keyword
https://read.qxmd.com/read/38531708/in-hospital-outcomes-and-trends-of-patients-with-autoimmune-diseases-undergoing-percutaneous-coronary-intervention-a-nationwide-analysis
#1
JOURNAL ARTICLE
Akanimo Antia, Kessiena Aomreore, Ndausung Udongwo, Sharika Menon, Uzoma Ibebuogu
BACKGROUND: The risk of coronary artery disease is exaggerated in patients with autoimmune diseases (AID). A higher risk of complications has been reported during and after percutaneous coronary intervention (PCI) in these patients. We aimed to analyze the in-hospital outcomes and trends of patients with AID, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) undergoing PCI. METHOD: We identified all PCI procedures using the National In-patient Sample database from 2016 to 2020...
March 9, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38523562/incident-use-of-hydroxychloroquine-for-the-treatment-of-rheumatoid-arthritis-and-systemic-lupus-erythematosus-during-the-covid-19-pandemic
#2
JOURNAL ARTICLE
Núria Mercadé-Besora, Yuchen Guo, Mike Du, Xintong Li, Juan Manuel Ramírez-Anguita, Alberto Moreno, António Valente, Felipe Villalobos, Iek Leng Cheng, Lucía A Carrasco-Ribelles, Maaike Mh van Swieten, Manon Merkelbach, Mary Magoya, Paolo Lasalvia, Pau Pericàs Pulido, Paul Berg, Pauline Bosco-Lévy, Roberto Lillini, Rogerio Ribeiro, Trinamjot Kaur Bagga, Vittoria Ramella, Sara Khalid, Miguel Angel Mayer, Angela Leis, Annika M Jödicke, Edward Burn, Daniel Prieto-Alhambra, Martí Català, Albert Prats-Uribe
OBJECTIVE: We studied whether the use of hydroxychloroquine (HCQ) for COVID-19 resulted in supply shortages for patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). METHODS: We used US claims data (IQVIA PHARMETRICS® Plus for Academics [PHARMETRICS]) and hospital electronic records from Spain (IMASIS) to estimate monthly rates of HCQ use between January 2019 and March 2022, in the general population, and in RA and SLE patients. Methotrexate (MTX) was use was estimated as a control...
March 25, 2024: Arthritis Care & Research
https://read.qxmd.com/read/38519107/medication-utilisation-trends-during-pregnancy-and-factors-influencing-adverse-pregnancy-outcomes-in-patients-with-rheumatoid-arthritis
#3
JOURNAL ARTICLE
Yeo-Jin Song, Soo-Kyung Cho, Yu-Seon Jung, Sun-Young Jung, Jihyun Keum, Eunwoo Nam, Yoon-Kyoung Sung, Dae Hyun Yoo
OBJECTIVES: We aimed to investigate medication utilisation trends during pregnancy and identify factors associated with adverse pregnancy outcomes (APOs) in patients with rheumatoid arthritis (RA). METHODS: Female patients with RA aged 20-50 years were identified from the Korean national health insurance database between 2010 and 2020. Pregnancy episodes were divided into two groups according to pregnancy outcome: the delivery group and the APO group (abortion and stillbirth)...
March 22, 2024: RMD Open
https://read.qxmd.com/read/38505738/trends-in-systemic-glucocorticoid-utilization-in-the-united-kingdom-from-1990-to-2019-a-population-based-serial-cross-sectional-analysis
#4
JOURNAL ARTICLE
Andrew N Menzies-Gow, Trung N Tran, Brooklyn Stanley, Victoria Ann Carter, Josef S Smolen, Arnaud Bourdin, J Mark Fitzgerald, Tim Raine, Jatin Chapaneri, Benjamin Emmanuel, David J Jackson, David B Price
PURPOSE: Associations between systemic glucocorticoid (SGC) exposure and risk for adverse outcomes have spurred a move toward steroid-sparing treatment strategies. Real-world changes in SGC exposure over time, after the introduction of steroid-sparing treatment strategies, reveal areas of successful risk mitigation as well as unmet needs. PATIENTS AND METHODS: A population-based ecological study was performed from the Optimum Patient Care Research Database to describe SGC prescribing trends of steroid-sparing treatment strategies in primary care practices before and after licensure of biologics in the United Kingdom from 1990 to 2019...
