Eliseu A Münchow, Adriana F da Silva, Evandro Piva, Carlos E Cuevas-Suárez, Maria T P de Albuquerque, Rodolfo Pinal, Richard L Gregory, Lorenzo Breschi, Marco C Bottino
Despite all the advances in adhesive dentistry, dental bonds are still fragile due to degradation events that start during application of adhesive agents and the inherent hydrolysis of resin-dentin bonds. Here, we combined two outstanding processing methods (electrospinning and cryomilling) to obtain bioactive (antimicrobial and anti-metalloproteinase) fiber-based fillers containing a potent matrix metalloproteinase (MMP) inhibitor (doxycycline, DOX). Poly(ε)caprolactone solutions containing different DOX amounts (0, 5, 25, and 50 wt%) were processed via electrospinning, resulting in non-toxic submicron fibers with antimicrobial activity against Streptococcus mutans and Lactobacillus...
December 21, 2020: Journal of Materials Chemistry. B, Materials for Biology and Medicine