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https://read.qxmd.com/read/30765106/corrigendum-to-exosomes-derived-from-trail-engineered-mesenchymal-stem-cells-with-effective-anti-tumor-activity-in-a-mouse-melanoma-model-international-journal-of-pharmaceutics-549-2018-218-229
#1
Fazileh Hosseini Shamili, Houshang Rafatpanah Bayegi, Zahra Salmasi, Kayvan Sadri, Mahmoud Mahmoudi, Mahmoudreza Kalantari, Mohammad Ramezani, Khalil Abnous
Exosomes are biological nano-sized vesicles (~30-200 nm in diameter) that are produced by a wide range of cells and play several roles in cell-cell communications. These vesicles contain membrane and cytoplasmic components of producing cells. Mesenchymal stem cells (MSCs) are the ideal producer of exosomes. The secreted vesicles from MSCs are promising biological vehicles for cell-free therapy in regenerative medicine, cancer therapy and targeted delivery of therapeutic agents to the tumor cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising member of the TNF family with selective effect on cancerous cells...
March 10, 2019: International Journal of Pharmaceutics
https://read.qxmd.com/read/30763634/core-matched-nanoassemblies-for-targeted-co-delivery-of-chemotherapy-and-photosensitizer-to-treat-drug-resistant-cancer
#2
Di Jiang, Minjun Xu, Yuanyuan Pei, Yukun Huang, Yu Chen, Fenfen Ma, Huiping Lu, Jun Chen
Emergence of drug resistance in tumors causes therapeutic failure or tumor relapse. Combination of chemotherapy and photodynamic therapy holds significant promise to treat drug-resistant tumors. However, stubborn hydrophobicity of photosensitizer (PS), low encapsulation efficiency and leaking problem of PS in organic carrier, and disparate physicochemical properties of PS and chemotherapeutics make the combination unachievable. Thus how to efficiently co-deliver the two functional agents to enable photo-chemotherapy seems to be one of the key challenges...
February 11, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30763573/proteomic-characterization-of-early-lung-response-to-breast-cancer-metastasis-in-mice
#3
Anna Kurpińska, Joanna Suraj, Emilia Bonar, Agnieszka Zakrzewska, Marta Stojak, Magdalena Sternak, Agnieszka Jasztal, Maria Walczak
INTRODUCTION: The tumor-promoting rearrangement of the lungs facilitates the process of cancer cell survival in a foreign microenvironment and enables their protection against immune defense. The study aimed to define the fingerprint of the early rearrangement of the lungs via the proteomic profiling of the lung tissue in the experimental model of tumor metastasis in a murine 4 T1 mammary adenocarcinoma. MATERIALS AND METHODS: The studies were performed on 7-8-week-old BALB/c female mice...
February 11, 2019: Experimental and Molecular Pathology
https://read.qxmd.com/read/30759891/the-romp-a-powerful-approach-to-synthesize-novel-ph-sensitive-nanoparticles-for-tumor-therapy
#4
REVIEW
Philippe Bertrand, Christophe Blanquart, Valérie Héroguez
Fast clearance, metabolism, and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects, despite displaying promising anti-tumor properties on tumor cells in vitro and in in vivo models of cancer. The specific delivery of anti-cancer drugs into the tumor should improve their clinical benefit by limiting systemic toxicity and by increasing the anti-tumor effect. This paper deals with the synthesis of the polymeric nanoparticle platform, which was produced by Ring-Opening Metathesis Polymerization (ROMP), able to release anti-cancer drugs in dispersion, such as histone deacetylase inhibitors, into mesothelioma tumors...
February 12, 2019: Biomolecules
https://read.qxmd.com/read/30743049/nucleus-targeted-nano-delivery-system-eradicates-cancer-stem-cells-by-combined-thermotherapy-and-hypoxia-activated-chemotherapy
#5
Hongjuan Li, Weixiao Yan, Xiaomin Suo, Haotong Peng, Xinjian Yang, Zhenhua Li, Jinchao Zhang, Dandan Liu
Many efforts have focused on the cancer stem cell (CSC) targeting nano delivery system, however, the anticancer therapy efficacy is relative low due to the highly drug-resistance and drug efflux. Nucleus-targeted drug delivery is a promising strategy for reverse the drug resistance and drug efflux of CSCs, but in vivo nucleus-targeted drug delivery has been challenging. Herein, we designed a mesoporous silica nanoparticle (MSN)-based nucleus-targeted system, which could directly target the CSCs and further enter the nucleus by the surface modification of anti-CD133 and thermal-triggered exposure of TAT peptides under an alternating magnetic field (AMF)...
