keyword
https://read.qxmd.com/read/38518381/platycodin-d-facilitates-antiviral-immunity-through-inhibiting-cytokine-storm-via-targeting-k63-linked-traf6-ubiquitination
#21
JOURNAL ARTICLE
Hui Liu, Lirong Xu, Enhao Lu, Chenchen Tang, Hanxiao Zhang, Yanwu Xu, Yuanyuan Yu, Naomi Ong, Xiao-Dong Yang, Qilong Chen, Yuejuan Zheng
Influenza virus infection is a worldwide challenge that causes heavy burdens on public health. The mortality rate of severe influenza patients is often associated with hyperactive immunological abnormalities characterized by hypercytokinemia. Due to the continuous mutations and the occurrence of drug-resistant influenza virus strains, the development of host-directed immunoregulatory drugs is urgently required. Platycodon grandiflorum is among the top 10 herbs of traditional Chinese medicine used to treat pulmonary diseases...
March 22, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38517389/viral-anterior-uveitis-differences-in-retinal-vessel-area-density-between-the-affected-and-non-affected-eye-using-optical-coherence-tomography-angiography
#22
JOURNAL ARTICLE
Anna-Karina B Maier, Daniel Mandrossa, Emanuel Reitemeyer, Sibylle Winterhalter, Anne Rübsam, Uwe Pleyer
PURPOSE: To investigate differences in the retinal vessel area density (VAD) on optical coherence tomography angiography (OCTA) between eyes with unilateral herpetic viral anterior uveitis (VAU) (herpes-simplex virus (HSV) and varicella-zoster virus (VZV)) and the non-affected fellow eye. METHODS: In this monocentric, observational, prospective case series we analyzed the VAD of the macula, optic disc, and peripapillary region in affected and non-affected eyes of 22 patients with HSV-positive and 22 patients with VZV-positive VAU using OCTA...
March 22, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38515747/decidual-leukocytes-respond-to-african-lineage-zika-virus-infection-with-mild-anti-inflammatory-changes-during-acute-infection-in-rhesus-macaques
#23
JOURNAL ARTICLE
Michelle R Koenig, Jessica Vazquez, Fernanda B Leyva Jaimes, Ann M Mitzey, Aleksandar K Stanic, Thaddeus G Golos
Zika virus (ZIKV) can be vertically transmitted during pregnancy resulting in a range of adverse pregnancy outcomes. The decidua is commonly found to be infected by ZIKV, yet the acute immune response to infection remains understudied in vivo . We hypothesized that in vivo African-lineage ZIKV infection induces a pro-inflammatory response in the decidua. To test this hypothesis, we evaluated the decidua in pregnant rhesus macaques within the first two weeks following infection with an African-lineage ZIKV and compared our findings to gestationally aged-matched controls...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38515187/hypermethylation-of-the-glutathione-peroxidase-4-gene-promoter-is-associated-with-the-occurrence-of-immune-tolerance-phase-in-chronic-hepatitis-b
#24
JOURNAL ARTICLE
Xing Su, Zhaohui Wang, Jihui Li, Shuai Gao, Yuchen Fan, Kai Wang
BACKGROUND: Hepatitis B virus (HBV) infection is a public health problem that seriously threatens human health. This study aimed to investigate the clinical significance of glutathione peroxidase 4(GPX4) in the occurrence and development of chronic hepatitis B (CHB). METHODS: A total of 169 participants including 137 patients with CHB and 32 healthy controls (HCs) were recruited. We detected the expression of GPX4 and stimulator of interferon genes (STING) in peripheral blood mononuclear cells (PBMCs) by real-time quantitative polymerase chain reaction (RT-qPCR)...
March 21, 2024: Virology Journal
https://read.qxmd.com/read/38515147/changes-in-the-innate-immune-response-to-sars-cov-2-with-advancing-age-in-humans
#25
JOURNAL ARTICLE
Sudhanshu Agrawal, Michelle Thu Tran, Tara Sinta Kartika Jennings, Marlaine Maged Hosny Soliman, Sally Heo, Bobby Sasson, Farah Rahmatpanah, Anshu Agrawal
BACKGROUND: Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations and mortality. The recent COVID-19 pandemic has highlighted this as elderly subjects have emerged as vulnerable populations that display increased susceptibility and severity to SARS-CoV-2. There is an urgent need to identify the probable mechanisms underlying this to protect against future outbreaks of such nature. Innate immunity is the first line of defense against viruses and its decline impacts downstream immune responses...
