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Synthesis of nanoparticles

Kavita Kadu, Goutam Ghosh, Lata Panicker, Meenal Kowshik, Sutapa Roy Ramanan
Magnetic hydroxyapatite (MHAp) exhibits excellent biocompatibility, making it an ideal candidate as a biomaterial. Recent investigations have shown that the combined effect of magnetite and hydroxyapatite nanostructures provide efficient means for diagnostic and therapeutic applications which can be controlled with an external magnetic field. For these applications an important aspect to be considered is the interaction of the MHAp nanoparticles (NPs) with biomolecules such as protein (P) and the subsequent biological response...
February 12, 2019: Colloids and Surfaces. B, Biointerfaces
Yifan Li, Shensheng Chen, Serkan Demirci, Shiyi Qin, Zihao Xu, Emily Olson, Fei Liu, Devin Palm, Xin Yong, Shan Jiang
Emulsion polymerization is a versatile approach to produce different polymeric nanoparticle morphologies, which can be useful in a variety of applications. However, the detailed mechanism of the morphology formation is not entirely clear. We study the kinetics of nanoparticle morphology evolution during a seeded emulsion polymerization using both experimental and computational tools. Lightly crosslinked polystyrene seeds were first synthesized using dispersion polymerization. Then the seed particles were swollen in tert-butyl acrylate and styrene monomers, and subsequently polymerized into nanoparticles of dumbbell and multilobe morphologies...
January 25, 2019: Journal of Colloid and Interface Science
Jamshaid Rashid, Ammara Abbas, Leng Chee Chang, Aneela Iqbal, Ihsan Ul Haq, Adeela Rehman, Saif Ullah Awan, Muhammad Arshad, Mohsin Rafique, M A Barakat
The present study for the first time reports facile in-situ room temperature synthesis of butterfly cluster like lamellar BiOBr deposited over TiO2 nanoparticles for photocatalytic breakdown of ciprofloxacin (CIP). The butterfly cluster arrangement of BiOBr resulted in an increase in surface area from 124.6 to 160.797 m2 ·g-1 and subsequently increased incident light absorption by the composite photocatalyst. The XRD indicated the existence of TiO2 as spherical ≈10-15 nm diameter particles with [101] preferential growth planes of anatase phase while the lamellar BiOBr showing growth along [110] and [102] preferential planes that were also confirmed by the HR-TEM images...
February 11, 2019: Science of the Total Environment
Mina Karimpour, Mohammad Ali Hosseinpour Feizi, Majid Mahdavi, Barbara Krammer, Thomas Verwanger, Farhood Najafi, Esmaeil Babaei
BACKGROUND: Curcumin, the polyphenolic constituent of turmeric, has been recognized as an effective anticancer agent in the treatment of breast cancer. However, the poor bioavailability of curcumin triggers finding of new approaches for elevating its therapeutic efficiency. PURPOSE: We aimed to use gemini surfactant nanocarriers for curcumin in order to overcome its limitations. STUDY DESIGN: We investigated the in vitro characterization of gemini surfactant-curcumin (Gemini-Cur) and examined its antiproliferative & apoptotic activities on breast cancer cell lines...
November 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Pramod V Chavan, Uday V Desai, Prakash P Wadgaonkar, Savita R Tapase, Kisan M Kodam, Amit Choudhari, Dhiman Sarkar
A series of spirochromenocarbazole tethered 1,2,3-triazoles were synthesized via click chemistry based one-pot, five component reaction between N-propargyl isatins, malononitrile, 4-hydroxycarbazole, aralkyl halides and sodium azide using cellulose supported CuI nanoparticles (Cell-CuI NPs) as the heterogeneous catalyst. Antiproliferative activity of all the synthesized compounds was investigated against panel of cancer cell lines such as MCF-7, MDA-MB-231, HeLa, PANC-1, A-549, and THP-1. Many of the synthesized compounds exhibited good anti-proliferative activity against breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cells with IC50 values less than 10 μM...
February 8, 2019: Bioorganic Chemistry
T Rajkumar, Andras Sapi, Gitishree Das, Trishna Debnath, AbuZar Ansari, Jayanta Kumar Patra
Silver nanoparticles (AgNPs) possesses a number of exceptional pharmaceutical properties and applications as compared with other types of metallic nanoparticles. Currently, AgNPs was biosynthesized using an aqueous extract of Zea mays L. (corn flour) powder. Further, the effect of concentration of reagents, extract, temperature and time of synthesis was also studied along with the cytotoxicity and radical scavenging potential. UV-vis spectra of AgNPs gave a surface plasmon resonance at ~420 nm. The absorption peak became sharp with the increase in time...
January 17, 2019: Journal of Photochemistry and Photobiology. B, Biology
Zhilong Yu, Wei Wang, Fanbin Kong, Mengshi Lin, Azlin Mustapha
Cellulose nanofibrils (CNFs) and silver nanoparticles (AgNPs) are nano-sized fillers widely used for enhancing the active functions of food packaging materials. However, nanomaterials may pose unexpected toxic effects on humans. Thus, the objective of this work was to develop a novel CNF/AgNP composite and investigate its properties and cytotoxicity. The CNF/AgNP composite was prepared via a reduction method using NaBH4 . The AgNPs embedded in the composite showed an average size of 10.72 ± 4.96 nm and a surface plasmon resonance (SPR) absorption peak at 397 nm...
