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Laura E Navas, Fernando D Martínez, María E Taverna, Morgan M Fetherolf, Lindsay D Eltis, Verónica Nicolau, Diana Estenoz, Eleonora Campos, Graciela B Benintende, Marcelo F Berretta
Laccases are multicopper oxidases that are being studied for their potential application in pretreatment strategies of lignocellulosic feedstocks for bioethanol production. Here, we report the expression and characterization of a predicted laccase (LAC_2.9) from the thermophilic bacterial strain Thermus sp. 2.9 and investigate its capacity to delignify lignocellulosic biomass. The purified enzyme displayed a blue color typical of laccases, showed strict copper dependence and retained 80% of its activity after 16 h at 70 °C...
February 12, 2019: AMB Express
Ilmara Cecilia Pinheiro de Silva Morais, Iris Jordânia Luz Moura, Carla Kelly Barroso Sabino, Lucas Antonio Duarte Nicolau, Fabiana de Moura Souza, José Couras da Silva-Filho, Rita de Cássia Meneses Oliveira, Jand Venes Rolim Medeiros, Sidney Gonçalo de Lima, Aldeidia Pereira de Oliveira
Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200-220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10-9 M-3 × 10-4 M) produced a concentration-dependent relaxation in aortic rings precontracted with phenylephrine (1 μM), exhibiting Emax value of 55...
February 8, 2019: Journal of Medicinal Food
Ana Paula Mendes-Silva, Patricia Tiemi Fujimura, Jéssica Regina da Costa Silva, Antonio Lucio Teixeira, Erica Marciano Vieira, Pedro Henrique Gonçalves Guedes, Lucélia Scarabeli Silva Barroso, Mariana de Souza Nicolau, Jéssica Diniz Rodrigues Ferreira, Laiss Bertola, Eduardo de Souza Nicolau, Gesiane Thamire Tolentino-Araújo, Camila Moreira Silva Ferreira Berlezzi, Tamiris Sabrina Rodrigues, Luiza Diniz Ferreira Borges, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ana Maria Bonetti, Carlos Ueira-Vieira, Breno Satler Diniz
Changes in microRNAs (miRNAs) expression have been described in major depressive disorder in young and middle-aged adults. However, no study has evaluated miRNA expression in older adults with major depression (or late-life depression [LLD]). Our primary aim was to evaluate the expression of miRNAs in subjects with LLD. We first evaluated the miRNA expression using next-generation sequencing (NGS) and then we validated the miRNAs found in NGS in an independent sample of LLD patients, using RT-qPCR. Drosophila melanogaster model was used to evaluate the impact of changes in miRNA expression on behavior...
January 23, 2019: Journal of Psychiatric Research
Lindsay M Avery, Joseph L Kuti, Maja Weisser, Adrian Egli, Michael J Rybak, Evan J Zasowski, Cesar A Arias, German A Contreras, Pearlie P Chong, Samuel L Aitken, Adam J DiPippo, Jann-Tay Wang, Nicholas S Britt, David P Nicolau
No abstract text is available yet for this article.
January 30, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Sara Kheireddine, Ayyappasamy Sudalaiyadum Perumal, Zachary J Smith, Dan V Nicolau, Sebastian Wachsmann-Hogiu
In this paper we present for the first time a system comprised of two mobile phones, one for illumination and the other for microscopy, as a portable, user-friendly, and cost-effective microscopy platform for a wide range of applications. Versatile and adaptive illumination is made with a Retina display of an Apple mobile phone device. The phone screen is used to project various illumination patterns onto the specimen being imaged, each corresponding to a different illumination mode, such as bright-field, dark-field, point illumination, Rheinberg illumination, and fluorescence microscopy...
January 30, 2019: Lab on a Chip
Bhaskara P Shelley, Prasanth Prasad, Malla M Manjunath, Shrijeet Chakraborti
A case of Nicolau syndrome (NS) in a 36-year-old adult taking an unusual and devastating hyperacute irreversible paraplegia after an intramuscular injection of benzathine penicillin as a part of routine chemoprophylaxis of her rheumatic heart disease is reported. Although this syndrome is a considerably rare, iatrogenic and underappreciated dermatologic entity, we reiterate in this report, its extracutaneous systemic potential for a catastrophic neurovascular phenomenon and morbidity as well as its possible preventive measures...
January 2019: Annals of Indian Academy of Neurology
E C Constantinescu, C Nicolau, A Săftoiu
A long-standing trend that will continue to grow in healthcare is providing high quality services for all the patient, no matter the distance and no matter the place. One approach currently being used to increase population access to healthcare services is telemedicine. This narrative review presents one branch of e-health, in particular the use of teleultrasonography (TUS) in clinical practice, the challenges and barriers encountered. Current advances in ultrasound technology, including the growth of portable and small ultrasound devices have increased the range of applications of TUS, from traumatic patients in emergency medicine, maternal ultrasound and even for monitoring and screening for chronic illnesses...
