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Vaccine HPV

Thomas Mertens
The epidemiological effect of vaccination is that it primarily reduces the incidence and prevalence of infectious agents and diseases, providing ideal conditions (also from an economic point of view) for prevention. Goal of vaccination is first the individual protection. Other goals may be "herd immunity", regional repression and global extinction. The STIKO provides recommendations for the implementation of vaccinations and for the implementation of other measures for the specific prevention of communicable diseases and develops criteria for the differentiation of a customary vaccination reaction and damage to health beyond the usual extent of a vaccination reaction...
February 2019: Deutsche Medizinische Wochenschrift
Camila Andrea Picchio, Mireia Garcia Carrasco, Maria Sagué-Vilavella, Cristina Rius
BackgroundHealthcare professionals are a reliable and impactful source of information on vaccination for parents and children.ObjectivesWe aimed to describe the knowledge, attitudes and beliefs primary care professionals involved in administration of childhood vaccines in Barcelona have about vaccines and vaccination.MethodsIn 2016/17, surveys were administered in person to every public primary care centre (PCC) with a paediatrics department (n = 41). Paediatricians and paediatric nurses responded to questions about disease susceptibility, severity, vaccine effectiveness, vaccine safety, confidence in organisations, key immunisation beliefs, and how they vaccinate or would vaccinate their own children...
February 2019: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Frank DeStefano, Heather Monk Bodenstab, Paul A Offit
Concerns about vaccine safety can lead to decreased acceptance of vaccines and resurgence of vaccine-preventable diseases. We summarize the key evidence on some of the main current vaccine safety controversies in the United States, including: 1) MMR vaccine and autism; 2) thimerosal, a mercury-based vaccine preservative, and the risk of neurodevelopmental disorders; 3) vaccine-induced Guillain-Barré Syndrome (GBS); 4) vaccine-induced autoimmune diseases; 5) safety of HPV vaccine; 6) aluminum adjuvant-induced autoimmune diseases and other disorders; and 7) too many vaccines given early in life predisposing children to health and developmental problems...
February 12, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Kemin Li, Qingli Li, Liang Song, Danqing Wang, Rutie Yin
We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status...
February 12, 2019: Cancer
Paula K Braverman
Human papillomavirus (HPV), the most common sexually transmitted viral infection worldwide, is the causative agent for cervical cancer and attributed to anogenital cancers as well as oropharyngeal cancer. Three effective, safe, prophylactic HPV vaccines have been licensed, and studies have demonstrated decreases in HPV prevalence and HPV-related disease endpoints without evidence of waning protection to date. In the United States, only the 9-valent vaccine, which covers 90% of the cancers attributed to HPV in US registries, is available...
February 1, 2019: Pediatric Annals
Nastaran Taleghani, Ali Bozorg, Amin Azimi, Homa Zamani
Monophosphoryl lipid A (MPL), a purified and detoxified product of lipopolysaccharide (LPS) of Salmonella minnesota R595, has been used as an adjuvant in different vaccines. In this study, the efficacy of human papillomaviruses (HPV) and hepatitis B virus (HBV) vaccines formulated with aluminum hydroxide combined with two different synthetic MPLs, 3D-(6-acyl)-PHAD or 3D-PHAD, or aluminum hydroxide combined with the mixtures of such MPLs, has been assessed. The immunogenicity in female BALB/c mice was verified by two intramuscular injections of differently formulated HPV and HBV vaccines and the total immunoglobulin G (IgG) antibody response was considered to compare the employed adjuvants...
March 2019: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Ikram Yazghich, Mohamed Berraho
INTRODUCTION: Cervical cancer is a public health problem in the Maghreb countries with high mortality and socio-economic impact. The objective of this subject is exposed the epidemiological profile, programs of prevention and the support of cervical cancer in Maghreb (Morocco, Tunisia and Algeria). METHODS: To implement this work, we carried out research on morbidity and mortality; cancer plans for Maghreb countries (Morocco, Algeria and Tunisia); cervical cancer surveillance for each country; the prevention programs of cervical cancer including vaccination, screening, information campaigns, awareness and education; and research conducted in Morocco, Algeria and Tunisia...
