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https://read.qxmd.com/read/30874724/antithrombotic-treatment-in-patients-with-atrial-fibrillation-and-acute-coronary-syndromes-results-of-the-european-heart-rhythm-association-survey
#1
Deirdre A Lane, Nikolaos Dagres, Gheorghe-Andrei Dan, Javier García Seara, Konstantinos Iliodromitis, Radoslaw Lenarczyk, Gregory Y H Lip, Jacques Mansourati, Francisco Marín, Daniel Scherr, Tatjana S Potpara
The management of an acute coronary syndrome (ACS) in a patient with existing atrial fibrillation (AF) often presents a management dilemma both in the acute phase and post-ACS, since the majority of AF patients will already be receiving oral anticoagulation (OAC) for stroke prevention and will require further antithrombotic treatment to reduce the risk of in-stent thrombosis or recurrent cardiac events. Current practice recommendations are based largely on consensus option as there is limited evidence from randomized controlled trials...
March 14, 2019: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/30870065/epigenomic-profiling-of-newborns-with-isolated-orofacial-clefts-reveals-widespread-dna-methylation-changes-and-implicates-metastable-epiallele-regions-in-disease-risk
#2
Semira Gonseth, Gary M Shaw, Ritu Roy, Mark R Segal, Kripa Asrani, Jasper Rine, Joseph Wiemels, Nicholas J Marini
Cleft lip with or without cleft palate (CL/P) is a common human birth defect whose etiologies remain largely unknown. Several studies have demonstrated that periconceptional supplementation of folic acid can reduce risk of CL/P in offspring. In this study, we tested the hypothesis that the preventive effect of folic acid is manifested through epigenetic modifications by determining whether DNA methylation changes are associated with CL/P. To more readily observe the potential effects of maternal folate on the offspring epigenome, we focused on births prior to mandatory dietary folate fortification in the United States (i...
March 14, 2019: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/30869568/non-vitamin-k-antagonist-oral-anticoagulants-versus-warfarin-in-atrial-fibrillation-patients-with-intracerebral-hemorrhage
#3
Peter Brønnum Nielsen, Flemming Skjøth, Mette Søgaard, Jette Nordstrøm Kjældgaard, Gregory Y H Lip, Torben Bjerregaard Larsen
Background and Purpose- Recurrent bleeding associated with oral anticoagulants (OACs) causes a dilemma in patients with atrial fibrillation (AF) sustaining an intracerebral hemorrhage. Treatment recommendations guiding clinical practice on optimal OAC agent selection in this population are lacking. This study aimed to investigate the comparative effectiveness and safety of non-vitamin K antagonist OAC (NOAC) versus warfarin in patients with AF sustaining an intracerebral hemorrhage. Methods- We conducted a nationwide observational cohort study including patients with AF sustaining an intracerebral hemorrhage and who subsequently claimed an OAC prescription...
March 14, 2019: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/30865768/soft-tissue-facial-profile-in-class-iii-malocclusion-long-term-post-pubertal-effects-produced-by-the-face-mask-protocol
#4
Chiara Pavoni, Francesca Gazzani, Lorenzo Franchi, Saveria Loberto, Roberta Lione, Paola Cozza
OBJECTIVES: The objective of this study was to analyze soft tissue changes produced by rapid maxillary expansion and facial mask therapy in growing Class III patients. MATERIALS: The treated group consisted of 32 Caucasian patients (15 females and 17 males) with dentoskeletal Class III malocclusion treated with the Face Mask Protocol (FMP, rapid maxillary expander, facial mask, and removable lower bite-block). All patients were evaluated before treatment (T1; mean age, 8...
March 13, 2019: European Journal of Orthodontics
https://read.qxmd.com/read/30854838/oral-mucosal-complications-in-orthodontic-treatment
#5
Maurizio Manuelli, Marta Marcolina, Nico Nardi, Dario Bertossi, Daniele De Santis, Giulia Ricciardi, Umberto Luciano, Riccardo Nocini, Alberto Mainardi, Alessandra Lissoni, Silvio Abati, Alessandra Lucchese
BACKGROUND: Orthodontic therapy is used to solve numerous oral problems, but the use of fixed oral devices can also impact negatively the oral cavity, if the treatment is not steadily under control. The aim of this study is to evaluate tooth, bone and soft tissues lesions due to the presence of fixed orthodontic appliances. METHODS: One hundred patients with fixed orthodontic appliances were included in the study. In particular, 20 patients with rapid palatal expander (RPE), 20 patients with Forsus appliance, 20 patients with a fixed multibracket appliance treatment, 20 patients with just the lower vestibular multibracket treatment and 20 patients with both upper and lower vestibular multibracket treatment...