2024: Pragmatic and Observational Research
https://read.qxmd.com/read/38498141/efficacy-and-safety-of-risankizumab-for-active-psoriatic-arthritis-100-week-results-from-the-phase%C3%A2-3-keepsake%C3%A2-1-randomized-clinical-trial
#5
JOURNAL ARTICLE
Lars Erik Kristensen, Mauro Keiserman, Kim Papp, Leslie McCasland, Douglas White, Kyle Carter, Ralph Lippe, Huzefa Photowala, Leonidas Drogaris, Ahmed M Soliman, Michael Chen, Byron Padilla, Frank Behrens
INTRODUCTION: Patients with psoriatic arthritis (PsA) require treatment providing durable long-term efficacy in different disease domains as well as safety. We present 100-week efficacy and safety results of risankizumab in patients with active PsA and previous inadequate response/intolerance to ≥ 1 conventional synthetic disease-modifying antirheumatic drug (csDMARD-IR). METHODS: KEEPsAKE 1 (NCT03675308) is a global phase 3 study, including a 24-week, double-blind, placebo-controlled and ongoing open-label extension periods...
March 18, 2024: Rheumatology and Therapy
https://read.qxmd.com/read/38495893/associations-of-perchlorate-nitrate-and-thiocyanate-exposure-with-arthritis-and-inflammation-indicators-in-young-and-middle-aged-adults-nhanes-2005-2016
#6
JOURNAL ARTICLE
Hui Zhao, Xuyang Chen, Jianping Ni, Lanlan Fang, Yuting Chen, Yubo Ma, Guoqi Cai, Faming Pan
BACKGROUND: Perchlorates, nitrates, and thiocyanates are prevalent environmental chemicals. Their potential association with arthritis remains unexplored. This study aimed to investigate the link between perchlorate, nitrate, and thiocyanate exposure and arthritis, as well as the potential role of inflammation in this context. METHODS: Utilizing the National Health and Nutrition Examination Survey (NHANES) data spanning from 2005 to 2016, the study enrolled 6597 participants aged 20-59 (young and middle-aged), of which 1045 had arthritis...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38489323/potential-efficacy-of-t-and-b-lymphocyte-targeted-therapies-on-articular-involvement-of-patients-with-rheumatoid-arthritis-and-systemic-sclerosis-overlap-syndrome-results-from-a-2-centre-series-of-22-cases
#7
JOURNAL ARTICLE
Nans Lebel, Isabelle Marie, Julien Grosjean, Pauline Brevet, Mathilde Leclercq, Anaël Dumont, Hervé Levesque, Ygal Benhamou, Christian Marcelli, Thierry Lequerre, Olivier Vittecoq
OBJECTIVES: To analyse in routine practice the efficacy of targeted therapies on joint involvement of patients with rheumatoid arthritis/systemic sclerosis (RA/SSc) overlap syndrome. METHODS: This was a retrospective analysis of medical records of two academic centres over a 10-year period. Joint response to targeted therapies was measured according to EULAR criteria based on Disease Activity Score (DAS)-28. In addition, changes in CRP level and glucocorticoid consumption were recorded...
March 13, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38487524/longitudinal-rheumatoid-factor-autoantibody-responses-after-sars-cov-2-vaccination-or-infection
#8
JOURNAL ARTICLE
Sofie Keijzer, Nienke Oskam, Pleuni Ooijevaar-de Heer, Maurice Steenhuis, Jim B D Keijser, Luuk Wieske, Koos P J van Dam, Eileen W Stalman, Laura Y L Kummer, Laura Boekel, Taco W Kuijpers, Anja Ten Brinke, S Marieke van Ham, Filip Eftimov, Sander W Tas, Gerrit J Wolbink, Theo Rispens
BACKGROUND: Rheumatoid factors (RFs) are autoantibodies that target the Fc region of IgG, and are found in patients with rheumatic diseases as well as in the healthy population. Many studies suggest that an immune trigger may (transiently) elicit RF responses. However, discrepancies between different studies make it difficult to determine if and to which degree RF reactivity can be triggered by vaccination or infection. OBJECTIVE: We quantitatively explored longitudinal RF responses after SARS-CoV-2 vaccination and infection in a well-defined, large cohort using a dual ELISA method that differentiates between true RF reactivity and background IgM reactivity...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38444043/methotrexate-treatment-strategies-for-rheumatoid-arthritis-a-scoping-review-on-doses-and-administration-routes
#9
JOURNAL ARTICLE
Esteban Rubio-Romero, César Díaz-Torné, María José Moreno-Martínez, Julen De-Luz
BACKGROUND: To describe the evidence of methotrexate (MTX) initiation strategies in patients with rheumatoid arthritis (RA) and, in the case of non-responders, analyse the efficacy and safety of route and dose optimisation. METHODS: We conducted a comprehensive scoping review of randomised controlled trials according to PRISMA Scoping Reviews Checklist and the framework proposed by Arksey and O'Malley. PubMed, EMBASE, and Cochrane were searched without language restriction, and hand searches of relevant articles were examined...