October 2018: La Tunisie Médicale
Howa Yeung, Kevin M Luk, Suephy C Chen, Brian A Ginsberg, Kenneth A Katz
Lesbian, gay, bisexual, and transgender (LGBT) persons face important health issues relevant to dermatologists. Men who have sex with men (MSM) are at higher risk of certain infectious diseases, including HIV, syphilis and other sexually transmitted diseases (STDs), methicillin-resistant Staphylococcus aureus infections, and invasive meningococcal disease, and might be at higher risk of non-infectious conditions, including skin cancer. Recommendations for preventive health care, including screening for HIV and other STDs, sexual health-related vaccinations, and HIV pre-exposure prophylaxis, differ for MSM compared with non-MSM...
March 2019: Journal of the American Academy of Dermatology
Yang Yang, Yuxin Che, Yan Zhao, Xuelian Wang
No licensed therapeutic human papillomavirus (HPV) vaccine is currently available, so it remains a high priority to develop a therapeutic HPV vaccine or prophylactic/therapeutic HPV vaccine for cervical cancer. In this current study, we designed an HPV vaccine including CpG oligodeoxynucleotides 1826 as an adjuvant and HPV16 E7 43-77 peptide as antigen, which contains a CD8 T cell epitope (E7 49-57), and two CD4 T cell epitopes (E7 43-77 and E7 50-62). The prophylactic and therapeutic effect on cervical cancer induced by a single administration of vaccine, were comprehensively evaluated by examining the tumor size and the percentage of tumor-free/bearing mice...
February 8, 2019: International Immunopharmacology
Gem M Le, Kate Radcliffe, Courtney Lyles, Helena C Lyson, Byron Wallace, George Sawaya, Rena Pasick, Damon Centola, Urmimala Sarkar
INTRODUCTION: Cervical cancer prevention is possible through use of the HPV vaccine and Pap tests, yet the vaccine remains underutilized. METHODS: We obtained publicly-available Twitter data from 2014 using three sampling strategies (top-ranked, simple random sample, and topic model) based on key words related to cervical cancer prevention. We conducted a content analysis of 100 tweets from each of the three samples and examined the extent to which the narratives and frequency of themes differed across samples...
2019: PloS One
Muhammad Amith, Anna Zhu, Rachel Cunningham, Rebecca Lin, Lara Savas, Laura Shay, Yong Chen, Yang Gong, Julie Boom, Kirk Roberts, Cui Tao
With the emerging use of speech technology in consumer goods, we experimented with the application of conversational agents for the communication of health information relating to HPV vaccine. Research have stated that one-to-one contact between providers and patients have a variety of positive influences on patients' perception towards vaccines, even leading to uptake, compared to paper-based methods. We implemented a Wizard of Oz experiment that counsels adults with children (n=18) on the HPV vaccine, using an iPad tablet and dialogue script developed by public health collaborators, and for early testing of a prospective conversational agent in this area...
2019: Studies in Health Technology and Informatics
Kyung Jin Min, Sang Hoon Kwon, Kidong Kim, Sunghoon Kim, Hyun Jung Kim, Seok Ju Seong, Yong Jung Song, Keun Ho Lee, Shin Wha Lee, Jeong Won Lee, Suk Joon Chang, Woong Ju, Young Tak Kim, Jae Kwan Lee
In 2016, 9-valent human papillomavirus (HPV) vaccine has been newly introduced in Korea, thus the need to develop recommendations for the vaccine has raised. Until we decide to develop a guideline, no further studies on the bi-valent or quadri-valent HPV vaccine have been announced. We searched and reviewed the literatures focused on the efficacy of 9-valent HPV vaccine, the ideal age of 3-dose schedule vaccination, the efficacy of 9-valent HPV vaccine in middle-aged women, the efficacy of the 2-dose schedule vaccination, the safety of 9-valent HPV vaccine, the possibility of additional 9-valent HPV vaccination, and cross-vaccination of 9-valent HPV vaccine...
January 9, 2019: Journal of Gynecologic Oncology
Martin Ryser, Valérie Berlaimont, Naveen Karkada, Attila Mihalyi, Rino Rappuoli, Robbert van der Most
BACKGROUND: Substantial heterogeneity has been reported in efficacy against high-grade cervical intraepithelial neoplasia (CIN) irrespective of type in phase III results for bivalent and quadrivalent human papillomavirus virus (HPV) vaccines (AS04-HPV and qHPV). Real-world data recently confirmed very high overall impact of AS04-HPV, supporting the validity of the observed heterogeneity. To explore the reasons for heterogeneous efficacy, we assessed vaccine impact on high-grade lesions not caused by vaccine types...
