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Loose skin

Evgeni V Nikolaev, Andrew Zloza, Eduardo D Sontag
It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapable of migrating back to the tumor site. At the same time, co-infection virus-specific CD8+ T cells remained functional while the infection was cleared. It was also unexpectedly found that PD-1 blockade immunotherapy reversed this effect...
2019: Frontiers in Immunology
Furkan Certel, Mehmet Bayramicli, Merdan Serin
Flap surgery is a wide field in plastic and reconstructive surgery practice and experimental research is needed to improve surgical success. These research is often performed on rats. Rat is a loose-skinned animal and contraction of skin flaps on rats is an underestimated condition. Besides this variable contraction of survived and necrotic tissues may mislead calculations and results. In this study, contraction patterns of epigastric and dorsal island skin flaps were investigated to identify this phenomenon...
February 3, 2019: Journal of Plastic Surgery and Hand Surgery
Zhenhua Lü, Feng Hu, Haiyan Li, Xiru Zhang, Sanchuan Yu, Meihong Liu, Congjie Gao
The development of high performance membrane is crucial for enhanced separation efficiency of nanofiltration process in treating wastewaters from dye and textile industries. In this work, a novel thin-film composite nanofiltration membrane with an asymmetric separation layer composed of relatively compact skin and loose body was designed and fabricated for improved perm-selectivity and antifouling property. Nascent composite membrane with loose poly(piperazine amide) (PA) separation layer was interfacially synthesized and performed with secondary surface reaction using an aqueous tannic acid (TA) solution...
January 25, 2019: Journal of Hazardous Materials
E G Okuneva, A A Kozina, N V Baryshnikova, A Yu Krasnenko, K Yu Tsukanov, O I Klimchuk, E I Surkova, V V Ilinsky
BACKGROUND: Cutis laxa (CL) is a rare connective tissue disorder characterized by loose, redundant, inelastic and wrinkled skin. Patients develop a prematurely aged appearance. Inheritance can be autosomal dominant or autosomal recessive. The X-linked form is now classified in the group of copper transport diseases. Autosomal dominant CL is characterized by wrinkled, redundant and sagging, inelastic skin and in some cases is associated with internal organ involvement. CASE PRESENTATION: We report a familial case of autosomal dominant CL, which includes a 33-year-old woman and her 11-year-old son with dry, thin and wrinkled skin that appeared prematurely aged...
January 31, 2019: BMC Dermatology
Lei Zhang, Tian Ren, Mingyu Qiao, Tung-Shi Huang, Xiaodong Xia
Chickens with high populations of various microorganisms arrive at processing facilities. Salmonella species are one of the important foodborne pathogens commonly found in poultry products. Various intervention strategies are implemented during poultry processing to reduce microorganisms in the products, including pre-scald bird brushes, multi-stage scalding, antimicrobial applications, etc. In this study, the effects of adding sodium dodecyl sulfate (SDS) to chlorine (Cl) and peracetic acid (PAA) against Salmonella were investigated...
January 25, 2019: Poultry Science
Diego Henrique Mirandola Dias Vieira, Vanessa Doro Abdallah, Reinaldo José da Silva, Rodney Kozlowiski de Azevedo
A new myxozoan species, Henneguya sp., is described based on material from skin of Cyphocharax modestus. Mature myxospores are were elongate and ellipsoidal, measuring 21.4 ± 1.2 (19.4-23.2) μm in total length, 5.1 ± 0.3 (4.5-5.8) μm in width, 11.9 ± 0.5 (10.9-12.7) μm in body length and 9.6 ± 0.7 (8.4-10.5) μm in length of the caudal process. The polar capsules were elongated and had unequal sizes, with length of 5.1 ± 0.4 (4.5-6.0) μm and 5.6 ± 0.4 (4.9-6.3) μm for smaller and larger respectively and width of 1...
January 17, 2019: Microbial Pathogenesis
Ibrahim Tekedereli, Emine Demiral, Ismail K Gokce, Zeynep Esener, Emine Camtosun, Aysehan Akinci
FBLN5-related cutis laxa (CL) is a rare syndrome that can be inherited in an autosomal dominant or recessive manner. Autosomal recessive cutis laxa (ARCL), type IA, has been reported to be more severe. The disease is characterized by microcephaly, sagging cheeks, loose, wrinkled and redundant skin, emphysema, aorta or pulmonary artery abnormalities, inguinal hernia, and anomalies of internal organs. Homozygous mutations in the FBLN5 gene are responsible for the clinical manifestations. We report a family study of a child with ARCL...
