Liqin Liang, Shijia Li, Yuanyuan Huang, Jing Zhou, Dongsheng Xiong, Shaochuan Li, Hehua Li, Baoyuan Zhu, Xiaobo Li, Yuping Ning, Xiaohui Hou, Fengchun Wu, Kai Wu
The microbiome-gut-brain axis (MGBA) plays a critical role in schizophrenia (SZ). However, the underlying mechanisms of the interactions among the gut microbiome, brain networks, and symptom severity in SZ patients remain largely unknown. Fecal samples, structural and functional magnetic resonance imaging (MRI) data, and Positive and Negative Syndrome Scale (PANSS) scores were collected from 38 SZ patients and 38 normal controls, respectively. The data of 16S rRNA gene sequencing were used to analyze the abundance of gut microbiome and the analysis of human brain networks was applied to compute the nodal properties of 90 brain regions...
January 17, 2024: NeuroImage: Clinical