Jian Yu, Wen Li, Guo-Jun Hou, Da-Peng Sun, Yuan Yang, Sheng-Xian Yuan, Zhi-Hui Dai, Hao-Zan Yin, Shu-Han Sun, Gang Huang, Wei-Ping Zhou, Fu Yang
Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further investigation. In this study, we found that cFAM210A (a circular RNA derived from the third exon of transcript NM_001098801 of the FAM210A gene; CircBase ID: hsa_circ_0003979) can be silenced by HBx. cFAM210A expression was downregulated and negatively correlated with tumorigenesis in patients with HBV-related HCC. Furthermore, cFAM210A reduced the proliferation, stemness, and tumorigenicity of HCC cells...
November 1, 2023: Experimental & Molecular Medicine