March 21, 2024: Immunity & Ageing: I & A
https://read.qxmd.com/read/38514268/-research-progress-on-the-role-of-hepatitis-b-virus-dna-integration-in-chronic-hepatitis-b
#26
JOURNAL ARTICLE
Y M Chen, J Liu, C W Zhu, L Zhu
Chronic hepatitis B virus (HBV) infection will greatly contribute to raising the occurrence probability of cirrhosis and hepatocellular carcinoma in patients. Although existing antiviral treatment regimens have a certain effect on delaying disease progression and improving prognosis, it is still not effective in attaining functional cures. Hepatitis B virus DNA integration may be one of the reasons for this phenomenon. Therefore, this paper reviews the possible mechanisms of HBV DNA integration in maintaining chronic inflammation of the liver, evading existing antiviral treatment methods, and inducing hepatocellular carcinoma so as to further deepen the understanding of the role of HBV DNA integration in the occurrence and development of chronic hepatitis B, providing ideas and references for formulating better treatment strategies...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38514093/gasdermin-b-an-asthma-susceptibility-gene-promotes-mavs-tbk1-signaling-and-airway-inflammation
#27
JOURNAL ARTICLE
Tao Liu, Siqi Liu, Xianliang Rui, Ye Cao, Julian Hecker, Feng Guo, Yihan Zhang, Lu Gong, Yihan Zhou, Yuzhen Yu, Nandini Krishnamoorthyni, Samuel Bates, Sung Chun, Nathan Boyer, Shuang Xu, Jin-Ah Park, Mark A Perrella, Bruce D Levy, Scott T Weiss, Hongmei Mou, Benjamin A Raby, Xiaobo Zhou
RATIONALE: Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of IFN-stimulated genes (ISGs). How asthma genetic susceptible genes modulate cellular response upon viral infection through fine-tuning ISGs induction and subsequent airway inflammation in genetically susceptible asthmatics remains largely unknown. OBJECTIVES: To decipher the functions of GSDMB in respiratory virus-induced lung inflammation...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38513656/opposing-diet-microbiome-and-metabolite-mechanisms-regulate-inflammatory-bowel-disease-in-a-genetically-susceptible-host
#28
JOURNAL ARTICLE
Gabriel Vasconcelos Pereira, Marie Boudaud, Mathis Wolter, Celeste Alexander, Alessandro De Sciscio, Erica T Grant, Bruno Caetano Trindade, Nicholas A Pudlo, Shaleni Singh, Austin Campbell, Mengrou Shan, Li Zhang, Qinnan Yang, Stéphanie Willieme, Kwi Kim, Trisha Denike-Duval, Jaime Fuentes, André Bleich, Thomas M Schmidt, Lucy Kennedy, Costas A Lyssiotis, Grace Y Chen, Kathryn A Eaton, Mahesh S Desai, Eric C Martens
Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived gut microbiota promotes the deterioration of colonic mucus, leading to lethal colitis. Inflammation starts with the expansion of natural killer cells and altered immunoglobulin-A coating of some bacteria...
March 18, 2024: Cell Host & Microbe
https://read.qxmd.com/read/38513523/hypoxia-inducible-factor-1%C3%AE-facilitates-transmissible-gastroenteritis-virus-replication-by-inhibiting-type-i-and-type-iii-interferon-production
#29
JOURNAL ARTICLE
Yunhang Zhang, Xue Rui, Yang Li, Yue Zhang, Yifei Cai, Chen Tan, Ning Yang, Yuanyuan Liu, Yuguang Fu, Guangliang Liu
Transmissible gastroenteritis virus (TGEV) is characterized by watery diarrhea, vomiting, and dehydration and is associated with high mortality especially in newborn piglets, causing significant economic losses to the global pig industry. Hypoxia inducible factor-1α (HIF-1α) has been identified as a key regulator of TGEV-induced inflammation, but understanding of the effect of HIF-1α on TGEV infection remains limited. This study found that TGEV infection was associated with a marked increase in HIF-1α expression in ST cells and an intestinal organoid epithelial monolayer...
March 16, 2024: Veterinary Microbiology
https://read.qxmd.com/read/38512283/subclinical-inflammation-in-asymptomatic-schoolchildren-with-plasmodium-falciparum-parasitemia-correlates-with-impaired-cognition
#30
JOURNAL ARTICLE
Alexander E Johnson, Aditi Upadhye, Veronicah Knight, Erik L Gaskin, Lindsey B Turnbull, David Ayuku, Mark Nyalumbe, Emily Abuonji, Chandy C John, Megan S McHenry, Tuan M Tran, George Ayodo
BACKGROUND: Subclinical inflammation and cognitive deficits have been separately associated with asymptomatic Plasmodium falciparum infections in schoolchildren. However, whether parasite-induced inflammation is associated with worse cognition has not been addressed. We conducted a cross-sectional pilot study to better assess the effect of asymptomatic P. falciparum parasitemia and inflammation on cognition in Kenyan schoolchildren. METHODS: We enrolled 240 children aged 7-14 years residing in high malaria transmission in Western Kenya...