February 6, 2019: Biomaterials
https://read.qxmd.com/read/30738974/inhalable-dry-powder-prepared-from-folic-acid-conjugated-docetaxel-liposomes-alters-pharmacodynamic-and-pharmacokinetic-properties-relevant-to-lung-cancer-chemotherapy
#6
Xiaojie Zhu, Ying Kong, Qi Liu, Yayuan Lu, Han Xing, Xiaoyu Lu, Yue Yang, Jiaqiu Xu, Ning Li, Di Zhao, Xijing Chen, Yang Lu
Pulmonary delivery of anti-cancer drugs in the form of nanoparticulate dry powders is considered a promising modality for treating lung cancer. However, it is not known whether the pharmacodynamics and pharmacokinetics of nano-preparations are altered after co-spray drying. In this study, we compared the physicochemical property, anti-cancer activity, tumor targeting and pharmacokinetic behavior of docetaxel-loaded folic acid-conjugated liposomes (LPs-DTX-FA) with those of dry powder prepared by co-spray-drying LPs-DTX-FA...
February 7, 2019: Pulmonary Pharmacology & Therapeutics
https://read.qxmd.com/read/30736291/novel-targeted-anti-tumor-nanoparticles-developed-from-folic-acid-modified-2-deoxyglucose
#7
Shaoming Jin, Zhongyao Du, Huiyuan Guo, Hao Zhang, Fazheng Ren, Pengjie Wang
The glucose analog, 2-deoxyglucose (2-DG), specifically inhibits glycolysis of cancer cells and interferes with the growth of cancer cells. However, the excellent water solubility of 2-DG makes it difficult to be concentrated in tumor cells. In this study, a targeted nano-pharmacosome was developed with folic acid-modified 2-DG (FA-2-DG) by using amino ethanol as a cleavable linker. FA-2-DG was able to self-assemble, forming nano-particles with diameters of 10⁻30 nm. The biological effects were evaluated with cell viability assays and flow cytometry analysis...
February 6, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30724288/a-new-3d-organotypic-model-of-ovarian-cancer-to-help-evaluate-the-antimetastatic-activity-of-rapta-c-conjugated-micelles
#8
Mingxia Lu, Claire E Henry, Haiwang Lai, Yee Yee Khine, Caroline E Ford, Martina H Stenzel
INTRODUCTION: Ovarian cancer is often diagnosed at a late stage, when disease has spread to extra-pelvic regions such as the omentum. There are limited treatment options available for women with extensive disease and tumours often relapse after current chemotherapy regimens. Therefore, novel drugs should be investigated for the treatment of ovarian cancer. A 3D organotypic model of ovarian cancer can provide a specific platform for the evaluation of nano-drugs. Using patient derived primary cells, the 3D model mimics the ovarian metastatic microenvironment allowing efficient and reproducible testing of many nanoparticles...
February 6, 2019: Biomaterials Science
https://read.qxmd.com/read/30724283/supramolecular-self-assembly-of-triazine-based-small-molecules-targeting-the-endoplasmic-reticulum-in-cancer-cells
#9
Chandramouli Ghosh, Aditi Nandi, Sudipta Basu
The endoplasmic reticulum (ER) is one of the most important organelles controlling myriads of cellular functions including protein folding/misfolding/unfolding, calcium ion homeostasis and lipid biosynthesis. Subsequently, due to its functional dysregulation in cancer cells, it has emerged as an interesting target for anti-cancer therapy. However, specific targeting of the ER in cancer cells remains a major challenge due to the lack of ER-selective chemical tools. Furthermore, for performing multiple cellular functions the ER is dependent on the nucleus through complicated cross-talk...
February 6, 2019: Nanoscale
https://read.qxmd.com/read/30710640/surface-functionalized-folate-targeted-oleuropein-nano-liposomes-for-prostate-tumor-targeting-in-vitro-and-in-vivo-activity
#10
Anmar M Nassir, Ibrahim A A Ibrahim, Shadab Md, Md Waris, Tanuja, Mohammad Ruhal Ain, Iqbal Ahmad, Naiyer Shahzad
AIMS: This study aims to develop and evaluate oleuropein loaded surface functionalized folate-targeted - PEG liposomes for the effective management of prostate cancer in an animal model. MATERIALS AND METHODS: Film hydration-cum-extrusion technique was used to produce liposomes. Particle size, entrapment efficiency, drug loading, electron microscopy, and drug release study were performed for the characterization. Cell viability and various in vitro studies (phosphatidylserine internalization, TUNEL assay, measurement of mitochondrial membrane potential and caspase-3 assay) were performed to compare the anticancer and apoptotic effects of developed liposomes against the plain oleuropein...
