Jinxia Zhang, Lihong Sun, Ling Jiang, Xinxin Xie, Yuan Wang, Ruiqi Wu, Qingshuang Tang, Suhui Sun, Shiwei Zhu, Xiaolong Liang, Ligang Cui
Immunotherapy is showing good potential for colorectal cancer therapy, however, low responsive rates and severe immune-related drug side effects still hamper its therapeutic effectiveness. Herein, a highly stable cerasomal nano-modulator (DMC@P-Cs) with ultrasound (US)-controlled drug delivery capability for selective sonodynamic-immunotherapy is fabricated. DMC@P-Cs' lipid bilayer is self-assembled from cerasome-forming lipid (CFL), pyrophaeophorbid conjugated lipid (PL), and phospholipids containing unsaturated chemical bonds (DOPC), resulting in US-responsive lipid shell...
March 29, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)