig, Shengtao Yuan
BACKGROUND: Aggressive behavior of tumor metastasis comes from certain mutations, changes in cellular metabolic and signaling pathways that are majorly altered by tumor microenvironment (TME), its other components and growth factors like transforming growth factor-β1 (TGF-β1) which is chiefly known for its epithelial to mesenchymal transformation (EMT). EMT is a critical step of metastasis cascade in actual human lung cancer scenario. OBJECTIVE: Our present study is focused to unveil the in-vivo metastatic behavior of TGF-β1 treated lung cancer cells that undergone EMT...
March 6, 2019: Current Molecular Pharmacology
Eleonora P M Corssmit, Olaf M Dekkers
PURPOSE OF REVIEW: Adrenal tumors are mostly encountered as incidentalomas in patients undergoing imaging not performed for suspected adrenal disease; although the majority are benign and nonfunctioning, malignant tumors and functioning tumors need to be excluded. The purpose of this review is to highlight recent advances in the evaluation of adrenal tumors. RECENT FINDINGS: As a consequence of increased use of technologically improved imaging techniques, the detection of adrenal incidentalomas has continued to increase...
March 5, 2019: Current Opinion in Oncology
Sadiye Altun Tuzcu, Zafer Pekkolay
AIM: The aim of this study was to evaluate a new imaging method 68Ga-DOTATATE PET/CT as an alternative method to diagnose evidence of neuroendocrine tumors or their metastasis (if any) in patient with MEN 2A. METHODS: Three patients( 2F, 1M; age 28,46 and 50 years) with MEN 2A syndrome who underwent 68Ga-DOTATATE PET/CT scan were prospectively evaluated. PET/CT images were analyzed with measurement of maximum standardized uptake value (SUVmax). RESULTS: All patients had adrenal masses with increased uptake of 68Ga-DOTATATE (first case adrenal mass SUVmax: 9,1, second case adrenal mass SUVmax: 32,4(right), 30,3(left) and third case SUVmax:12,4)...
March 4, 2019: Annali Italiani di Chirurgia
Suheil Albert Atallah-Yunes, Jackson Clark, Shazia Samanani, Myat Soe
BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Although pituitary gland metastasis is rare, it is underestimated, as it is commonly misdiagnosed with pituitary gland adenoma due to the lack of clear radiological criteria differentiating between both...
February 17, 2019: American Journal of Case Reports
Tadashi Tsukamoto, Shingo Togano, Eijiro Edagawa, Ryoji Kaizaki, Takaaki Hori, Satoshi Takatsuka
A 68-year-old man presented with generalfatigue due to anemia. Gastrointestinalendoscopy showed a tumor approximately 60mm in diameter in the lesser curvature of the angle of the stomach. Large cell neuroendocrine carcinoma was diagnosed by biopsy of a tumor specimen. Computed tomography revealed bulky regional lymph node metastases, solitary liver metastasis, and left adrenal metastasis. After three courses of combined chemotherapy with S-1 and CDDP, the gastric lesion and lymph node metastases shrunk, but the liver metastasis and left adrenal metastasis enlarged...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kojiro Ono, Takuo Takehana, Kazuhiro Yamamoto, Shunsuke Kawai, Michitaka Nagase
A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Contrast computed tomography(CT)showed upper gastric wall thickening, and #1, #3, #7, #8a, and #11p enlarged lymph nodes but no distant metastasis. We diagnosed gastric cancer, UM, Less, Type 3, gastric neuroendocrine carcinoma, cT4aN3M0P0CY0, Stage ⅢC...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Zhe Wang, Shu-Geng Gao, Qi Xue, Xiao-Tong Guo, Li-Xu Wang, Xin Yu, Yi-Kun Yang, Ju-Wei Mu
Background: Previous studies have demonstrated that survival of patients with non-small cell lung cancer (NSCLC) with oligometastasis may benefit from local treatment. The purpose of this study was to compare the efficacy of local surgical treatment with systematic chemoradiotherapy in NSCLC with oligometastasis. Methods: Data from a total of 172 patients with NSCLC with oligometastasis were collected at our Cancer Hospital from January 2006 to December 2016. The patients were divided into two groups: group A (82 cases) underwent primary surgical treatment and adjuvant chemotherapy was performed after operation, while group B (90 cases) received systematic chemotherapy and local radiotherapy...
December 2018: Journal of Thoracic Disease
Krishnan Ravindran, Brandon M Zsigray, Michael P Wemhoff, John D Spencer, Ewa Borys, Chirag R Patel, Anand V Germanwala
Background: Pituitary metastasis of cervical adenocarcinoma is an exceedingly rare phenomenon. Case Description: The authors present a case of a 66-year-old female with cervical adenocarcinoma who was discovered to have a rapidly growing intrasellar mass in the work-up of adrenal insufficiency and hypothyroidism. The patient underwent subsequent endoscopic endonasal subtotal resection of the mass. Histopathological analysis of the resected lesion demonstrated features consistent with metastatic mucinous adenocarcinoma of the cervix...
