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Lyme Or Borrelia

Salima Gasmi, Nicholas H Ogden, Marion Ripoche, Patrick A Leighton, Robbin L Lindsay, Mark P Nelder, Erin Rees, Catherine Bouchard, Linda Vrbova, Richard Rusk, Curtis Russell, Yann Pelcat, Samir Mechai, Serge-Olivier Kotchi, Jules K Koffi
Lyme disease, the most commonly reported vector-borne disease in North America, is caused by the spirochete Borrelia burgdorferi sensu stricto, which is transmitted by Ixodes scapularis in eastern Canada and Ixodes pacificus in western Canada. Recently, the northward range expansion of I. scapularis ticks, in south-eastern Canada, has resulted in a dramatic increase in the incidence of human Lyme disease. Detecting emerging areas of Lyme disease risk allows public health to target disease prevention efforts...
2019: PloS One
V Cicculli, L Capai, Y Quilichini, S Masse, A Fernández-Alvarez, L Minodier, P Bompard, R Charrel, A Falchi
Although livestock farming (sheep, goats, pigs, and cattle) is an important economic activity in Corsica, a French Mediterranean island, knowledge about the tick fauna and microorganisms carried by them remains scarce. This study aimed to investigate the presence and perform molecular characterization of Anaplasmataceae, Rickettsia spp., and Borrelia burgdorferi sensu lato (sl) in tick species collected in Corsica. Ticks from cattle (Bos taurus), sheep (Ovis aries), and rodents (Rattus rattus) were collected from May to September 2016...
February 13, 2019: Ticks and Tick-borne Diseases
Nina Król, Anna Obiegala, Franz Maximilian Kretschmar, Dietmar Hamel, Martin Pfeffer
The European polecat, Mustela putorius, occurs almost throughout Europe. However, there is a lack of data on the ectoparasite fauna and the potential role in the circulation of tick-borne pathogens (TBP) of this mustelid species. The aim of this study was to investigate whether M. putorius contributes to the maintenance of TBP in Germany. DNA samples extracted from spleen tissue of 117 M. putorius, which had been collected mainly in North-western Germany from 2012 to 2015, were tested by real-time and conventional PCRs for Anaplasma phagocytophilum, Babesia spp...
February 11, 2019: Ticks and Tick-borne Diseases
Laurence Geebelen, Dieter Van Cauteren, Brecht Devleesschauwer, Sarah Moreels, Katrien Tersago, Herman Van Oyen, Niko Speybroeck, Tinne Lernout
Lyme borreliosis (LB) is an important tick-borne disease which can cause a broad range of symptoms mainly affecting the skin, the nervous system and the joints. This study aims to estimate the incidence of the different clinical manifestations of LB in Belgium. The incidence of erythema migrans (EM) was estimated through the network of sentinel general practices at 97.6/100,000 inhabitants (uncertainty interval [UI] 82.0-113.0) for the period 2015-2017. This result was used to estimate the incidence of other LB manifestations based on their proportional distribution (ratios) to EM reported in the neighboring countries of Belgium...
December 28, 2018: Ticks and Tick-borne Diseases
S Ranque-Garnier, C Eldin, C Sault, D Raoult, A Donnet
Lyme disease is caused by bacteria of the B. burgdorferi sensu lato complex, and can give polymorphic clinical manifestations that can affect several organs such as the skin, the central nervous system, or the joints. In recent years, patients' associations and physicians have been supporting the hypothesis that this infection would manifest as chronic generalized musculoskeletal pain symptoms, named "chronic Lyme disease". Fibromyalgia is a clinical presentation characterized by chronic generalized musculoskeletal pain with a major impact on quality of life and social and psychological functioning...
February 11, 2019: Médecine et Maladies Infectieuses
Carole Eldin, Benoit Jaulhac, Oleg Mediannikov, Jean-Pierre Arzouni, Didier Raoult
Bacteria of the Borrelia burgdorferi sensu lato complex, responsible for Lyme disease, are members of the spirochetes phylum. Diagnostic difficulties of Lyme disease are partly due to the characteristics of spirochetes as their culture is tedious or even impossible for some of them. We performed a literature review to assess the value of the various diagnostic tests of spirochetes infections of medical interest such as Lyme borreliosis, relapsing fever borreliae, syphilis, and leptospirosis. We were able to draw similarities between these four infections...
