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Osteoporosis paraplegia

Yajing Peng, Samantha L Shapiro, Varuna C Banduseela, Inca A Dieterich, Kyle J Hewitt, Emery H Bresnick, Guangyao Kong, Jing Zhang, Kathryn L Schueler, Mark P Keller, Alan D Attie, Timothy A Hacker, Ruth Sullivan, Elle Kielar-Grevstad, Sebastian I Arriola Apelo, Dudley W Lamming, Rozalyn M Anderson, Luigi Puglielli
The membrane transporter AT-1/SLC33A1 translocates cytosolic acetyl-CoA into the lumen of the endoplasmic reticulum (ER), participating in quality control mechanisms within the secretory pathway. Mutations and duplication events in AT-1/SLC33A1 are highly pleiotropic and have been linked to diseases such as spastic paraplegia, developmental delay, autism spectrum disorder, intellectual disability, propensity to seizures, and dysmorphism. Despite these known associations, the biology of this key transporter is only beginning to be uncovered...
October 2018: Aging Cell
Yukiyo Shimizu, Hideki Kadone, Shigeki Kubota, Kenji Suzuki, Tetsuya Abe, Tomoyuki Ueno, Yuichiro Soma, Yoshiyuki Sankai, Yasushi Hada, Masashi Yamazaki
Patients with complete paraplegia after spinal cord injury (SCI) are unable to stand or walk on their own. Standing exercise decreases the risk of decubitus ulcers, osteoporosis, and joint deformities in patients with SCI. Conventional gait training for complete paraplegia requires excessive upper limb usage for weight bearing and is difficult in cases of complete quadriplegia. The purpose of this study was to describe voluntary ambulation triggered by upper limb activity using the Hybrid Assistive Limb® (HAL) in patients with complete quadri/paraplegia after chronic SCI...
2017: Frontiers in Neuroscience
Brian Andrews, James Shippen, Monica Armengol, Robin Gibbons, William Holderbaum, William Harwin
FES assisted activities such as standing, walking, cycling and rowing induce forces within the leg bones and have been proposed to reduce osteoporosis in spinal cord injury (SCI). However, details of the applied mechanical stimulus for osteogenesis is often not reported. Typically, comparisons of bone density results are made after costly and time consuming clinical trials. These studies have produced inconsistent results and are subject to sample size variations. Here we propose a design process that may be used to predict the clinical outcome based on biomechanical simulation and mechano-biology...
September 15, 2016: European Journal of Translational Myology
Cecilia Smith Simonsen, Elisabeth Gulowsen Celius, Cathrine Brunborg, Chantal Tallaksen, Erik Fink Eriksen, Trygve Holmøy, Stine Marit Moen
BACKGROUND: Although disability is considered the main cause of low bone mineral density (BMD) in multiple sclerosis (MS), other factors related to the disease process or treatment could also be involved. The aim of this study was to assess whether patients with MS are more likely to develop low BMD (osteopenia or osteoporosis) than patients with the non-inflammatory neurological diseases Hereditary Spastic Paraplegia (HSP) and Hereditary Ataxia (HA). METHODS: We performed a case control study comparing BMD (spine, hip and total body) and biochemical measures of bone metabolism in 91 MS patients and 77 patients with HSP or HA, matched for age, gender and disability...
December 5, 2016: BMC Neurology
Dragana Kljajić, Fadilj Eminović, Milivoj Dopsaj, Dragan Pavlović, Sladjana Arsić, Jadranka Otašević
OBJECTIVES: Studying the quality of life of people with a spinal cord injury is of great importance as it allows the monitoring of both functioning and adaptation to disability. The aim of this study was to determine the difference between persons with a spinal cord injury involved in sports activities and those not involved in sports activities in relation to their quality of life and the presence of secondary health conditions (pressure ulcers, urinary infections, muscle spasms, osteoporosis, pain, kidney problems-infections, calculosis and poor circulation)...
June 1, 2016: Zdravstveno Varstvo
Renato Varoto, Alberto Cliquet
Cybernetics-based concepts can allow for complete independence for paralyzed individuals, including sensory motor recovery. Spinal cord injuries are responsible for a huge stress on health and a financial burden to society. This article focuses on novel procedures such as functional diagnosis for paraplegics and tetraplegics, cybertherapies toward lessening comorbidities such as cardiovascular diseases, osteoporosis, etc., and the production of new technology for upper and lower limb control. Functional electrical stimulation reflects a unique opportunity for bipedal gait to be achieved by paraplegics and tetraplegics...