March 5, 2024: BMC rheumatology
https://read.qxmd.com/read/38440072/autoimmune-findings-in-patients-with-silicosis-in-spain
#10
JOURNAL ARTICLE
Coral González Fernández, Jose Antonio Ros Lucas, Maria Molina Molina, Juan Rigual Bobillo, Rogelio Alejandro García Montenegro, Raquel Fernández González, Ana Jaureguiza Oriol, Jose Abal Arca
BACKGROUND: Occupational exposure to silica is related to autoimmune diseases and features of autoimmunity, mainly autoantibodies. The study objectives were to estimate the prevalence of silicosis with associated autoimmune findings or diagnosed autoimmune diseases in Spain, and to assess the clinical and functional characteristics of affected patients. METHODS: This is a multicentre prospective study in patients diagnosed with silicosis. Autoantibodies analysed were antinuclear antibodies, isotypes IgA, IgM and IgG, rheumatoid factor, anticyclic citrullinated peptide, anti-Scl70, anti-Ro, and anti-LA...
2024: Drugs in Context
https://read.qxmd.com/read/38427130/rheumatoid-arthritis-and-cardiovascular-complications-during-delivery-a-united-states-inpatient-analysis
#11
JOURNAL ARTICLE
Salman Zahid, Mohamed S Mohamed, Aardra Rajendran, Anum S Minhas, Muhammad Zia Khan, Noreen T Nazir, Anthony J Ocon, Brittany N Weber, Ijeoma Isiadinso, Erin D Michos
BACKGROUND AND AIMS: Persons with rheumatoid arthritis (RA) have an increased risk of obstetric-associated complications, as well as long-term cardiovascular (CV) risk. Hence, the aim was to evaluate the association of RA with acute CV complications during delivery admissions. METHODS: Data from the National Inpatient Sample (2004-2019) were queried utilizing ICD-9 or ICD-10 codes to identify delivery hospitalizations and a diagnosis of RA. RESULTS: A total of 12 789 722 delivery hospitalizations were identified, of which 0...
March 1, 2024: European Heart Journal
https://read.qxmd.com/read/38421486/p2x7-receptors-a-bibliometric-review-from-2002-to-2023
#12
REVIEW
Haiting Tang, Wei Wei, Yu Luo, Xiaoqing Lu, Jun Chen, Shenqiao Yang, Fei Wu, Haiyan Zhou, Wenbin Ma, Xin Yang
For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A comprehensive, systematic, and objective evaluation of the scientific output and status of P2X7R will be instrumental in guiding future research directions. This study aims to present the status and trends of P2X7R research from 2002 to 2023. Publications related to P2X7R were retrieved from the Web of Science Core Collection database. Quantitative analysis and visualization tools were Microsoft Excel, VOSviewer, and CiteSpace software...
February 29, 2024: Purinergic Signalling
https://read.qxmd.com/read/38420362/retinal-microvascular-alterations-in-patients-with-active-rheumatoid-arthritis-without-cardiovascular-risk-factors-the-potential-effects-of-t-cell-co-stimulation-blockade
#13
JOURNAL ARTICLE
Silvia Piantoni, Francesca Regola, Fabrizio Angeli, Alessia Caproli, Annalisa Trovati, Cesare Tomasi, Giulia Chiarini, Claudia Rossini, Claudia Agabiti Rosei, Carolina De Ciuceis, Franco Franceschini, Maria Lorenza Muiesan, Damiano Rizzoni, Paolo Airò
BACKGROUND: The evaluation of microvascular alterations might provide clinically useful information for patients with an increased cardiovascular (CV) risk, such as those with rheumatoid arthritis (RA), being the small artery remodeling the earliest form of target organ damage in primary CV diseases, such as arterial hypertension. The evaluation of retinal arterioles is a non-invasive technique aimed to identify an early microvascular damage, represented by the increase of the wall-to-lumen ratio (WLR) index...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38411210/updates-on-interstitial-lung-disease-and-other-selected-extra-articular-manifestations-of-rheumatoid-arthritis
#14
JOURNAL ARTICLE
Elena Myasoedova, Eric L Matteson
PURPOSE OF REVIEW: To discuss changes in epidemiology, recent advances in understanding of the pathogenesis and management of selected extraarticular manifestations of rheumatoid arthritis (ExRA). RECENT FINDINGS: The incidence of ExRA overall and subcutaneous rheumatoid nodules in particular is declining after 2000. These trends reflect improved RA disease activity with early effective immunosuppressive treatments; changing environmental risk factors can be contributing...
