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LDL cholesterol

Kylie Karnebeek, Supriya Thapar, Maartje Willeboordse, Onno C P van Schayck, Anita C E Vreugdenhil
CONTEXT: Childhood obesity increases the risk of diseases as diabetes, cardiovascular disease and non-alcoholic fatty liver disease. OBJECTIVE: To evaluate the prevalence of comorbidities in school-age children with obesity and to compare its prevalence and the effect of a lifestyle intervention between children in primary and secondary school and between boys and girls. DESIGN: Cross-sectional analysis and lifestyle intervention. SETTING: Centre for Overweight Adolescent and Children's Healthcare...
February 18, 2019: Journal of Clinical Endocrinology and Metabolism
Ali R Rahbar, Eisa Safavi, Maryam Rooholamini, Fateme Jaafari, Sadegh Darvishi, Amin Rahbar
Background: Insulin-like growth factor-1 (IGF-1) and interleukin-2 (IL-2) play an essential role in pathophysiology of several chronic diseases. As a stressor, fasting in Ramadan may increase inflammatory markers such as IGF-1 and IL-2 in Muslims. The aim of this before-after study was to investigate the effects of fasting in Ramadan on IGF-1 and IL-2 levels in individuals. Methods: In all, 34 men age 16-64 years were selected out of the overall number of individuals who were ready for fasting entirely throughout Ramadan...
2019: International Journal of Preventive Medicine
Azza Gaber Antar Farag, Eman Ae Badr, Abdel Monem A Eltorgoman, Mohamed Fa Assar, Eman N Elshafey, Nermin Reda Tayel, Hossam Ea Aboutaleb
Background: 11β HSD1 generates cortisol from cortisone. 11β HSD1 single-nucleotide polymorphism (SNP) was associated with metabolic syndrome (MeTS). Although the relation of acne vulgaris (AV) and skin tags (STs) with MeTS has been reported, the relationship between 11β HSD 1 SNP and cortisol activity in those patients has not studied till now. Aims: To investigate, two 11β-HSD1 SNPs (rs846910 and rs12086634), serum lipid profile and cortisol levels in patients with AV and STs in an Egyptian population...
2019: Clinical, Cosmetic and Investigational Dermatology
Naeti Suksomboon, Nalinee Poolsup, Wei Lin
Background: Kiwifruit seems to have beneficial effect on metabolic health because it contains abundant phytochemicals and antioxidants. This study aimed to assess the effect of kiwifruit on metabolic health in participants with cardiovascular risk factors. Methods: Literature was searched from PubMed, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus, Proquest, Latin American and Carib-bean Health Sciences Literature, International Clinical Trials Registry Platform, Australia New Zealand Clinical Trials Registry, https://clinicaltrials...
2019: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Kian-Keong Poh, Chee Tang Chin, Khim Leng Tong, Julian Ko Beng Tan, Jee Seong Lim, Weixuan Yu, Martin Horack, Ami Vyas, Dominik Lautsch, Baishali Ambegaonkar, Philippe Brudi, Anselm K Gitt
INTRODUCTION: Dyslipidaemia is a major risk factor for coronary heart disease (CHD). There is a lack of data on the extent of lipid abnormalities and lipid-lowering therapy (LLT) in Singapore. METHODS: The Dyslipidemia International Study (DYSIS) II was a multinational observational study of patients with stable CHD and hospitalised patients with an acute coronary syndrome (ACS). A full lipid profile and use of LLT were documented at baseline, and for the ACS cohort, at four months post-hospitalisation...
February 18, 2019: Singapore Medical Journal
Kate J Bowen, Penny M Kris-Etherton, Sheila G West, Jennifer A Fleming, Philip W Connelly, Benoît Lamarche, Patrick Couture, David J A Jenkins, Carla G Taylor, Peter Zahradka, Shatha S Hammad, Jyoti Sihag, Xiang Chen, Valérie Guay, Julie Maltais-Giguère, Danielle Perera, Angela Wilson, Sandra Castillo San Juan, Julia Rempel, Peter J H Jones
BACKGROUND: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists. OBJECTIVES: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial...
February 15, 2019: Journal of Nutrition
Subha Mary Varghese, Jibu Thomas
Mulberry (M. alba L.) has prominent use in traditional Chinese medicine since ancient times but its therapeutic properties have not been sufficiently explored in India. Present study was designed to isolate and identify the polyphenolic constituents present in mulberry leaf (M. latifolia) using HPLC and to evaluate its antihyperglycemic and antihyperlipedemic properties in streptozotocin (STZ) induced diabetic wistar rat models. HPLC analysis identified chlorogenic acid (103mg/100gm), caffeic acid (4.3mg/100gm), coumaric acid (11...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Ching-Lung Cheung, Kathryn C B Tan, Philip C M Au, Gloria H Y Li, Bernard M Y Cheung
BACKGROUND: Growth differentiation factor 15 (GDF15) is a key regulator of body weight in animals by regulating food intake. Its receptor, glial cell-derived neurotrophic factor receptor alpha-like (GFRAL), was identified recently. Pre-clinical studies showed that it is a promising therapeutic target for cardiometabolic diseases and anorexia/cachexia. Although many pharmaceutical companies are developing drugs targeting GFRAL, whether the findings from animal studies can be extrapolated to man is unknown...
