keyword
https://read.qxmd.com/read/38536769/reversible-c%C3%A2-n-bond-formation-controls-charge-separation-in-an-aza-diarylethene-photoswitch
#1
JOURNAL ARTICLE
Maximilian Sacherer, Sofia Gracheva, Harald Maid, Christian Placht, Frank Hampel, Henry Dube
Diarylethenes belong to the most eminent photoswitches and have been studied for many decades. They are found in virtually every field of application and have become highly valuable molecular tools for instilling light-responsiveness into materials, catalysts, biological systems, or pharmacology. In this work, we present a novel and distinct type of pyrimidine-based aza-diarylethene, which undergoes a highly unusual zwitterion-forming photoreaction. During this fully reversible process, a CN double bond is established under concomitant aromatization and thiophene-ring opening...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38536552/il-6-enhances-the-activation-of-pi3k-akt-mtor-gsk-3%C3%AE-by-upregulating-grpr-in-hippocampal-neurons-of-autistic-mice
#2
JOURNAL ARTICLE
Heli Li, Xinyuan Wang, Cong Hu, Jinru Cui, Hao Li, Xiaoping Luo, Yan Hao
Autism spectrum disorder (ASD) is a neurological disorder associated with brain inflammation. The underlying mechanisms could be attributed to the activation of PI3K signaling in the inflamed brain of ASD. Multiple studies highlight the role of GRPR in regulating ASD like abnormal behavior and enhancing the PI3K signaling. However, the molecular mechanism by which GRPR regulates PI3K signaling in neurons of individuals with ASD is still unclear. In this study, we utilized a maternal immune activation model to investigate the effects of GRPR on PI3K signaling in the inflamed brain of ASD mice...
March 27, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/38536191/-recommendations-for-the-diagnostic-and-therapy-of-behavioural-and-psychological-symptoms-of-dementia-bpsd
#3
JOURNAL ARTICLE
Egemen Savaskan, Dan Georgescu, Stefanie Becker, Brigitte Benkert, Andreas Blessing, Markus Bürge, Ansgar Felbecker, Martin Hatzinger, Ulrich Michael Hemmeter, Therese Hirsbrunner, Stefan Klöppel, Gabriela Latour Erlinger, Finn Jacob Lornsen, Theofanis Ngamsri, Jessica Peter, Mathias Schlögl, Marc Sollberger, Henk Verloo, Samuel Vögeli, Franziska Zúñiga
The «Recommendations for the Diagnosis and Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD)» were developed in parallel with the Swiss National Dementia Strategy 2014-2019 under the auspices of the Swiss Society for Geriatric Psychiatry and Psychotherapy (SGAP) and mark the beginning of a series of recommendations for geriatric psychiatric disorders. They depict the evidence-based state of knowledge about diagnostics and therapy, based on the clinical experience of the experts, and are designed for interprofessional and interdisciplinary use...
February 2024: Praxis
https://read.qxmd.com/read/38535456/jasmonates-and-ethylene-shape-floridoside-synthesis-during-carposporogenesis-in-the-red-seaweed-grateloupia-imbricata
#4
JOURNAL ARTICLE
Pilar Garcia-Jimenez, Diana Del Rosario-Santana, Rafael R Robaina
Floridoside is a galactosyl-glycerol compound that acts to supply UDP-galactose and functions as an organic osmolyte in response to salinity in Rhodophyta. Significantly, the UDP-galactose pool is shared for sulfated cell wall galactan synthesis, and, in turn, affected by thallus development alongside carposporogenesis induced by volatile growth regulators, such as ethylene and methyl jasmonate, in the red seaweed Grateloupia imbricata . In this study, we monitored changes in the floridoside reservoir through gene expression controlling both the galactose pool and glyceride pool under different reproductive stages of G...
February 28, 2024: Marine Drugs
https://read.qxmd.com/read/38535452/synthesis-and-hypoglycemic-effect-of-insulin-from-the-venom-of-sea-anemone-exaiptasia-diaphana
#5
JOURNAL ARTICLE
Qiqi Guo, Tianle Tang, Jingyue Lu, Meiling Huang, Junqing Zhang, Linlin Ma, Bingmiao Gao
Sea anemone venom, abundant in protein and peptide toxins, serves primarily for predatory defense and competition. This study delves into the insulin-like peptides (ILPs) present in sea anemones, particularly focusing on their role in potentially inducing hypoglycemic shock in prey. We identified five distinct ILPs in Exaiptasia diaphana , exhibiting varied sequences. Among these, ILP-Ap04 was successfully synthesized using solid phase peptide synthesis (SPPS) to evaluate its hypoglycemic activity. When tested in zebrafish, ILP-Ap04 significantly reduced blood glucose levels in a model of diabetes induced by streptozotocin (STZ) and glucose, concurrently affecting the normal locomotor behavior of zebrafish larvae...