April 2018: Current Health Sciences Journal
Lavinia L Ruta, Ioana Nicolau, Claudia V Popa, Ileana C Farcasanu
Transient potential receptor (TRP) channels are conserved cation channels found in most eukaryotes, known to sense a variety of chemical, thermal or mechanical stimuli. The Saccharomyces cerevisiae TRPY1 is a TRP channel with vacuolar localization involved in the cellular response to hyperosmotic shock and oxidative stress. In this study, we found that S. cerevisiae diploid cells with heterozygous deletion in TRPY1 gene are haploinsufficient when grown in synthetic media deficient in essential metal ions and that this growth defect is alleviated by non-toxic Mn2+ surplus...
January 22, 2019: Cells
Caroline Klingebiel, Yannick Chantran, Rihane Arif-Lusson, Angelica E Ehrenberg, Jonas Östling, Alain Poisson, Valérie Liabeuf, Chantal Agabriel, Joëlle Birnbaum, Françoise Porri, Anne Sarrat, Pol-André Apoil, Mylène Vivinus, Lorna Garnier, Anca Mirela Chiriac, Davide-Paolo Caimmi, Jean-Luc Bourrain, Pascal Demoly, Stéphane Guez, Franck Boralevi, Bertrand Lovato, Céline Palussière, Sylvie Leroy, Thierry Bourrier, Lisa Giovannini-Chami, Marion Gouitaa, Agnès Aferiat-Derome, Denis Charpin, Tünde Sofalvi, Isabelle Cabon-Boudard, Yann-Patrick Massabie-Bouchat, Bernard Hofmann, Nathalie Bonardel, Mireille Dron-Gonzalvez, Benoît Sterling, Ania Carsin, Serge Vivinus, Bernard Poitevin, Laureline Nicolau, Geneviève Liautard, Christophe Soler, Soraya Mezouar, Isabella Annesi-Maesano, Jean-Louis Mège, Jonas Lidholm, Joana Vitte
BACKGROUND: Peach is a common elicitor of food allergic reactions. Peach-induced immediate reactions may occur as benign pollen-food syndromes, usually due to birch pollen related PR-10 cross-reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has has gained recent attention as a potential peach allergy severity marker. Sensitisation to Pru p 7 and its allergenic homologues of the gibberellin-related protein family occurs in areas with high Cupressaceae tree pollen exposure...
January 23, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Tomefa E Asempa, Ana Motos, Kamilia Abdelraouf, Caterina Bissantz, Claudia Zampaloni, David P Nicolau
Nacubactam is a novel broad spectrum β-lactamase inhibitor that is currently under development as combination therapy with meropenem. This study evaluated the efficacy of human-simulated epithelial lining fluid (ELF) exposures of meropenem, nacubactam, and the combination meropenem-nacubactam against class A serine carbapenemase-producing Enterobacteriaceae isolates in the neutropenic murine lung infection model. Twelve clinical meropenem-resistant Klebsiella pneumoniae, Escherichia coli , and Enterobacter cloacae isolates all harboring KPC or IMI-type β-lactamases were utilized in the study...
January 22, 2019: Antimicrobial Agents and Chemotherapy
Christina A Sutherland, Can Ozbal, David P Nicolau
Aim: We describe the validation of an HPLC-MS/MS method to analyze ceftolozane and tazobactam simultaneously in saline matrixes. Materials & methods: An Agilent 1260 HPLC interfaced to an Agilent 6470 triple-quadrupole mass spectrometer was used for quantification. A reverse-phase column running a gradient of water and acetonitrile containing 0.1% formic acid mobile phase at a flow rate of 1.0 ml/min provided chromatographic fractionation. Tazobactam15 N3 was used as the internal standard...
January 2019: Future Science OA
Jairo Herrera-Morales, Taylor A Turley, Miguel Betancourt-Ponce, Eduardo Nicolau
The prevalence of emerging organic contaminants (EOCs) in ground and surface water has sparked the search for more effective methods to remove EOCs from the environment. In pursuit of a solution for this environmental concern, herein we present the development of reusable films based on cellulose nanofibers (CNFs) and the block copolymer, poly(4-vinylpyridine-b-ethylene oxide) (P4VP-PEO) to adsorb sulfamethoxazole (SMX) as an EOC model compound. We hypothesize that the adsorption of SMX was achieved mainly by π-π interactions between the pyridine functionalities of the block copolymer and the electron deficient phenyl group of the SMX...
January 11, 2019: Materials
Abbas Jessani, Jolanta Aleksejuniene, Leeann Donnelly, J Craig Phillips, Belinda Nicolau, Mario Brondani
OBJECTIVES: To identify the predisposing, enabling, and need factors of the Andersen and Newman (A&N) model and their associations with the pattern of dental service utilization in a sample of people living with HIV (PLHIV) in British Columbia. METHODS: Participants responded anonymously to a 40-item online questionnaire to explore the patterns of dental service utilization. Following the descriptive statistics, the associations between A&N model factors and main outcome variables (having a dental visit in the last year and reasons for the dental visit) were evaluated using simple and multiple logistic regression analyses...
