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Vitamin K2 hemodialysis

Mabel Aoun, Maha Makki, Hiba Azar, Hiam Matta, Dania Nehme Chelala
BACKGROUND: Vascular calcifications are highly prevalent in hemodialysis patients. Dephosphorylated-uncarboxylated MGP (dp-ucMGP) was found to increase in vitamin K-deficient patients and may be associated with vascular calcifications. Supplementation of hemodialysis patients with vitamin K2 (menaquinone-7) has been studied in Europe with a maximum 61% drop of dp-ucMGP levels. The aim of this study is to assess first the drop of dp-ucMGP in an Eastern Mediterranean cohort after vitamin K2 treatment and second the correlation between baseline dp-ucMGP and vascular calcification score...
June 7, 2017: BMC Nephrology
Katarzyna Wyskida, Agnieszka Żak-Gołąb, Jarosław Wajda, Dariusz Klein, Joanna Witkowicz, Rafał Ficek, Sylwia Rotkegel, Urszula Spiechowicz, Joanna Kocemba Dyczek, Jarosław Ciepał, Magdalena Olszanecka-Glinianowicz, Andrzej Więcek, Jerzy Chudek
PURPOSE: Functional vitamin K deficiency (both K1 and K2) is postulated to be one of the most relevant links between chronic kidney disease and vascular calcification in hemodialysis (HD) patients. Recommended dietary restrictions in HD patients superimposed on diversity of eating habits across the countries may affect the prevalence of functional vitamin K deficiency. The aim of this study was to determine the level of functional vitamin K deficiency and its relation to vitamin K1 intake in HD patients in Upper Silesia in Poland...
May 2016: International Urology and Nephrology
Emma Zaragatski, Jochen Grommes, Leon J Schurgers, Stephan Langer, Lieven Kennes, Miriam Tamm, Thomas A Koeppel, Jennifer Kranz, Tina Hackhofer, Karen Arakelyan, Michael J Jacobs, Maria Kokozidou
Arteriovenous fistula (AVF) is the common vascular access type for a hemodialysis patient. Its failure is due to neointimal hyperplasia. Vitamin K antagonists are given to lower thrombosis tendency, but have side effects that enhance arterial calcifications. Here, we investigated the effects of vitamin K antagonists and vitamin K2 (K2) treatment on neointimal hyperplasia development and calcification in rats and in arterialized human veins. AVF was generated in female rats while chronic kidney disease (CKD) was induced using an adenine-enriched diet...
March 2016: Kidney International
Maria Fusaro, Marianna Noale, Valentina Viola, Francesco Galli, Giovanni Tripepi, Nicola Vajente, Mario Plebani, Martina Zaninotto, Giuseppe Guglielmi, Diego Miotto, Luca Dalle Carbonare, Angela D'Angelo, Agostino Naso, Cristina Grimaldi, Davide Miozzo, Sandro Giannini, Maurizio Gallieni
Vitamin K (vitamin K1 or phylloquinone and vitamin K2, a series of menaquinones [MKs]) is involved in the production of bone and matrix amino acid γ-carboxy-glutamic acid (Gla) proteins, regulating bone and vascular calcification. Low vitamin K concentrations are associated with increased risks of fractures and vascular calcification, and frequent complications in hemodialysis patients. We carried out an observational study to establish the prevalence of vitamin K deficiency and to assess the relationship between vitamin K status, vertebral fractures, vascular calcification, and survival in 387 patients on hemodialysis for ≥1 year...
November 2012: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Ralf Westenfeld, Thilo Krueger, Georg Schlieper, Ellen C M Cranenburg, Elke J Magdeleyns, Stephan Heidenreich, Stefan Holzmann, Cees Vermeer, Willi Jahnen-Dechent, Markus Ketteler, Jürgen Floege, Leon J Schurgers
BACKGROUND: Vascular calcification is a predictor of cardiovascular morbidity and mortality. Hemodialysis patients experience severe vascular calcifications. Matrix Gla protein (MGP) is a central calcification inhibitor of the arterial wall; its activity depends on vitamin K-dependent γ-glutamate carboxylation. Uncarboxylated MGP, formed as a result of vitamin K deficiency, is associated with cardiovascular disease. Recent studies suggest poor vitamin K status in hemodialysis patients...
February 2012: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Georg Schlieper, Ralf Westenfeld, Thilo Krüger, Ellen C Cranenburg, Elke J Magdeleyns, Vincent M Brandenburg, Zivka Djuric, Tatjana Damjanovic, Markus Ketteler, Cees Vermeer, Nada Dimkovic, Jürgen Floege, Leon J Schurgers
The mechanisms for vascular calcification and its associated cardiovascular mortality in patients with ESRD are not completely understood. Dialysis patients exhibit profound vitamin K deficiency, which may impair carboxylation of the calcification inhibitor matrix gla protein (MGP). Here, we tested whether distinct circulating inactive vitamin K-dependent proteins associate with all-cause or cardiovascular mortality. We observed higher levels of both desphospho-uncarboxylated MGP (dp-ucMGP) and desphospho-carboxylated MGP (dp-cMGP) among 188 hemodialysis patients compared with 98 age-matched subjects with normal renal function...
February 2011: Journal of the American Society of Nephrology: JASN
Ayumu Nakashima, Noriaki Yorioka, Shigehiro Doi, Takao Masaki, Takafumi Ito, Satoru Harada
In patients with adynamic bone disease, the bone contains few osteoblasts or osteoclasts and bone turnover is slow, so the risk of fracture is increased. The decrease of bone remodeling may also decrease the capacity of bone to buffer calcium, leading to an increase of the calcium x phosphate product and an increased risk of arterial calcification. Such findings emphasize that an effective treatment for adynamic bone disease is required. The present study investigated the influence of vitamin K2 (menatetrenone) on hemodialysis patients with low serum parathyroid hormone levels by using bone metabolism markers...
March 2004: Bone
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