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Orbit tumor

Breno Nery, Fred Bernardes Filho, Rodrigo Antônio Fernandes Costa, Leandro César Tângari Pereira, Eduardo Quaggio, Rodolfo Mendes Queiroz, Lucas Giansante Abud, Daniela Pretti da Cunha Tirapelli
Background: Intraventricular and extraventricular central neurocytomas (CN) are equally frequent among 20-40-year-old men and women. However, sellar and suprasellar extraventricular CN are extremely rare, with only 12 reported cases. Case Description: The authors report the case of a Brazilian 27-year-old man who presented with progressive vision loss during the last 4 years and serious bilateral keratoconus. We also review the epidemiological, clinical, radiological, pathological, and treatment features of the 12 reported cases...
2019: Surgical Neurology International
Shahzeb Hassan, Bahram Rahmani, Jeffrey C Rastatter, Alok I Jaju, Sudhi P Kurup
Pott's puffy tumor is a significant complication of frontal sinusitis that leads to frontal bone osteomyelitis and can be associated with frontal swelling, subperiosteal abscess, and intracranial abscess. It may be associated with antecedent trauma and typically presents in adolescents. Orbital involvement is rarely reported. We describe the case of a 15-year-old male who presented after blunt facial trauma with orbital hematoma and developed Pott's puffy tumor with orbital cellulitis and subperiosteal abscess...
February 18, 2019: Orbit
Vinita Gupta, Kirti Aggarwal, Prateek Nishant, Rajnish Kumar Arora
We hereby report a case of metastatic Ewing's sarcoma presenting with rapid-onset total ophthalmoplegia, optic atrophy, and right temporal hemianopia. Comprehensive ophthalmic and neurological evaluation with targeted radioimaging revealed a tumor mass centered over the sella, compressing optic chiasma, extending to involve the left cavernous sinus and the left orbital apex. Whole-body imaging revealed the evidence of multifocal lung and mediastinal metastasis with focal lytic defect in the left femoral head...
January 2019: Journal of Neurosciences in Rural Practice
Hadeel Eid, Gabriel Crevier-Sorbo, Ahmed Aldraihem, Flavia Menegotto, Nagwa Wilson
OBJECTIVE: Neurofibromatosis type 1 (NF1) is a multisystemic genetic disease in which patients develop benign tumors including optic nerve gliomas (ONG). Optic nerve thickening and tortuosity are radiologic markers of tumors but can also be present in children with NF1 who do not have gliomas, thus complicating screening and diagnosis. We undertook this study to retrospectively determine quantitative and qualitative diagnostic criteria using MRI of the orbits for ONG in children with NF1...
February 11, 2019: AJR. American Journal of Roentgenology
Haoqi Ni, Su Yang, Felix Siaw-Debrah, Jiangnan Hu, Ke Wu, Zibin He, Jianjing Yang, Sishi Pan, Xiao Lin, Haotuo Ye, Zhu Xu, Fan Wang, Kunlin Jin, Qichuan Zhuge, Lijie Huang
Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Although treatment guidelines have been developed, no best treatment option or medicine for this condition exists. Recently, mesenchymal stem cells (MSCs)-derived exosomes have shown lots of promise for the treatment of brain disorders, with some results highlighting the neuroprotective effects through neurogenesis and angiogenesis after TBI. However, studies focusing on the role of exosomes in the early stages of neuroinflammation post-TBI are not sufficient...
2019: Frontiers in Neuroscience
Davin C Ashraf, Evan Kalin-Hajdu, Marc H Levin, Robert C Kersten
Purpose: To report a diagnostically challenging case of cranial neuropathy due to perineural invasion by a basal cell carcinoma presenting 7.5 years after treatment of the primary tumor with Mohs micrographic surgery. Observations: A 62-year-old male with a history of Mohs micrographic surgery for basal cell carcinoma (BCC) of the left brow presented with insidious onset of diplopia and paresthesia localizing to the ipsilateral cranial nerves V1 , V2 , and VI. He had no evidence of recurrent cutaneous BCC...
