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https://read.qxmd.com/read/30763669/long-term-and-high-dose-dexamethasone-injection-decreases-the-expression-of-immunoglobulin-heavy-light-chain-variable-region-genes-igh-l-vs-in-the-mouse-spleen
#1
Yuanhui Qi, Qiying Yi, Yamin Liu, Yanxia Hu, Dongshen Ni, Jianing Liu, Qin Zhou, Yajun Xie
Glucocorticoid hormones have been widely used in clinical practice as potent anti-inflammatory and immunosuppressive agents. However, the underlying mechanisms of how they work remain unaddressed. Here, we used RNA-set to profile spleen gene expression in adult mice after consistent intraperitoneal injection of dexamethasone. We identified 13565 genes in control (injected with 0.9% NaCl) and 13702 genes in dexamethasone-injected group, 12920 genes were expressed in both, but 645 genes were identified only in control and 782 genes were identified only in the dexamethasone group...
February 11, 2019: Gene
https://read.qxmd.com/read/30763648/are-there-distinct-clinical-and-pathological-features-distinguishing-idiopathic-from-drug-induced-subacute-cutaneous-lupus-erythematosus-a-european-retrospective-multicenter-study
#2
Federica Guicciardi, Laura Atzori, Angelo Valerio Marzano, Simona Tavecchio, Giampiero Girolomoni, Chiara Colato, Axel Patrice Villani, Jean Kanitakis, Christina Mitteldorf, Rosanna Satta, Bernard Cribier, Laurence Gusdorf, Maria Teresa Rossi, Piergiacomo Calzavara-Pinton, Isabel Bielsa, Maria Teresa Fernandez-Figueras, Werner Kempf, Giorgio Filosa, Luca Pilloni, Franco Rongioletti
BACKGROUND: Clinical and pathological criteria to distinguish drug-induced subacute lupus erythematosus (DI-SCLE) from idiopathic (I-SCLE) are controversial. OBJECTIVE: Aim of the survey was a retrospective analysis of a consistent number of iatrogenous and idiopathic SCLE cases, by means of clinical and histopathological investigation. METHODS: Eleven European University Dermatology Units collected all diagnosed cases from January 2000 to December 2016...
February 11, 2019: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30763633/blood-brain-barrier-disruption-and-neuroinflammation-as-pathophysiological-mechanisms-of-the-diffuse-manifestations-of-neuropsychiatric-systemic-lupus-erythematosus
#3
REVIEW
Nancy P Duarte Delgado, Gloria Vásquez, Blanca L Ortiz-Reyes
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE...
February 11, 2019: Autoimmunity Reviews
https://read.qxmd.com/read/30763261/the-effect-of-doac-stop-on-lupus-anticoagulant-testing-in-plasma-samples-of-venous-thromboembolism-patients-receiving-direct-oral-anticoagulants
#4
Michał Ząbczyk, Magdalena Kopytek, Joanna Natorska, Anetta Undas
Background Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects of DOACs, on LA testing in anticoagulated patients. Methods We assessed 75 venous thromboembolism patients aged 44.5±14.6 years. Blood samples were collected 2-28 h since intake of DOACs, including 50 patients on rivaroxaban, 20 on dabigatran and five on apixaban. LA testing was performed at baseline and after DOAC-Stop treatment. Positive LA was defined as the normalized (patient/standard plasma clotting time) LA screening and screening (LA1)/confirmation (LA2) ratios exceeding 1...
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/30762968/skin-inflammation-associated-with-arthritis-synovitis-and-enthesitis-part-2-rheumatoid-arthritis-reactive-arthritis-reiter-s-syndrome-lyme-borreliosis-dermatomyositis-and-lupus-erythematosus
#5
Christoph M Schempp, Franziska Schauer, Christian K Huhn, Nils Venhoff, Stephanie Finzel
Syndromes associated with concurrent skin and joint inflammation frequently pose a therapeutic challenge for both dermatologists and rheumatologists. In part 1 of this review, we discussed psoriatic arthritis as well as the autoinflammatory disorders SAPHO syndrome, Still's disease and Behçet's disease. Part 2 will address rheumatoid arthritis, reactive arthritis, Reiter's syndrome and Lyme borreliosis. In addition, we will discuss dermatomyositis and lupus erythematosus, two common autoimmune disorders that frequently present with both cutaneous and joint involvement...
February 2019: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://read.qxmd.com/read/30762961/hautentz%C3%A3-ndungen-mit-arthritis-synovitis-und-enthesitis-teil-2-rheumatoide-arthritis-reaktive-arthritis-morbus-reiter-lyme-borreliose-dermatomyositis-und-lupus-erythematodes
#6
Christoph M Schempp, Franziska Schauer, Christian K Huhn, Nils Venhoff, Stephanie Finzel
No abstract text is available yet for this article.
