keyword
https://read.qxmd.com/read/38531673/natural-proliferative-phase-frozen-embryo-transfer-a-new-approach-which-may-facilitate-scheduling-without-hindering-pregnancy-outcomes
#1
JOURNAL ARTICLE
Catarina Mendes Godinho, Sérgio Reis Soares, Sofia Gouveia Nunes, Juan M Mascarós Martínez, Samuel Santos-Ribeiro
STUDY QUESTION: How does a natural proliferative phase (NPP) strategy for frozen embryo transfer (FET) compare with the conventional artificial (AC) and natural (NC) endometrial preparation protocols in terms of live birth rates (LBR)? SUMMARY ANSWER: This study supports the hypothesis that, just as for NC, NPP-FET may be a superior alternative to AC in terms of LBR. WHAT IS KNOWN ALREADY: Although FETs are increasing worldwide, the optimal FET protocol is still largely controversial...
March 26, 2024: Human Reproduction
https://read.qxmd.com/read/38527992/the-influence-of-sepsis-on-erythrocytes-morphology-case-report-and-literature-review
#2
JOURNAL ARTICLE
Cristian Mircea Nicolescu, Silviu Daniel Moldovan
This paper highlights a clinical case of sepsis caused by soft tissue infection. Peripheral blood smear, plasma value of inflammatory biomarkers and the white blood cells count were performed. Significant morphological changes were revealed through peripheral blood smear test two days after patient admission. Patient developed septic shock after the third day in intensive care unit (ICU). Laboratory results showed major morphological changes (erythrocytes deformity, abnormal neutrophils); these were correlated with elevated plasma value of interleukin-6 and procalcitonin...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527991/chronic-sclerosing-sialadenitis-of-the-bilateral-submandibular-glands-in-childhood-a-diagnostic-dilemma
#3
JOURNAL ARTICLE
Octavian Marius Dincă, Alexandru Bucur, Sabina Andrada Zurac, Tiberiu Niţă, Gheorghiţă Jugulete, George Cristian Vlădan, Lavinia Cristina Pădurariu
Chronic sclerosing sialadenitis (CSS), currently included in the group of immunoglobulin G4 (IgG4)-related diseases, is an under-recognized inflammatory lesion that afflicts mostly the submandibular gland of 40-60 years adults. To our knowledge, only one case of CSS located in the submandibular gland has been reported in childhood to date. We present a case of CSS in a 5-year-old male child. He presented with bilateral submandibular swellings that clinically resembled discrete lumps, suspected to be tumors...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527989/the-importance-of-combined-hpv-and-cintec%C3%A2-plus-genotyping-testing-for-p16-in-women-with-cervical-squamous-cell-carcinoma
#4
JOURNAL ARTICLE
Toader Septimiu Voidăzan, Mihaela Alexandra Budianu, Ovidiu Simion Cotoi, Sabin Gligore Turdean
INTRODUCTION: Immunohistochemistry (IHC) for p16INK4A (p16) is a reliable surrogate test for the presence of a high-risk, potentially transformative human papillomavirus (HPV) infection in precursor and malignant lesions of the cervix. The purpose of this study was to evaluate changes in cervical cells caused by persistent HPV infection, by IHC (p16 protein) by comparison with HPV genotyping. PATIENTS, MATERIALS AND METHODS: The study included female patients aged between 26 and 57 years who presented to a public hospital, with complaints related to the genital area, namely vaginal bleeding and dyspareunia...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527988/magnetic-resonance-imaging-combined-with-histological-evaluation-of-repair-process-using-the-microfracture-technique-in-an-association-of-osteocartilaginous-and-meniscal-surgically-induced-lesions-of-the-knee-in-vivo-experiment-on-a-rabbit-model
#5
JOURNAL ARTICLE
Jenel Marian Pătraşcu, Sorin Florescu, Silviu Brad, Bogdan Corneliu Andor, Iosif Ilia, Ştefan Iulian Stănciugelu, Romeo Teodor Cristina
The present research study aimed to assess magnetic resonance imaging (MRI) changes and histological findings in the therapeutic effects of microfractures in the treatment of complex animal knee lesions resulting from osteochondral and meniscal defects resulting from non-total meniscectomies. The anterior cruciate ligament lesions are also proven to facilitate the development of osteoarthritis in the knee and worsen the prognosis. Surgery was performed on the right knee joint of 22 male rabbits in order to partially remove the anterior horn of the internal meniscus and to induce an osteochondral defect at the level of the internal femoral condyle...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527987/the-role-of-fine-needle-aspiration-biopsy-in-the-diagnosis-of-malignant-tumors