March 2019: American Journal of Ophthalmology Case Reports
V I Vasilyev, T N Safonova, E V Socol, N A Probatova, N V Kokosadze, A I Pavlovskaya, A M Kovrigina, S G Radenska-Lopovok, V R Gorodetsky, E B Rodionova, S G Palshina, E N Aleksandrova, N S Shornikova, I V Gaiduk
AIM: To provide demographic, clinical, laboratory, ultrasound, radiological, morphological/ immunomorphological phenotype of IgG4-related ophthalmic diseases, which allowsmaking a differential diagnosis with granulomatous, autoimmune, inflammatory, endocrine and hematologic diseases affecting the eye and orbits. MATERIALS AND METHODS: From 2004 to 2016 108 (78.2%) of the 138 patients were diagnosed with non-tumoral lesions of eye and orbits. In 48 patients (35%) at admission and 5 patients in the follow were diagnosed IgG4-related ophthalmic disease...
May 11, 2018: Terapevticheskiĭ Arkhiv
Karin Berggren, Nils Wallin Håkansson
OBJECTIVE: To describe a surgical approach for preplanned orbital exenteration. ANIMALS STUDIED: Indications included intraconal orbital mass lesions. Four dogs were included, 3 with neoplasia and one with retro bulbar nodular fasciitis. PROCEDURE: To facilitate complete removal of lesions, exenteration was performed by a new procedure for wide access. The frontalis and temporalis muscles were elevated and retracted through a single U-shaped skin incision...
January 30, 2019: Veterinary Ophthalmology
Takao Oda, Hiroshi Kato, Shoichi Watanabe, Akimichi Morita
Basal cell carcinoma (BCC) occurs preferentially on the face. We retrospectively analyzed 200 cases of BCC treated at Nagoya City University Hospital from April 2004 to October 2015 and examined regional features based on modified facial aesthetic units. BCC occurred more frequently on the cheek, nasal and orbital areas. There was no significant difference between sides, and age was the only factor affecting tumor size.
February 2019: Experimental Dermatology
Qian Li, Hongguang Pan, Lan Li, Juan Cao
RATIONALE: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base. PATIENT CONCERNS: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss...
January 2019: Medicine (Baltimore)
Rasmus Ejstrup, Lauge Hjorth Mikkelsen, Mette Klarskov Andersen, Erik Clasen-Linde, Lise Mette Rahbek Gjerdrum, Setareh Safavi, Steffen Heegaard
The aim of the present study was to describe a rare case of orbital precursor B-lymphoblastic lymphoma (B-LBL) in an adult. A 56-year-old male in complete remission of a gastric precursor B-LBL was referred to our orbital clinic due to rapid development of left-sided painless periorbital swelling, diplopia, and proptosis. Complete ophthalmoplegia was observed. Notably, magnetic resonance imaging showed swelling of the medial and inferior rectus muscles in the left orbit and biopsies were performed. Following histological diagnosis of precursor B-LBL, the patient was treated with radiotherapy (2Gy × 20) and chemotherapy according to the NOPHO ALL 2008 protocol...
February 2019: Oncology Letters
Edinson Najera, Huy Q Truong, Joao T Alves Belo, Hamid Borghei-Razavi, Paul A Gardner, Juan Fernandez-Miranda
BACKGROUND: The endoscopic endonasal approach is a surgical alternative for midline anterior skull base tumors. A detailed understanding of the proximal anterior cerebral artery (ACA) branches' anatomy from an endonasal perspective is essential for avoiding vascular complications. OBJECTIVE: To evaluate, from an endonasal perspective, the anatomic variations of the ACA and its proximal branches, specifically the recurrent artery of Heubner (RAH), and the fronto-orbital (FOA) and frontopolar (FPA) arteries...
January 12, 2019: Operative Neurosurgery (Hagerstown, Md.)
Leandro J Chaves, Bradley Huth, James J Augsburger, Zelia M Correa
The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the information obtained by histopathology is useful for tumor staging and treatment planning. Due to the lack of evidence of survival improvement, orbital exenteration is being performed with diminishing frequency. We describe a patient with diffuse invasive conjunctival melanoma and lymph node involvement treated by tumor debulking, brachytherapy (custom unshielded radioactive device), and adjuvant ipilimumab who has had a favorable outcome without emergence of local tumor relapse or distant metastasis during 16 months of follow up...
June 2018: Ocular Oncology and Pathology
Tatyana Milman, Carol L Shields, John S J Brooks, Sara E Lally, Jerry A Shields, Madalina Tuluc, Ralph C Eagle
Primary cutaneous angiosarcoma is a rare vasoformative malignant neoplasm that can present a diagnostic and therapeutic challenge. We describe a 76-year-old Caucasian man with right upper eyelid swelling and nodularity, initially suspected clinically to represent either ocular adnexal lymphoma or basal cell carcinoma. Incisional biopsy and wide resection of the mass with frozen section control of margins were interpreted as compatible with hobnail (Dabska-retiform) hemangioendothelioma. Foci of atypia were noted in the tumor, raising speculation of evolution into a more aggressive neoplasm, such as conventional angiosarcoma...