April 2019: Minerva Stomatologica
https://read.qxmd.com/read/30854005/study-on-the-differences-between-traditional-chinese-medicine-syndromes-in-nyha-i-iv-classification-of-chronic-heart-failure
#6
Jun Shi, Liangtao Luo, Jing Chen, Juan Wang, Huihui Zhao, Wei Wang
Objectives: This study investigated the distribution of characteristics of traditional Chinese medicine syndromes and their association with symptoms in 1027 patients with chronic heart failure (CHF). Methods: An observational study was performed by researchers, collecting data from 1036 patients with CHF from 24 Chinese medicine hospitals from May 2009 to December 2014. Due to incomplete information from nine patients, 1027 patients with CHF were analysed. The distribution of syndromes in CHF and association between high-frequency syndromes and symptoms were investigated...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30848855/review-of-risk-assessment-of-major-anatomical-variations-in-clinical-dentistry-part-i-accessory-foramina-of-the-mandible
#7
REVIEW
Joe Iwanaga, Shogo Kikuta, Tsuyoshi Tanaka, Yasuhiko Kamura, R Shane Tubbs
Most of the studies of the mandible's anatomical variations have presented the authors' speculations, and only a limited number has provided evidence that demonstrated the actual complications injury to the variant structures caused. To our knowledge, no study has evaluated the risks associated with these variant anatomical structures' injury. We reviewed articles that described clinical cases of the injury to, and anatomical studies of, three anatomical variants of the mandible-the accessory mental, lingual, and retromolar foramina-with which dentists are relatively familiar and that are mentioned often in the context of implant and third molar surgeries, to describe risk assessment methods with which to evaluate potential complications preoperatively...
March 8, 2019: Clinical Anatomy
https://read.qxmd.com/read/30845087/do-cleft-lip-and-palate-types-affect-health-related-quality-of-life-of-adolescents
#8
Thainara Alves Crepaldi, Luciana Lourenço Ribeiro Vitor, Cleide Felicio Carvalho Carrara, Daniela Rios, Thiago Cruvinel, Ana Lúcia Pompéia Fraga Almeida, Simone Soares, Maria Aparecida Andrade Moreira Machado, Thais Marchini Oliveira
The adolescent with oral cleft must deal with the process of body changing and the psychological implications caused by morphological, functional, and esthetic impairments of the cleft itself. This study aimed to evaluate whether the cleft lip and palate types affects health-related quality of life of adolescents through Short-form Health Survey (SF-36) questionnaire. Fifty-seven adolescents (29 males and 28 females; mean age 15 years and 11 months ± 1 year and 2 months) were divided into 2 groups: Group 1-single cleft-unilateral or bilateral CL or CP; Group 2-complex cleft-unilateral or bilateral cleft lip and palate...
February 9, 2019: Journal of Craniofacial Surgery
https://read.qxmd.com/read/30840052/head-and-neck-cancer-prevention-from-primary-prevention-to-impact-of-clinicians-on-reducing-burden
#9
Dana Hashim, Eric Genden, Marshall Posner, Mia Hashibe, Paolo Boffetta
Survival from head and neck cancers (HNCs) of the lip, oral cavity, pharynx, and larynx has increased by 10% over the past few decades. Little over half of patients who develop HNCs will survive beyond five years. Survival is lower for individuals in many countries where traditional risk factors such as tobacco smoking, alcohol drinking, and betel quid chewing are highly prevalent but tertiary healthcare center access is limited or unavailable. Early diagnosis of HNC is the most important prognostic factor for each tumor site...
March 6, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/30839156/a-pilot-study-of-occupational-exposure-to-pathogenic-microorganisms-through-lip-cosmetics-among-dental-hygienists
#10
Im-Hee Jung, Ji-Hye Kim, Yun-Jung Yoo, Bo-Young Park, Eun-Sil Choi, Hiejin Noh
OBJECTIVES: In dental clinics, dental hygienists are exposed to aerosolized pathologic bacteria, which can be transmitted to the oral cavity via lip cosmetics. Accordingly, such contamination poses a consistent health risk among staffs. Our study examined the bacterial contamination of lip cosmetics used by dental hygienists while in a clinic setting. METHODS: Sixteen dental hygienists were surveyed regarding their job assignments and habits associated with lip cosmetic...