#6
JOURNAL ARTICLE
Marius Rus, Mircea Ioachim Popescu, Ioana Adrian Ardelean, Felicia Liana Andronie-Cioară, Mihaela Gabriela Bonţea, Răzvan Marius Vicaş, Iulia Denisa Bogdan
Cytopathology and histopathology play a key role in the process of diagnosing oncological diseases and premalignant conditions. Fine-needle aspiration (FNA) is one of the techniques used for obtaining biopsy of a wide variety of body tissues, causing patients minimal discomfort. Therefore, it is often considered to be the best strategy for investigating and diagnosing some precancerous or potential malignant lesions. Being successful as a means of confirming the clinical suspicion of metastatic recurrence in the cases of an already known cancer, the interest has further focused on the preliminary diagnosis of various types of benign or malignant tumors...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527982/epidemiological-and-histopathological-aspects-of-ocular-melanomas-in-northeastern-romania
#7
JOURNAL ARTICLE
Claudia Florida Costea, Andrei Ionuţ Cucu, Gabriela Florenţa Dumitrescu, Anca Sava, Gabriela Dimitriu, Tina Boţoc, Mihaela Roxana Popescu, Cătălin Mihai Buzdugă, Ana Maria Dumitrescu, Alexandra Stărică, Georgiana Macovei, Iulian Prutianu, Laurenţiu Andrei Blaj, Daniela Maria Tănase, Dragoş Viorel Scripcariu
Ocular melanoma is a rare but complex disease in current medical practice. Our retrospective study spans over a period of 28 years and analyzed uveal and conjunctival melanomas that were consecutively admitted, diagnosed, and treated in the 2nd Ophthalmology Clinic of Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania. The patients were selected from the records of the Department of Pathology of our Hospital, being diagnosed by standard histopathological techniques. The aim of this study was to summarize the epidemiological and pathological aspects of uveal and conjunctival melanomas in Northeastern region of Romania...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527979/neurobiological-mechanisms-and-therapeutic-impact-of-electroconvulsive-therapy-ect
#8
JOURNAL ARTICLE
Ana Maria Cojocaru, Antonia Ioana Vasile, Simona Corina Trifu
Electroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefrontal region of the brain and spreads to the cortex and subcortex, including the diencephalic structures. This is achieved by creating a transcranial electric field and synchronously depolarizing neuronal membranes...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527978/primitive-neuroectodermal-tumors-of-the-ovary-a-multidecade-review-of-the-scientific-literature
#9
JOURNAL ARTICLE
Tiberiu Augustin Georgescu, Antonia Carmen Georgescu, Andrei Dennis Voichiţoiu, Dragoş Creţoiu, Nicolae Suciu, Adriana Irina Ciuvică
Primitive neuroectodermal tumor (PNET) is a general term used in scientific literature for a heterogeneous group of small round-cell malignant tumors primarily arising from neural crest cells. These are extremely aggressive neoplasms which usually occur within soft tissue or bone of young adults. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare, with only few case reports in scientific literature. Due to being so exceedingly rare, PNETs are frequently misdiagnosed and there are no standard therapeutic guidelines...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38525119/the-cavernous-sinus-an-anatomic-study-with-clinical-implication
#10
JOURNAL ARTICLE
Myles L Pensak
OBJECTIVE: The management of lesions involving the cavernous sinus remains a formidable challenge. To optimize care for patients with tumors extending into this skull base region a detailed understanding of the surrounding osteology as well as neural and vascular relationships is requisite. This thesis examines the gross anatomy of the region and highlights important surgical implications drawn from these as well as previously published studies. METHODS: A review of the historical scientific, anatomic, clinical, and surgical literature extending to the present (1992) relating to the cavernous sinus has been performed and discussed...
April 2024: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/38524215/clinical-embryology-education-programs-must-prepare-graduates-for-the-future
#11
EDITORIAL
Heather Shapiro, Danielle C Bentley, G Scot Hamilton, Pat Chronis-Brown, Avrum I Gotlieb, Theodore J Brown
No abstract text is available yet for this article.