February 11, 2019: Expert Review of Vaccines
Jing Wang, Dandan Tang, Jialu Wang, Zhaoxia Zhang, Yanxia Chen, Kai Wang, Xueliang Zhang, Cailing Ma
BACKGROUND: Genotype distribution and prevalence of human papillomavirus (HPV) among women vary from different regions and crowds, prophylactic HPV vaccin could prevent some diseases related to HPV, which include cervical precancerous lesions and cancer. Baseline surveys prior to mass HPV vaccination are critical to determine vaccine efficacy and detect changes in HPV type after vaccination. OBJECTIVE: The aim of this study is to study the HPV type-specific prevalence in 698 women with cytological abnormalities, aging from 18 to 77 years old...
February 8, 2019: Human Vaccines & Immunotherapeutics
Stacey B Griner, Erika L Thompson, Cheryl A Vamos, Anil K Chaturvedi, Coralia Vazquez-Otero, Laura K Merrell, Nolan S Kline, Ellen M Daley
Evidence suggests a causal connection between the Human Papillomavirus (HPV) and oropharyngeal cancers. HPV-related oropharyngeal cancers are increasing and are the most common HPV-associated cancer. Previous research suggests that dental professionals recognize a role in the prevention of HPV and oropharyngeal cancers. As an initial step to investigating effective mechanisms of incorporating HPV prevention into dental practices, including the HPV vaccine, this qualitative study explored dental opinion leaders' perspectives on barriers and facilitators to HPV-related prevention in the dental profession...
February 8, 2019: Human Vaccines & Immunotherapeutics
Kristin Oliver, Colleen McCorkell, Ilana Pister, Noora Majid, Denise H Benkel, Jane R Zucker
OBJECTIVE: To identify characteristics associated with human papilloma virus (HPV) vaccination rates, describe barriers and facilitators to vaccine uptake and the potential role for clinician-to-clinician Assessment, Feedback, Incentives, and eXchange (AFIX) visits in school-based health centers (SBHCs). METHODS: We conducted clinician-to-clinician AFIX visits at 24 New York City (NYC) high-school and middle-school SBHCs with up-to-date adolescent vaccination rates below 40%...
February 8, 2019: Human Vaccines & Immunotherapeutics
Catherine A Panozzo, Melissa B Gilkey, Melanie L Kornides, J Frank Wharam
BACKGROUND: Health insurers are well-positioned to address low HPV vaccination coverage in the US through initiatives such as provider assessment and feedback. However, little is known about the feasibility of using administrative claims data to assess provider performance on vaccine delivery. METHODS: We used administrative claims data from a regional health plan to estimate provider performance on the 2013-2015 Healthcare Effectiveness Data and Information Set (HEDIS) measure for HPV vaccine...
February 8, 2019: Human Vaccines & Immunotherapeutics
Manami Bhattacharya, Paul L Reiter, Annie-Laurie McRee
Over 43 million immigrants live in the United States (U.S.). Foreign-born populations experience multiple disparities related to human papillomavirus (HPV), including higher cervical cancer mortality rates, yet little research has examined the prevalence of genital HPV infection among this population. We used data from 1,822 women and 1,622 men ages 20-59 in the U.S. who participated in the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Participants reported their nativity status (foreign- vs...
February 8, 2019: Human Vaccines & Immunotherapeutics
Alvaro J Idrovo, Gabriel D Pinilla-Monsalve, Edgar F Manrique-Hernández
The interesting article by Simas et. al. describes an outbreak case with over 600 individuals who exhibited neurological symptoms and which occurred in a town located at the northern region of Colombia in 2014. The community associated this event to the second-dose vaccination campaign against the Human Papillomavirus (HPV) and scientists defined it as a mass psychogenic illness.1,2 Unfortunately, the authors did not include in their article important findings related to a case-control study (with n = 137 and n = 437, respectively), conducted by the Colombian government...
February 8, 2019: Human Vaccines & Immunotherapeutics
Ovidiu Tatar, Gilla K Shapiro, Samara Perez, Kristina Wade, Zeev Rosberger
BACKGROUND: Achieving optimal human papillomavirus (HPV) vaccine uptake can be delayed by parents' HPV vaccine hesitancy, which is as a multi-stage intention process rather than a dichotomous (vaccinated/not vaccinated) outcome. Our objective was to longitudinally explore HPV related attitudes, beliefs and knowledge and to estimate the effect of psychosocial factors on HPV vaccine acceptability in HPV vaccine hesitant parents of boys and girls. METHODS: We used an online survey to collect data from a nationally representative sample of Canadian parents of 9-16 years old boys and girls in September 2016 and July 2017...
February 8, 2019: Human Vaccines & Immunotherapeutics
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