June 2018: Ocular Oncology and Pathology
Wenwen Zhu, Di Li, Lihua Xiao
Objective: This study aimed to investigate the relationship between VCP expression and the prognosis of orbital B-cell lymphoma patients and the influence of downregulation of VCP on the apoptosis and invasion abilities of lymphoma cells. Methods: We recruited 66 orbital B-cell lymphoma patients. VCP expression in 66 samples of orbital B-cell lymphoma was determined by immunohistochemistry using monoclonal VCP antibodies. Based on VCP-expression levels detected by immunohistochemistry, we chose ten cases of orbital tumor paraffin tissue from the patients...
2019: OncoTargets and Therapy
Chuandi Zhou, Fan Wu, Peiwei Chai, Yingyun Shi, Juan Ye, Xin Shi, Jia Tan, Yi Ding, Yingxiu Luo, Bita Esmaeli, Renbing Jia, Xianqun Fan
BACKGROUND: The decision to perform Mohs micrographic surgery (MMS) or wide local excision (WLE) for eyelid sebaceous carcinoma (SC) is controversial. OBJECTIVE: To compare local recurrence, metastasis, and tumor-related mortality of patients with eyelid SC who were initially treated with MMS versus WLE. METHODS: A multicenter cohort study. Medical records were reviewed for factors associated with recurrence, metastasis and tumor-related mortality...
January 9, 2019: Journal of the American Academy of Dermatology
Takahiro Hongo, Junichi Fukushima, Yoshinori Uchida, Fumihide Rikimaru, Satoshi Toh, Yuichiro Higaki, Muneyuki Masuda
OBJECTIVE: In the case of deep invasion of an infratemporal fossa (ITF) tumor, surgeons find it difficult to gain sufficient visualization and working space by conventional surgical approaches. To overcome these limitations, we have developed a novel surgical technique, maxillo-orbito-zygomatic (MOZ) approach, by combining partial lateral maxillectomy with the conventional orbito-zygomatic approach. METHODS: A 63-year-old male presented with the fifth recurrent adenoid-cystic carcinoma in the right deep ITF...
January 6, 2019: Auris, Nasus, Larynx
Seanna R Grob, Katherine G Chen, Jeremiah P Tao
PURPOSE: To describe a surgical technique of orbital roof reconstruction with a thin nylon foil implant. METHODS: This study is a description of a surgical technique with a retrospective chart review of 3 consecutive patients treated with a nylon foil implant for a complete superior orbital defect after meningioma resection via craniotomy approach. RESULTS: The nylon foil reconstruction achieved an anatomically stable orbit without globe dystopia, pulsatile proptosis, cerebrospinal fluid leak, or other serious cranio-orbital problems, in all cases...
January 7, 2019: Ophthalmic Plastic and Reconstructive Surgery
Marialuisa Framarino-Dei-Malatesta, Annalisa Chiarito, Federico Bianciardi, Marco Fiorelli, Azzurra Ligato, Giuseppe Naso, Irene Pecorella
BACKGROUND: Unilateral or bilateral metastases to extraocular muscles are very rare in breast cancer. CASE PRESENTATION: We describe a case of inferior rectus extraocular muscle involved by ductal luminal B/Her-2 neu negative breast cancer, observed in a cohort of 580 patients. Our patient had received chemotherapy and hormonal therapy (tamoxifen for 3 years and letrozole in the following 3 years) for her primary cancer and developed an orbital metastasis while she was under aromatase inhibitor-based therapy...
January 8, 2019: BMC Cancer
R Tom Liu, Erika Henkelman, Oana Popescu, Vivian T Yin
Purpose: To review the clinical and histopathological features of nodular fasciitis, a rare benign periorbital tumor that mimics orbital malignancy, by presenting a case involving an infant with marked orbital wall erosion requiring repair. Observations: A 9-month-old boy developed a rapidly growing periorbital mass concerning for a soft tissue malignancy. Computerized tomography (CT) scans showed bony erosion of the lateral orbital wall. Incisional biopsy revealed nodular fasciitis...
March 2019: American Journal of Ophthalmology Case Reports
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