February 27, 2024: Marine Drugs
https://read.qxmd.com/read/38535273/anti-inflammatory-antipyretic-and-analgesic-potential-of-chitin-and-chitosan-derived-from-cockroaches-periplaneta-americana-and-termites
#6
JOURNAL ARTICLE
Khushbakht Asad, Sumaira Shams, Eliana Ibáñez-Arancibia, Patricio R De Los Ríos-Escalante, Farhad Badshah, Farooq Ahmad, Muhammad Salman Khan, Asar Khan
The chitin and chitosan biopolymers are extremely valuable because of their numerous industrial and pharmacological uses. Chitin and chitosan were extracted from the exoskeleton of Periplaneta americana (cockroaches) and termites using various acid and alkali techniques. The extraction process involves an initial demineralization step, during which integument dry powder was subjected to 500 mL (2.07 mol/L) of concentrated HCl at 100 degrees Celsius for 30 min, followed by meticulous rinsing with distilled water to restore the pH to its baseline...
March 21, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38533868/case-study-of-invalid-to-valid-shift-in-cognitive-performance-following-successful-treatment-of-psychogenic-nonepileptic-seizure-events
#7
JOURNAL ARTICLE
Daniel L Drane, Kelsey C Hewitt, Michele E Price, Beth K Rush, Karen Blackmon, Noah Okada, Taylor Shade, Edward Valentin, Joseph Vinson, Phyllis Rosen, David W Loring
Patients with psychogenic nonepileptic seizure (PNES) who fail performance validity testing (PVT) may appear to produce non-valid cognitive profiles. Consequently, they may not get referred to treatment and events persist, with worsening disability and high resource utilization. As a result, we report pre- and post-treatment neuropsychological evaluation findings in a 59-year-old woman with a confirmed diagnosis of PNES established using video-EEG monitoring. At pre-treatment baseline neuropsychological evaluation, PNES events occurred weekly to daily...
March 27, 2024: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/38533688/-in-vitro-evaluation-of-physicochemical-dependent-effects-of-polymeric-nanoparticles-on-their-cellular-uptake-and-co-localization-using-pulmonary-calu-3-cell-lines
#8
JOURNAL ARTICLE
Nashwa Osman, Paul Curley, Helen Box, Neill Liptrott, Darren Sexton, Imran Saleem
OBJECTIVE: The study evaluated physicochemical properties of eight different polymeric nanoparticles (NPs) and their interaction with lung barrier and their suitability for pulmonary drug delivery. METHODS: Eight physiochemically different NPs were fabricated from Poly lactic-co-glycolic acid (PLGA, PL) and Poly glycerol adipate-co-ω-pentadecalactone (PGA-co-PDL, PG) via emulsification-solvent evaporation. Pulmonary barrier integrity was investigated in vitro using Calu-3 under air-liquid interface...
March 27, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38533154/easing-the-burden-of-tinnitus-a-narrative-review-for-exploring-effective-pharmacological-strategies
#9
REVIEW
Seung Ho Kim, Ikhee Kim, Hantai Kim
Many individuals seek medical attention for tinnitus, desiring relief from the distress caused by the condition; however, the treatment process is far from straightforward. The most effective treatments for chronic subjective tinnitus, such as tinnitus retraining therapy (TRT) and cognitive behavioral therapy (CBT), require considerable time and efforts. As a result, many of them express a desire for alleviation through medication. While it is true that medication is not generally recommended in treatment guidelines for chronic subjective tinnitus, in specific situations such as when accompanied by symptoms of depression or anxiety-drugs like antidepressants or anxiolytics may have a meaningful impact on symptom reduction...
