keyword
https://read.qxmd.com/read/38380907/a-novel-bartonella-like-bacterium-forms-an-interdependent-mutualistic-symbiosis-with-its-host-the-stored-product-mite-tyrophagus-putrescentiae
#1
JOURNAL ARTICLE
Qing Xiong, Bruno Sopko, Pavel B Klimov, Jan Hubert
A novel Bartonella -like symbiont (BLS) of Tyrophagus putrescentiae was characterized. BLS formed a separate cluster from the Bartonella clade together with an ant symbiont. BLS was present in mite bodies (103 16S DNA copies/mite) and feces but was absent in eggs. This indicated the presence of the BLS in mite guts. The BLS showed a reduction in genome size (1.6 Mb) and indicates gene loss compared to Bartonella apis . The BLS can be interacted with its host by using host metabolic pathways (e.g., the histidine and arginine metabolic pathways) as well as by providing its own metabolic pathways (pantothenate and lipoic acid) to the host, suggesting the existence of a mutualistic association...
February 21, 2024: MSystems
https://read.qxmd.com/read/38168374/tet1-regulates-responses-to-house-dust-mite-by-altering-chromatin-accessibility-dna-methylation-and-gene-expression-in-airway-epithelial-cells
#2
Anthony P Brown, Sreeja Parameswaran, Lucy Cai, Sweeney Elston, Chi Pham, Artem Barski, Matthew T Weirauch, Hong Ji
Background Previous studies have identified TET1 as a potential key regulator of genes linked to asthma. TET1 has been shown to transcriptionally respond to house dust mite extract, an allergen known to directly cause allergic asthma development, and regulate the expression of genes involved in asthma. How TET1 regulates expression of these genes, however, is unknown. TET1 is a DNA demethylase; therefore, most prior research on TET1-based gene regulation has focused on how TET1 affects methylation. However, TET1 can also interact directly with transcription factors and histone modifiers to regulate gene expression...
December 13, 2023: Research Square
https://read.qxmd.com/read/38146799/comparative-analysis-of-cysteine-proteases-reveals-gene-family-evolution-of-the-group-1-allergens-in-astigmatic-mites
#3
JOURNAL ARTICLE
Ling Shi, Qing Xiong, Fu Kiu Ao, Tsz Yau Wan, Xiaojun Xiao, Xiaoyu Liu, Baoqing Sun, Anchalee Tungtrongchitr, Ting Fan Leung, Stephen Kwok Wing Tsui
BACKGROUND: Astigmatic mites contain potent allergens that can trigger IgE-mediated immune responses, leading to allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. In house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae, group 1 allergens (Der p 1 and Der f 1), characterized as papain-like cysteine proteases, have been defined as the major allergens that have high prevalence and potency. Previous studies of mite group 1 allergens mainly focused on identification, comparison of sequence and structure, as well as the investigation of cross-reactivity...
December 2023: Clinical and Translational Allergy
https://read.qxmd.com/read/38106417/-dermatophagoides-farinae-micrornas-released-to-external-environments-via-exosomes-regulate-inflammation-related-gene-expression-in-human-bronchial-epithelial-cells
#4
JOURNAL ARTICLE
Kaiyue He, Ting Yang, Jinyan Yu, Xiao Zang, Shangde Jiang, Shuyue Xu, Jiaxi Liu, Zuyu Xu, Wei Wang, Shanchao Hong
BACKGROUND: Dermatophagoides farinae (DFA) is an important species of house dust mites (HDMs) that causes allergic diseases. Previous studies have focused on allergens with protein components to explain the allergic effect of HDMs; however, there is little knowledge on the role of microRNAs (miRNAs) in the allergic effect of HDMs. This study aimed to unravel the new mechanism of dust mite sensitization from the perspective of cross-species transport of extracellular vesicles-encapsulated miRNAs from HDMs...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38047312/lung-pro-inflammatory-microrna-and-cytokine-expression-in-a-mouse-model-of-allergic-inflammation-role-of-sex-chromosome-complement-and-gonadal-hormones
#5
JOURNAL ARTICLE
Sarah Commodore, Carolyn Damilola Ekpruke, Dustin Rousselle, Rachel Alford, Maksat Babayev, Shikha Sharma, Aaron Buechlein, Douglas B Rusch, Patricia Silveyra
Epigenetic alterations such as dysregulation of microRNAs (miRNAs) have been reported to play important roles in interactions between genetic and environmental factors. In this study, we tested the hypothesis that induction of lung inflammation by inhaled allergens triggers a sex-specific miRNA regulation that is dependent on chromosome complement and hormonal milieu. We challenged the four core genotypes (FCG) model through intranasal sensitization with a house dust mite (HDM) solution (or PBS as a control) for 5 weeks...