March 2024: F&S reports
https://read.qxmd.com/read/38519450/tgf%C3%AE-signalling-a-nexus-between-inflammation-placental-health-and-preeclampsia-throughout-pregnancy
#12
JOURNAL ARTICLE
Monika Horvat Mercnik, Carolin Schliefsteiner, Gonzalo Sanchez-Duffhues, Christian Wadsack
BACKGROUND: The placenta is a unique and pivotal organ in reproduction, controlling crucial growth and cell differentiation processes that ensure a successful pregnancy. Placental development is a tightly regulated and dynamic process, in which the transforming growth factor beta (TGFβ) superfamily plays a central role. This family of pleiotropic growth factors is heavily involved in regulating various aspects of reproductive biology, particularly in trophoblast differentiation during the first trimester of pregnancy...
March 22, 2024: Human Reproduction Update
https://read.qxmd.com/read/38518283/a-comprehensive-review-on-the-development-of-sporadic-cerebral-arteriovenous-malformations-from-padget-to-next-generation-sequencing
#13
JOURNAL ARTICLE
Stephanie A Coffman, Keyan Peterson, Nicholas Contillo, Kyle M Fargen, Stacey Q Wolfe
Cerebral arteriovenous malformations (AVMs) are a leading cause of intracerebral hemorrhage in both children and young adults. With the continued advancement of science and technology, the understanding of the pathophysiology behind the development of these lesions has evolved. From early theory published by Harvey Cushing and Percival Bailey in 1928, Tumors Arising from the Blood-vessels of the Brain: Angiomatous Malformations and Hemangioblastoma, which regarded AVMs as tumors arising from blood vessels, to the meticulous artistry of Dorcas Padget's embryological cataloguing of the cerebral vasculature in 1948, to the proliferative capillaropathy theory of Yaşargil in 1987, to Ramey's 2014 hierarchical model of vascular development, there have been multiple hypotheses of congenital, developmental, and genetic two-hit theories in the pathogenesis of AVMs...
March 22, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38514452/ready-for-polygenic-risk-scores-an-analysis-of-regulation-of-preimplantation-genetic-testing-in-european-countries
#14
JOURNAL ARTICLE
M Siermann, V van der Schoot, E M Bunnik, P Borry
STUDY QUESTION: Would the different regulatory approaches for preimplantation genetic testing (PGT) in Europe permit the implementation of preimplantation genetic testing using polygenic risk scores (PGT-P)? SUMMARY ANSWER: While the regulatory approaches for PGT differ between countries, the space provided for potential implementation of PGT-P seems limited in all three regulatory models. WHAT IS KNOWN ALREADY: PGT is a reproductive genetic technology that allows the testing for hereditary genetic disorders and chromosome abnormalities in embryos before implantation...
March 21, 2024: Human Reproduction
https://read.qxmd.com/read/38514451/urinary-gonadotropin-assay-on-24-h-collections-as-a-tool-to-detect-early-central-puberty-onset-in-girls-determination-of-predictive-thresholds
#15
JOURNAL ARTICLE
Clément Janot, Pauline Perrin, Véronique Raverot, Patricia Bretones, René Ecochard, Sarah Malburet-Testori, Marc Nicolino, Zoé Robert, Florence Roucher-Boulez, Carine Villanueva, Kevin Perge, Ingrid Plotton
STUDY QUESTION: Is the 24-h urinary gonadotropin assay an effective diagnostic tool in central precocious puberty (CPP) in girls? SUMMARY ANSWER: This study is the first to provide 24-h urinary gonadotropin assay data, using an electrochemiluminescent immunoassay (CMIA), and to report its usefulness as a tool for the diagnosis of CPP. WHAT IS KNOWN ALREADY: Data about the GnRH test in the diagnosis of CPP are variable and there is no consensus regarding its interpretation...
March 21, 2024: Human Reproduction
https://read.qxmd.com/read/38514450/adolescents-diagnosed-with-polycystic-ovary-syndrome-under-the-rotterdam-criteria-but-not-meeting-the-diagnosis-under-the-updated-guideline
#16
JOURNAL ARTICLE
Jin Ju Kim, Kyu Ri Hwang, Dayong Lee, Sunmie Kim, Young Min Choi
STUDY QUESTION: What are the characteristics of adolescents diagnosed with polycystic ovary syndrome (PCOS) based on the 2003 Rotterdam criteria, but who do not meet the diagnosis according to the international evidence-based guideline? SUMMARY ANSWER: Adolescents who had features of PCOS but did not meet the evidence-based guideline adolescent criteria exhibited unfavorable metabolic profiles compared to controls and shared considerable metabolic and hormonal features with adolescents who did meet the adolescent criteria...
