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Alper Sen, Kadir Özdamar
OBJECTIVES: To compare the functional and anatomical success rates of the fascial versus perichondrial grafts in pediatric endoscopic type 1 tympanoplasties. METHODS: This retrospective clinical study was conducted on 40 pediatric patients (23 females and 17 males; mean age: 10.0 ± 1.7 years; the age range: 6-13) who were operated with a transcanal endoscopic type 1 tympanoplasty. The study participants were assigned to two groups by graft types. The patients were assigned to either the tragal cartilage perichondrium group (Group A) or the fascia of the temporal muscle (Group B)...
March 1, 2019: International Journal of Pediatric Otorhinolaryngology
Li Baogui, Chen Juwen
OBJECTIVE: For odontoid fractures, surgical treatment approaches including anterior odontoid screw fixation approach and the posterior C1-C2 arthrodesis approach are generally adopted in practice. However, the choice of different surgical procedures remains controversial. In addition to surgical technique, the fusion rate is an important factor contributing to the clinical efficacy. Therefore, this study was aimed to investigate the discrepancy in fusion rate between these two surgical approaches through synthesizing the currently available evidence on the topic...
March 15, 2019: Archives of Orthopaedic and Trauma Surgery
Alexandre Peixoto de Mello, Glaucus Cajaty Dos Santos Martins, André Raposo Heringer, Raphael Barbosa Gamallo, Luiz Felippe Dos Santos Martins Filho, Antônio Vítor de Abreu, Antonio Carlos Pires Carvalho, Maurício de Pinho Gama
OBJECTIVE: The objective of this research was to evaluate the prevalence of cervical and lumbar pain in obese patients eligible for bariatric surgery and to investigate possible changes in sagittal spine alignment in these patients. METHODS: The following parameters were compared in 30 obese patients and a control group of 25 non-obese volunteers: body mass index, prevalence of cervical and lumbar pain assessed by visual analog scale (VAS), Neck Disability Index [NDI] and Oswestry Disability Index [ODI], as well as radiographic parameters of the spine and pelvis measured with Surgimap software...
March 15, 2019: European Spine Journal
Christopher R Brydges, Allison A M Bielak
OBJECTIVE: Non-significant p values derived from null hypothesis significance testing do not distinguish between true null effects or cases where the data are insensitive in distinguishing the hypotheses. This study aimed to investigate the prevalence of Bayesian analyses in gerontological psychology, a statistical technique that can distinguish between conclusive and inconclusive non-significant results, by using Bayes factors (BFs) to reanalyze non-significant results from published gerontological research...
March 16, 2019: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Arjun K Manrai, John P A Ioannidis, Chirag J Patel
Massive datasets are often regarded as a panacea to the underpowered studies of the past. At the same time, it is becoming clear that in many of these datasets where thousands of variables are measured across hundreds of thousands or millions of individuals, almost any desired relationship can be inferred with a suitable combination of covariates or analytic choices. Inspired by the Genome-Wide Association Study (GWAS) analysis paradigm that has transformed human genetics, "X-Wide Association Studies" or "XWASs" have emerged as a popular approach to systematically analyze non-genetic datasets and guard against false positives...
March 16, 2019: American Journal of Epidemiology
Wouter Broos, Maurits Wondergem, Friso van der Zant, Remco Knol
18 F-fluorocholine (FCH) PET/CT is a promising and increasingly used scan technique in preoperative imaging of parathyroid adenoma. Several acquisition methods have been evaluated in literature but the optimal image acquisition time point after administration of the tracer is still under debate. Methods: Patients with hyperparathyroidism, who received a dual-time-point FCH PET/CT (image acquisition 5 min and 60 min post injection) with histologically proven pathological parathyroid glands were retrospectively included in the study...
March 15, 2019: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Gustavo de Los Campos, Daniel Alberto Sorensen, Miguel Angel Toro
The genetic architecture of complex human traits and diseases is affected by large number of possibly interacting genes, but detecting epistatic interactions can be challenging. In the last decade, several studies have alluded to problems that linkage disequilibrium can create when testing for epistatic interactions between DNA markers. However, these problems have not been formalized nor have their consequences been quantified in a precise manner. Here we use a conceptually simple three locus model involving a causal locus and two markers to show that imperfect LD can generate the illusion of epistasis, even when the underlying genetic architecture is purely additive...