March 21, 2024: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38511730/risk-of-multiple-sclerosis-in-individuals-with-infectious-mononucleosis-a-national-population-based-cohort-study-using-hospital-records-in-england-2003-2023
#31
JOURNAL ARTICLE
Raphael Goldacre
BACKGROUND: Epstein-Barr virus (EBV) is thought to be a necessary causative agent in the development of multiple sclerosis (MS). Infectious mononucleosis (IM), which occurs up to 70% of adolescents and young adults with primary EBV infection, appears to be a further risk factor but few studies have been highly powered enough to explore this association by time since IM diagnosis. OBJECTIVE: The objective was to quantify the risk of MS in individuals with IM compared with the general population, with particular focus on time since IM diagnosis...
March 21, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38511593/longitudinal-analysis-of-csf-hiv-rna-in-untreated-people-with-hiv-identification-of-csf-controllers
#32
JOURNAL ARTICLE
Mattia Trunfio, Bin Tang, Oluwakemi Okwuegbuna, Jennifer E Iudicello, Ajay Bharti, David J Moore, Benjamin B Gelman, Susan Morgello, Payal B Patel, Leah H Rubin, Beau M Ances, Sara Gianella, Robert K Heaton, Ronald J Ellis, Scott L Letendre
Interindividual variation of human immunodeficiency virus (HIV) RNA setpoint in cerebrospinal fluid (CSF) and its determinants are poorly understood, but relevant for HIV neuropathology, brain reservoirs, viral escape, and reseeding after antiretroviral interruptions. Longitudinal multicentric study on demographic, clinical, and laboratory correlates of CSF HIV RNA in 2000 follow-up visits from 597 people with HIV (PWH) off antiretroviral therapy (ART) and with plasma HIV RNA > the lower limit of quantification (LLQ)...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38511327/virus-associated-cd8-t-cells-are-not-activated-through-antigen-mediated-interaction-inside-atherosclerotic-lesions
#33
JOURNAL ARTICLE
Maaike J M de Jong, Frank H Schaftenaar, Marie A C Depuydt, Fernando Lozano Vigario, George M C Janssen, Judith A H M Peeters, Lauren Goncalves, Anouk Wezel, Harm J Smeets, Johan Kuiper, Ilze Bot, Peter van Veelen, Bram Slütter
INTRODUCTION: Viral infections have been associated with the progression of atherosclerosis and CD8+ T-cells directed against common viruses, such as influenza, Epstein-Barr virus, and cytomegalovirus, have been detected inside human atherosclerotic lesions. These virus-specific CD8+ T-cells have been hypothesized to contribute to the development of atherosclerosis; however, whether they affect disease progression directly remains unclear. In this study, we aimed to characterize the activation status of virus-specific CD8+ T-cells in the atherosclerotic lesion...
March 21, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38511285/neurotropin%C3%A2-ameliorates-chronic-pain-associated-with-scar-formation-in-a-mouse-model-a-gene-expression-analysis-of-the-inflammatory-response
#34
JOURNAL ARTICLE
Xuan Zhou, Hiroki Iida, Yugiang Li, Akinobu Ota, Lisheng Zhuo, Reiko Nobuhara, Yuki Terajima, Mitsuru Naiki, A Hari Reddi, Koji Kimata, Takahiro Ushida
BACKGROUND: Scar formation after trauma and surgery involves an inflammatory response and can lead to the development of chronic pain. Neurotropin® (NTP) is a nonprotein extract from inflamed skin of rabbits inoculated with vaccinia virus and has been widely used for the treatment of chronic pain. However, the in vivo effects of NTP on painful scar formation have not been determined. To investigate the molecular mechanisms underlying the effects of NTP on the inflammatory response, we evaluated gene expression in the scar tissues and dorsal root ganglions (DRGs) of mice administered NTP and control mice...