February 2019: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://read.qxmd.com/read/30762712/cutaneous-lupus-associated-with-pembrolizumab-therapy-for-advanced-melanoma-a-report-of-three-cases
#7
Elizabeth A Blakeway, Noha Elshimy, Andrew Muinonen-Martin, Maria Marples, Bipin Mathew, Angana Mitra
Checkpoint blockade immunotherapy has revolutionized the treatment of advanced melanoma, with impressive survival benefits attained through upregulation of the anticancer immune response. Blockade of regulatory checkpoint molecules can, however, also result in aberrant immune activation leading to undesirable inflammation and autoimmunity. Although many genetic determinants have been described in patients with primary autoimmune diseases, it is uncertain whether patients developing autoimmune skin disease as an adverse effect of anti-PD-1 therapy share the same genetic risks...
February 11, 2019: Melanoma Research
https://read.qxmd.com/read/30761837/abnormal-retinal-microvasculature-found-in-active-rheumatoid-arthritis-a-different-perspective-of-microvascular-health
#8
Hakan Babaoğlu, Ata Baytaroğlu, Murat Torğutalp, Abdulsamet Erden, Sibel Kadayıfçılar, Umut Kalyoncu
Background/aim: We aimed to assess the association between retinal vascular caliber (RVC) scores and disease activity in rheumatoid arthritis (RA) patients. Materials and methods: Forty-seven RA patients, 32 systemic lupus erythematosus (SLE) patients, and 45 healthy people were enrolled. RA and SLE patients were subdivided into groups according to C-reactive protein (CRP) levels. RA patients were also grouped according to Disease Activity Score-28 (DAS-28). Fundus photography was performed for all patients...
February 11, 2019: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/30761135/autoantibodies-against-c3b-functional-consequences-and-disease-relevance
#9
REVIEW
Vasil V Vasilev, Maria Radanova, Valentin J Lazarov, Marie-Agnes Dragon-Durey, Veronique Fremeaux-Bacchi, Lubka T Roumenina
The complement component C3 is at the heart of the complement cascade. It is a complex protein, which generates different functional activated fragments (C3a, C3b, iC3b, C3c, C3d). C3b is a constituent of the alternative pathway C3 convertase (C3bBb), binds multiple regulators, and receptors, affecting thus the functioning of the immune system. The activated forms of C3 are a target for autoantibodies. This review focuses on the discovery, disease relevance, and functional consequences of the anti-C3b autoantibodies...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30760894/yield-of-screening-blood-work-and-mri-of-the-brain-and-orbits-in-the-work-up-of-unilateral-chronic-optic-neuropathy
#10
Elie Côté, Ari Aharon Shemesh, Lili Tong, Cindy T Y Lam, Edward Margolin
BACKGROUND/OBJECTIVES: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy...
February 13, 2019: Eye
https://read.qxmd.com/read/30760702/baicalin-ameliorates-lupus-autoimmunity-by-inhibiting-differentiation-of-tfh-cells-and-inducing-expansion-of-tfr-cells
#11
Ji Yang, Xue Yang, Jie Yang, Ming Li
Baicalin is a natural compound isolated from Chinese herb, which has been reported as an anti-inflammatory drug. Here, we demonstrated that Baicalin treatment could reduce urine protein, inhibit anti-ds-DNA antibody titers, and ameliorate lupus nephritis in MRL/lpr lupus-prone mice. Baicalin inhibited Tfh cell differentiation and IL-21 production, but promoted Foxp3+ regulatory T cell differentiation including part of follicular regulatory T (Tfr) cells. Intravenous injection of Baicalin-induced Foxp3+ regulatory T cells could relieve nephritis, inhibit Tfh cell differentiation and IL-21 production...
February 13, 2019: Cell Death & Disease
https://read.qxmd.com/read/30760468/evolving-and-expanding-scope-of-lupus-inducing-drugs
#12
Robert L Rubin
No abstract text is available yet for this article.
February 13, 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30760090/antibodies-to-m-type-phospholipase-a2-receptor-pla-2-r-in-membranous-lupus-nephritis
#13
E Garcia-Vives, C Solé, T Moliné, A M Alvarez-Rios, M Vidal, I Agraz, J Ordi-Ros, J Cortés-Hernández
BACKGROUND: Antibodies to M-type phospholipase A2 receptor (a-PLA2 R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLA2 R antibodies in a large cohort of patients with lupus nephritis. METHODS: a-PLA2 R antibodies were measured by ELISA in serum from patients with systemic lupus erythematosus ( n = 190), of whom 37 had a biopsy-proven MLN...
February 13, 2019: Lupus
https://read.qxmd.com/read/30760089/downregulation-of-mir-633-activated-akt-mtor-pathway-by-targeting-akt1-in-lupus-cd4-t-cells
#14
S Chen, Y Wang, H Qin, J Lin, L Xie, S Chen, J Liang, J Xu
BACKGROUND: Accumulating evidence suggests that the AKT/mTOR pathway plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) through activating T cells, and there are few studies looking into the role of microRNA (miRNAs) in the mechanism. We first found that miR-633 expression in CD4+ T cells of SLE patients was significantly reduced. OBJECTIVE: To investigate the role of miR-633 in the AKT/mTOR pathway in lupus CD4+ T cells. METHODS: Samples of 17 SLE cases and 16 healthy controls were collected to detect the expression of miR-633, AKT1, mTOR mRNA and proteins by quantitative polymerase chain reaction (qPCR) and Western-blot, respectively...