February 13, 2019: EBioMedicine
Ben Li, Konrad Salata, Charles de Mestral, Mohamad A Hussain, Badr A Aljabri, Thomas F Lindsay, Subodh Verma, Mohammed Al-Omran
BACKGROUND: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group. METHODS: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. RESULTS: Forty-eight participants (30%) completed the survey...
February 13, 2019: Annals of Vascular Surgery
Pilar Ángeles Oriol Torón, Teresa Badía Farré, Amparo Romaguera Lliso
OBJECTIVE: To ascertain the degree of lipidic control before the first cardiovascular accident in population attended during 2013 at Primary Care. To analyze the distribution of these events depending on control intervals of cholesterol LDL (LDL-chol), cholesterol HDL (HDL-chol) and triglycerides (TG). METHOD: A multicentric cross-sectional, descriptive study on above 18-year-old people attended at the centres of the Primari Care Service (PCS) Baix Llobregat Nord, who had suffered a first cardiac or cerebral ischemic attack from 01/01/2013 to 31/12/2013...
February 12, 2019: Clínica e Investigación en Arteriosclerosis
Takashi Miki, Toru Miyoshi, Kazuhiko Kotani, Kunihisa Kohno, Hirohiko Asonuma, Satoru Sakuragi, Yasushi Koyama, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND AND AIMS: Oxidized high-density lipoprotein (oxHDL) is characterized by reduced anti-inflammatory properties compared with HDL. However, the role of oxHDL in the pathogenesis of coronary artery calcification (CAC), a marker of subclinical atherosclerosis, remains unclear. We prospectively investigated the association between the change in oxHDL and progression of CAC in a substudy of a multicenter study. METHODS: In the principal study, patients with a CAC score of 1-999 were treated with pitavastatin with/without eicosapentaenoic acid...
February 1, 2019: Atherosclerosis
Meijiao Wang, Dan Zhao, Liangzhi Xu, Wenjing Guo, Li Nie, Yi Lei, Yun Long, Min Liu, Yichen Wang, Xueqin Zhang, Li Zhang, Hanna Li, Jinhu Zhang, Dongzhi Yuan, Limin Yue
BACKGROUND: Proprotein convertase subtilisin / kexin type 9 (PCSK9) plays a critical role in the cholesterol metabolism by negatively regulating the low-density lipoprotein receptor (LDLR). Lipid metabolic and ovarian disorders are the common clinical manifestation of polycystic ovary syndrome (PCOS). Here, we intended to elucidate the role of PCSK9 in the pathogenesis of PCOS conducted on a human population in case-control design and animal part in an interventional study. METHODS: We firstly investigated the serum levels of PCSK9 in 46 PCOS patients compared with 49 healthy women as controls, and then developed a PCOS mouse model induced by dehydroepiandrosterone (DHEA) and a high-fat diet (HFD) to determine the role of PCSK9 in abnormal lipid metabolism and ovarian dysfunction of PCOS in four groups (n = 40 per group): control, PCOS mice, PCOS plus alirocumab group, and PCOS plus vehicle group...
February 12, 2019: Metabolism: Clinical and Experimental
James Gill, Kathrin Kucharski, Barbara Turk, Chunshen Pan, Wenhui Wei
This prospective, randomized, real-world study aimed to examine the impact of electronic health record-based clinical decision support (CDS) tools on the management of diabetes in small- to medium-sized primary care practices participating in Delaware's patient-centered medical home project. Overall, use of CDS systems was associated with greater reductions from baseline in hemoglobin A1c and low-density lipoprotein cholesterol, and more patients achieving treatment goals. Physicians and staff reported that the CDS toolkit empowered them to be more involved in clinical decision-making, thereby helping to improve diabetes care...
February 13, 2019: Journal of Ambulatory Care Management
Mary Alaba Aderibigbe, Tajudeen Olabisi Obafemi, Mary Tolulope Olaleye, Afolabi Clement Akinmoladun
Background: Type 2 Diabetes Mellitus (T2DM) is associated with diabetic nephropathy and hyperlipidemia. Gender, age, medication adherence, lifestyle, culture and socioeconomic status could be sources of diversity in T2DM leading to differences in predisposition, development and clinical presentation. Objectives: Therefore, this study aimed to investigate the influence of gender, age and treatment duration on kidney and lipid-related biochemical indices of T2DM patients attending Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria (EKSUTH)...
