Sofie Keijzer, Nienke Oskam, Pleuni Ooijevaar-de Heer, Maurice Steenhuis, Jim B D Keijser, Luuk Wieske, Koos P J van Dam, Eileen W Stalman, Laura Y L Kummer, Laura Boekel, Taco W Kuijpers, Anja Ten Brinke, S Marieke van Ham, Filip Eftimov, Sander W Tas, Gerrit J Wolbink, Theo Rispens
BACKGROUND: Rheumatoid factors (RFs) are autoantibodies that target the Fc region of IgG, and are found in patients with rheumatic diseases as well as in the healthy population. Many studies suggest that an immune trigger may (transiently) elicit RF responses. However, discrepancies between different studies make it difficult to determine if and to which degree RF reactivity can be triggered by vaccination or infection. OBJECTIVE: We quantitatively explored longitudinal RF responses after SARS-CoV-2 vaccination and infection in a well-defined, large cohort using a dual ELISA method that differentiates between true RF reactivity and background IgM reactivity...
2024: Frontiers in Immunology