March 21, 2024: Molecular Pain
https://read.qxmd.com/read/38511216/targeting-osteopontin-alleviates-endometriosis-and-inflammation-by-inhibiting-the-rhoa-ros-axis-and-achieves-non-invasive-in-vitro-detection-via-menstrual-blood
#35
JOURNAL ARTICLE
Han Wang, Binming Wang, Meiling Wu, Jiefang Lu, Ping Duan
STUDY QUESTION: How does osteopontin (OPN) in endometriosis ectopic stromal cells (EESCs) participate in the pathogenesis of endometriosis and achieve non-invasive detection in vitro? SUMMARY ANSWER: Targeted OPN regulates endometriosis's necroptosis and inflammatory state by inhibiting the RhoA/reactive oxygen species (ROS) axis, thereby alleviating endometriosis and enabling non-invasive detection of menstrual blood in vitro. WHAT IS KNOWN ALREADY: Endometriosis is a chronic inflammatory disease...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38509833/targeted-repair-of-spinal-cord-injury-based-on-mirna-124-3p-loaded-mesoporous-silica-camouflaged-by-stem-cell-membrane-modified-with-rabies-virus-glycoprotein
#36
JOURNAL ARTICLE
Xiangchuang Fan, Lusen Shi, Zimeng Yang, Yiwei Li, Chi Zhang, Baoshuai Bai, Lu Chen, Elzat Elham-Yilizati Yilihamu, Zhangyang Qi, Wenxiang Li, Peng Xiao, Mingshan Liu, Jichuan Qiu, Fan Yang, Ning Ran, Yifan Shang, Jiaxing Liu, Tehan Zhang, Xiaohong Kong, Hong Liu, Hengxing Zhou, Shiqing Feng
Spinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood-spinal cord barrier (BSCB). To address these challenges, a new nano complex that achieves targeted drug delivery to the damaged spinal cord is proposed, which contains a mesoporous silica nanoparticle core loaded with microRNA and a cloaking layer of human umbilical cord mesenchymal stem cell membrane modified with rabies virus glycoprotein (RVG)...
March 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38509227/viral-infections-in-pregnancy-and-impact-on-offspring-neurodevelopment-mechanisms-and-lessons-learned
#37
REVIEW
Emma F Yates, Sarah B Mulkey
Pregnant individuals with viral illness may experience significant morbidity and have higher rates of pregnancy and neonatal complications. With the growing number of viral infections and new viral pandemics, it is important to examine the effects of infection during pregnancy on both the gestational parent and the offspring. Febrile illness and inflammation during pregnancy are correlated with risk for autism, attention deficit/hyperactivity disorder, and developmental delay in the offspring in human and animal models...
March 20, 2024: Pediatric Research
https://read.qxmd.com/read/38508315/non-transcriptional-irf7-interacts-with-nf-%C3%AE%C2%BAb-to-inhibit-viral-inflammation
#38
JOURNAL ARTICLE
Shumin Fan, Sonam Popli, Sukanya Chakravarty, Ritu Chakravarti, Saurabh Chattopadhyay
Interferon (IFN) regulatory factors (IRF) are key transcription factors in cellular antiviral responses. IRF7, a virus-inducible IRF, expressed primarily in myeloid cells, is required for transcriptional induction of IFNα and antiviral genes. IRF7 is activated by virus-induced phosphorylation in the cytoplasm, leading to its translocation to the nucleus for transcriptional activity. Here, we revealed a non-transcriptional activity of IRF7 contributing to its antiviral functions. IRF7 interacted with the pro-inflammatory transcription factor NF-κB-p65 and inhibited the induction of inflammatory target genes...
March 18, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38508309/highly-pathogenic-prrsv-upregulates-il-13-production-through-nonstructural-protein-9-mediated-inhibition-of-n6-methyladenosine-m-6-a-demethylase-fto
#39
JOURNAL ARTICLE
Xingyu Gong, Yuan Liang, Jingjing Wang, Yipeng Pang, Xiaohan Chen, Qiaoya Zhang, Chengchuang Song, Yanhong Wang, Chunlei Zhang, Xingtang Fang, Xi Chen
Porcine reproductive and respiratory syndrome virus (PRRSV), a highly infectious and causes severe losses in the swine industry by regulating the inflammatory response, inducing tissue damage, suppressing the innate immune response, and promoting persistent infection in hosts. Interleukin-13 (IL-13) is a cytokine that plays a critical role in regulating immune responses and inflammation, particularly in immune-related disorders, certain types of cancer, and numerous bacterial and viral infections; however, the underlying mechanisms of IL-13 regulation during PRRSV infection are not well understood...
March 18, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38508121/gene-expression-profiling-of-endomyocardial-biopsies-from-dogs-with-dilated-cardiomyopathy-phenotype
#40
JOURNAL ARTICLE
A Di Loria, C Ferravante, Y D'Agostino, G Giurato, M Tursi, E Grego, M Perego, A Weisz, P Ciaramella, R Santilli
INTRODUCTION: The employment of advanced molecular biology technologies has expanded the diagnostic investigation of cardiomyopathies in dogs; these technologies have predominantly been performed on postmortem samples, although the recent use of endomyocardial biopsy in living dogs has enabled a better premortem diagnostic approach to study the myocardial injury. ANIMALS, MATERIALS, AND METHODS: Endomyocardial biopsies were collected in nine dogs with a dilated cardiomyopathy phenotype (DCM-p) and congestive heart failure and submitted to histologic examination, next-generation sequencing (NGS), and polymerase chain reaction analysis...
February 22, 2024: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
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