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Vitamin B on PTB

John Allotey, Anca Matei, Shahid Husain, Sian Newton, Julie Dodds, Anthony B Armson, Khalid S Khan, Joshua P Vogel
OBJECTIVE: To identify research priorities of interventions for the primary prevention of preterm birth (PTB), by conducting an international stakeholder survey. STUDY DESIGN: A prospective cross-sectional online survey was conducted in November 2016. Fifteen interventions to prevent spontaneous PTB were identified and ranked by stakeholders (n = 159) in the field of maternal and perinatal health research, using nine equally weighted criteria. Medians and interquartile ranges (IQRs) were calculated and the interventions ranked accordingly...
January 25, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Saeedeh Salimi, Farzaneh Farajian-Mashhadi, Roya Alavi-Naini, Golbarg Talebian, Mehrnaz Narooie-Nejad
The vitamin D receptor (VDR) is an important factor in activating immune response in different infectious diseases. The aim of the present study was to investigate the association between the VDR gene polymorphisms and pulmonary tuberculosis (PTB). The case control study was performed on 120 PTB patients and 131 healthy controls. Genetic analysis was performed by polymerase chain reaction and the restriction fragment length polymorphism method. The VDR Fok1 Ff genotype was associated with TB and the risk of PTB was two times higher in individuals with the Ff genotype...
March 2015: Biomedical Reports
Anna P Ralph, Govert Waramori, Gysje J Pontororing, Enny Kenangalem, Andri Wiguna, Emiliana Tjitra, Sandjaja, Dina B Lolong, Tsin W Yeo, Mark D Chatfield, Retno K Soemanto, Ivan Bastian, Richard Lumb, Graeme P Maguire, John Eisman, Ric N Price, Peter S Morris, Paul M Kelly, Nicholas M Anstey
BACKGROUND: Vitamin D (vitD) and L-arginine have important antimycobacterial effects in humans. Adjunctive therapy with these agents has the potential to improve outcomes in active tuberculosis (TB). METHODS: In a 4-arm randomised, double-blind, placebo-controlled factorial trial in adults with smear-positive pulmonary tuberculosis (PTB) in Timika, Indonesia, we tested the effect of oral adjunctive vitD 50,000 IU 4-weekly or matching placebo, and L-arginine 6.0 g daily or matching placebo, for 8 weeks, on proportions of participants with negative 4-week sputum culture, and on an 8-week clinical score (weight, FEV1, cough, sputum, haemoptysis)...
2013: PloS One
Muayad Merza, Parissa Farnia, Sabar Anoosheh, Mohammed Varahram, Mehdi Kazampour, Omid Pajand, Shima Saeif, Mehdi Mirsaeidi, Mohammad Reza Masjedi, Ali Akbar Velayati, Sven Hoffner
The natural resistance-associated macrophage protein (NRAMP1), Vitamin-D receptor (VDR) and Tumor necrosis factor (TNF-alpha) have been associated in susceptibility to tuberculosis, but the results have been inconsistent. This study aimed to determine the association of NRAMP1, VDR, and TNF-á variant with development of pulmonary tuberculosis (PTB) among Iranian patients. The single nucleotide polymorphisms (SNPs) at INT4, D543, 3'UTR of NRAMP1 gene, SNPs in restriction sites of BsmI, and FokI of the VDR gene and SNPs of TNF-alpha at -238,-308, -244,857,-863 positions were analyzed by PCR-RFLP among two groups of individual; patients with PTB (n=117) and healthy controls (n=60)...
August 2009: Brazilian Journal of Infectious Diseases
Henrik Friis, Nyagosya Range, Marianne L Pedersen, Christian Mølgaard, John Changalucha, Henrik Krarup, Pascal Magnussen, Christian Søborg, Ase B Andersen
Vitamin D is essential to immune function, but little is known about the vitamin D status in equatorial populations. A cross-sectional study was conducted among pulmonary tuberculosis (PTB) patients in Mwanza, Tanzania to identify the predictors of their vitamin D status. Data on sociodemography, season, and intake of food, alcohol, tobacco, and soil were collected, anthropometric measurements taken, and serum alpha(1)-antichymotrypsin (ACT), ferritin and soluble transferrin receptor (sTfR), and serum 25-hydroxy-(ergocalciferol+cholecalciferol) [25(OH)D] determined...
December 2008: Journal of Nutrition
Zane Lombard, Desiré-Lee Dalton, Philip A Venter, Robert C Williams, Liza Bornman
The vitamin D receptor (VDR) and the human leukocyte antigen (HLA) class II complex affect innate and/or adaptive immunity against Mycobacterium tuberculosis. HLA-DRB1, HLA-DQB1, and VDR gene (VDR) polymorphisms were previously associated with tuberculosis (TB) and are here investigated as candidates for TB susceptibility in the Venda population of South Africa. Genomic DNA from 95 patients with pulmonary tuberculosis (PTB) and 117 ethnically matched, healthy controls were typed for HLA-DRB1, DRB3, DRB4, DRB5, DQB1, and VDR polymorphisms FokI, BsmI, ApaI, and TaqI using polymerase chain reaction-sequence specific primers (PCR-SSP)...
August 2006: Human Immunology
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