March 6, 2019: Journal of Occupational Health
https://read.qxmd.com/read/30820419/clinicopathologic-trends-in-pediatric-oral-biopsies-a-10-year-institutional-archival-study
#11
Varsha Salian, Pushparaja Shetty
Aim: The aim of this study is to determine the clinicopathologic trends in oral pathological biopsies in children aged 14 years and below received for histopathological diagnosis in the institution. Materials and Methods: The archives of the Department of Oral Pathology and Microbiology were retrospectively analyzed. Biopsy records of all oral lesions from pediatric patients, aged 0-14 years, in the files of the Department of Oral Pathology and Microbiology, A B Shetty Memorial Institute of Dental Sciences, Mangalore, DK, from 2007 to 2017 were considered...
January 2019: International Journal of Applied and Basic Medical Research
https://read.qxmd.com/read/30820086/perception-of-smile-attractiveness-among-orthodontists-restorative-dentists-and-laypersons-in-saudi-arabia
#12
Raed Almanea, Alanood Modimigh, Fayyad Almogren, Emad Alhazzani
Background: A smile is defined as a universal welcome. The perception of smile attractiveness is affected by the persons' social background and their own experiences. The existing literature states that orthodontists, restorative dentists, and laypersons have different opinions. Aims: The aim of this study is to compare the perception of orthodontists, restorative dentists, and laypersons regarding smile esthetics. Materials and Methods: A survey-based study was conducted...
January 2019: Journal of Conservative Dentistry: JCD
https://read.qxmd.com/read/30819360/direct-oral-anticoagulants-in-patients-with-nonvalvular-atrial-fibrillation-and-low-body-weight
#13
So-Ryoung Lee, Eue-Keun Choi, Chan Soon Park, Kyung-Do Han, Jin-Hyung Jung, Seil Oh, Gregory Y H Lip
BACKGROUND: It is unclear whether the overall effectiveness and safety of direct oral anticoagulants (DOACs) are consistent in patients with nonvalvular atrial fibrillation (AF) and extremely low body weight (<50 kg). OBJECTIVES: This study compared DOACs with warfarin in AF patients with low body weight. METHODS: Using data from the Korean National Health Insurance Service database from January 2014 to December 2016, AF patients with body weight ≤60 kg and who were treated with oral anticoagulants (n = 14,013 taking DOACs and n = 7,576 taking warfarin) were included and examined for ischemic stroke, intracranial hemorrhage (ICH), gastrointestinal bleeding, major bleeding, all-cause death, and composite outcome...
March 5, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30817507/difference-in-degrees-of-satisfaction-with-orthognathic-surgery-and-orthodontic-treatment-between-skeletal-class-iii-and-cleft-patients
#14
Sunjin Yim, Seung-Hak Baek
OBJECTIVE: The aim of this study was to compare the degrees of satisfaction with orthognathic surgery and orthodontic treatment between skeletal Class III and cleft patients. MATERIALS AND METHODS: The samples consisted of Class III group (N = 25) and Cleft group (N = 16). The Modified Orthognathic Quality of Life Questionnaires, which had 5 domains (oral function [OF], awareness of dentofacial deformity [ADD], social relationship [SR], facial esthetics [FE], and nose/lip esthetics [NLE]), were evaluated with 5 rates (0 [very satisfactory] to 4 [very unsatisfactory]) at initial visit (T1), just before surgery (T2), 3 to 6 months after surgery (T3), and at debonding or 1 year after surgery (T4)...
February 25, 2019: Journal of Craniofacial Surgery
https://read.qxmd.com/read/30816013/association-between-mortality-and-implantable-cardioverter-defibrillators-by-aetiology-of-heart-failure-a-propensity-matched-analysis-of-the-warcef-trial
#15
Tetz C Lee, Min Qian, Lan Mu, Marco R Di Tullio, Susan Graham, Douglas L Mann, Koki Nakanishi, John R Teerlink, Gregory Y H Lip, Ronald S Freudenberger, Ralph L Sacco, Jay P Mohr, Arthur J Labovitz, Piotr Ponikowski, Dirk J Lok, Conrado Estol, Stefan D Anker, Patrick M Pullicino, Richard Buchsbaum, Bruce Levin, John L P Thompson, Shunichi Homma, Siqin Ye
AIMS: There is debate on whether the beneficial effect of implantable cardioverter-defibrillators (ICDs) is attenuated in patients with non-ischaemic cardiomyopathy (NICM). We assess whether any ICD benefit differs between patients with NICM and those with ischaemic cardiomyopathy (ICM), using data from the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) trial. METHODS AND RESULTS: We performed a post hoc analysis using WARCEF (N = 2293; ICM, n = 991 vs...