December 2018: African Health Sciences
Anna M Piotrowska, Monika Bigosińska, Halina Potok, Urszula Cisoń-Apanasewicz, Olga Czerwińska-Ledwig, Łukasz M Tota, Roxana Zuziak, Tomasz Pałka, Wanda Pilch
Introduction: Vibration therapy interventions are an attractive alternative for people with contraindications to physical activity or manifesting kinesiophobia; they constitute an equivalent to physical activity. Material and methods: A group of female volunteers with hypercholesterolemia (LDL over 3 mmol/l) aged over 65 years were randomized into 2 subgroups: the study group (taking part in interventions on mattresses generating oscillatory-cycloid vibrations) and the control group (receiving interventions on placebo mattresses)...
December 2018: Przeglad Menopauzalny, Menopause Review
Leila Pirmoradi, Nayer Seyfizadeh, Saeid Ghavami, Amir A Zeki, Shahla Shojaei
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor known with a poor survival rate despite current advances in the field of cancer. Additional research into the pathophysiology of GBM is urgently needed given the devastating nature of this disease. Recent studies have revealed the unique cellular physiology of GBM cells as compared with healthy astrocytes. Intriguingly, GBM cells are incapable of de novo cholesterol synthesis via the mevalonate pathway. Thus, the survival of GBM cells depends on cholesterol uptake via low-density lipoprotein receptors (LDLRs) in the form of apolipoprotein-E-containing lipoproteins and ATP-binding cassette transporter A1 (ABCA1) that efflux surplus cholesterol out of cells...
February 14, 2019: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Erin S Morgan, Li-Jung Tai, Nguyen C Pham, Julia K Overman, Lynnetta M Watts, Anne Smith, Shiangtung W Jung, Martin Gajdošík, Martin Krššák, Michael Krebs, Richard S Geary, Brenda F Baker, Sanjay Bhanot
OBJECTIVE: To evaluate the safety and efficacy of IONIS-GCGRRx , a 2'- O -methoxyethyl antisense oligonucleotide targeting the glucagon receptor (GCGR), and the underlying mechanism of liver transaminase increases in patients with type 2 diabetes on stable metformin therapy. RESEARCH DESIGN AND METHODS: In three phase 2, randomized, double-blind studies, patients with type 2 diabetes on metformin received weekly subcutaneous injections of IONIS-GCGRRx (50-200 mg) or placebo for 13 or 26 weeks...
February 14, 2019: Diabetes Care
Antonio Ceriello, Maria Chiara Rossi, Salvatore De Cosmo, Giuseppe Lucisano, Roberto Pontremoli, Paola Fioretto, Carlo Giorda, Antonio Pacilli, Francesca Viazzi, Giuseppina Russo, Antonio Nicolucci
OBJECTIVE: An association between variability in clinical parameters (HbA1c , blood pressure, cholesterol, and uric acid) and risk of complications in type 2 diabetes has been reported. In this analysis, we investigated to what extent such variability is associated with overall quality of care. RESEARCH DESIGN AND METHODS: The quality of care summary score (Q-score) represents a validated, overall quality of care indicator ranging between 0 and 40; the higher the score, the better the quality of care provided by the diabetes center...
February 14, 2019: Diabetes Care
Bruno Halpern, Marcio C Mancini, Clarissa Bueno, Isabella P Barcelos, Maria Edna de Melo, Marcos S Lima, Camila G Carneiro, Marcelo T Sapienza, Carlos Alberto Buchpiguel, Fernanda Gaspar do Amaral, José Cipolla-Neto
Melatonin, a pineal hormone synthesized at night, is critical for the synchronization of circadian and seasonal rhythms, being a key regulator of energy metabolism in many animal species. Although studies in humans are lacking, several reports, mainly on hibernating animals, demonstrate that melatonin supplementation and short photoperiod increase brown adipose tissue (BAT) mass. The present proof-of-concept study is the first, to our knowledge, to evaluate BAT in melatonin non-proficient patients (radiotherapy or surgical removal of pineal gland) before and after daily melatonin (3 mg) replacement for three months...
February 14, 2019: Diabetes
Miao-Miao Zhao, Jeremy Krebs, Xi Cao, Jing Cui, Dong-Ning Chen, Yu Li, Lin Hua, Jim Mann, Jin-Kui Yang
BACKGROUND: Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in a Chinese population. METHODS: Using a case-control approach we studied 617 subjects with 13 C-urea breath test (13 C-UBT) values ≥10‰ who were defined as being positive for H. pylori (cases), while 617 sex and age- matched subjects with 13 C-UBT values ≤1‰ were defined as H...
February 14, 2019: BMC Infectious Diseases
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