January 30, 2019: Life Sciences
https://read.qxmd.com/read/30706776/comprehensive-review-on-graphene-oxide-for-use-in-drug-delivery-system
#11
Muhammad Daniyal, Bin Liu, Wei Wang
Motivated by the accomplishment of carbon nano tubes (CNTs), graphene and graphene oxide (GO) have been widely investigated in the previous quite a long while as an innovative medication nanocarrier for the stacking of a variety of therapeutics as well as anti-cancer medications, ineffectively dissolvable medications, anti-microbials, antibodies, peptides, DNA, RNA and genes. The greatly huge surface region of graphene, with each molecule uncovered on its two sides, is took into consideration ultra-high medication stacking effectiveness...
February 1, 2019: Current Medicinal Chemistry
https://read.qxmd.com/read/30685472/emerging-role-of-plumbagin-cytotoxic-potential-and-pharmaceutical-relevance-towards-cancer-therapy
#12
Surya Kant Tripathi, Munmun Panda, Bijesh K Biswal
Plumbagin is a naphthoquinone derived yellow crystalline phytochemical. Plumbagin has a wide range of biological effects including cytotoxicity against cancer cells both in vitro and in vivo. Due to the pleiotropic nature of plumbagin, it shows the anticancer effect by targeting several molecular mechanisms including apoptosis and autophagic pathways, cell cycle arrest, anti-angiogenic pathways, anti-invasion and anti-metastasis pathways. Among many signaling pathways the key regulatory genes regulated by plumbagin are NF-kβ, STAT3, and AKT, etc...
January 24, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/30678981/production-surface-modification-and-biomedical-applications-of-nanodiamonds-a-sparkling-tool-for-theranostics
#13
REVIEW
Hussain Tinwala, Sarika Wairkar
Diamond nano-particles or nanodiamonds (NDs) are nano-scale carbon allotropes and exhibit characteristic mechanical and optical properties. Unlike other nanocarbon materials NDs are highly bio-compatible and comparatively safe which makes them the material of future interest in the field of medicine. NDs are synthesized by various techniques which includes detonation technique, chemical vapour deposition, high pressure high temperature etc. and followed by post-synthesis processing such as purification, surface modification and functionalization...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30678901/synthesis-and-evaluation-of-the-antiproliferative-efficacy-of-brm270-phytocomposite-nanoparticles-against-human-hepatoma-cancer-cell-lines
#14
Meeta Gera, Nameun Kim, Mrinmoy Ghosh, Neelesh Sharma, Do Luong Huynh, Nisansala Chandimali, Hyebin Koh, Jiao Jiao Zhang, Tae Yoon Kang, Yang Ho Park, Taeho Kwon, Dong Kee Jeong
BRM270 is the most leading phytochemical extract that possesses potent anticancer properties. A major challenge associated with this drug is its low bioavailability and thus requires high dosages for cancer treatment. Here, we report the novel nano-synthesis of phyto-composite, BRM270 for the first time by mechanical milling method with specific modifications for enhanced cytotoxicity against HepG2 human hepatoma cancer cells. Unlike free BRM270 and other phytomedicines, BRM270 nanoparticles (BRM270 NPs) are well-dispersed and small sized (23 to 70 nm) which is believed to greatly enhanced cellular uptake...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30673275/histidine-rich-cell-penetrating-peptide-for-cancer-drug-delivery-and-its-uptake-mechanism
#15
Lei Zhang, Jiang Xu, Feng Wang, Yong Ding, Toby Wang, Grace Jin, Matthew Martz, Zhongzheng Gui, Pingkai Ouyang, Pu Chen
In this work, we report a drug delivery system based on the pH-responsive self-assembly and -disassembly behaviors of peptides. Here, a systematically designed histidine-rich lipidated peptide (NP1) is presented to encapsulate and deliver an anti-cancer drug ellipticine (EPT) into two model cells: non-small cell lung carcinoma and Chinese hamster ovary cells. The mechanism of pH-responsive peptide self-assembly and -disassembly involved in the drug encapsulation and release process are extensively investigated...