March 21, 2024: Human Reproduction
https://read.qxmd.com/read/38511217/systematic-molecular-analyses-for-115-karyotypically-normal-men-with-isolated-non-obstructive-azoospermia
#17
JOURNAL ARTICLE
Yuki Muranishi, Yoshitomo Kobori, Yuko Katoh-Fukui, Satoshi Tamaoka, Atsushi Hattori, Akiyoshi Osaka, Hiroshi Okada, Kazuhiko Nakabayashi, Kenichiro Hata, Tomoko Kawai, Hiroko Ogata-Kawata, Toshiyuki Iwahata, Kazuki Saito, Masafumi Kon, Nobuo Shinohara, Maki Fukami
STUDY QUESTION: Do copy-number variations (CNVs) in the azoospermia factor (AZF) regions and monogenic mutations play a major role in the development of isolated (non-syndromic) non-obstructive azoospermia (NOA) in Japanese men with a normal 46, XY karyotype? SUMMARY ANSWER: Deleterious CNVs in the AZF regions and damaging sequence variants in eight genes likely constitute at least 8% and approximately 8% of the genetic causes, respectively, while variants in other genes play only a minor role...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38511216/targeting-osteopontin-alleviates-endometriosis-and-inflammation-by-inhibiting-the-rhoa-ros-axis-and-achieves-non-invasive-in-vitro-detection-via-menstrual-blood
#18
JOURNAL ARTICLE
Han Wang, Binming Wang, Meiling Wu, Jiefang Lu, Ping Duan
STUDY QUESTION: How does osteopontin (OPN) in endometriosis ectopic stromal cells (EESCs) participate in the pathogenesis of endometriosis and achieve non-invasive detection in vitro? SUMMARY ANSWER: Targeted OPN regulates endometriosis's necroptosis and inflammatory state by inhibiting the RhoA/reactive oxygen species (ROS) axis, thereby alleviating endometriosis and enabling non-invasive detection of menstrual blood in vitro. WHAT IS KNOWN ALREADY: Endometriosis is a chronic inflammatory disease...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38511208/the-impact-of-ovarian-stimulation-on-the-human-endometrial-microenvironment
#19
JOURNAL ARTICLE
Anat Chemerinski, May Shen, Nuriban Valero-Pacheco, Qingshi Zhao, Trystn Murphy, Lea George, Alex Lemenze, Lauren Sherman, Debra Heller, Xiaowei Chen, Tracy Wu, Peter G McGovern, Sara S Morelli, Ripla Arora, Aimee M Beaulieu, Nataki C Douglas
STUDY QUESTION: How does ovarian stimulation (OS), which is used to mature multiple oocytes for ART procedures, impact the principal cellular compartments and transcriptome of the human endometrium in the periovulatory and mid-secretory phases? SUMMARY ANSWER: During the mid-secretory window of implantation, OS alters the abundance of endometrial immune cells, whereas during the periovulatory period, OS substantially changes the endometrial transcriptome and impacts both endometrial glandular and immune cells...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38509860/estimating-the-impact-of-bias-in-causal-epidemiological-studies-the-case-of-health-outcomes-following-assisted-reproduction
#20
JOURNAL ARTICLE
Adrian R Walker, Christos A Venetis, Signe Opdahl, Georgina M Chambers, Louisa R Jorm, Claire M Vajdic
Researchers interested in causal questions must deal with two sources of error: random error (random deviation from the true mean value of a distribution), and bias (systematic deviance from the true mean value due to extraneous factors). For some causal questions, randomization is not feasible, and observational studies are necessary. Bias poses a substantial threat to the validity of observational research and can have important consequences for health policy developed from the findings. The current piece describes bias and its sources, outlines proposed methods to estimate its impacts in an observational study, and demonstrates how these methods may be used to inform debate on the causal relationship between medically assisted reproduction (MAR) and health outcomes, using cancer as an example...
March 20, 2024: Human Reproduction
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