February 2024: Curēus
https://read.qxmd.com/read/38533079/-scutellaria-baicalensis-georgi-stems-and-leaves-flavonoids-promote-neuroregeneration-and-ameliorate-memory-loss-in-rats-through-camp-pka-creb-signaling-pathway-based-on-network-pharmacology-and-bioinformatics-analysis
#10
JOURNAL ARTICLE
Yinhui Yao, Qianqian Liu, Shengkai Ding, Yan Chen, Tangtang Song, Yazhen Shang
The aim of this study was to investigate the possible molecular mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids (SSF) in Alzheimer's disease (AD). The active ingredients of SSF and their targets were identified via network pharmacology and bioinformatics analysis. To test the successful establishment of a rat model of AD by Aβ25-35 combined with RHTGF- β 1 and AlCl3 , the Morris water maze test was used. To intervene, three different doses of SSF were administered. The model group and the control group were included among the parallel groups...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533074/hotspots-and-frontiers-in-helicobacter-pylori-biofilm-research-a-bibliometric-and-visualization-analysis-from-1998-to-2023
#11
JOURNAL ARTICLE
Jinyun Wang, Yang Hu, Yong Xie
BACKGROUND: Helicobacter pylori ( H. pylori ) biofilm formation is a key factor in refractory H. pylori infection. The aim of this study was to understand research trends in H. pylori biofilms. METHODS: The Web of Science Core Collection database was used to retrieve publications published from 1998 to 2023. Different kinds of software, EXCEL, an online bibliometric analysis platform, and the VOS viewer were used to evaluate and visualize the bibliometric data. RESULTS: In total, 184 publications were identified, and the number of publications increased annually...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533054/utilizing-network-pharmacology-and-experimental-validation-to-investigate-the-underlying-mechanism-of-denglao-qingguan-decoction-against-hcov-229e
#12
JOURNAL ARTICLE
Yajing Xue, Xuejun Cai, Yutao Wang, Li Ban, Manxue Mei, Shuqi Chen, Qihua Xu, Boqian Chen, Shuhua Liang, Xinhua Wang
BACKGROUND: Denglao Qingguan decoction (DLQGD) has been extensively utilized for the treatment of colds, demonstrating significant therapeutic efficacy. Human Coronavirus 229E (HCoV-229E) is considered a crucial etiological agent of influenza. However, the specific impact and underlying mechanisms of DLQGD on HCoV-229E remain poorly understood. METHODS: Active ingredients and targets information of DLQGD were collected from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), literature search, and Swiss ADEM database...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533036/clinical-effects-and-mechanisms-of-a-chinese-patent-medicine-tongxinluo-capsule-as-an-adjuvant-treatment-in-coronary-heart-disease
#13
REVIEW
Jing Wang, Tian Li Li, Pei Fen Chang, Yu Qian Gao, Jia Sai Fan, Chen Hao Zhang, Hai Yan Zhu
Coronary heart disease (CHD) is the leading cause of death globally, posing a serious threat to human health. However, the current treatment approaches available for CHD fall short of the ideal results. Tongxinluo (TXL) is a traditional Chinese medicine (TCM) that has been employed in the clinical treatment of cardiovascular and cerebrovascular diseases (such as angina pectoris, stroke, etc.) in China for many years and holds great potential as a prospective treatment. TXL either as a standalone treatment or in combination with interventions recommended in CHD guidelines has been shown to be effective and well tolerated in clinical trials for CHD...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533033/elucidating-the-anti-cancer-potential-of-cinnamomum-tamala-essential-oil-against-non-small-cell-lung-cancer-a-multifaceted-approach-involving-gc-ms-profiling-network-pharmacology-and-molecular-dynamics-simulations
#14
JOURNAL ARTICLE
Debajani Mohanty, Sucheesmita Padhee, Arpita Priyadarshini, Bibhuti Bhusan Champati, Prabhat Kumar Das, Sudipta Jena, Ambika Sahoo, Pratap Chandra Panda, Sanghamitra Nayak, Asit Ray
Cinnamomum tamala (Buch.-Ham.) T.Nees & Eberm., or Indian Bay Leaf, is a well-known traditional ayurvedic medicine used to treat various ailments. However, the molecular mechanism of action of Cinnamomum tamala essential oil (CTEO) against non-small cell lung cancer (NSCLC) remains elusive. The present study aims to decipher the molecular targets and mechanism of CTEO in treating NSCLC. GC-MS analysis detected 49 constituents; 44 successfully passed the drug-likeness screening and were identified as active compounds...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532902/anxiety-and-school-avoidance-in-an-8-year-old-child-with-epilepsy
#15
JOURNAL ARTICLE
Jay Salpekar, D Dilara Ertenu