January 23, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/30672353/advances-in-curcumin-loaded-nanopreparations-improving-bioavailability-and-overcoming-inherent-drawbacks
#16
Yanan Zhang, Abdur Rauf Khan, Manfei Fu, Yujia Zhai, Jianbo Ji, Larisa Bobrovskaya, Guangxi Zhai
Curcumin (CUR), one of the major extracts of Turmeric, has gained extensive attention owing to its extraordinary benefits as anti-cancer, anti-bacterial, anti-ulcerative, anti-depressant, anti-inflammatory and wound healing agent. However, a major barrier in its application lies in its inherent nature of low water solubility, instability, and short half-life. Different strategies have been adopted to overcome these barriers like preparing nano-sized formulations and exploiting stable and hydrophilic derivatives, and collaborative drug delivery...
January 23, 2019: Journal of Drug Targeting
https://read.qxmd.com/read/30662529/molecular-mechanism-of-anti-cancer-activity-of-the-nano-drug-c-pc-cmc-cd59sp-nps-in-cervical-cancer
#17
Liangqian Jiang, Yujuan Wang, Feng Zhu, Guoxiang Liu, Huihui Liu, Huanhuan Ji, Shuhua Zheng, Bing Li
The novel tumor targeted nano-drug C-PC/CMC-CD59sp nanoparticles were constructed with carbocymethyl chitosan (CMC), C-phycocyanin (C-PC) and CD59 specific ligand peptide (CD59sp). The anti-tumor drug mechanism of the C-PC/CMC-CD59sp NPs was further explored in cervical cancer cells (HeLa and SiHa) in vitro and in vivo . We found that the C-PC/CMC-CD59sp NPs could inhibit the proliferation and induce G0/G1 cell cycle arrest in cervical cancer HeLa and SiHa cells, and the cell proliferation was reduced in a dose-dependent manner...
2019: Journal of Cancer
https://read.qxmd.com/read/30660179/combining-hydrophilic-chemotherapy-and-hydrophobic-phytotherapy-via-tumor-targeted-albumin-qds-nano-hybrids-covalent-coupling-and-phospholipid-complexation-approaches
#18
Dina G Zayed, Shaker M Ebrahim, Maged W Helmy, Sherine N Khattab, Mohammed Bahey-El-Din, Jia-You Fang, Kadria A Elkhodairy, Ahmed O Elzoghby
BACKGROUND: The rationale of this study is to combine the merits of both albumin nanoparticles and quantum dots (QDs) in improved drug tumor accumulation and strong fluorescence imaging capability into one carrier. However, premature drug release from protein nanoparticles and high toxicity of QDs due to heavy metal leakage are among challenging hurdles. Following this platform, we developed cancer nano-theranostics by coupling biocompatible albumin backbone to CdTe QDs and mannose moieties to enhance tumor targeting and reduce QDs toxicity...
January 19, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30657034/new-perspectives-on-the-efficacy-of-gallic-acid-in-cosmetics-nanocosmeceuticals
#19
Barkat Ali Khan, Tariq Mahmood, Farid Menaa, Yasser Shahzad, Abid Mehmood Yousaf, Talib Hussain, Sidhartha D Ray
BACKGROUND: Gallic acid (GA - 3,4,5-trihydroxybenzoic acid), a phenolic phytochemical, is an ubiquitous secondary metabolite found in most plants, with appreciable concentrations in grapes seed, rose flowers, sumac, oak and witch hazel. GA often results from the hydrolysis of terpenes and the polyphenol tannic acid. APPLICATIONS: It exhibits powerful antioxidant, anti-inflammatory, antimicrobial, and anti-cancer activities. Most intriguing benefit has been reported to be on the skin...
January 18, 2019: Current Pharmaceutical Design
https://read.qxmd.com/read/30654213/doxorubicin-polyglycerol-nanodiamond-composites-stimulate-glioblastoma-cell-immunogenicity-through-activation-of-autophagy
#20
Tong-Fei Li, Yong-Hong Xu, Ke Li, Chao Wang, Xin Liu, Yuan Yue, Zhuo Chen, Shen-Jun Yuan, Yu Wen, Quan Zhang, Min Han, Naoki Komatsu, Li Zhao, Xiao Chen
Immunosuppression is a salient feature of GBM associated with the disease's grim prognosis and the limited success of anti-GBM immunotherapy. Stimulating immunogenicity of the GBM cells (GC) is a promising approach to subverting the GBM-associated immunosuppression. We had previously devised a drug composite based on polyglycerol-functionalized nanodiamonds bearing doxorubicin (Nano-DOX) and demonstrated that Nano-DOX effectively modulated GBM's immunosuppressive microenvironment through stimulating the immunogenicity of GC and initiated anti-GBM immune responses...
January 14, 2019: Acta Biomaterialia
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