February 11, 2019: Médecine et Maladies Infectieuses
Cynthia Yeung, Adrian Baranchuk
The incidence of Lyme disease, a tick-borne bacterial infection, is dramatically increasing in North America. The diagnosis of Lyme carditis (LC), an early disseminated manifestation of Lyme disease, has important implications for patient management and preventing further extracutaneous complications. High-degree atrioventricular block is the most common presentation of LC, and usually resolves with antibiotic therapy. A systematic approach to the diagnosis of LC in patients with high-degree atrioventricular block will facilitate the identification of this usually transient condition, thus preventing unnecessary implantation of permanent pacemakers in otherwise healthy young individuals...
February 19, 2019: Journal of the American College of Cardiology
Benoît Thomas, Sophie Poussing
A 59-year-old woman, admitted to the emergency department for a fall, had a subfebrile episode up to 38 °C without localized symptoms of infection. She had relapsed follicular lymphoma. She had not recently been administered chemotherapy nor had she travelled outside of France. Laboratory tests revealed elevated CRP (164 mg/L) without hyperleucocytosis. Her urinary strip test was negative. No stool culture was performed. After 4 days of incubation, only the aerobic blood culture was positive (BACT'ALERT), with Gram-negative spiral-shaped bacteria resembling spirochetes (A,B,C x1000)...
February 11, 2019: Clinical Microbiology and Infection
Christoph M Schempp, Franziska Schauer, Christian K Huhn, Nils Venhoff, Stephanie Finzel
Syndromes associated with concurrent skin and joint inflammation frequently pose a therapeutic challenge for both dermatologists and rheumatologists. In part 1 of this review, we discussed psoriatic arthritis as well as the autoinflammatory disorders SAPHO syndrome, Still's disease and Behçet's disease. Part 2 will address rheumatoid arthritis, reactive arthritis, Reiter's syndrome and Lyme borreliosis. In addition, we will discuss dermatomyositis and lupus erythematosus, two common autoimmune disorders that frequently present with both cutaneous and joint involvement...
February 2019: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Christoph M Schempp, Franziska Schauer, Christian K Huhn, Nils Venhoff, Stephanie Finzel
No abstract text is available yet for this article.
February 2019: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Agustín Estrada-Peña, Alejandro Cabezas-Cruz
BACKGROUND: The evolutionary history of a species is frequently derived from molecular sequences, and the resulting phylogenetic trees do not include explicit functional information. Here, we aimed to assess the functional relationships among bacteria in the Spirochaetes phylum, based on the biological processes of 42,489 proteins in reference proteomes of 34 Spirochaetes species. We tested the hypothesis that the species in the genus Borrelia might be sufficiently different to warrant splitting them into two separate genera...
February 13, 2019: BMC Evolutionary Biology
Peter Novak, Donna Felsenstein, Charlotte Mao, Nadlyne R Octavien, Nevena Zubcevik
OBJECTIVES: To examine whether post-treatment Lyme disease syndrome (PTLDS) defined by fatigue, cognitive complaints and widespread pain following the treatment of Lyme disease is associated with small fiber neuropathy (SFN) manifesting as autonomic and sensory dysfunction. METHODS: This single center, retrospective study evaluated subjects with PTLDS. Skin biopsies for assessment of epidermal nerve fiber density (ENFD), sweat gland nerve fiber density (SGNFD) and functional autonomic testing (deep breathing, Valsalva maneuver and tilt test) were performed to assess SFN, severity of dysautonomia and cerebral blood flow abnormalities...
2019: PloS One
Robert A Jordan, Andrea Egizi
As human cases of tick-borne disease continue to increase, there is a heightened imperative to collect data on human-tick encounters to inform disease prevention. Passive tick surveillance programs that encourage members of the public to submit ticks they have encountered can provide a relatively low-cost means of collecting such data. We report the results of 11 years of tick submissions (2006-2016) collected in Monmouth County, New Jersey, an Atlantic coastal county long endemic for Lyme disease. A total of 8,608 ticks acquired in 22 U...