December 4, 2023: Physiological Genomics
https://read.qxmd.com/read/38047309/transcriptomics-analysis-of-allergen-induced-inflammatory-gene-expression-in-the-four-core-genotype-mouse-model
#6
JOURNAL ARTICLE
Carolyn Damilola Ekpruke, Rachel Alford, Dustin Rousselle, Maksat Babayev, Shikha Sharma, Sarah Commodore, Aaron Buechlein, Douglas B Rusch, Patricia Silveyra
Sex differences in allergic inflammation have been reported, but the mechanisms underlying these differences remain unknown. Contributions of both sex hormones and sex-related genes to these mechanisms have been previously suggested in clinical and animal studies. Here, Four Core Genotypes (FCG) mouse model was used to study the inflammatory response to house dust mite (HDM) challenge and identify differentially expressed genes (DEGs) and regulatory pathways in lung tissue. Briefly, adult mice (8-10 weeks old) of the FCG (XXM, XXF, XYM, XYF) were challenged intranasally with 25μg of HDM or vehicle (PBS-control group) 5 days/week for 5 weeks (n=3/10group)...
December 4, 2023: Physiological Genomics
https://read.qxmd.com/read/37876035/predicting-blomia-tropicalis-allergens-using-a-multiomics-approach
#7
JOURNAL ARTICLE
Jan Hubert, Susanne Vrtala, Bruno Sopko, Scot E Dowd, Qixin He, Pavel B Klimov, Karel Harant, Pavel Talacko, Tomas Erban
BACKGROUND: The domestic mite Blomia tropicalis is a major source of allergens in tropical and subtropical regions. Despite its great medical importance, the allergome of this mite has not been sufficiently studied. Only 14 allergen groups have been identified in B. tropicalis thus far, even though early radioimmunoelectrophoresis techniques (27 uncharacterized allergen complexes) and comparative data based on 40 allergen groups officially recognized by the World Health Organization (WHO)/IUIS in domestic astigmatid mites suggest the presence of a large set of additional allergens...
October 2023: Clinical and Translational Allergy
https://read.qxmd.com/read/37840229/update-on-the-role-of-genetic-factors-environmental-factors-and-allergens-in-canine-atopic-dermatitis
#8
REVIEW
Patrick Hensel, Manolis Saridomichelakis, Melissa Eisenschenk, Chie Tamamoto-Mochizuki, Cherie Pucheu-Haston, Domenico Santoro
BACKGROUND: Canine atopic dermatitis (cAD) is a common, complex and multifactorial disease involving, among others, genetic predisposition, environmental factors and allergic sensitisation. OBJECTIVE: This review summarises the current evidence on the role of genetic and environmental factors and allergic sensitisation in the pathogenesis of cAD since the last review by ICADA in 2015. MATERIALS AND METHODS: Online citation databases and proceedings from international meetings on genetic factors, environmental factors and allergens relevant to cAD that had been published between 2015 and 2022 were reviewed...