February 13, 2019: Lupus
https://read.qxmd.com/read/30758851/dnase1-deficient-mice-spontaneously-develop-a-systemic-lupus-erythematosus-like-disease
#15
Elaine F Kenny, Bärbel Raupach, Ulrike Abu Abed, Volker Brinkmann, Arturo Zychlinsky
Systemic lupus erythematosus (SLE) is an autoimmune disease that has high morbidity and can result in multi-organ damage. SLE is characterized by dysregulated activation of T- and B-lymphocytes and the production of autoantibodies directed against nuclear components. The endonuclease deoxyribonuclease 1 (DNase1) is abundant in blood and a subset of SLE patients have mutations in DNASE1. Furthermore, a report showed that Dnase1-deficient mice develop an SLE-like disease, but these mice also carry a deletion of the gene adjacent to Dnase1, which encodes the chaperone TRAP1/HSP75...
February 13, 2019: European Journal of Immunology
https://read.qxmd.com/read/30756081/cardiac-manifestations-in-systemic-lupus-erythematosus-clinical-correlates-of-subclinical-echocardiographic-features
#16
Alaa A A Mohamed, Nevin Hammam, Mona H El Zohri, Tamer A Gheita
Objectives: This study aims to correlate subclinical echocardiographic features with the clinical, laboratory, and therapeutic profiles of the patients to characterize risks for systemic lupus erythematosus (SLE) cardiac diseases. Methods: The study included 59 SLE patients. Demographic data, disease characteristics, and current therapies were recorded, and the anthropometric measurements and routine laboratory tests were performed. The disease activity by the SLE Disease Activity Index-2K (SLEDAI2K) and the presence of metabolic syndrome (MetS) were assessed...
2019: BioMed Research International
https://read.qxmd.com/read/30755448/prediction-of-fetal-loss-in-chinese-pregnant-patients-with-systemic-lupus-erythematosus-a-retrospective-cohort-study
#17
Jiayue Wu, Wei-Hong Zhang, Jinghang Ma, Chunde Bao, Jinlin Liu, Wen Di
OBJECTIVE: To develop a predictive model for fetal loss in women with systemic lupus erythematosus (SLE). DESIGN: A retrospective cohort study. SETTING: Data were collected in a tertiary medical centre, located in Shanghai, China, from September 2011 to May 2017. PARTICIPANTS: 338 pregnancies with SLE were analysed retrospectively. Cases of multiple pregnancy and those in which artificial abortion was performed for personal reasons were excluded...
February 11, 2019: BMJ Open
https://read.qxmd.com/read/30755423/posterior-reversible-encephalopathy-syndrome-due-to-hypercalcaemia-a-rare-cause
#18
Nandakrishna Bolanthakodi, Sudha Vidyasagar, Muralidhar Varma, Avinash Holla
Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey et al in late 90's, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism...
February 11, 2019: BMJ Case Reports
https://read.qxmd.com/read/30755159/roseomonas-mucosa-infective-endocarditis-in-patient-with-systemic-lupus-erythematosus-case-report-and-review-of-literature
#19
Shayuan Shao, Xin Guo, Penghao Guo, Yingpeng Cui, Yili Chen
BACKGROUND: Roseomonas mucosa, as a Gram-negative coccobacilli, is an opportunistic pathogen that has rarely been reported in human infections. Here we describe a case of bacteremia in an infective endocarditis patient with systemic lupus erythematosus (SLE). CASE PRESENTATIONS: A 44-year-old female patient with SLE suffered bacteremia caused by Roseomonas mucosa complicated with infective endocarditis (IE). The patient started on treatment with piperacillin-tazobactam and levofloxacin against Roseomonas mucosa, which was switched after 4 days to meropenem and amikacin for an additional 2 weeks...
February 12, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30755146/complete-renal-response-at-12-months-after-induction-therapy-is-associated-with-renal-relapse-free-rate-in-lupus-nephritis-a-single-center-retrospective-cohort-study
#20
K Ichinose, M Kitamura, S Sato, M Eguchi, M Okamoto, Y Endo, S Tsuji, A Takatani, T Shimizu, M Umeda, S Fukui, R Sumiyoshi, T Koga, S Kawashiri, N Iwamoto, T Igawa, M Tamai, H Nakamura, T Origuchi, T Nishino, A Kawakami
BACKGROUND: Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in systemic lupus erythematosus (SLE). METHODS: We retrospectively analyzed cases of proliferative and membranous LN patients who underwent a renal biopsy at our hospital in 1993-2016. We analyzed the association between complete renal response (CR) rates at 12 months after induction therapy and predictive factors for CR and their association with renal flares. RESULTS: Of the 95 cases analyzed, we were able to track the therapeutic responses of 81 patients at 12 months after their induction therapy...
February 12, 2019: Lupus
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