February 26, 2024: Current Opinion in Rheumatology
https://read.qxmd.com/read/38370992/assessment-of-covid-19-morbidity-and-mortality-among-patients-with-autoimmune-diseases-at-king-abdulaziz-university-hospital
#15
JOURNAL ARTICLE
Abdullah Altuwairqi, Abdulah H Ali, Abdulaziz A Alariefy, Sami Bahlas, Samer K AlZahrani, Essam W Zarei, Adnan E Alshaikh, Ahmed H Khan, Abdullah A Attar
Background The coronavirus disease 2019 (COVID-19) pandemic has raised significant concerns about the effects of the virus on patients with autoimmune diseases. Therefore, understanding the COVID-19 outcomes in this population is crucial for effective prevention and management. Objective This study aimed to investigate the association between autoimmune diseases and the severity of COVID-19 in terms of mortality and morbidity. Despite substantial advancements in pandemic-related research concerning COVID-19 and autoimmune diseases, there remain noteworthy gaps in our comprehension of this association, particularly due to limited investigations conducted in Saudi Arabia...
January 2024: Curēus
https://read.qxmd.com/read/38368583/disease-modifying-medications-in-patients-with-rheumatoid-arthritis-in-the-usa-trends-from-2016-to-2021
#16
JOURNAL ARTICLE
Samuel K Peasah, Elizabeth C S Swart, Yan Huang, Sandra L Kane-Gill, Amy L Seybert, Urvashi Patel, Chronis Manolis, Chester B Good
BACKGROUND: Disease-modifying anti-rheumatic drugs (DMARDs), since their introduction in 1990, have revolutionized the management of rheumatoid arthritis. Newer DMARDs have recently been approved, influencing treatment patterns and clinical guidelines. OBJECTIVE: To update the current prescribing patterns of DMARDs in the pharmacotherapy of rheumatoid arthritis (RA) to include the pandemic era. METHODS: This was a retrospective cross-sectional multi-year study...
February 18, 2024: Drugs—Real World Outcomes
https://read.qxmd.com/read/38358097/population-based-epidemiological-projections-of-rheumatoid-arthritis-in-germany-until-2040
#17
JOURNAL ARTICLE
J Wang, S Vordenbäumen, M Schneider, R Brinks
OBJECTIVES: Our aim was to conduct a population-based projection to estimate the number of rheumatoid arthritis (RA) cases in Germany until 2040. METHOD: Data obtained from a report published in 2017 (doi:10.20364/VA-17.08) were used for future prediction analysis. The data were originally collected by the German Central Institute for Statutory Health Insurance. We used the illness-death model to estimate future numbers of RA cases, considering nine possible scenarios based on different incidence and mortality rates...
February 15, 2024: Scandinavian Journal of Rheumatology
https://read.qxmd.com/read/38355391/metabolic-dysregulation-of-lymphocytes-in-autoimmune-diseases
#18
REVIEW
Shuyi Wang, Niansheng Yang, Hui Zhang
Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic reprogramming determines the autoreactive and proinflammatory nature of lymphocytes in SLE and RA, unraveling molecular mechanisms and providing therapeutic targets for human autoimmune diseases...
February 13, 2024: Trends in Endocrinology and Metabolism: TEM
https://read.qxmd.com/read/38343412/managing-disease-modifying-antirheumatic-drugs-dmards-for-patients-undergoing-elective-spine-surgery-a-pilot-survey
#19
JOURNAL ARTICLE
James C Mamaril-Davis, Pedro Aguilar-Salinas, Salvador Fabián Gutiérrez Aguirre, Mauricio J Avila, Michel Villatoro-Villar, Katherine Riordan, Travis M Dumont
INTRODUCTION: Patients affected by autoimmune pathologies such as rheumatoid arthritis require surgery for various reasons. However, the systemic inflammatory nature of these disease processes often necessitates therapy with disease-modifying antirheumatic drugs (DMARDs). Alteration of these agents in the perioperative period for surgery requires a careful risk-benefit analysis to limit disease flares, infection rates, and secondary revisions. We therefore queried North and South American practices for perioperative management of DMARDs in patients undergoing elective spine surgery...
January 27, 2024: Spine surgery and related research
https://read.qxmd.com/read/38320350/identification-of-serum-exosomal-mirna-biomarkers-for-diagnosis-of-rheumatoid-arthritis
#20
JOURNAL ARTICLE
Jianmin Gong, Xiaoshan Zhang, Adeel Khan, Jun Liang, Tao Xiong, Ping Yang, Zhiyang Li
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation-induced joint damage, which can cause lasting disability. Therefore, early diagnosis and treatment of RA are crucial. Herein, we evaluated whether exosomal microRNAs (miRNAs) could be served as promising biomarkers that can accelerate the diagnosis of RA and development of therapies for RA. METHODS: First, we performed small RNA sequencing to determine the miRNA profiles of serum exosomes within a screening cohort comprised of 18 untreated active RA patients, along with 18 age and gender-matched healthy controls (HCs)...
February 5, 2024: International Immunopharmacology
keyword
keyword
159168
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.