October 15, 2023: Veterinary Dermatology
https://read.qxmd.com/read/37724950/evaluation-of-genetic-variants-in-ferroptosis-related-genes-and-house-dust-mite-induced-allergic-rhinitis-risk
#9
JOURNAL ARTICLE
Yi-Fan Yang, Rui Zheng, Xiang Gu, Fang Gao, Min Chen, Mu-Long Du, Zheng-Dong Zhang, Mei-Ping Lu, Lei Cheng
BACKGROUND: Ferroptosis-related genes disrupt iron homeostasis and enhance lipid peroxidation to initiate respiratory system diseases. However, the association between genetic variants in the ferroptosis-related genes with house dust mite (HDM)-induced allergic rhinitis (AR) susceptibility remains unclear. METHODS: A case-control study, involving 222 cases and 237 healthy controls from a Chinese population, was conducted to evaluate the relationship between single nucleotide polymorphisms (SNPs) in ferroptosis-related genes and HDM-induced AR risk...
February 2023: International Immunopharmacology
https://read.qxmd.com/read/37227431/a-meta-analysis-of-genome-wide-association-studies-of-childhood-wheezing-phenotypes-identifies-anxa1-as-a-susceptibility-locus-for-persistent-wheezing
#10
JOURNAL ARTICLE
Raquel Granell, John A Curtin, Sadia Haider, Negusse Tadesse Kitaba, Sara A Mathie, Lisa G Gregory, Laura L Yates, Mauro Tutino, Jenny Hankinson, Mauro Perretti, Judith M Vonk, Hasan S Arshad, Paul Cullinan, Sara Fontanella, Graham C Roberts, Gerard H Koppelman, Angela Simpson, Steve W Turner, Clare S Murray, Clare M Lloyd, John W Holloway, Adnan Custovic
BACKGROUND: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of 'doctor-diagnosed asthma', thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes. METHODS: We conducted a novel multivariate GWAS meta-analysis of wheezing phenotypes jointly derived using unbiased analysis of data collected from birth to 18 years in 9,568 individuals from five UK birth-cohorts...
May 25, 2023: ELife
https://read.qxmd.com/read/36572876/gene-network-analysis-for-identification-of-microrna-biomarkers-for-asthma
#11
JOURNAL ARTICLE
Paulene Cay, Cherie A Singer, Mariam A Ba
BACKGROUND: To date, reliable biomarkers for asthma have not been identified. MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate post-transcriptional gene expression, and they are involved in various diseases, including asthma. MiRNAs may serve as ideal biomarkers due to their ability to regulate multiple pathways. This study aims to identify miRNA biomarker signatures for asthma. METHODS: We used the house dust mite (HDM) mouse model of allergic inflammation...
December 26, 2022: Respiratory Research
https://read.qxmd.com/read/36511188/rna-viruses-alter-house-dust-mite-physiology-and-allergen-production-with-no-detected-consequences-for-allergenicity
#12
JOURNAL ARTICLE
José Cristian Vidal-Quist, Jozefien Declercq, Stijn Vanhee, Bart N Lambrecht, José Gómez-Rial, Carmen Vidal, Eylem Aydogdu, Stephane Rombauts, Pedro Hernández-Crespo
RNA viruses have recently been detected in association with house dust mites, including laboratory cultures, dust samples, and mite-derived pharmaceuticals used for allergy diagnosis. This study aimed to assess the incidence of viral infection on Dermatophagoides pteronyssinus physiology and on the allergenic performance of extracts derived from its culture. Transcriptional changes between genetically identical control and virus-infected mite colonies were analysed by RNAseq with the support of a new D. pteronyssinus high-quality annotated genome (56...
December 13, 2022: Insect Molecular Biology
https://read.qxmd.com/read/36306937/allergen-induced-dna-release-by-the-airway-epithelium-amplifies-type-2-immunity
#13
JOURNAL ARTICLE
Yotesawee Srisomboon, Koji Iijima, Mathia Colwell, Peter J Maniak, Marissa Macchietto, Christopher Faulk, Hirohito Kita, Scott M O'Grady
BACKGROUND: Alternaria alternata and house dust mite (HDM) exposure evokes interleukin-33 secretion from the airway epithelium, which functions as an alarmin to stimulate type 2 immunity. Extracellular DNA (eDNA) is also an alarmin that intensifies inflammation in cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. OBJECTIVE: Investigate mechanisms underlying allergen-evoked DNA mobilization and release from the airway epithelium and determine the role of eDNA in type 2 immunity...