January 9, 2019: Journal of Public Health Dentistry
Claudie Laprise, Sreenath Arekunnath Madathil, Nicolas F Schlecht, Geneviève Castonguay, Denis Soulières, Phuc Felix Nguyen-Tan, Paul Allison, François Coutlée, Michael Hier, Marie-Claude Rousseau, Eduardo L Franco, Belinda Nicolau
BACKGROUND: This study aimed to estimate the extent to which oral sex behavior is associated with an increased risk of oropharyngeal cancers (OPCs), and how much of the association is mediated by oral human papillomavirus (HPV) infection. METHODS: We used data from a hospital-based case-control study conducted in Montreal, Canada. Information on oral sex behaviors was collected. Oral rinse and oral brush specimens were analyzed for HPV positivity and genotyping...
January 3, 2019: Head & Neck
Alexandru Eugen Nicolau, Adrian Lobonţiu
Transoral Incisionless Fundoplication (TIF) with EsophyX device for a well selected GERD patient population has proven its efficacy, safety and durability. We present a case report of a male, 63 y old, with typical and atypical GERD symptoms started 15 years ago. The esophagogastroduodenoscopy (EGD) showed a Hiatal Hernia (HH) of 3 cm and an erosive esophagitis Los Angeles Grade B. The first surgery was performed 7 years ago, in March 2009: a TIF with the EsophyX 2® device (EndoGastric Solution, Inc., Redmond, WA, United States)...
November 2018: Chirurgia
Hanjing Emily Wu, Antonio L Teixeira, Lucelia Barroso, Ana Paula Mendes Silva, Mariana de Souza Nicolau, Jéssica Diniz Rodrigues Ferreira, Laiss Bertola, Erica Marciano Vieira, Breno Satler Diniz
Epidermal growth factor (EGF) and Fibroblast Growth Factor-2 (FGF-2) are growth factors involved neuronal growth and synaptic plasticity. These markers have been implicated in neuropsychiatric disorders, including major depression. However, no particular studies of EGF and FGF-2 have been conducted in older adults with major depressive disorder (MDD). In this study, we aim to investigate the plasma levels of EGF and FGF-2 in elderly with MDD. We included 89 older adults with MDD and 51 older (healthy control, HC) adults...
December 18, 2018: Psychiatry Research
Natàlia Castrejón, Carlos Nicolau, Ana González-Cordón, Iván Archilla, Manel Solé
No abstract text is available yet for this article.
December 14, 2018: Annals of Diagnostic Pathology
Francesc X Marin-Gomez, Francesc Garcia Cuyas, Ramon Reig-Bolano, Jacobo Mendioroz, Pere Roura-Poch, Margalida Pico-Nicolau, Josep Vidal-Alaball
BACKGROUND: Several studies have been conducted to analyze the role social networks play in communication between patients and health professionals. However, there is a shortage of studies in relation to communication among primary health professionals, in a professional context, using the various mobile phone apps available. OBJECTIVE: The objective of our study was to explore mobile phone social networking app use among primary health care professionals for work-related purposes, by comparing the most widely used apps in the market...
December 21, 2018: JMIR MHealth and UHealth
Marc P Bonaca, Stephen D Wiviott, David A Morrow, P Gabriel Steg, Christian Hamm, Deepak L Bhatt, Robert F Storey, Marc Cohen, Julia Kuder, KyungAh Im, Giulia Magnani, Andrzej Budaj, José C Nicolau, Alexander Parkhomenko, José López-Sendón, Mikael Dellborg, Rafael Diaz, Frans Van de Werf, Ramón Corbalán, Assen Goudev, Eva C Jensen, Per Johanson, Eugene Braunwald, Marc S Sabatine
Background Ticagrelor reduced cardiovascular death, myocardial infarction (MI), or stroke in patients with prior MI in PEGASUS-TIMI 54 (Prevention of Cardiovascular Events [eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke] in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin). MI can occur in diverse settings and with varying severity; therefore, understanding the types and sizes of MI events prevented is of clinical importance. Methods and Results MIs were adjudicated by a blinded clinical events committee and categorized by subtype and fold elevation of peak cardiac troponin over the upper limit of normal...
November 20, 2018: Journal of the American Heart Association
Michael Yaoyao Yin, Shane Ruckel, Abdallah G Kfoury, Stephen H McKellar, Iosef Taleb, Edward M Gilbert, Jose Nativi-Nicolau, Josef Stehlik, Bruce B Reid, Antigone Koliopoulou, Gregory J Stoddard, James C Fang, Stavros G Drakos, Craig H Selzman, Omar Wever-Pinzon
BACKGROUND: Gastrointestinal bleeding (GIB) is a leading cause of morbidity during continuous-flow left ventricular assist device (CF-LVAD) support. GIB risk assessment could have important implications for candidate selection, informed consent, and postimplant therapeutic strategies. The aim of the study is to derive and validate a predictive model of GIB in CF-LVAD patients. METHODS AND RESULTS: CF-LVAD recipients at the Utah Transplantation Affiliated Hospitals program between 2004 and 2017 were included...
November 2018: Circulation. Heart Failure
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