2019: Case Reports in Neurological Medicine
Eric Levesque, Patrick Caron, Louis Lacombe, Veronique Turcotte, David Simonyan, Yves Fradet, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Chantal Guillemette
BACKGROUND: In men with localized prostate cancer (PCa) who are undergoing radical prostatectomy (RP), it is uncertain whether their hormonal environment is associated with outcomes. The objective of the study was to examine the association between the steroid metabolome with prognostic factors and progression. PATIENTS AND METHODS: The prospective PROCURE cohort was recruited from 2007-2012, and comprises 1766 patients with localized PCa who provided blood samples prior to RP...
February 7, 2019: Cancer Epidemiology, Biomarkers & Prevention
Ajit Nimmagadda, V S Krishna Mohan, Ranadheer Manthri, Tek Chand Kalawat
Papillary carcinoma thyroid is the most common type of thyroid cancer. Papillary thyroid cancer metastasizes commonly to regional lymph nodes, distant organ involvement is to lungs and bone are rare and is associated with poor prognosis. Metastases to intra-abdominal organs are extremely rare. Here, we report a case of 50-year-old female diagnosed with papillary microcarcinoma thyroid who initially treated total thyroidectomy, later presented with metastasis to liver, bone, left adrenal gland, and bilateral lungs...
January 2019: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Amany Abdulgader Fathaddin, Maria Abdulrahim Arafah
One of the very rare forms of gestational neoplastic diseases is the malignant placental site trophoblastic tumor. Due to its rarity, the data regarding its diagnosis and management are limited. The prognosis of this tumor is unpredictable with potential malignant behavior and metastasis. We report a case of malignant placental site trophoblastic tumor with multiple metastatic deposits in the ovaries, lungs, kidneys, adrenals, and pancreas. The patient was treated by surgery and an extensive subsequent chemotherapy...
January 2019: Indian Journal of Pathology & Microbiology
Reyhaneh Manafi-Farid, Narjess Ayati, Mohammad Eftekhari, Babak Fallahi, Fardad Masoumi
Colorectal carcinoma is one of the most common causes of cancer-related death, worldwide. Recently, due to the introduction of novel imaging and therapeutic techniques, five-year survival of patients has increased. However, distant metastasis is still expected in half of the patients. Colorectal cancer tends to target the abdominal cavity, liver, lungs, and bones as the common sites of metastasis. Nevertheless, rare cases of muscle metastasis have been reported. This report presents a 23-year-old male, who despite chemotherapy, demonstrated gradual progressive disease and metastases to the submandibular region, lungs, adrenal gland as well as muscles and subcutaneous tissues...
2019: Asia Oceania Journal of Nuclear Medicine & Biology
H H Chen, S T Wu, Y C Lin, C S Lin
We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right kidney and a mass over the left suprarenal area, which were further delineated by magnetic resonance imaging. The patient underwent laparoscopic right radical nephrectomy and left adrenalectomy. Histopathological analysis confirmed the diagnoses of clear cell renal cell carcinoma of the right kidney with metastasis to the lung; and atypical pheochromocytoma of the left adrenal gland...
January 2019: Journal of Postgraduate Medicine
Yoshiyuki Nakasone, Akino Uejo, Kiyoshi Iha, Kazufumi Miyagi, Tsuyoshi Tamae, Yasukazu Ikehara, Ryo Ikemura, Toshimitsu Irei, Masaomi Eguchi, Isao Nishijima, Hiroaki Kawamoto, Yuto Tedokon, Motoshi Miyagi, Masafumi Tsuchida
We herein report a case of cecum cancer with synchronous adrenal solitary metastasis. A 62-year-old woman who had been treated for other disease complained of weight loss. Lower endoscopy revealed cecum cancer, and computed tomography( CT)demonstrated a solitary left adrenal tumor; thus, she was diagnosed with a metastatic tumor. We concluded that the patient was a possible candidate for surgical resection because she did not present with local metastasis other than in the adrenal glands. Ileocecal resection and left adrenalectomy were performed...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Jon Griffin, Fawzia Tahir
We present a case of synchronous renal cell carcinoma and urothelial carcinoma. Our case was a true collision tumor and both components were high grade. Metastasis to the adrenal gland by the urothelial carcinoma was observed. The morphologic impression was confirmed with GATA3 expression by the urothelial carcinoma component and PAX8 expression by the renal cell carcinoma component. We have reviewed the contemporary literature of this unusual dual diagnosis.
January 21, 2019: Applied Immunohistochemistry & Molecular Morphology: AIMM
Sang-Ji Choi, Seong Kweon Hong, Gibong Chae, Young-Joon Ryu, Sung-Bae Park, Yang Hee Kim, Suk-Bae Moon, Song-Yi Kim, Hwansoo Kim
RATIONALE: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. PATIENT CONCERNS: A 74-year-old man was admitted to the emergency room with abdominal pain and vomiting, and abdominal computed tomography (CT) indicated obstruction of the ascending colon due to a huge mass...
January 2019: Medicine (Baltimore)
Yonghua Shen, Ling Nie, Yuling Yao, LiQing Yuan, Zhenqing Liu, Ying Lv
RATIONALE: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. PATIENT CONCERNS: A 56-year-old Asian man presented at hospital with a 9-year history of orthotopic LT because of HCC. The patient underwent surgery and radiotherapy for HCC metastasis to adrenal gland and 1 year later, chemotherapy for peritoneal metastasis...
January 2019: Medicine (Baltimore)
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