October 25, 2022: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/36230980/hedgehog-signaling-as-a-therapeutic-target-for-airway-remodeling-and-inflammation-in-allergic-asthma
#14
JOURNAL ARTICLE
Anthony Tam, Emmanuel Twumasi Osei, Chung Y Cheung, Michael Hughes, Chen X Yang, Kelly M McNagny, Delbert R Dorscheid, Gurpreet K Singhera, Teal S Hallstrand, Stephanie Warner, James C Hogg, Tillie L Hackett, Chinten J Lim, Don D Sin
Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 ( PTCH1 ) are associated with lung function abnormalities in the general population. It has also been shown that sonic hedgehog (SHH), an important ligand for PTCH1, is upregulated in the airway epithelium of patients with asthma and is suggested to be involved in airway remodeling. The contribution of hedgehog signaling to airway remodeling and inflammation in asthma is poorly described. To determine the biological role of hedgehog signaling-associated genes in asthma, gene silencing, over-expression, and pharmacologic inhibition studies were conducted after stimulating human airway epithelial cells or not with transforming growth factor β1 (TGFβ1), an important fibrotic mediator in asthmatic airway remodeling that also interacts with SHH pathway...
September 27, 2022: Cells
https://read.qxmd.com/read/36059920/the-specific-microrna-profile-and-functional-networks-for-children-with-allergic-asthma
#15
JOURNAL ARTICLE
Xiyan Zhang, Xude Zhang, Shaojie Feng, Xijuan Wang, Beibei Guo, Jingjing Liu, Donghua Xu, Fengxia Liu
Background: Allergic asthma is the most common type of asthma and often occurs in early life with increasing comorbidities, including atopic dermatitis and allergic rhinitis. MicroRNAs (miRNAs) are involved in the pathogenesis of numerous immune and inflammatory disorders, particularly allergic inflammation. The specific miRNA profiles of children with allergic asthma have not been fully delineated and still require in-depth study. Objective: This study aimed to identify the expression profile of miRNAs and constructed a network of the interactions between differentially expressed miRNAs and target mRNAs to provide novel insights into understanding the pathogenesis of allergic asthma...
2022: Journal of Asthma and Allergy
https://read.qxmd.com/read/36017065/microbiome-profiling-of-nasal-extracellular-vesicles-in-patients-with-allergic-rhinitis
#16
JOURNAL ARTICLE
Tsai-Yeh Chiang, Yu-Ru Yang, Ming-Ying Zhuo, Feng Yang, Ying-Fei Zhang, Chia-Hsiang Fu, Ta-Jen Lee, Wen-Hung Chung, Liang Chen, Chih-Jung Chang
BACKGROUND: Nasal microbiota is crucial for the pathogenesis of allergic rhinitis (AR), which has been reported to be different from that of healthy individuals. However, no study has investigated the microbiota in nasal extracellular vesicles (EVs). We aimed to compare the microbiome composition and diversity in EVs between AR patients and healthy controls (HCs) and reveal the potential metabolic mechanisms in AR. METHODS: Eosinophil counts and serum immunoglobulin E (IgE) levels were measured in patients with AR (n = 20) and HCs (n = 19)...
August 2022: World Allergy Organization Journal
https://read.qxmd.com/read/35627266/single-cell-rna-seq-analysis-reveals-lung-epithelial-cell-type-specific-responses-to-hdm-and-regulation-by-tet1
#17
JOURNAL ARTICLE
Tao Zhu, Anthony P Brown, Lucy P Cai, Gerald Quon, Hong Ji
Tet1 protects against house dust mite (HDM)-induced lung inflammation in mice and alters the lung methylome and transcriptome. In order to explore the role of Tet1 in individual lung epithelial cell types in HDM-induced inflammation, we established a model of HDM-induced lung inflammation in Tet1 knockout and littermate wild-type mice, then studied EpCAM+ lung epithelial cells using single-cell RNA-seq analysis. We identified eight EpCAM+ lung epithelial cell types, among which AT2 cells were the most abundant...