October 2015: Artificial Organs
Sylvie Coupaud, Alan N McLean, Mariel Purcell, Matthew H Fraser, David B Allan
BACKGROUND: Disuse osteoporosis occurs in response to long-term immobilization. Spinal cord injury (SCI) leads to a form of disuse osteoporosis that only affects the paralyzed limbs. High rates of bone resorption after injury are evident from decreases in bone mineral content (BMC), which in the past have been attributed in the main to loss of trabecular bone in the epiphyses and cortical thinning in the shaft through endocortical resorption. METHODS: Patients with motor-complete SCI recruited from the Queen Elizabeth National Spinal Injuries Unit (Glasgow, UK) were scanned within 5weeks of injury (baseline) using peripheral Quantitative Computed Tomography (pQCT)...
May 2015: Bone
Chelsea A Pelletier, Frédéric S Dumont, Jean Leblond, Luc Noreau, Lora Giangregorio, B Catharine Craven
BACKGROUND: Sublesional declines in hip and knee region bone mass are a well-established consequence of motor complete spinal cord injury (SCI), placing individuals with SCI at risk for fragility fracture, hospitalization, and fracture-related morbidity and mortality. OBJECTIVES: To describe the 1-year incidence of fracture and osteoporosis prevalence in a community cohort of Canadians with chronic SCI. METHODS: As part of the SCI Community Survey, consenting adult participants with chronic SCI completed an online or telephone survey regarding their self-reported medical comorbidities, including fracture and osteoporosis, in the 12 months prior to survey conduct...
2014: Topics in Spinal Cord Injury Rehabilitation
J Bredow, J Oppermann, K Keller, F Beyer, C K Boese, K Zarghooni, R Sobottke, P Eysel, J Siewe
Background Context. Percutaneous balloon kyphoplasty is an established minimally invasive technique to treat painful vertebral compression fractures, especially in the context of osteoporosis with a minor complication rate. Purpose. To describe the heparin anticoagulation treatment of paraplegia following balloon kyphoplasty. Study Design. We report the first case of an anterior spinal artery syndrome with a postoperative reversible paraplegia following a minimally invasive spine surgery (balloon kyphoplasty) without cement leakage...
2014: Case Reports in Orthopedics
J Matějka, J Skála-Rosenbaum, M Krbec, J Zeman, T Matějka, P Zeman
PURPOSE OF THE STUDY: Type B3 thoracic and lumbar fractures are often found in spines with previous hyperossification processes such as ankylosing spondylarthritis (AS) or diffuse idiopathic skeletal hyperostosis (DISH). They occur most frequently due to high-energy trauma in a healthy spine and as fall-related domestic injury in a spine affected by hyperossification. Generally, they are less frequent than type B3 cervical spine fractures. In this retrospective study involving two centres, the incidence of these fractures, their characterisation, therapy and complications associated with them were investigated...
2013: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Edward R Hammond, Heather M Metcalf, John W McDonald, Cristina L Sadowsky
OBJECTIVE: To describe the prevalence of osteoporosis and its association with functional electrical stimulation (FES) use in individuals with spinal cord injury (SCI)-related paralysis. DESIGN: Retrospective cross-sectional evaluation. SETTING: Clinic. PARTICIPANTS: Consecutive persons with SCI (N=364; 115 women, 249 men) aged between 18 and 80 years who underwent dual-energy x-ray absorptiometry (DXA) examinations...
December 2014: Archives of Physical Medicine and Rehabilitation
Magnus K Gislason, Sylvie Coupaud, Keisuke Sasagawa, Yuji Tanabe, Mariel Purcell, David B Allan, K Elizabeth Tanner
The disuse-related bone loss that results from immobilisation following injury shares characteristics with osteoporosis in post-menopausal women and the aged, with decreases in bone mineral density leading to weakening of the bone and increased risk of fracture. The aim of this study was to use the finite element method to: (i) calculate the mechanical response of the tibia under mechanical load and (ii) estimate of the risk of fracture; comparing between two groups, an able-bodied group and spinal cord injury patients group suffering from varying degrees of bone loss...
February 2014: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
An H Do, Po T Wang, Christine E King, Sophia N Chun, Zoran Nenadic
BACKGROUND: Excessive reliance on wheelchairs in individuals with tetraplegia or paraplegia due to spinal cord injury (SCI) leads to many medical co-morbidities, such as cardiovascular disease, metabolic derangements, osteoporosis, and pressure ulcers. Treatment of these conditions contributes to the majority of SCI health care costs. Restoring able-body-like ambulation in this patient population can potentially reduce the incidence of these medical co-morbidities, in addition to increasing independence and quality of life...
2013: Journal of Neuroengineering and Rehabilitation
S A Alavizadeh, M R Mohajeri-Tehrani, A Rostamian, H R Aghaei Meybodi, M Qorbani, A A Keshtkar, S S Panahi, F Rahdari, P Khashayar
OBJECTIVES: The present study was conducted to determine the prevalence of T-score discordance and its risk factors in a group of patients with spinal cord injury in a university teaching hospital in the Iranian capital of Tehran. METHODS: This cross-sectional study was conducted on paraplegic men undergoing bone density testing in an outpatient clinic at a hospital in the Iranian capital, Tehran, between March 2011 and 2012. A questionnaire on demographic and anthropometric characteristics, including age, height, weight, engagement in physical activity and personal smoking habits, was filled out for each subject...