January 11, 2019: Clinical Dysmorphology
Long Wen, Yunfeng Zhang, Linglin Zhang, Xiaojing Liu, Peiru Wang, Shuzhan Shen, Chan Hu, Lehang Guo, Wencai Jiang, Xiuli Wang
BACKGROUND: Hemoporfin-mediated photodynamic therapy (HMME-PDT) is an effective method for treating port wine stains (PWS). While, it still lacks methods to evaluate the treatment of HMME-PDT for PWS effectively and objectively. OBJECTIVE: This study aimed to compare the value of different non-invasive diagnostic techniques used for HMME-PDT treatment evaluation in PWS. METHODS: Thirty-one lesions of 22 patients with PWS were treated with HMME-PDT...
January 6, 2019: Photodiagnosis and Photodynamic Therapy
Y J Qi, X Wang, Y Jiao, H M Gong, Y Pan, D Y Jiang
Objective: To investigate the preparation of bioactive denatured acellular dermal matrix (DADM) from burn mice riched in mice bone marrow mesenchymal stem cells. Methods: Twelve BALB/c mice were collected and 20% total body surface area scalds (hereinafter referred to as burns) with deep partial thickness were inflicted on the back skin of each mouse. After removing epidermis, the burned skin were collected and divided into Triton X-100 group and elhylene diamine tetraacetic acid (EDTA) group according to the random number table, with 15 samples in each group...
December 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Kun Hyung Kim, Myeong Soo Lee, Tae-Young Choi, Tae-Hun Kim
BACKGROUND: Gastroparesis, a state of delayed gastric emptying in the absence of mechanical obstruction of the stomach, has a substantial impact on people's daily function and quality of life when symptomatic. Current treatment options are based on limited evidence of benefits. Acupuncture is widely used to manage gastrointestinal disorders, although its role in people with symptomatic gastroparesis is unclear. We therefore undertook a systematic review of the evidence. OBJECTIVES: To assess the benefits and harms of acupuncture, in comparison with no treatment, sham acupuncture, conventional medicine, standard care, or other non-pharmacological active interventions for symptom management in people with gastroparesis...
December 18, 2018: Cochrane Database of Systematic Reviews
Claire F Smith, Scott Border
Anatomy, has in history, been linked to helpful ways to remember structures, branches of nerves, structures passing through foramina et cetera. Scalp is even a mnemonic in itself (Skin, Connective tissue, Aponeurosis, Loose areolar tissue, Pericranium). There has been concern by some educators that using mnemonics or rhymes promotes a surface approach to learning and is unhelpful in establishing long term and meaningful deep learning. This article argues that mnemonics and rhyme can be used, in the appropriate way, at the right time, by students as an important learning strategy...
December 11, 2018: Anatomical Sciences Education
Burton I Korelitz, Bernard Partiula, Kelly Teagle, Arun Swaminath, Judy Schneider, Martin Ellington, Guillaume Stoffels
Objective: To seek the habits of pediatricians by which anorectal skin tags (AST) of Crohn's disease might be overlooked. Methods: Questionnaires were sent to pediatricians affiliated with the Northwell Health System. Results: Based on the responses, the majority of pediatricians did feel the abdomen of children presenting with abdominal pain or diarrhea but did not spread the buttocks to seek the presence of AST unless there was rectal pain, rectal bleeding, or, in some cases, loose stools...
November 2018: Inflammatory Intestinal Diseases
Takefumi Mori, Shinichi Sato, Ikuko Oba-Yabana, Takuo Hirose, Satoshi Kinugasa, Yoshikazu Muroya, Kohei Ota, Shingo Nakayama, Hannah Nakamura, Junichi Tani, Chika Takahashi, Sadayoshi Ito
Exit-site infection poses a risk for peritonitis and can shorten peritoneal dialysis (PD) vintage. A loose fit of the skin around the catheter at the exit site can push bacteria surrounding the catheter into the subcutaneous tunnel. Negative-pressure wound therapy (NPWT) has been used to hasten healing of the wound after an operation or to treat pressure ulcers. We hypothesized that NPWT could speed the healing of the exit site and tighten the fit of the skin around the catheter. Using a V.A.C. Therapy system [vacuum-assisted closure (KCI, San Antonio, TX, U...