February 15, 2019: International Journal of Biological Macromolecules
Zhilu Rao, Shumin Liu, Ruiyue Wu, Guanglin Wang, Zhixiang Sun, Liangjiu Bai, Wenxiang Wang, Hou Chen, Huawei Yang, Donglei Wei, Yuzhong Niu
In this manuscript, dual network self-healing alginate/guar gum hydrogels with polydopamine-type microcapsules from mesoporous silica nanoparticles were facilely prepared through one-pot method. Glutaraldehyde (GA) was used as a crosslinking agent to crosslink guar gum and sodium alginate, respectively. Metal-ligand interactions as reversible non-covalent bond make the dual network hydrogels have a high degree of self-healing ability, which FeCl3 ·6H2 O was coordinated with sodium alginate and polydopamine on the surface of microcapsules, respectively...
February 15, 2019: International Journal of Biological Macromolecules
Hongyan Li, Dandan Liu, Shenghui Li, Changhu Xue
A 1,6-α-D-glucan (CPA) with a high molecular weight of 2.0 × 103  kDa was isolated from the fruits of Castanea mollissima Blume. CPA showed good water solubility, low side effects on normal cells, and moderate cytotoxicity on cancer cells. Selenium nanoparticles (SeNPs) possess significant anticancer effects, but poor water solubility and dispersity. Therefore, an effective nanocomposite was designed in order to enhance the stability and anticancer effects of SeNPs decorated with CPA. Water soluble and dispersed selenium nanoparticles (CPA-SeNPs) were fabricated using CPA and Na2 SeO3 by redox reaction with ascorbic acid...
February 15, 2019: International Journal of Biological Macromolecules
Jie Feng, Yingyue Zhang, Simon A McManus, Rolane Qian, Kurt D Ristroph, Hanu Ramachandruni, Kai Gong, Claire E White, Aditya Rawal, Robert K Prud'homme
More than 40% of newly developed drug molecules are highly hydrophobic and, thus, suffer from low bioavailability. Kinetically trapping the drug as a nanoparticle in an amorphous state enhances solubility. However, enhanced solubility can be compromised by subsequent recrystallization from the amorphous state during drying processes. We combine Flash NanoPrecipitation (FNP) to generate nanoparticles with spray-drying to produce stable solid powders. We demonstrate that the continuous nanofabrication platform for nanoparticle synthesis and recovery does not compromise the dissolution kinetics of the drug...
February 18, 2019: Soft Matter
Zhihua Lin, Xunhui Xiong, Mengna Fan, Dong Xie, Gang Wang, Chenghao Yang, Meilin Liu
Pyrite (FeS2) has been considered as one of the most potential anode materials for sodium ion batteries (SIBs) due to its low cost, environmentally friendly features and high theoretical capacity. However, the huge volume changes during a charge/discharge process and poor conductivity of FeS2 hindered its practical applications. Herein, we propose a facile scalable approach to prepare nanostructured FeS2 embedded in an N-doped carbon nanosheet composite (FeS2/CNS) via a combined template method and a solid state sulfuration method...
February 18, 2019: Nanoscale
Xiaoxiong Cai, Qionghao Xu, Gaomei Tu, Yanghe Fu, Fumin Zhang, Weidong Zhu
The synthesis of heterogeneous cooperative catalysts in which two or more catalytically active components are spatially separated within a single material has generated considerable research efforts. The multiple functionalities of catalysts can significantly improve the efficiency of existing organic chemical transformations. Herein, we introduce ruthenium (Ru) nanoparticles (NPs) on the surfaces of a metal-organic framework pre-encapsulated with polyoxometalate silicotungstic acid (SiW) UiO-66 (University of Oslo [UiO]) and prepared a 2...
2019: Frontiers in Chemistry
Hui Liu, Caiqin Wang, Peixi Wang, Nan Liu, Qingfeng Du
Extremely stable and biocompatible 3D magnetically responsive photonic crystals (MRPCs) are successfully prepared in aqueous solution. Classic hydrothermal synthesis was applied for preparation of the Fe3 O4 @C core. Modified Stöber method was then employed for synthesis of the different size of Fe3 O4 @C@SiO2 . Unlike the traditional magnetic nanoparticles, the highly negative charged superparamagnetic nanospheres (SMNs), i.e., the double-shell structure Fe3 O4 @C@SiO2 are capable of rapidly self-assembling into 3D MRPCs with full visible and various colors that can be periodically and reversibly tuned under different kinds of external magnetic fields (EMFs) within 1 s...