April 2014: Spinal Cord
Laia Gifre, Joan Vidal, Josep Carrasco, Enric Portell, Josep Puig, Ana Monegal, Núria Guañabens, Pilar Peris
OBJECTIVE: To analyse the incidence and factors related to the development and clinical evolution of fractures in patients with traumatic spinal cord injury. DESIGN: A retrospective 10-year follow-up study. SETTING: Neurorehabilitation centre. SUBJECTS: Sixty-three patients (50M/13F) with a mean age of 36 ± 20 years with recent traumatic spinal cord injury attended over a one-year period (January to December 2000). MAIN MEASURES: Medical reports were reviewed, evaluating risk factors for osteoporosis, fracture incidence during the 10 years following spinal cord injury, severity (ASIA score) and level of spinal cord injury (paraplegia/tetraplegia), type of lesion (spastic/flaccid), weight-bearing standing activity, and the cause, location and evolution of the fracture...
April 2014: Clinical Rehabilitation
Panagiotis Korovessis, Konstantinos Vardakastanis, Thomas Repantis, Vasilios Vitsas
STUDY DESIGN: Prospective, parallel-group, controlled comparative randomized study. OBJECTIVE: This study compares the efficacy in sagittal vertebral height and wedge deformity restoration, polymethylmethacrylate cement leakage safety, and functional outcome of balloon kyphoplasty (BK) versus KIVA (a novel vertebral augmentation technique) implant for the augmentation of fresh osteoporotic vertebral body fractures. SUMMARY OF BACKGROUND DATA: Minimally invasive vertebral augmentation procedures have been widely used to treat vertebral compression fractures caused by osteoporosis...
February 15, 2013: Spine
Tetsuya Suzuki, Eiji Abe, Naohisa Miyakoshi, Hajime Murai, Takashi Kobayashi, Toshiki Abe, Kazuma Kikuchi, Yoichi Shimada
STUDY DESIGN: A retrospective clinical study. OBJECTIVE: To assess the efficacy of a new spinal reconstruction technique (posterior-approach vertebral replacement with rectangular parallelepiped cages: PAVREC) for the treatment of osteoporotic late vertebral collapse with neurological deficits. SUMMARY OF BACKGROUND DATA: Poor bone quality and medically complicated situations obfuscate precise treatment for paraplegia caused by osteoporotic vertebral collapse...
July 2013: Journal of Spinal Disorders & Techniques
Mohammad Taghi Karimi, Omid Esrafilian, Amir Esrafilian, Mohammad Jafar Sadigh, Pouya Amiri
BACKGROUND: Spinal cord injury is a damage to spinal cord that results in loss of function and mobility below the level of injury. The patients use various orthoses to improve their general health, to decrease bone osteoporosis, and to improve bone mineral density. It was controversial if how much percentage of the loads applied on an orthosis and body complex is transmitted by orthosis. Therefore, it was aimed to determine the magnitude of the loads transmitted by orthosis to find the influence of walking with orthosis on bone mineral density...
March 2013: Clinical Biomechanics
Milad Alizadeh-Meghrazi, Kei Masani, Milos R Popovic, Beverley Catharine Craven
BACKGROUND: To date, few pharmacologic or rehabilitation interventions for sublesional osteoporosis (SLOP) or low bone mass of the hip and knee regions after spinal cord injury (SCI) have produced significant or sustained increases in lower extremity bone mineral density. Whole body vibration (WBV) is a potential intervention for the prevention and/or treatment of SLOP. OBJECTIVE: To identify the optimal WBV conditions (ie, plate, frequency, amplitude, and subject posture) among men with chronic SCI during passive standing and facilitate the implementation and future evaluation of the efficacy of WBV and passive standing for prevention and treatment of SLOP in men with SCI...
December 2012: PM & R: the Journal of Injury, Function, and Rehabilitation
Tetsuro Ohba, Shigeto Ebata, Devin Clinton, Kenske Koyama, Hirotaka Haro
PURPOSE: To describe two unique cases of osteoporotic vertebral compression fracture (OVCF) treated with balloon kyphoplasty (BKP) that were complicated by spinal instability and resultant lower extremity paraparesis. METHODS: Kyphoplasty was performed in two patients with OVCF that had persistent back pain despite a course of conservative care. Immediately following BKP, both patients had a marked improvement in back pain. However, they developed progressive bilateral lower extremity weakness...
May 2013: European Spine Journal
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