November 2018: Advances in Peritoneal Dialysis
İlker Karacan, Reyhan Diz Küçükkaya, Fatma Nur Karakuş, Seyhun Solakoğlu, Aslıhan Tolun, Veysel Sabri Hançer, Eda Tahir Turanlı
OBJECTIVE: Autosomal recessive cutis laxa type IIA (ARCL2A) is a rare congenital disorder characterized by loose and elastic skin, growth and developmental delay, and skeletal anomalies. It is caused by biallelic mutations in ATP6V0A2 . Those mutations lead to increased pH in secretory vesicles and thereby to impaired glycosyltransferase activity and organelle trafficking. We aimed to identify the genetic and molecular cause of the unexpected haematological findings in a Turkish family...
November 26, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Joseph Michaels
Excess thigh laxity is a problem for many patients following significant weight loss. Thigh laxity has both vertical and horizontal components that require correction to optimize the aesthetic appearance of the thigh. The vertical vector is best corrected first with a lower body lift or extended abdominoplasty. The remaining loose skin in the medial thigh can then be removed using a horizontal vector resulting in a vertical incision. Residual vertical skin excess is also removed parallel to the groin crease...
January 2019: Clinics in Plastic Surgery
Takunori Shimazaki, Yuzu Kuwahara, Masaya Kimoto, Shinsuke Hara, Hiroyuki Yomo
Photoplethysmography (PPG) is simple, non-invasive and unobtrusive, so it has been commonly used for heart rate (HR) sensing during exercise. PPG-based HR sensor can be applied for almost any part of human body where there is an artery close to the sensor, just by stabilizing it on the skin surface with belt. However, in order to make the HR sensor stable even during vigorous exercise, it requires a high fastening belt pressure, which results in discomfort for the sensor wearer. In this paper, we investigate the relationship between fastening belt pressure and accuracy for PPG-based HR sensors put on two positions such as forearm and wrist...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Weibin Wu, Christian Lutz, Simon Mersch, Richard Thelen, Christian Greiner, Guillaume Gomard, Hendrik Hölscher
Lizards of the genus Scincus are widely known under the common name sandfish due to their ability to swim in loose, aeolian sand. Some studies report that this fascinating property of sandfish is accompanied by unique tribological properties of their skin such as ultra-low adhesion, friction and wear. The majority of these reports, however, is based on experiments conducted with a non-standard granular tribometer. Here, we characterise microscopic adhesion, friction and wear of single sandfish scales by atomic force microscopy...
2018: Beilstein Journal of Nanotechnology
Waseem M Hajjar, Areej S Alrajeh, Lulwah S Alturki, Sami A Al-Nassar, Adnan W Hajjar
Cutis laxa (CL) is a rare connective tissue disease characterized by a loose, wrinkled, and inelastic skin. Here, we report an unusual presentation in a 15-year-old male patient who is a known patient of CL who presented with bilateral pneumothorax. He was successfully managed initially by chest tube insertion and then he was treated surgically with bilateral staged thoracoscopy, apical bullectomy, and pleurodesis with full uneventful recovery.
October 2018: Annals of Thoracic Medicine
Saori Nojo, Yasuo Ihara
Despite the generally low level of inter-population genetic differentiation in humans as compared with great apes, it has long been acknowledged that there is a considerable amount of geographic variations in human phenotypes, for example, skin pigmentation, cranial morphology, and soft-tissue facial morphology, to name but a few. Indeed, recent studies have suggested that the extent of inter-population diversity in some human phenotypes is greater than expected from random drift alone. Such an excess of phenotypic diversity is often attributed to adaptation to local environment...
November 2, 2018: Journal of Theoretical Biology
Dong Wook Kim, Sang-Woo Kim, Unyong Jeong
It is familiar to everyone that human skin and hair easily lose electrons and cause static electricity as they undergo friction with other materials. Such natural regenerative substances take a high ranking in the triboelectric series. Even though the static electricity of regenerative natural substances has been a long-term curiosity in human history, it is not yet clear which of their components causes the positive static charges. This study reveals that lipid layers on the surface of regenerative substances (skin, hair, leaves, cells) and even synthetic lipids are responsible for this positive static electricity and shows that it is possible to manufacture lipid-based triboelectric nanogenerators (TENGs)...
November 2, 2018: Advanced Materials
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