February 27, 2019: ESC Heart Failure
https://read.qxmd.com/read/30815431/evaluation-of-facial-appearance-in-patients-with-repaired-cleft-lip-and-palate-comparing-the-assessment-of-laypeople-and-healthcare-professionals
#16
Samar Alhayek, Mohammed Alsalem, Yazeed Alotaibi, Aamir Omair
Background: The present study aimed to determine whether laypeople and professionals rate the facial appearance of individuals with repaired complete unilateral or bilateral cleft lip and palate (UCLP, BCLP) similarly based on viewing full facial images. Methods: The study followed a cross-sectional analytical design where five young patients aged 10 to 14 years, who had completed all stages of their unilateral or bilateral cleft lip and palate treatment (bilateral: three, unilateral: two), were evaluated by two groups...
December 2019: Maxillofacial Plastic and Reconstructive Surgery
https://read.qxmd.com/read/30815213/refined-approach-to-preservation-of-the-inferior-alveolar-nerve-during-resection-and-primary-reconstruction-of-the-mandible
#17
Sergey Tereshchuk, Vladimir Sukharev
Sacrifice of the inferior alveolar nerve (IAN) during resection of the mandible is taken as a rule. In 1987, Jensen and Nock described a technique that permitted placement of dental implants in the atrophied mandibular alveolar ridge that lacked sufficient vertical height superior to the mandibular canal. This technique was used by some authors to preserve continuity of the IAN during resection of the mandible in patients with benign tumors. The described techniques are traumatic, time-consuming, and not precise...
March 2019: Craniomaxillofacial Trauma & Reconstruction
https://read.qxmd.com/read/30807497/modified-selective-neurectomy-for-the-treatment-of-post-facial-paralysis-synkinesis
#18
Babak Azizzadeh, Leslie E Irvine, Jaqueline Diels, William H Slattery, Guy G Massry, Babak Larian, Kiersten L Riedler, Grace Lee Peng
BACKGROUND: In order to address functional and smile dysfunction associated with post-facial paralysis synkinesis, the senior author (BA) has offered "modified selective neurectomy" of the lower division of the facial nerve as a long-term solution. This article examines technical considerations and outcomes of this procedure. METHODS: A retrospective review was conducted of patients who underwent modified selective neurectomy of buccal and cervical branches of the facial nerve by a single surgeon over a four-and-a-half-year period...
February 14, 2019: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/30805813/cancer-incidence-in-the-agricultural-health-study-after-20-years-of-follow-up
#19
Catherine C Lerro, Stella Koutros, Gabriella Andreotti, Dale P Sandler, Charles F Lynch, Lydia M Louis, Aaron Blair, Christine G Parks, Srishti Shrestha, Jay H Lubin, Paul S Albert, Jonathan N Hofmann, Laura E Beane Freeman
PURPOSE: To evaluate cancer incidence in the Agricultural Health Study (AHS), a cohort of private pesticide applicators, their spouses, and commercial applicators, based on 12,420 cancers, adding 5,989 cancers, and 9 years of follow-up since last evaluation. METHODS: We calculated age, year, sex, and race-adjusted standardized incidence ratios (SIR) and 95% confidence intervals (CI) for cancer sites in the AHS relative to the general population. RESULTS: Overall AHS cancer incidence was lower than the general population (SIRprivate  = 0...
February 25, 2019: Cancer Causes & Control: CCC
https://read.qxmd.com/read/30804066/effects-of-weakness-of-orofacial-muscles-on-swallowing-and-communication-in-fshd
#20
Karlien Mul, Kiera N Berggren, Mattie Y Sills, Ayla McCalley, Baziel G M van Engelen, Nicholas E Johnson, Jeffrey M Statland
OBJECTIVE: This study explores the use of quantitative data on strength and fatigability of orofacial muscles in patients with facioscapulohumeral muscular dystrophy (FSHD) and assesses the frequency of swallowing and communication difficulties and their relationship to orofacial muscle involvement. METHODS: We included 43 patients with FSHD and 35 healthy controls and used the Iowa Oral Performance Instrument (IOPI) to obtain quantitative measurements of strength and endurance of lip compression, cheek (buccodental) compression, and tongue elevation...
February 26, 2019: Neurology
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