March 15, 2019: G3: Genes—Genomes—Genetics
Sheng Zhang, Xin Zhang, Ying Ling, Aiming Li
OBJECTIVE: To develop and validate a risk scoring model for predicting recurrent hypertensive cerebral hemorrhage (RHCH) occurring within one year after initial hypertensive cerebral hemorrhage (HICH) and to facilitate preemptive clinical intervention for the prevention of secondary hemorrhage. METHODS: Patient gender, age, blood pressure, Glasgow Coma Scale (GCS), location of cerebral hemorrhage, surgery, past medical history, blood biochemical parameters, and Glasgow Outcome Scale (GOS) were analyzed using logistic regression analysis to determine independent predictors of RHCH...
March 12, 2019: World Neurosurgery
Anthony V Perruccio, Matthew Got, Suzanne Li, Yang Ye, Dafna D Gladman, Vinod Chandran
OBJECTIVE: The Psoriatic Arthritis Disease Activity Score (PASDAS) is a composite measure of psoriatic arthritis (PsA) disease activity. The length of its patient-reported components raises concern about questionnaire burden. The PASDAS includes the SF-36 measure. We investigated the agreement between PASDAS and a modified PASDAS (mPASDAS) which substituted the SF-36 with the shortened SF-12. METHODS: 100 patients meeting CASPAR criteria for PsA were consecutively recruited...
March 15, 2019: Arthritis Care & Research
Michael Figl, Rainer Hoffmann, Marcus Kaar, Johann Hummel
US image registration is an important task e.g. in Computer Aided Surgery. Due to tissue deformation occurring between pre-operative and interventional images often deformable registration is necessary. We present a registration method focused on surface structures (i.e. saliencies) of soft tissues like organ capsules or vessels. The main concept follows the idea of representative landmarks (so called leading points). These landmarks represent saliencies in each image in a certain region of interest. The determination of deformation was based on a geometric model assuming that saliencies could locally be described by planes...
2019: PloS One
Hoang-Anh Tran, Jessica B O'Connell, Urie K Lee, John C Polanco, Tina I Chang, Arthur H Friedlander
OBJECTIVE: Males with peripheral arterial disease (PAD) are at high risk of ischaemic stroke given that atherogenic risk factors for both diseases are similar. We hypothesized that neurologically asymptomatic males diagnosed with PAD would demonstrate calcified carotid artery plaques (CCAP) on panoramic images (PI) significantly more often than similarly aged males not having PAD. METHODS: Investigators implemented a retrospective cross-sectional study. Subjects were male patients over age 50 diagnosed with PAD by ankle-brachial systolic pressure index results of <mml:math xmlns:mml="http://www...
March 15, 2019: Dento Maxillo Facial Radiology
Alfredo Campennì, Ernesto Amato, Riccardo Laudicella, Angela Alibrandi, Davide Cardile, Salvatore Antonio Pignata, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Lucrezia Auditore, Sergio Baldari
PURPOSE: In DTC patients, 131-radioiodine therapy has routinely been used for many years for thyroid remnant ablation after thyroid surgery. To date, two different strategies can be used to achieve sufficient TSH stimulation on thyroid remnant: (I) Levo-thyroxine withdrawal or (II) rhTSH stimulation. The aim of our study was to compare the abdominal absorbed dose ratio between differentiated thyroid cancer patients who underwent thyroid remnant ablation after either L-T4 withdrawal or rhTSH stimulation...
March 14, 2019: Endocrine
Rita Cacace, Bavo Heeman, Sara Van Mossevelde, Arne De Roeck, Julie Hoogmartens, Peter De Rijk, Helena Gossye, Kristof De Vos, Wouter De Coster, Mojca Strazisar, Greet De Baets, Joost Schymkowitz, Frederic Rousseau, Nathalie Geerts, Tim De Pooter, Karin Peeters, Anne Sieben, Jean-Jacques Martin, Sebastiaan Engelborghs, Eric Salmon, Patrick Santens, Rik Vandenberghe, Patrick Cras, Peter P De Deyn, John C van Swieten, Cornelia M van Duijn, Julie van der Zee, Kristel Sleegers, Christine Van Broeckhoven
Emerging evidence suggested a converging mechanism in neurodegenerative brain diseases (NBD) involving early neuronal network dysfunctions and alterations in the homeostasis of neuronal firing as culprits of neurodegeneration. In this study, we used paired-end short-read and direct long-read whole genome sequencing to investigate an unresolved autosomal dominant dementia family significantly linked to 7q36. We identified and validated a chromosomal inversion of ca. 4 Mb, segregating on the disease haplotype and disrupting the coding sequence of dipeptidyl-peptidase 6 gene (DPP6)...