Anxiety is ubiquitous in school age children. Co-occurring medical illness adds to the complexity of identifying pathologic anxiety as opposed to that of typical development such as with social interactions or academic pressures. Anxiety may also occur in the context of cognitive difficulties or inattention, both of which may be exacerbated by epilepsy or by anti-seizure medicines themselves. Treatment strategies may require patience and long-term observations to account for the typical range of stressors that may be expected with disease progression or with development through childhood...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38532901/a-6-year-old-with-childhood-absence-epilepsy-and-motor-hyperactivity
#16
JOURNAL ARTICLE
Stéphane Auvin
A case study of a child with childhood absence epilepsy and hyperactivity introduces the discussion around the psychiatric diagnosis, differential considerations, and pharmacologic treatment options for ADHD/hyperactivity in children with epilepsy. Most of the time, ADHD in children with epilepsy is an inattentive form. The assessment emphasizes the need to differentiate ADHD symptoms from other psychiatric comorbidities. This is also crucial to evaluate when symptoms emerged, their impact on daily life, and if it could be a potential medication side effect...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38532354/the-impact-of-depressive-and-anxious-symptoms-on-non-suicidal-self-injury-behavior-in-adolescents-a-network-analysis
#17
JOURNAL ARTICLE
Muzhen Guan, Junchang Liu, Xinhong Li, Min Cai, Jing Bi, Ping Zhou, Zhongheng Wang, Songwen Wu, Li Guo, Huaning Wang
PURPOSE: Conceptualizing adolescent NSSI and emotional symptoms as a system of causal elements could provide valuable insights into the development of non-suicidal self-injury (NSSI) in adolescent. This study aimed to explore the intricate relationship between NSSI, depressive symptoms, and anxious symptoms in adolescents, identifying key symptoms to establish a theoretical foundation for targeted and effective interventions addressing NSSI behaviors in this population. METHODS: A total of 412 adolescents with NSSI behaviors were selected from outpatients...
March 26, 2024: BMC Psychiatry
https://read.qxmd.com/read/38530678/the-similarities-and-differences-of-nurse-postoperative-patient-dyads-attitudes-social-norms-and-behaviors-regarding-pain-and-pain-management
#18
JOURNAL ARTICLE
Nur Pinar Ayaz, Deborah Witt Sherman
PURPOSE: Pain is an expected symptom in surgical patients, despite advances in pharmacology, surgical procedures, and perioperative care. The aim of this study was to examine the similarities and differences between nurse-postoperative patient dyads of the same or differing cultures/ethnicities with regard to perceptions, social norms, and behaviors related to pain and pain management. DESIGN: This was a descriptive qualitative study. METHODS: The sample consisted of six nurses (2 Hispanic, 2 Black, 2 Caucasian) and 12 patients of the same and different culture/ethnicity than their nurse) on a postoperative unit within 48 hours of surgery...
March 26, 2024: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://read.qxmd.com/read/38529861/-identifying-the-neurostimulation-target-for-treatment-of-cognitive-impairment-in-aging-and-early-cerebral-small-vessel-disease
#19
JOURNAL ARTICLE
L A Dobrynina, Z Sh Gadzhieva, O R Dobrushina, S N Morozova, E I Kremneva, A V Volik, M V Krotenkova
OBJECTIVE: To develop individualized approaches to the use of neuromodulation as a non-pharmacological treatment of cognitive impairment (CI) based on the assessment of compensatory brain reserves in functional MRI (fMRI). MATERIAL AND METHODS: Twenty-one adults over 45 years of age, representing a continuum from healthy norm to mild cognitive impairment due to aging and early cerebral small vessel disease, were studied. All participants underwent fMRI while performing two executive tasks - a modified Stroop task and selective counting...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529191/antibacterial-activity-of-cinnamon-essential-oil-and-its-main-component-of-cinnamaldehyde-and-the-underlying-mechanism
#20
JOURNAL ARTICLE
Chengjie Shu, Ling Ge, Zhuohang Li, Bin Chen, Shengliang Liao, Lu Lu, Qinlin Wu, Xinyi Jiang, Yuhan An, Zongde Wang, Man Qu
Background: Plant essential oils have long been regarded as repositories of antimicrobial agents. In recent years, they have emerged as potential alternatives or supplements to antimicrobial drugs. Although literature reviews and previous studies have indicated that cinnamon essential oil (CIEO) and its major component, cinnamaldehyde (CID), possess potent antibacterial activities, their antibacterial mechanisms, especially the in vivo antibacterial mechanisms, remain elusive. Methods: In this study, we utilized the in vivo assessment system of Caenorhabditis elegans ( C...
2024: Frontiers in Pharmacology
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