2019: Frontiers in Chemistry
Fei-Xiang Ma, Cheng-Yan Xu, Fucong Lyu, Bo Song, Shu-Chao Sun, Yang Yang Li, Jian Lu, Liang Zhen
Developing noble-metal-free based electrocatalysts with high activity, good stability, and low cost is critical for large-scale hydrogen production via water splitting. In this work, hollow FeP nanoparticles densely encapsulated in carbon nanosheet frameworks (donated as hollow FeP/C nanosheets), in situ converted from Fe-glycolate precursor nanosheets through carbonization and subsequent phosphorization, are designed and synthesized as an advanced electrocatalyst for the hydrogen evolution reaction. FeP hollow nanoparticles are transformed from intermediate Fe3 O4 nanoparticles through the nanoscale Kirkendall effect...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Muna A AbuDalo, Ismaeel R Al-Mheidat, Alham W Al-Shurafat, Colleen Grinham, Vinka Oyanedel-Craver
Background: Silver nanoparticles (AgNPs) have attracted great attention due to their outstanding electrical, optical, magnetic, catalytic, and antimicrobial properties. However, there is a need for alternative production methods that use less toxic precursors and reduce their undesirable by-products. Phyto-extracts from the leaves of olive and rosemary plants can be used as reducing agents and (in conjunction with Tollens' reagent) can even enhance AgNP antimicrobial activity. Methods: Conditions for the proposed hybrid synthesis method were optimized for olive leaf extracts (OLEs) and rosemary leaf extracts (RLEs)...
2019: PeerJ
A Pia P Kröger, Muhabbat I Komil, Naomi M Hamelmann, Alberto Juan, Martina H Stenzel, Jos M J Paulusse
Naturally occurring glycoconjugates possess carbohydrate moieties that fulfill essential roles in many biological functions. Through conjugation of carbohydrates to therapeutics or imaging agents, naturally occurring glycoconjugates are mimicked and efficient targeting or increased cellular uptake of glycoconjugated macromolecules is achieved. In this work, linear and cyclic glucose moieties were functionalized with methacrylates via enzymatic synthesis and used as building blocks for intramolecular cross-linked single-chain glycopolymer nanoparticles (glyco-SCNPs)...
January 15, 2019: ACS Macro Letters
Mani Gajendiran, Heejung Jo, Kyobum Kim, Sengottuvelan Balasubramanian
Background: Surface functionalization of gold nanoparticles (AuNPs) has emerged as a promising field of research with enormous biomedical applications. The folate (FA)-attached polymer-gold nanoconjugates play vital role in targeting the cancer cells. Methods: AuNPs were synthesized by using di- or tri-carboxylate-polyethylene glycol (PEG) polymers, including citrate-PEG (CPEG), malate-PEG (MAP), and tartrate-PEG (TAP), as a reducing and stabilizing agent. After synthesis of polymer-AuNPs, the freely available hydroxyl and carboxylate groups of CPEG, MAP, and TAP were used to attach a cancer cell-targeting agent, FA, via a 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxy succinimide coupling reaction to obtain FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanocon-jugates, respectively...
2019: International Journal of Nanomedicine
Shuwen Zhao, Ying Tao, Yunxiang Chen, Yijie Zhou, Rong Li, Lingling Xie, Aibin Huang, Ping Jin, Shidong Ji
Vanadium dioxide is one kind of desirable infrared modulators for sensors because of its remarkable temperature-responsive infrared modulation ability via autogeneic metal-insulator transition. However, the detriments of poor chemical stability and narrow scope of extensive-researched application (e.g. smart windows) restrict its mass production. Here, we propose a VO2@MgF2@PDA inorganic-organic hybrid coated architecture for great enhancing the optical durability more than 13 times in contrast to the pristine VO2, meanwhile the transmittance difference between room and high temperature changed within 20% (decreasing from 25% to 20...
February 18, 2019: ACS Applied Materials & Interfaces
Bingqian Guo, Jiulong Zhao, Chenyao Wu, Yuting Zheng, Changqing Ye, Mingxian Huang, Shige Wang
With an excellent near-infrared (NIR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). Herein, we reported the PVP mediated one-pot synthesis of colloidal stable and biocompatible PPy nanoparticles (PPy-PVP NPs) for combined tumor photothermal-chemotherapy. The influence of molecular weight and PVP concentration on the spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency of the resultant PPy-PVP NPs was systematically studied...
February 8, 2019: Colloids and Surfaces. B, Biointerfaces
Han-Bin Meng, Xiao-Fang Zhang, Yu-Lu Pu, Xue-Lu Chen, Jiu-Ju Feng, De-Man Han, Ai-Jun Wang
Pt-based nanocomposites with low Pt utilization and high-activity by incorporating with other transition metals have received significant interest in catalysis. Meanwhile, loading Pt-based catalysts on graphene has great research value for improved stability and dispersity of the catalysts. Herein, a facile l-proline-mediated solvothermal strategy was reported to construct reduced graphene oxide (rGO) supported sheet-like PtCo nanocrystals (Pt78 Co22 NCs/rGO) in ethylene glycol (EG). The as-synthesized nanocomposite manifested remarkably improved catalytic properties and chemical stability for oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER), surpassing home-made Pt29 Co71 nanoparticles (NPs)/rGO, Pt83 Co17 NPs/rGO, Pt52 Co48 NPs, commercial Pt/C and Pt black catalysts...
January 28, 2019: Journal of Colloid and Interface Science
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