March 14, 2019: Acta Neuropathologica
Alison M Dixon, Colleen M Fitzgerald, Cynthia Brincat
INTRODUCTION AND HYPOTHESIS: Our aim was to assess severity and bother of pelvic organ prolapse (POP) in women with pelvic floor myofascial pain (PFMP). METHODS: We conducted a retrospective chart review assessing new patients within a hospital-based multispecialty group from January 2010 through September 2014 using the International Classification of Diseases, 9th edition, diagnosis codes for POP. Data from Pelvic Organ Prolapse Quantification (POP-Q) system assessment, Pelvic Floor Distress Inventory-20, (PFDI-20), and clinical assessment of pelvic floor muscles were collected...
March 14, 2019: International Urogynecology Journal
Victor W Zhong, Linda Van Horn, Marilyn C Cornelis, John T Wilkins, Hongyan Ning, Mercedes R Carnethon, Philip Greenland, Robert J Mentz, Katherine L Tucker, Lihui Zhao, Arnita F Norwood, Donald M Lloyd-Jones, Norrina B Allen
Importance: Cholesterol is a common nutrient in the human diet and eggs are a major source of dietary cholesterol. Whether dietary cholesterol or egg consumption is associated with cardiovascular disease (CVD) and mortality remains controversial. Objective: To determine the associations of dietary cholesterol or egg consumption with incident CVD and all-cause mortality. Design, Setting, and Participants: Individual participant data were pooled from 6 prospective US cohorts using data collected between March 25, 1985, and August 31, 2016...
March 19, 2019: JAMA: the Journal of the American Medical Association
Samuel I Berchuck, Jean-Claude Mwanza, Angelo P Tanna, Donald L Budenz, Joshua L Warren
Glaucoma is the leading cause of irreversible blindness worldwide and requires regular monitoring upon diagnosis to ascertain whether the disease is stable or progressing. However, making this determination remains a difficult clinical task. Recently, a novel spatiotemporal boundary detection predictor of glaucomatous visual field (VF) progression (STBound) was developed. In this work, we explore the ability of STBound to differentiate progressing and non-progressing glaucoma patients in comparison to existing methods...
March 15, 2019: Scientific Reports
Luciano Lima Correia, Hermano Alexandre Lima Rocha, Sabrina Gabriele Maia Oliveira Rocha, Lucas Silveira Do Nascimento, Anamaria Cavalcante E Silva, Jocileide Sales Campos, Álvaro Jorge Madeiro Leite
BACKGROUND: Cross-sectional studies are fundamental studies in the practice of epidemiological science. This article aims to present in detail the methodology for conducting a series of cross-sectional studies, as well as the analysis of data through pooled data. METHODS: The series of studies are population cross-sectional studies, with statewide coverage, searching for representative sample of reproductive aged women and pre-school children in Ceará, Brazil. The sampling plan followed simple random, stratified, systematic and by conglomerates, in sequence...
March 4, 2019: Annals of Global Health
Chighaly El Hadj Sidi, Imen Mgarrech, Amine Tarmiz, Sofiane Jerbi
OBJECTIVE: The main objective of this study is to evaluate the performance of the predictive model (EuroSCORE II) on a Tunisian population to validate its use in our country. METHODS: This is a retrospective study of data from 418 adult patients undergoing cardiac surgery with cardiopulmonary bypass between 1 January 2015 and 31 December 2016 in the department of cardiovascular and thoracic surgery of the Sahloul University Hospital of Sousse. The EuroSCORE ΙΙ is calculated using the application validated on the site www...
March 14, 2019: Journal of Cardiac Surgery
David S Robertson, Jan Wildenhain, Adel Javanmard, Natasha A Karp
SUMMARY: In many areas of biological research, hypotheses are tested in a sequential manner, without having access to future p-values or even the number of hypotheses to be tested. A key setting where this online hypothesis testing occurs is in the context of publicly available data repositories, where the family of hypotheses to be tested is continually growing as new data is accumulated over time. Recently, Javanmard and Montanari (Ann. Stat. 46:526-554, 2018) proposed the first procedures that control the FDR for online hypothesis testing...
March 14, 2019: Bioinformatics
Nisha Thakur, Pallavi Singhal, Ravi Mehrotra, Mausumi Bharadwaj
Cervical cancer is the second major female cancer in India and constitutes one fourth of the world's burden. Human Papilloma Virus (HPV) infection is an essential but insufficient cause for cervical cancer. Genetic variants in MicroRNAs (miRNAs/miRs) play an important role in the susceptibility of various types of cancers. To evaluate the association of Single Nucleotide Polymorphisms (SNPs) in miR-146a (rs2910164), miR-196a2 (rs11614913) and miR-499 (rs3746444), with cervical cancer susceptibility in Indian population...
March 14, 2019: Bioscience Reports
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