2019: PloS One
Lenka Krbková, Kateřina Kybicová, Dušan Pícha, Hana Roháčová, Dita Smíšková
The national guideline aims to highlight the latest knowledge about clinical manifestations of the infection, to summarize the diagnostic algorithm and to recommend the appropriate antibiotic therapy with respect to evidence-based medicine. The recommendations are consistent with most European guidelines as well as those published by the IDSA. The guideline provides the most recent information on the epidemiology, etiology and pathogenesis of Lyme borreliosis, dermatological, neurological and musculoskeletal involvement, the appropriate diagnostic procedure and prevention...
September 2018: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
D Campo-Caballero, A Munoz-Lopetegi, G Fernandez-Garcia de Eulate, J Rodriguez-Antiguedad, A Gabilondo, F Gonzalez, J Villanua, A Lopez de Munain
No abstract text is available yet for this article.
February 16, 2019: Revista de Neurologia
Tanya Laudenslager, Sheila Q Hartung
Lyme disease is the most common vector-borne disease in the United States with Lyme arthritis becoming one of the most common symptoms of Lyme disease. It is imperative that school nurses become familiar with vector-borne disease and promptly consider Lyme arthritis to be contemplated as a differential diagnosis of a child presenting to the office with a limp and joint pain and swelling with no history of acute injury. The following article will discuss the overview, implications and management of Lyme arthritis in the school setting and includes a relevant IHP for school nurses to utilize in practice...
February 9, 2019: NASN School Nurse
Joseph J Modarelli, John M Tomeček, Julie Piccione, Pamela J Ferro, Maria D Esteve-Gasent
Tick-borne diseases (TBD), caused by borrelial, rickettsial, and babesial pathogens, are common across the United States and can cause severe clinical disease in susceptible hosts, such as domestic dogs. However, there are limited TBD molecular epidemiological reports for dogs in Texas, and none for the non-Lyme borrelial pathogen responsible for causing tick-borne relapsing fever (TBRF). Therefore, data to support the prevalence of TBRF in the canine population is inadequate. This study aimed to characterize the molecular prevalence of 11 causative agents responsible for three TBD groups within domestic dogs with an emphasis on pathogen distribution within Texas ecoregions...
February 10, 2019: Transboundary and Emerging Diseases
E Guedj, C Eldin, D Raoult, J M Azorin, R Belzeaux
Approximately 10% of patients presenting with Lyme disease experience fatigue, musculoskeletal pain, concentration disorders, or short-term memory deficits in the six months following treatment. This entity has been defined as post-Lyme disease syndrome or post-treatment Lyme disease syndrome. The pathophysiology of this syndrome is unknown, but neither persistence of the bacterium nor effectiveness of antibiotics are currently reported in the literature. The French High Council for Public Health (French acronym HCSP) has recently defined a new entity called "persistent polymorphic symptoms after a tick bite" allowing for designing studies to better understand these subjective presentations, for which objective biomarkers are currently lacking...
February 5, 2019: Médecine et Maladies Infectieuses
N Boulanger, P Boyer, E Talagrand-Reboul, Y Hansmann
Ticks are a major group of arthropod vectors, characterized by the diversity of pathogens they transmit, by their impact on human and animal health, and by their socioeconomic implication especially in countries of the Southern Hemisphere. In Europe, Ixodes is the most important tick due to its wide distribution in the ecosystems and the variety of transmitted pathogens, in particular Borrelia (responsible for Lyme borreliosis), but also the tick-borne encephalitis virus. Their increased presence in the environment since the beginning of the 20th century is undeniable, because of major modifications in the biodiversity caused by humans...
February 5, 2019: Médecine et Maladies Infectieuses
Sebastián Muñoz-Leal, Marcos G Lopes, Arlei Marcili, Thiago F Martins, Daniel González-Acuña, Marcelo B Labruna
Microorganisms harbored by Chilean autochthonous ticks have been scarcely studied and current knowledge is restricted to three species of hard ticks only. The current study aimed to assess the presence of Anaplasmataceae, Borrelia and Hepatozoon agents in ticks collected directly from the environment, on reptiles, birds and mammals in twelve localities from northern, central and southern regions of the country and Antarctica. Ticks were identified by means of a morphological and molecular approach. PCR detections point the occurrence of an Anaplasma-like agent and a relapsing fever Borrelia sp...
February 5, 2019: Acta Tropica
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