May 14, 2022: Genes
https://read.qxmd.com/read/35535514/comparative-genomics-reveals-insights-into-the-divergent-evolution-of-astigmatic-mites-and-household-pest-adaptations
#18
JOURNAL ARTICLE
Qing Xiong, Angel Tsz-Yau Wan, Xiaoyu Liu, Cathy Sin-Hang Fung, Xiaojun Xiao, Nat Malainual, Jinpao Hou, Lingyi Wang, Mingqiang Wang, Kevin Yi Yang, Yubao Cui, Elaine Lai-Han Leung, Wenyan Nong, Soo-Kyung Shin, Shannon Wing-Ngor Au, Kyoung Yong Jeong, Fook-Tim Chew, Jerome Ho-Lam Hui, Ting-Fan Leung, Anchalee Tungtrongchitr, Nanshan Zhong, Zhigang Liu, Stephen Kwok-Wing Tsui
Highly diversified astigmatic mites comprise many medically important human household pests such as house dust mites causing approximately 1-2% of all allergic diseases globally; however, their evolutionary origin and diverse lifestyles including reversible parasitism have not been illustrated at the genomic level, which hampers allergy prevention and our exploration of these household pests. Using six high-quality assembled and annotated genomes, this study not only refuted the monophyly of mites and ticks, but also thoroughly explored the divergence of Acariformes and the diversification of astigmatic mites...
May 10, 2022: Molecular Biology and Evolution
https://read.qxmd.com/read/35527433/-bioinformatics-analysis-of-nasal-epithelial-cell-gene-expression-in-seasonal-and-perennial-allergic-rhinitis
#19
JOURNAL ARTICLE
L W Sun, Z Y Liu, J C Sha, C D Meng, D D Zhu
Objective: Transcriptome sequencing and bioinformatics analysis were performed on the gene expression of nasal epithelial cells in patients with seasonal allergic rhinitis (AR) and perennial AR, so as to obtain the differences in the gene expression of nasal epithelial cells between seasonal AR and perennial AR. Methods: The human nasal epithelial cell line(HNEpC) was cultured in vitro , treated with 100 μg/ml mugwort or house dust mite (HDM) extracts for 24 hours. Total cell RNA was extracted, and quantitative real-time polymerase chain reaction (qPCR) was used to detect the expression of cytokines, including IL-6, IL-8, IL-33 and thymic stromal lymphopoietin (TSLP)...
April 7, 2022: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://read.qxmd.com/read/35489562/a-time-dependently-regulated-gene-network-reveals-that-aspergillus-protease-affects-mitochondrial-metabolism-and-airway-epithelial-cell-barrier-function-via-mitochondrial-oxidants
#20
JOURNAL ARTICLE
Yun Hee Kim, Taesoo Kim, Kon-Young Ji, In-Sik Shin, Joo Young Lee, Kwang Hoon Song, Bu-Yeo Kim
The airway epithelium maintains tight barrier integrity to prevent penetration of pathogens; thus, impairment of the barrier function is an important and common histological feature in asthmatic patients. Proteolytic allergens from fungi, pollen, and house dust mites can disrupt epithelial barrier integrity, but the mechanism remains unclear. Aspergillus oryzae protease (AP)-induced mitochondrial reactive oxygen species (ROS) contribute to the epithelial inflammatory response. However, as mitochondrial ROS affect various cellular functions, such as metabolism, cell death, cell proliferation, and redox homeostasis through signal transduction, it is difficult to understand the detailed action mechanism of AP by measuring changes in a single gene or protein of a specific signaling pathway...
May 20, 2022: Free Radical Biology & Medicine
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